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Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders 丘脑皮质类器官可以对与神经精神疾病相关的22 q11.2微缺失进行体外建模 Shin, David; Kim, Chang N.; Ross, Jayden; Hennick, Kelsey M.; Wu, Sih-Rong; Paranjape, Neha; Leonard, Rachel; Wang, Jerrick C.; Keefe, Matthew G.; Pavlovic, Bryan J.; Donohue, Kevin C.; Moreau, Clara; Wigdor, Emilie M.; Larson, H. Hanh; Allen, Denise E.; Cadwell, Cathryn R.; Bhaduri, Aparna; Popova, Galina; Bearden, Carrie E.; Pollen, Alex A.; Jacquemont, Sebastien; Sanders, Stephan J.; Haussler, David; Wiita, Arun P.; Frost, Nicholas A.; Sohal, Vikaas S.; Nowakowski, Tomasz J. 分享 收藏
Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy Zhu, Danqing; Brookes, David H.; Busia, Akosua; Carneiro, Ana; Fannjiang, Clara; Popova, Galina; Shin, David; Donohue, Kevin C.; Lin, Li F.; Miller, Zachary M.; Williams, Evan R.; Chang, Edward F.; Nowakowski, Tomasz J.; Listgarten, Jennifer; Schaffer, David V. 分享 收藏
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Tropism of SARS-CoV-2 for human cortical astrocytes SARS-CoV-2对人皮质星形胶质细胞的嗜性 Andrews, Madeline G.; Mukhtar, Tanzila; Eze, Ugomma C.; Simoneau, Camille R.; Ross, Jayden; Parikshak, Neelroop; Wang, Shaohui; Zhou, Li; Koontz, Mark; Velmeshev, Dmitry; Siebert, Clara-Vita; Gemenes, Kaila M.; Tabata, Takako; Perez, Yonatan; Wang, Li; Mostajo-Radji, Mohammed A.; de Majo, Martina; Donohue, Kevin C.; Shin, David; Salma, Jahan; Pollen, Alex A.; Nowakowski, Tomasz J.; Ullian, Erik; Kumar, G. Renuka; Winkler, Ethan A.; Crouch, Elizabeth E.; Ott, Melanie; Kriegstein, Arnold R. 分享 收藏
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids 人类小胶质细胞状态在实验模型中是保守的，并调节嵌合类器官中的神经干细胞反应 Popova, Galina; Soliman, Sarah S.; Kim, Chang N.; Keefe, Matthew G.; Hennick, Kelsey M.; Jain, Samhita; Li, Tao; Tejera, Dario; Shin, David; Chhun, Bryant B.; McGinnis, Christopher S.; Speir, Matthew; Gartner, Zev J.; Mehta, Shalin B.; Haeussler, Maximilian; Hengen, Keith B.; Ransohoff, Richard R.; Piao, Xianhua; Nowakowski, Tomasz J. 分享 收藏
Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience Willsey, Helen Rankin; Exner, Cameron R. T.; Xu, Yuxiao; Everitt, Amanda; Sun, Nawei; Wang, Belinda; Dea, Jeanselle; Schmunk, Galina; Zaltsman, Yefim; Teerikorpi, Nia; Kim, Albert; Anderson, Aoife S.; Shin, David; Seyler, Meghan; Nowakowski, Tomasz J.; Harland, Richard M.; Willsey, A. Jeremy; State, Matthew W. 分享 收藏
Revealing architectural order with quantitative label-free imaging and deep learning 通过定量无标记成像和深度学习揭示建筑秩序 Guo, Syuan-Ming; Yeh, Li-Hao; Folkesson, Jenny; Ivanov, Ivan E.; Krishnan, Anitha P.; Keefe, Matthew G.; Hashemi, Ezzat; Shin, David; Chhun, Bryant B.; Cho, Nathan H.; Leonetti, Manuel D.; Han, May H.; Nowakowski, Tomasz J.; Mehta, Shalin B. 分享 收藏
Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations Tsutakawa, Susan E.; Sarker, Altaf H.; Ng, Clifford; Arvai, Andrew S.; Shin, David S.; Shih, Brian; Jiang, Shuai; Thwin, Aye C.; Tsai, Miaw-Sheue; Willcox, Alexandra; Her, Mai Zong; Trego, Kelly S.; Raetz, Alan G.; Rosenberg, Daniel; Bacolla, Albino; Hammel, Michal; Griffith, Jack D.; Cooper, Priscilla K.; Tainer, John A. 分享 收藏
Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1 X连锁肌张力障碍-帕金森病的疾病发作与TAF1中SVA逆转座子内六聚体重复序列的扩增有关 Bragg, D. Cristopher; Mangkalaphiban, Kotchaphorn; Vaine, Christine A.; Kulkarni, Nichita J.; Shin, David; Yadav, Rachita; Dhakal, Jyotsna; Ton, Mai-Linh; Cheng, Anne; Russo, Christopher T.; Ang, Mark; Acuna, Patrick; Go, Criscely; Franceour, Taylor N.; Multhaupt-Buell, Trisha; Ito, Naoto; Mueller, Ulrich; Hendriks, William T.; Breakefield, Xandra O.; Sharma, Nutan; Ozelius, Laurie J. 分享 收藏
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Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells Ito, Naoto; Hendriks, William T.; Dhakal, Jyotsna; Vaine, Christine A.; Liu, Christina; Shin, David; Shin, Kyle; Wakabayashi-Ito, Noriko; Dy, Marisela; Multhaupt-Buell, Trisha; Sharma, Nutan; Breakefield, Xandra O.; Bragg, D. Cristopher 分享 收藏
Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes Pratt, Ashley J.; Shin, David S.; Merz, Gregory E.; Rambo, Robert P.; Lancaster, W. Andrew; Dyer, Kevin N.; Borbat, Peter P.; Poole, Farris L., II; Adams, Michael W. W.; Freed, Jack H.; Crane, Brian R.; Tainer, John A.; Getzoff, Elizabeth D. 分享 收藏
Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes Tsutakawa, Susan E.; Shin, David S.; Mol, Clifford D.; Izumi, Tadahide; Arvai, Andrew S.; Mantha, Anil K.; Szczesny, Bartosz; Ivanov, Ivaylo N.; Hosfield, David J.; Maiti, Buddhadev; Pique, Mike E.; Frankel, Kenneth A.; Hitomi, Kenichi; Cunningham, Richard P.; Mitra, Sankar; Tainer, John A. 分享 收藏
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