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Fabrizio Chiti

university of florence

63H指数
240论文数
2.8W被引数
收录论文 116
发表时间
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Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome-linked mutations解析FMRP结构域在体外的相分离和聚集特性以及脆性X综合征相关突变的影响
errthe febs journal
IF0
err2026-05-02
err0
errOAAI
errFlavia Catalano; Alessandra Bigi; Francesca Troilo; Federica Gabriele; Gianluca Pistoia; Italia A. Asteriti; Francesco Angelucci; Giorgio Giardina; Fabrizio Chiti; Carlo Travaglini-Allocatelli; Adele Di Matteo
err分享
err收藏
Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates细胞朊蛋白和钙离子触发α-突触核蛋白聚集体的神经毒性
errCell & Bioscience
IF0
err2025-12-09
err0
errOAAI
errAlessandra Bigi; Andrea Carlotta Conti; Liliana Napolitano; Giuliana Fusco; Alfonso De Simone; Fabrizio Chiti; Roberta Cascella; Cristina Cecchi
err分享
err收藏
Natural aminosterols inhibit NMDA receptors with low nanomolar potency天然氨基类固醇以低纳摩尔级的效力抑制NMDA受体
errFEBS JOURNAL
IF4.2
err2025-03-24
err0
errOAAI
errGiulia Fani; Elisabetta Coppi; Silvia Errico; Federica Cherchi; Martina Gennari; Denise Barbut; Michele Vendruscolo; Michael Zasloff; Anna Maria Pugliese; Fabrizio Chiti
err分享
err收藏
Detection of an Intermediate in the Unfolding Process of the N-Terminal Domain of TDP-43
errACS OMEGA
IF4.3
err2025-02-05
err0
errOAAI
errMarzi, Isabella; Pieraccini, Giuseppe; Bemporad, Francesco; Chiti, Fabrizio
err分享
err收藏
Evolving concepts of the protein universe蛋白质宇宙的演变概念
errISCIENCE
IF4.1
err2025-02-01
err0
errOAAI
errKulkarni, Prakash; Porter, Lauren; Chou, Tsui-Fen; Chong, Shasha; Chiti, Fabrizio; Schafer, Joseph W.; Mohanty, Atish; Ramisetty, Sravani; Onuchic, Jose N.; Tuite, Mick; Weninger, Keith R.; Koonin, Eugene, V; Salgia, Ravi
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Structural commonalities determined by physicochemical principles in the complex polymorphism of the amyloid state of proteins蛋白质淀粉样状态的复杂多态性中由理化原理确定的结构共性
errBIOCHEMICAL JOURNAL
IF4.3
err2025-01-22
err0
errOAAI
errErrico, Silvia; Fani, Giulia; Ventura, Salvador; Schymkowitz, Joost; Rousseau, Frederic; Trovato, Antonio; Vendruscolo, Michele; Bemporad, Francesco; Chiti, Fabrizio
err分享
err收藏
Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain缺乏C末端结构域的TDP-43的相分离的生物物理表征
errCELLULAR & MOLECULAR BIOLOGY LETTERS
IF10.2
err2024-07-13
err0
errOAAI
errStaderini, Tommaso; Bigi, Alessandra; Lagreve, Clement; Marzi, Isabella; Bemporad, Francesco; Chiti, Fabrizio
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Leveraging Machine Learning-Guided Molecular Simulations Coupled with Experimental Data to Decipher Membrane Binding Mechanisms of Aminosterols
errJOURNAL OF CHEMICAL THEORY AND COMPUTATION
IF5.5
err2024-07-09
err0
errOAAI
errMuscat, Stefano; Errico, Silvia; Danani, Andrea; Chiti, Fabrizio; Grasso, Gianvito
err分享
err收藏
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein CondensatesΑ-突触核蛋白缩合物中间原纤维的结构-毒性关系
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-04-03
err6
errOAAI
errChen, Serene W.; Barritt, Joseph D.; Cascella, Roberta; Bigi, Alessandra; Cecchi, Cristina; Banchelli, Martina; Gallo, Angelo; Jarvis, James A.; Chiti, Fabrizio; Dobson, Christopher M.; Fusco, Giuliana; De Simone, Alfonso
err分享
err收藏
Putative novel CSF biomarkers of Alzheimer's disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort基于通用蛋白质错误折叠和蛋白质毒性的新概念，推定阿尔茨海默氏病的新型CSF生物标志物: PRAMA队列
errTRANSLATIONAL NEURODEGENERATION
IF15.2
err2024-03-08
err2
errOAAI
errBigi, Alessandra; Fani, Giulia; Bessi, Valentina; Napolitano, Liliana; Bagnoli, Silvia; Ingannato, Assunta; Neri, Lorenzo; Cascella, Roberta; Matteini, Paolo; Sorbi, Sandro; Nacmias, Benedetta; Cecchi, Cristina; Chiti, Fabrizio
