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L

Laura E. Stevens

Dana-Farber Cancer Institute
H指数:13
被引数:1,169

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Histone H4 lysine 20 tri-methylation safeguards breast cancer lineage fidelity and unfolded protein response

组蛋白H4赖氨酸20三甲基化保护乳腺癌谱系保真度和未折叠蛋白反应

Nature Communications
IF15.7
2026-08-220
OA
Zheqi Li; Amatullah Tawawalla; Pierre Foidart; Marco Seehawer; Jun Nishida; Ernesto Rojas Jimenez; Triet M. Bui; Xiao-Yun Huang; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Laura E. Stevens; Miguel Munoz Gomez; Rong Li; Henry W. Long; Kornelia Polyak
A phase I clinical trial on the intracranial administration of autologous CD1c(BDCA-1)+ /CD141(BDCA-3)+ myeloid dendritic cells (myDC) in combination with ipilimumab (IPI) and nivolumab (NIVO) in patients with recurrent high-grade glioma (rHGG)

一项关于在复发性高级别胶质瘤(rHGG)患者中，联合应用ipilimumab (IPI)和nivolumab (NIVO)，并进行自体CD1c(BDCA-1)+/CD141(BDCA-3)+髓系树突状细胞(myDC)颅内给药的I期临床试验。

ANNALS OF ONCOLOGY
IF65.4
2024-09-010
PRE
Neyns, B.; Dirven, I.; Lescrauwaet, L.; Cammaert, M.; Geens, W.; Geeraerts, X.; Stevens, L.; Brock, S.; Kockx, M.; Everaert, H.; Van Binst, A-M.; Tuyaerts, S.; Duerinck, J.
Intratumoral (IT) administration of autologous CD1c(BDCA-1)+/CD141(BDCA-3)+myeloid dendritic cells (myDC) with the immunologic adjuvant AS01B plus ipilimumab (IPI) and IV nivolumab (NIVO) in patients with refractory advanced melanoma: A phase Ib clinical trial

在难治性晚期黑色素瘤患者中，通过瘤内（IT）途径给予自体CD1c（BDCA-1）+/CD141（BDCA-3）+髓样树突状细胞（myDC），联合免疫佐剂AS01B、ipilimumab（IPI）以及静脉注射nivolumab（NIVO）：一项 Ib 期临床试验

ANNALS OF ONCOLOGY
IF65.4
2024-09-010
PRE
Vounckx, M.; Dirven, I.; Kessels, J. I.; Stevens, L.; Geeraerts, X.; Boisson, A.; Van Riet, I.; Forsyth, R.; Willard-Gallo, K.; Tuyaerts, S.; Neyns, B.
Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx- mediated resistance to HER2targeting therapies
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2024-05-062
OAAI
Goyette, Marie-Anne; Stevens, Laura E.; Depinho, Carolyn R.; Seehawer, Marco; Nishida, Jun; Li, Zheqi; Wilde, Callahan M.; Li, Rong; Qiu, Xintao; Pyke, Alanna L.; Zhao, Stephanie; Lim, Klothilda; Tender, Gabrielle S.; Northey, Jason J.; Riley, Nicholas M.; Long, Henry W.; Bertozzi, Carolyn R.; Weaver, Valerie M.; Polyak, Kornelia
KDM4C histone demethylase connects redox balance to chromatin remodeling via histone H3 tail clipping
CANCER RESEARCH
IF16.6
2024-02-010
PRE
Li, Zheqi; Peluffo, Guillermo; Stevens, Laura; Qiu, Xintao; Seehawer, Marco; Huang, Xiao-Yun; Egri, Shawn; Papanastasiou, Malvina; Kingston, Natalie; D'Santos, Clive; Papachristou, Eva; Nishida, Jun; Evans, Kyle; Seo, Ji-Heui; Clement, Kendell; Temko, Daniel; Ekram, Muhammad; Rees, Matthew; Ronan, Melissa; Roth, Jennifer; Simeonov, Anton; Kales, Stephen; Rai, Ganesha; Lal-Nag, Madhu; Maloney, David; Jadhav, Ajit; Michor, Franziska; Meissner, Alex; Balko, Justin; Carroll, Jason; Freedman, Matthew; Long, Henry; Jaffe, Jacob; Polyak, Kornelia
TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer

