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Yutaka Kōyama

Kobe Pharmaceutical University

34H指数
179论文数
3.9K被引数
收录论文 36
发表时间
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PNU-120596, an α7 nicotinic acetylcholine receptor positive allosteric modulator, attenuates microglial activation and protects dopaminergic neurons from inflammatory injury independently of canonical α7 nicotinic acetylcholine receptor signalingPNU-120596，一种α7烟碱型乙酰胆碱受体正向别构调节剂，可减轻小胶质细胞活化并独立于经典α7烟碱型乙酰胆碱受体信号通路保护多巴胺能神经元免受炎症损伤
errEuropean Journal of Pharmacology
IF4.7
err2026-07-01
err0
PREAI
errIzumi, Yasuhiko; Niwa, Kenta; Kamei, Yuichi; Akaike, Akinori; Koyama, Yutaka; Kume, Toshiaki
err分享
err收藏
Endothelin-1 induces Zfp36 family RNA binding proteins and restrains cytokine and chemokine production in reactive astrocytes内皮素-1诱导Zfp36家族RNA结合蛋白，并抑制反应性星形胶质细胞中细胞因子和趋化因子的产生。
errJournal of Biological Chemistry
IF3.9
err2026-04-02
err0
errOAAI
errYutaka Koyama; Aina Nishiuma; Nagi Takahashi; Eri Izumikawa; Chisato Hamada; Yasuhiko Izumi; Shigeru Hishinuma; Shotaro Michinaga
err分享
err收藏
Screening and identification of covalent Nrf2 activators with α,β-unsaturated imide structures筛选和鉴定具有α,β-不饱和亚胺结构的共价Nrf2激活剂
errBioorganic & Medicinal Chemistry
IF3
err2025-10-19
err0
PREAI
errYasuhiko Izumi; Norihiko Takeda; Shuzo Nishimoto; Honoka Niimi; Sayuri Ishizu; Natsumi Muneyasu; Yuto Takamatsu; Emi Mishiro-Sato; Keiko Kano; Kouya Yamaki; Takahiro Yamada; Yutaka Koyama; Masafumi Ueda
err分享
err收藏
Evaluation of the deep learning-based detection of dopaminergic neurons in primary culture: A practical alternative to manual counting基于深度学习的多巴胺能神经元原代培养物检测评估：一种替代人工计数的实用方法
errJournal of Neuroscience Methods
IF2.3
err2025-08-15
err0
PREAI
errYasuhiko Izumi; Saori Ikawa; Kouya Yamaki; Toshiaki Kume; Yutaka Koyama
err分享
err收藏
TPNA10168, an Nrf2 activator, attenuates LPS-induced inflammation in microglia through modulation of MAPK and NF-κB pathwaysTPNA10168，一种Nrf2激活剂，通过调节MAPK和NF-κB通路来减轻LPS诱导的小胶质细胞炎症。
errJournal of Pharmacological Sciences
IF2.9
err2025-07-03
err0
errOAAI
errYasuhiko Izumi; Eri Koide; Fumika Kobayashi; Saori Ikawa; Midai Takayama; Kouya Yamaki; Norihiko Takeda; Takahiro Yamada; Masafumi Ueda; Toshiaki Kume; Yutaka Koyama
err分享
err收藏
Nrf2-Independent Anti-Inflammatory Effects of Dimethyl Fumarate: Challenges and Prospects in Developing Electrophilic Nrf2 Activators for Neurodegenerative Diseases
errANTIOXIDANTS
IF6.6
err2024-12-13
err0
errOAAI
errIzumi, Yasuhiko; Koyama, Yutaka
err分享
err收藏
Endothelin-1 increases Na+-K+-2Cl- cotransporter-1 expression in cultured astrocytes and in traumatic brain injury model: An involvement of HIF1α activation
errGLIA
IF5.1
err2024-08-21
err0
PREAI
errKoyama, Yutaka; Hamada, Yasuhiro; Fukui, Yura; Hosogi, Nami; Fujimoto, Rina; Hishinuma, Shigeru; Ogawa, Yasuhiro; Takahashi, Kenta; Izumi, Yasuhiko; Michinaga, Shotaro
err分享
err收藏
THE NEUTROPHIL-LYMPHOCYTE RATIO (NLR) OF PERIPHERAL BLOOD IS AN INDICATOR OF ESTIMATING INTERFERON SIGNATURE IN SYSTEMIC LUPUS ERYTHEMATOSUS外周血中性粒细胞与淋巴细胞比值（NLR）是估算系统性红斑狼疮干扰素信号标记的指标。
errANNALS OF THE RHEUMATIC DISEASES
IF20.6
err2024-06-01
err0
PREAI
errKoyama, Y.; Sato, Y.; Nakai, Y.; Tokunaga, M.
err分享
err收藏
Roles of Astrocytic Endothelin ETB Receptor in Traumatic Brain Injury星形胶质细胞内皮素ETB受体在创伤性脑损伤中的作用
errCELLS
IF5.2
err2023-02-24
err6
errOAAI
errMichinaga, Shotaro; Hishinuma, Shigeru; Koyama, Yutaka
err分享
err收藏
TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway
errJOURNAL OF PHARMACOLOGICAL SCIENCES
IF2.9
err2022-05-01
err3
errOAAI
