未登录 Ribosomal RNA 2'-O-methylation dynamics impact cell fate decisions Hafner, Sophia J.; Jansson, Martin D.; Altinel, Kubra; Andersen, Kasper L.; Abay-Norgaard, Zehra; Menard, Patrice; Fontenas, Martin; Sorensen, Daniel M.; Gay, David M.; Arendrup, Frederic S.; Tehler, Disa; Krogh, Nicolai; Nielsen, Henrik; Kraushar, Matthew L.; Kirkeby, Agnete; Lund, Anders H. 分享 收藏
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target 代谢谱分析将结直肠癌分层并揭示腺苷同型半胱氨酸酶作为治疗靶标 Voorde, Johan Vande; Steven, Rory T.; Najumudeen, Arafath K.; Ford, Catriona A.; Dexter, Alex; Gonzalez-Fernandez, Ariadna; Nikula, Chelsea J.; Xiang, Yuchen; Ford, Lauren; Stavrakaki, Stefania Maneta; Gilroy, Kathryn; Zeiger, Lucas B.; Pennel, Kathryn; Hatthakarnkul, Phimmada; Elia, Efstathios A.; Nasif, Ammar; Murta, Teresa; Manoli, Eftychios; Mason, Sam; Gillespie, Michael; Lannagan, Tamsin R. M.; Vlahov, Nikola; Ridgway, Rachel A.; Nixon, Colin; Raven, Alexander; Mills, Megan; Athineos, Dimitris; Kanellos, Georgios; Nourse, Craig; Gay, David M.; Hughes, Mark; Burton, Amy; Yan, Bin; Sellers, Katherine; Wu, Vincen; De Ridder, Kobe; Shokry, Engy; Uribe, Alejandro Huerta; Clark, William; Clark, Graeme; Kirschner, Kristina; Thienpont, Bernard; Li, Vivian S. W.; Maddocks, Oliver D. K.; Barry, Simon T.; Goodwin, Richard J. A.; Kinross, James; Edwards, Joanne; Yuneva, Mariia O.; Sumpton, David; Takats, Zoltan; Campbell, Andrew D.; Bunch, Josephine; Sansom, Owen J. 分享 收藏
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A RAC-GEF network critical for early intestinal tumourigenesis Pickering, K. A.; Gilroy, K.; Cassidy, J. W.; Fey, S. K.; Najumudeen, A. K.; Zeiger, L. B.; Vincent, D. F.; Gay, D. M.; Johansson, J.; Fordham, R. P.; Miller, B.; Clark, W.; Hedley, A.; Unal, E. B.; Kiel, C.; McGhee, E.; Machesky, L. M.; Nixon, C.; Johnsson, A. E.; Bain, M.; Strathdee, D.; van Hoof, S. R.; Medema, J. P.; Anderson, K., I; Brachmann, S. M.; Stucke, V. M.; Malliri, A.; Drysdale, M.; Turner, M.; Serrano, L.; Myant, K.; Campbell, A. D.; Sansom, O. J. 分享 收藏
MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression Knight, John R. P.; Alexandrou, Constantinos; Skalka, George L.; Vlahov, Nikola; Pennel, Kathryn; Officer, Leah; Teodosio, Ana; Kanellos, Georgios; Gay, David M.; May-Wilson, Sebastian; Smith, Ewan M.; Najumudeen, Arafath K.; Gilroy, Kathryn; Ridgway, Rachel A.; Flanagan, Dustin J.; Smith, Rachael C. L.; McDonald, Laura; MacKay, Craig; Cheasty, Anne; McArthur, Kerri; Stanway, Emma; Leach, Joshua D.; Jackstadt, Rene; Waldron, Joseph A.; Campbell, Andrew D.; Vlachogiannis, Georgios; Valeri, Nicola; Haigis, Kevin M.; Sonenberg, Nahum; Proud, Christopher G.; Jones, Neil P.; Swarbrick, Martin E.; McKinnon, Heather J.; Faller, William J.; Le Quesne, John; Edwards, Joanne; Willis, Anne E.; Bushell, Martin; Sansom, Owen J. 分享 收藏
Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis (vol 63, pg 916, 2020) Smith, Anna L. M.; Whitehall, Julia C.; Bradshaw, Carla; Gay, David; Robertson, Fiona; Blain, Alasdair P.; Hudson, Gavin; Pyle, Angela; Houghton, David; Hunt, Matthew; Sampson, James N.; Stamp, Craig; Mallett, Grace; Amarnath, Shoba; Leslie, Jack; Oakley, Fiona; Wilson, Laura; Baker, Angela; Russell, Oliver M.; Johnson, Riem; Richardson, Claire A.; Gupta, Bhavana; McCallum, Iain; McDonald, Stuart A. C.; Kelly, Seamus; Mathers, John C.; Heer, Rakesh; Taylor, Robert W.; Perkins, Neil D.; Turnbull, Doug M.; Sansom, Owen J.; Greaves, Laura C. 分享 收藏
Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis Smith, Anna L. M.; Whitehall, Julia C.; Bradshaw, Carla; Gay, David; Robertson, Fiona; Blain, Alasdair P.; Hudson, Gavin; Pyle, Angela; Houghton, David; Hunt, Matthew; Sampson, James N.; Stamp, Craig; Mallett, Grace; Amarnath, Shoba; Leslie, Jack; Oakley, Fiona; Wilson, Laura; Baker, Angela; Russell, Oliver M.; Johnson, Riem; Richardson, Claire A.; Gupta, Bhavana; McCallum, Iain; McDonald, Stuart A. C.; Kelly, Seamus; Mathers, John C.; Heer, Rakesh; Taylor, Robert W.; Perkins, Neil D.; Turnbull, Doug M.; Sansom, Owen J.; Greaves, Laura C. 分享 收藏
Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress Kaymak, Irem; Maier, Carina R.; Schmitz, Werner; Campbell, Andrew D.; Dankworth, Beatrice; Ade, Carsten P.; Walz, Susanne; Paauwe, Madelon; Kalogirou, Charis; Marouf, Hecham; Rosenfeldt, Mathias T.; Gay, David M.; McGregor, Grace H.; Sansom, Owen J.; Schulze, Almut 分享 收藏
A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer MYC-GCN2-eIF2α 负反馈环限制蛋白质合成以防止结直肠癌中MYC依赖性细胞凋亡 Schmidt, Stefanie; Gay, David; Uthe, Friedrich Wilhelm; Denk, Sarah; Paauwe, Madelon; Matthes, Niels; Diefenbacher, Markus Elmar; Bryson, Sheila; Warrander, Fiona Clare; Erhard, Florian; Ade, Carsten Patrick; Baluapuri, Apoorva; Walz, Susanne; Jackstadt, Rene; Ford, Catriona; Vlachogiannis, Georgios; Valeri, Nicola; Otto, Christoph; Schuelein-Voelk, Christina; Maurus, Katja; Schmitz, Werner; Knight, John Raymond Philip; Wolf, Elmar; Strathdee, Douglas; Schulze, Almut; Germer, Christoph-Thomas; Rosenwald, Andreas; Sansom, Owen James; Eilers, Martin; Wiegering, Armin 分享 收藏
Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer (vol 10, 723, 2019) Gay, David M.; Ridgway, Rachel A.; Mueller, Miryam; Hodder, Michael C.; Hedley, Ann; Clark, William; Leach, Joshua D.; Jackstadt, Rene; Nixon, Colin; Huels, David J.; Campbell, Andrew D.; Bird, Thomas G.; Sansom, Owen J. 分享 收藏
Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer 在重现人类癌症的模型中，BCL9/9l的丢失抑制了Wnt驱动的肿瘤发生 Gay, David M.; Ridgway, Rachel A.; Mueller, Miryam; Hodder, Michael C.; Hedley, Ann; Clark, William; Leach, Joshua D.; Jackstadt, Rene; Nixon, Colin; Huels, David J.; Campbell, Andrew D.; Bird, Thomas G.; Sansom, Owen J. 分享 收藏
Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis 癌细胞对缺氧的适应涉及HIF-GPRC5A-YAP轴 Greenhough, Alexander; Bagley, Clare; Heesom, Kate J.; Gurevich, David B.; Gay, David; Bond, Mark; Collard, Tracey J.; Paraskeva, Chris; Martin, Paul; Sansom, Owen J.; Malik, Karim; Williams, Ann C. 分享 收藏
Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells Huels, D. J.; Bruens, L.; Hodder, M. C.; Cammareri, P.; Campbell, A. D.; Ridgway, R. A.; Gay, D. M.; Solar-Abboud, M.; Faller, W. J.; Nixon, C.; Zeiger, L. B.; McLaughlin, M. E.; Morrissey, E.; Winton, D. J.; Snippert, H. J.; van Rheenen, J.; Sansom, O. J. 分享 收藏
mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer mTORC2信号通路驱动胰腺癌的发生发展 Driscoll, David R.; Karim, Saadia A.; Sano, Makoto; Gay, David M.; Jacob, Wright; Yu, Jun; Mizukami, Yusuke; Gopinathan, Aarthi; Jodrell, Duncan I.; Evans, T. R. Jeffry; Bardeesy, Nabeel; Hall, Michael N.; Quattrochi, Brian J.; Klimstra, David S.; Barry, Simon T.; Sansom, Owen J.; Lewis, Brian C.; Morton, Jennifer P. 分享 收藏
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Comparison of amlodipine or nifedipine treatment with developing congestive heart failure: Effects on myocyte contractility McElmurray, JH; Mukherjee, R; Patterson, TM; Goldberg, A; King, MK; Hendrick, JW; Gay, DM; Clair, MJ; Jolly, JR; Spinale, FG 分享 收藏
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