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HER2-targeted star polymer conjugates for improved tumor distribution and efficacy 靶向HER2的星形聚合物偶联物，用于改善肿瘤分布和疗效 Sonzini, Silvia; England, Richard M.; Kapustin, Alexander N.; Moss, Jennifer I.; Sutton, Daniel; Smith, Aaron; Sharma, Soumya; Siouve, Elise; Mazza, Mariarosa; Ravn, Peter; Puri, Sanya; Ashford, Marianne 分享 收藏
Metabolism-driven in vitro/in vivo disconnect of an oral ERα VHL-PROTAC Hayhow, Thomas G.; Williamson, Beth; Lawson, Mandy; Cureton, Natalie; Braybrooke, Erin L.; Campbell, Andrew; Carbajo, Rodrigo J.; Cheraghchi-Bashi, Azadeh; Chiarparin, Elisabetta; Diene, Coura R.; Fallan, Charlene; Fisher, David I.; Goldberg, Frederick W.; Hopcroft, Lorna; Hopcroft, Philip; Jackson, Anne; Kettle, Jason G.; Klinowska, Teresa; Kuenzel, Ulrike; Lamont, Gillian; Lewis, Hilary J.; Maglennon, Gareth; Martin, Scott; Gutierrez, Pablo Morentin; Morrow, Christopher J.; Nikolaou, Myria; Nissink, J. Willem M.; O'Shea, Patrick; Polanski, Radoslaw; Schade, Markus; Scott, James S.; Smith, Aaron; Weber, Judith; Wilson, Joanne; Yang, Bin; Crafter, Claire 分享 收藏
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Efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients (pts) with solid tumors harboring specific HER2-activating mutations (HER2m): Primary results from the international phase II DESTINY-PanTumor01 (DPT-01) study Li, B. T.; Meric-Bernstam, F.; Bardia, A.; Naito, Y.; Siena, S.; Aftimos, P. G.; Anderson, I.; Curigliano, G.; De Miguel Luken, M. J.; Kalra, M.; Oh, D-Y.; Park, J. O.; Postel-Vinay, S.; Rha, S. Y.; Satoh, T.; Spanggaard, I.; Michelini, F.; Smith, A.; Machado, K. Kalil; Saura Manich, C. 分享 收藏
Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging Strittmatter, Nicole; Richards, Frances M.; Race, Alan M.; Ling, Stephanie; Sutton, Daniel; Nilsson, Anna; Wallez, Yann; Barnes, Jennifer; Maglennon, Gareth; Gopinathan, Aarthi; Brais, Rebecca; Wong, Edmond; Serra, Maria Paola; Atkinson, James; Smith, Aaron; Wilson, Joanne; Hamm, Gregory; Johnson, Timothy, I; Dunlop, Charles R.; Kaistha, Brajesh P.; Bunch, Josephine; Sansom, Owen J.; Takats, Zoltan; Andren, Per E.; Lau, Alan; Barry, Simon T.; Goodwin, Richard J. A.; Jodrell, Duncan, I 分享 收藏
Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution Strittmatter, Nicole; Moss, Jennifer, I; Race, Alan M.; Sutton, Daniel; Canales, Jaime Rodriguez; Ling, Stephanie; Wong, Edmond; Wilson, Joanne; Smith, Aaron; Howes, Colin; Bunch, Josephine; Barry, Simon T.; Goodwin, Richard J. A.; Ashford, Marianne B. 分享 收藏
Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response 用于评估药物药代动力学和治疗反应的片上肿瘤微流控平台 Petreus, Tudor; Cadogan, Elaine; Hughes, Gareth; Smith, Aaron; Reddy, Venkatesh Pilla; Lau, Alan; O'Connor, Mark James; Critchlow, Susan; Ashford, Marianne; O'Connor, Lenka Oplustil 分享 收藏
ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156 Koneru, Balakrishna; Farooqi, Ahsan; Nguyen, Thinh H.; Chen, Wan Hsi; Hindle, Ashly; Eslinger, Cody; Makena, Monish Ram; Burrow, Trevor A.; Wilson, Joanne; Smith, Aaron; Reddy, Venkatesh Pilla; Cadogan, Elaine; Durant, Stephen T.; Reynolds, C. Patrick 分享 收藏
AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib Flemington, Vikki; Davies, Emma J.; Robinson, David; Sandin, Linda C.; Delpuech, Oona; Zhang, Pei; Hanson, Lyndsey; Farrington, Paul; Bell, Sigourney; Falenta, Katarzyna; Gibbons, Francis D.; Lindsay, Nicola; Smith, Aaron; Wilson, Joanne; Roberts, Karen; Tonge, Michael; Hopcroft, Philip; Willis, Sophie E.; Roudier, Martine P.; Rooney, Claire; Coker, Elizabeth A.; Jaaks, Patricia; Garnett, Mathew J.; Fawell, Stephen E.; Jones, Clifford D.; Ward, Richard A.; Simpson, Iain; Cosulich, Sabina C.; Pease, J. Elizabeth; Smith, Paul D. 分享 收藏
Preclinical mechanistic PK/PD-efficacy modeling for AZD9833, a novel next generation oral SERD, to support dose selection during early clinical development Gutierrez, Pablo Morentin; Morrow, Christopher; Cureton, Natalie; Lawson, Mandy; Trueman, Dawn; Gangl, Eric; Wilson, Joanne; Smith, Aaron; Scott, James; Klinowska, Teresa 分享 收藏
Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically Riches, Lucy C.; Trinidad, Antonio G.; Hughes, Gareth; Jones, Gemma N.; Hughes, Adina M.; Thomason, Andrew G.; Gavine, Paul; Cui, Andy; Ling, Stephanie; Stott, Jonathan; Clark, Roger; Peel, Samantha; Gill, Pendeep; Goodwin, Louise M.; Smith, Aaron; Pike, Kurt G.; Barlaam, Bernard; Pass, Martin; O'Connor, Mark J.; Smith, Graeme; Cadogan, Elaine B. 分享 收藏
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AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity Fok, Jacqueline H. L.; Ramos-Montoya, Antonio; Vazquez-Chantada, Mercedes; Wijnhoven, Paul W. G.; Follia, Valeria; James, Neil; Farrington, Paul M.; Karmokar, Ankur; Willis, Sophie E.; Cairns, Jonathan; Nikkila, Jenni; Beattie, David; Lamont, Gillian M.; Finlay, M. Raymond, V; Wilson, Joanne; Smith, Aaron; O'Connor, Lenka Oplustil; Ling, Stephanie; Fawell, Stephen E.; O'Connor, Mark J.; Hollingsworth, Simon J.; Dean, Emma; Goldberg, Frederick W.; Davies, Barry R.; Cadogan, Elaine B. 分享 收藏
Quantifying Drug-Induced Bone Marrow Toxicity Using a Novel Haematopoiesis Systems Pharmacology Model Fornari, Chiara; O'Connor, Lenka Oplustil; Pin, Carmen; Smith, Aaron; Yates, James W. T.; Cheung, S. Y. Amy; Jodrell, Duncan, I; Mettetal, Jerome T.; Collins, Teresa A. 分享 收藏
Dose optimization of olaparib plus temozolomide in small cell lung cancer (SCLC) patient-derived xenograft (PDX) models for clinical translation Drapkin, Benjamin J.; Phat, Sarah; Myers, David T.; Zhong, Jun; Yeap, Beow Y.; Leo, Elisabetta; Stansiszewska, Anna; Smith, Aaron; Cadogan, Elaine; Pietanza, Maria C.; Dyson, Nicholas J.; Farago, Anna 分享 收藏
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Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic Ramurthy, Savithri; Taft, Benjamin R.; Aversa, Robert J.; Barsanti, Paul A.; Burger, Matthew T.; Lou, Yan; Nishiguchi, Gisele A.; Rico, Alice; Setti, Lina; Smith, Aaron; Subramanian, Sharadha; Tamez, Victoriano; Tanner, Huw; Wan, Lifeng; Hu, Cheng; Appleton, Brent A.; Mamo, Mulugeta; Tandeske, Laura; Tellew, John E.; Huang, Shenlin; Yue, Qn; Cliaudliary, Apurva; Tian, Hung; Iyer, Raman; Hassan, A. Quamrul; Griner, Lesley A. Mathews; La Bonte, Laura R.; Cooke, Vesselina G.; Van Abbema, Anne; Merritt, Hanne; Gampa, Kalyani; Feng, Fei; Yuan, Jing; Mishina, Yuji; Wang, Yingyun; Haling, Jacob R.; Vaziri, Sepideh; Hekmat-Nejad, Mohammad; Polyakov, Valery; Zang, Richard; Sethuraman, Vijay; Amiri, Payman; Singh, Mallika; Sellers, William R.; Lees, Emma; Shao, Wenlin; Dillon, Michael P.; Stuart, Darrin D. 分享 收藏
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