errIzumi, Yasuhiko; Tatsumoto, Ai; Horiuchi, Naoko; Arifuku, Monami; Uegomori, Momoko; Kume, Toshiaki; Koyama, Yutaka
err分享
err收藏
Down-regulation of astrocytic sonic hedgehog by activation of endothelin ETB receptors: Involvement in traumatic brain injury-induced disruption of blood brain barrier in a mouse model通过激活内皮素ETB受体下调星形胶质细胞sonic hedgehog: 在小鼠模型中参与创伤性脑损伤诱导的血脑屏障破坏
errNEUROCHEMISTRY INTERNATIONAL
IF4
err2021-06-01
err17
PREAI
errMichinaga, Shotaro; Inoue, Ayana; Sonoda, Kyomi; Mizuguchi, Hiroyuki; Koyama, Yutaka
err分享
err收藏
Endothelin-1 stimulates expression of cyclin D1 and S-phase kinase-associated protein 2 by activating the transcription factor STAT3 in cultured rat astrocytes
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2019-03-01
err18
errOAAI
errKoyama, Yutaka; Sumie, Satoshi; Nakano, Yasutaka; Nagao, Tomoya; Tokumaru, Shiho; Michinaga, Shotaro
err分享
err收藏
Delayed Administration of BQ788, an ETB Antagonist, after Experimental Traumatic Brain Injury Promotes Recovery of Blood-Brain Barrier Function and a Reduction of Cerebral Edema in Mice
errJOURNAL OF NEUROTRAUMA
IF3.8
err2018-07-01
err44
PREAI
errMichinaga, Shotaro; Kimura, Akimasa; Hatanaka, Shunichi; Minami, Shizuho; Asano, Arisa; Ikushima, Yuki; Matsui, Shingo; Toriyama, Yoshiya; Fujii, Manami; Koyama, Yutaka
err分享
err收藏
Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons
errEUROPEAN JOURNAL OF PHARMACOLOGY
IF4.7
err2018-01-01
err23
errOAAI
errIzumi, Yasuhiko; Kataoka, Harue; Inose, Yuri; Akaike, Akinori; Koyama, Yutaka; Kume, Toshiaki
err分享
err收藏
Dexamethasone Downregulates Endothelin Receptors and Reduces Endothelin-Induced Production of Matrix Metalloproteinases in Cultured Rat Astrocytes
errMOLECULAR PHARMACOLOGY
IF3
err2017-07-01
err8
errOAAI
errKoyama, Yutaka; Ukita, Ayano; Abe, Kana; Iwamae, Kuniaki; Tokuyama, Shogo; Tanaka, Keisuke; Kotake, Yuki
err分享
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Functional alterations of astrocytes in mental disorders: pharmacological significance as a drug target
errFRONTIERS IN CELLULAR NEUROSCIENCE
IF4
err2015-07-06
err42
errOAAI
errKoyama, Yutaka
err分享
err收藏
The activation of supraspinal GPR40/FFA1 receptor signalling regulates the descending pain control system
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2015-01-12
err39
errOAAI
errNakamoto, K.; Nishinaka, T.; Sato, N.; Aizawa, F.; Yamashita, T.; Mankura, M.; Koyama, Y.; Kasuya, F.; Tokuyama, S.
err分享
err收藏
Signaling molecules regulating phenotypic conversions of astrocytes and glial scar formation in damaged nerve tissues
errNEUROCHEMISTRY INTERNATIONAL
IF4
err2014-12-01
err64
PREAI
errKoyama, Yutaka
err分享
err收藏
Endothelin-1 stimulates cyclin D1 expression in rat cultured astrocytes via activation of Sp1
errNEUROCHEMISTRY INTERNATIONAL
IF4
err2013-07-01
err17
PREAI
errMichinaga, Shotaro; Ishida, Ayaka; Takeuchi, Risa; Koyama, Yutaka
err分享
err收藏
Different actions of endothelin-1 on chemokine production in rat cultured astrocytes: reduction of CX3CL1/fractalkine and an increase in CCL2/MCP-1 and CXCL1/CINC-1
errJOURNAL OF NEUROINFLAMMATION
IF10.1
err2013-04-30
err42
errOAAI
errKoyama, Yutaka; Kotani, Mao; Sawamura, Tadateru; Kuribayashi, Miho; Konishi, Rika; Michinaga, Shotaro
err分享
err收藏

研究方向

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合作学者
合作期刊
T
Takashi Fujita
H 指数: 93 · 论文数: 536
S
Shigeo Nakamura
H 指数: 86 · 论文数: 795
A
Akinori Akaike
H 指数: 69 · 论文数: 527
H
Hitoshi Hashimoto
H 指数: 66 · 论文数: 861
K
Kazuo Nakamoto
H 指数: 64 · 论文数: 554
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