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err收藏
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
errMOLECULAR NEURODEGENERATION
IF17.5
err2024-02-20
err22
errOAAI
errRinauro, Dillon J.; Chiti, Fabrizio; Vendruscolo, Michele; Limbocker, Ryan
err分享
err收藏
A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer's disease CSF单域抗体检测并中和阿尔茨海默氏病CSF中的有毒Aβ42寡聚体
errALZHEIMERS RESEARCH & THERAPY
IF7.6
err2024-01-18
err5
errOAAI
errBigi, Alessandra; Napolitano, Liliana; Vadukul, Devkee M.; Chiti, Fabrizio; Cecchi, Cristina; Aprile, Francesco A.; Cascella, Roberta
err分享
err收藏
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-07-11
err6
errOAAI
errErrico, Silvia; Lucchesi, Giacomo; Odino, Davide; Osman, Enass Youssef; Cascella, Roberta; Neri, Lorenzo; Capitini, Claudia; Calamai, Martino; Bemporad, Francesco; Cecchi, Cristina; Kinney, William A.; Barbut, Denise; Relini, Annalisa; Canale, Claudio; Caminati, Gabriella; Limbocker, Ryan; Vendruscolo, Michele; Zasloff, Michael; Chiti, Fabrizio
err分享
err收藏
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases对有毒和无毒错误折叠的蛋白质低聚物的表征阐明了蛋白质错误折叠疾病中低聚物毒性的结构决定因素
errACCOUNTS OF CHEMICAL RESEARCH
IF17.7
err2023-04-18
err16
errOAAI
errLimbocker, Ryan; Cremades, Nunilo; Cascella, Roberta; Tessier, Peter M.; Vendruscolo, Michele; Chiti, Fabrizio
err分享
err收藏
Reorganization of the outer layer of a model of the plasma membrane induced by a neuroprotective aminosterol
errCOLLOIDS AND SURFACES B-BIOINTERFACES
IF5.6
err2023-02-01
err7
PREAI
errBarletti, Beatrice; Lucchesi, Giacomo; Muscat, Stefano; Errico, Silvia; Barbut, Denise; Danani, Andrea; Zasloff, Michael; Grasso, Gianvito; Chiti, Fabrizio; Caminati, Gabriella
err分享
err收藏
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature对细胞质TDP-43内含物的原位和体外研究表明，不存在明显的淀粉样蛋白特征。
errANNALS OF MEDICINE
IF4.3
err2022-12-10
err3
errOAAI
errCascella, Roberta; Banchelli, Martina; Abolghasem Ghadami, Seyyed; Ami, Diletta; Gagliani, Maria Cristina; Bigi, Alessandra; Staderini, Tommaso; Tampellini, Davide; Cortese, Katia; Cecchi, Cristina; Natalello, Antonino; Adibi, Hadi; Matteini, Paolo; Chiti, Fabrizio
err分享
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Studying the trafficking of labeled trodusquemine and its application as nerve marker for light-sheet and expansion microscopy
errFASEB JOURNAL
IF4.2
err2022-11-24
err4
errOAAI
errCapitini, Claudia; Pesce, Luca; Fani, Giulia; Mazzamuto, Giacomo; Genovese, Massimo; Franceschini, Alessandra; Paoli, Paolo; Pieraccini, Giuseppe; Zasloff, Michael; Chiti, Fabrizio; Pavone, Francesco S.; Calamai, Martino
err分享
err收藏
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases淀粉样蛋白原纤维充当可溶性低聚物的储库，这是蛋白质沉积疾病的主要罪魁祸首
errBIOESSAYS
IF2.7
err2022-09-14
err23
errOAAI
errBigi, Alessandra; Cascella, Roberta; Chiti, Fabrizio; Cecchi, Cristina
err分享
err收藏
The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes结构动力学在超嗜热酶的热适应中的作用
errFRONTIERS IN MOLECULAR BIOSCIENCES
IF4
err2022-09-07
err4
errOAAI
errFusco, Giuliana; Bemporad, Francesco; Chiti, Fabrizio; Dobson, Christopher M. M.; De Simone, Alfonso
err分享
err收藏
Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2022-08-27
err16
errOAAI
errFani, Giulia; La Torre, Chiara Ester; Cascella, Roberta; Cecchi, Cristina; Vendruscolo, Michele; Chiti, Fabrizio
err分享
err收藏

研究方向

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合作学者
合作期刊
C
Christopher M. Dobson
H 指数: 162 · 论文数: 1.1K
C
Carol V. Robinson
H 指数: 132 · 论文数: 818
P
Philip N. Hawkins
H 指数: 127 · 论文数: 1.0K
G
Giampaolo Merlini
H 指数: 121 · 论文数: 1.1K
J
Jeffery W. Kelly
H 指数: 119 · 论文数: 612
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