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S

Saffie Mohran

university of washington
H指数:6
被引数:199

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Myosin Modulator Aficamten Inhibits Force by Altering Myosin's Biochemical Activity Without Changing Thick Filament Structure
JACC-BASIC TO TRANSLATIONAL SCIENCE
IF7.2
2026-01-010
OAAI
Mohran, Saffie; Kooiker, Kristina B.; Naim, Ateeqa; Pilagov, Matvey; Asencio, Anthony; Turner, Kyrah L.; Ma, Weikang; Flint, Galina; Jiang, Siyao; Zhao, Jing; Mcmillen, Timothy S.; Mandrycky, Christian; Mahoney-Schaefer, Max; Irving, Thomas C.; Tanner, Bertrand C. W.; Kad, Neil M.; Regnier, Michael; Moussavi-Harami, Farid
Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model1

β-肌球蛋白R403Q突变导致收缩功能改变的分子机制：猪心室肌及人源性干细胞诱导的心肌细胞模型研究1

Journal of Molecular and Cellular Cardiology
IF4.7
2025-10-280
PRE
Sonette Steczina; Saffie Mohran; Matthew C. Childers; Timothy S. McMillen; Ateeqa Naim; Matvey Pilagov; Marica Dente; Kristina B. Kooiker; Christian Mandrycky; Khushi Tawde; Jennifer Hesson; Jing Zhao; Julie Mathieu; J. Manuel Pioner; Michael A. Geeves; Weikang Ma; Farid Moussavi-Harami; Neil M. Kad; Michael Regnier
Danicamtiv, a selective agonist of cardiac myosin, for dilated cardiomyopathy: A Phase 2 open-label trial

Danicamtiv，一种心脏肌球蛋白选择性激动剂，用于扩张型心肌病：一项II期开放标签试验

JACC
IF0
2025-09-290
OAAI
Neal K. Lakdawala; Ray E. Hershberger; Pablo Garcia-Pavia; Perry Mark Elliott; Jonathan Ginns; Benjamin Meder; Scott Solomon; Jonathan W. Cunningham; Juan R. Gimeno; Roberto Barriales-Villa; Eric Adler; Brenda Gerull; Naveen L. Pereira; Brian P. Halliday; Wanying Li; Praneeth Jarugula; Sonomi Maruyama; Saffie E. Mohran; Maria Papadaki; Anu R. Anto; Robert L. Anderson; Hector M. Rodriguez; Carlos L. del Rio; Jay M. Edelberg; Gregory Kurio; Juan Maya; James L. Januzzi
MYBPC3-c.772G > A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
IF4.7
2024-06-012
PRE
Steczina, Sonette; Mohran, Saffie; Bailey, Logan R. J.; McMillen, Timothy S.; Kooiker, Kristina B.; Wood, Neil B.; Davis, Jennifer; Previs, Michael J.; Olivotto, Iacopo; Pioner, Jose Manuel; Geeves, Michael A.; Poggesi, Corrado; Regnier, Michael
Incomplete- penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2024-04-293
OAAI
Lee, Soah; Roestd, Alison S. Vander; Blair, Cheavar A.; Kaoh, Kerry; Bremner, Samantha B.; Childers, Matthew C.; Pathak, Divya; Heinrich, Paul; Lee, Daniel; Chirikian, Orlando; Mohran, Saffie E.; Roberts, Brock; Smith, Jacqueline E.; Jahng, James W.; Paik, David T.; Wu, Joseph C.; Gunawardane, Ruwanthi N.; Ruppel, Kathleen M.; Mack, David L.; Pruitt, Beth L.; Regnier, Michael; Wu, Sean M.; Spudich, James A.; Bernstein, Daniel
Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle
CIRCULATION RESEARCH
IF16.2
2023-08-1810
OAAI
Kooiker, Kristina B.; Mohran, Saffie; Turner, Kyrah L.; Ma, Weikang; Martinson, Amy; Flint, Galina; Qi, Lin; Gao, Chengqian; Zheng, Yahan; Mcmillen, Timothy S.; Mandrycky, Christian; Mahoney-Schaefer, Max; Freeman, Jeremy C.; Arenas, Elijah Gabriela Costales; Tu, An-Yu; Irving, Thomas C.; Geeves, Michael A.; Tanner, Bertrand C. W.; Regnier, Michael; Davis, Jennifer; Moussavi-Harami, Farid
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin

通过增加与肌动蛋白的静电相互作用，用2-脱氧-atp激活心脏肌球蛋白

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2019-05-2030
OAAI
Powers, Joseph D.; Yuan, Chen-Ching; McCabe, Kimberly J.; Murray, Jason D.; Childers, Matthew Carter; Flint, Galina V.; Moussavi-Harami, Farid; Mohran, Saffie; Castillo, Romi; Zuzek, Carla; Ma, Weikang; Daggett, Valerie; McCulloch, Andrew D.; Irving, Thomas C.; Regnier, Michael

研究方向

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M
Michael Regnier
H 指数:52论文数:386被引数:1.1万
W
Weikang Ma
H 指数:25论文数:172被引数:2,061
F
Farid Moussavi‐Harami
H 指数:17论文数:85被引数:1,238
K
Kristina B. Kooiker
H 指数:14论文数:63被引数:1,033
T
Thomas C. Irving
H 指数:52论文数:366被引数:1.0万
C
Christian Mandrycky
H 指数:14论文数:45被引数:2,383
T
Timothy S. McMillen
H 指数:22论文数:69被引数:1,570
G
Galina Flint
H 指数:9论文数:30被引数:672
M
Michael A. Geeves
H 指数:65论文数:333被引数:1.3万
M
Matthew C. Childers
H 指数:15论文数:90被引数:1,161