TBCRC 039: 术前ruxolitinib联合或不联合紫杉醇治疗三阴性炎性乳腺癌的II期研究

BREAST CANCER RESEARCH
IF5.6
2024-01-314
OAAI
Lynce, Filipa; Stevens, Laura E.; Li, Zheqi; Brock, Jane E.; Gulvady, Anushree; Huang, Ying; Nakhlis, Faina; Patel, Ashka; Force, Jeremy M.; Haddad, Tufia C.; Ueno, Naoto; Stearns, Vered; Wolff, Antonio C.; Clark, Amy S.; Bellon, Jennifer R.; Richardson, Edward T.; Balko, Justin M.; Krop, Ian E.; Winer, Eric P.; Lange, Paulina; Hwang, E. Shelley; King, Tari A.; Tolaney, Sara M.; Thompson, Alastair; Gupta, Gaorav P.; Mittendorf, Elizabeth A.; Regan, Meredith M.; Overmoyer, Beth; Polyak, Kornelia
Heterogeneity and transcriptional drivers of triple-negative breast cancer
CELL REPORTS
IF6.9
2023-12-015
OAAI
Jovanovic, Bojana; Temko, Daniel; Stevens, Laura E.; Seehawer, Marco; Fassl, Anne; Murphy, Katherine; Anand, Jayati; Garza, Kodie; Gulvady, Anushree; Qiu, Xintao; Harper, Nicholas W.; Daniels, Veerle W.; Huang, Xiao-Yun; Ge, Jennifer Y.; Aleckovic, Masa; Pyrdol, Jason; Hinohara, Kunihiko; Egri, Shawn B.; Papanastasiou, Malvina; Vadhi, Raga; Font-Tello, Alba; Witwicki, Robert; Peluffo, Guillermo; Trinh, Anne; Shu, Shaokun; Diciaccio, Benedetto; Ekram, Muhammad B.; Subedee, Ashim; Herbert, Zachary T.; Wucherpfennig, Kai W.; Letai, Anthony G.; Jaffe, Jacob D.; Sicinski, Piotr; Brown, Myles; Dillon, Deborah; Long, Henry W.; Michor, Franziska; Polyak, Kornelia
JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States
CANCER RESEARCH
IF16.6
2022-11-2142
OAAI
Stevens, Laura E.; Peluffo, Guillermo; Qiu, Xintao; Temko, Daniel; Fassl, Anne; Li, Zheqi; Trinh, Anne; Seehawer, Marco; Jovanovic, Bojana; Aleckovic, Masa; Wilde, Callahan M.; Geck, Renee C.; Shu, Shaokun; Kingston, Natalie L.; Harper, Nicholas W.; Almendro, Vanessa; Pyke, Alanna L.; Egri, Shawn B.; Papanastasiou, Malvina; Clement, Kendell; Zhou, Ningxuan; Walker, Sarah; Salas, Jacqueline; Park, So Yeon; Frank, David A.; Meissner, Alexander; Jaffe, Jacob D.; Sicinski, Piotr; Toker, Alex; Michor, Franziska; Long, Henry W.; Overmoyer, Beth A.; Polyak, Kornelia
EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis
CANCER RESEARCH
IF16.6
2019-08-1550
OAAI
Peluffo, Guillermo; Subedee, Ashim; Harper, Nicholas W.; Kingston, Natalie; Jovanovic, Bojana; Flores, Felipe; Stevens, Laura E.; Beca, Francisco; Trinh, Anne; Chilamakuri, Chandra Sekhar Reddy; Papachristou, Evangelia K.; Murphy, Katherine; Su, Ying; Marusyk, Andriy; D'Santos, Clive S.; Rueda, Oscar M.; Beck, Andrew H.; Caldas, Carlos; Carroll, Jason S.; Polyak, Kornelia
T24 HRAS transformed NIH/3T3 mouse cells (GhrasT-NIH/3T3) in serial tumorigenic in vitro/in vivo passages give rise to increasingly aggressive tumorigenic cell lines T1-A and T2-A and metastatic cell lines T3-HA and T4-PA
EXPERIMENTAL CELL RESEARCH
IF3.5
2016-01-013
OAAI
Ray, Durwood B.; Merrill, Gerald A.; Brenner, Frederic J.; Lytle, Laurie S.; Lam, Tan; McElhinney, Aaron; Anders, Joel; Rock, Tara Tauber; Lyker, Jennifer Kier; Barcus, Scott; Leslie, Kara Hust; Kramer, Jill M.; Rubenstein, Eric M.; Schanz, Karen Pryor; Parkhurst, Amy J.; Peck, Michelle; Good, Kimberly; Granath, Kristi Lemke; Cifra, Nicole; Detweiler, Jessalee Wantz; Stevens, Laura; Albertson, Richard; Deir, Rachael; Stewart, Elisabeth; Wingard, Katherine; Richardson, Micah Rose; Blizard, Sarah B.; Gillespie, Lauren E.; Kriley, Charles E.; Rzewnicki, Daniel I.; Jones, David H.

研究方向

暂未获取到该数据
K
Kornélia Polyák
H 指数:106论文数:673被引数:7.7万
M
Marco Seehawer
H 指数:15论文数:71被引数:2,146
H
Henry W. Long
H 指数:56论文数:622被引数:1.2万
Z
Zheqi Li
H 指数:29论文数:306被引数:2,860
D
Don X. Nguyen
H 指数:32论文数:246被引数:1.1万
X
Xintao Qiu
H 指数:31论文数:389被引数:4,945
Z
Zongzhi Liu
H 指数:35论文数:273被引数:4,494
J
Jun Nishida
H 指数:31论文数:199被引数:3,606
G
Guillermo Peluffo
H 指数:12论文数:73被引数:1,778
T
Thomas F. Westbrook
H 指数:48论文数:162被引数:1.4万