Alex R. Khomutov - Publications, H-index & Citations

Alex R. Khomutov

Engelhardt Institute of Molecular Biology

27H指数

161论文数

2.2K被引数

收录论文 52

发表时间

Aspartate-dependent polyamine biosynthesis in bacteria: chemical synthesis of carboxypolyamines and mechanism-based design of hydroxylamine-containing inhibitors of carboxyspermidine decarboxylase 细菌中天冬氨酸依赖的聚胺生物合成：羧基聚胺的化学合成以及基于机制设计含羟胺的羧基精胺脱羧酶抑制剂

Amino Acids

IF2.4

2026-08-29

OAAI

Arthur Salikhov; Alex Khomutov; Inna Karpenko; Yaroslav Tkachev; Anthony Michael; Maxim Khomutov

H-phosphinic analogs of natural amino acids: a novel and efficient treatment for preventing biodeterioration of treasured painted artworks 天然氨基酸的H-膦酸亚基类似物：一种新颖且高效的治疗方法，用于防止珍贵绘画艺术品的生物劣化

Frontiers in Microbiology

IF4.5

2026-04-03

OAAI

AA Alexander A. Zhgun; MA Maxim A. Khomutov; DA Darya A. Avdanina; ET Egor Troyan; MV Maria V. Dumina; AA Anna A. Ermolyuk; NS Nikolay Simonenko; KS Kirill Shumikhin; EN Elena N. Khurs; YZ Yuliya Zhuikova; VP Valery P. Varlamov; MV Mikhail V. Shitov; AR Alex R. Khomutov

Biodeterioration aspects of the 16th century icon “Deesis tier of thirteen figures” by the fungus Iodophanus sp. STG-150: a range of materials for biodegradation and selection of target antiseptics 16世纪圣像“十三人祈愿组像”受真菌Iodophanus sp. STG-150生物劣化的研究：生物降解材料的范围及目标防腐剂的选择

Journal of Cultural Heritage

IF3.3

2025-11-20

PREAI

Daria A. Avdanina; Olga B. Vorobyova; Anna A. Ermolyuk; Nikolay P. Simonenko; Ivan A. Volkov; Liudmila A. Alexandrova; Maxim V. Jasko; Dmitry A. Makarov; Maxim A. Khomutov; Elena N. Khurs; Alexey R. Khomutov; Olga B. Riabova; Vadim A. Makarov; Egor V. Troyan; Michael V. Shitov; Alexander A. Zhgun

Phospho-Switch: Regulation of the Activity of SAM-Dependent Methyltransferases Using H-Phosphinic SAM Analogue 磷酰开关：利用H-磷inic SAM类似物调控SAM依赖性甲基转移酶的活性

International Journal of Molecular Sciences 2025, Vol. 26, Page 8590

IF4.9

2025-09-04

OAAI

Vsevolod L. Filonov; Maxim A. Khomutov; Alexander Yu. Rudenko; Sofia S. Mariasina; Ratislav M. Ozhiganov; Alexander V. Sergeev; Sergei N. Kochetkov; Vladimir I. Polshakov; Elizaveta S. Gromova; Anastasia L. Khandazhinskaya; Alex R. Khomutov

Enzymatic Synthesis of Biologically Active H-Phosphinic Analogue of α-Ketoglutarate 酶催化合成具有生物活性的α-酮戊二酸H-磷inate类似物

BIOMOLECULES

IF4.8

2024-12-10

OAAI

Filonov, Vsevolod L.; Khomutov, Maxim A.; Tkachev, Yaroslav V.; Udod, Artem V.; Yanvarev, Dmitry V.; Giovannercole, Fabio; Khurs, Elena N.; Kochetkov, Sergei N.; De Biase, Daniela; Khomutov, Alex R.

Integrated multi-omics unveil the impact of H-phosphinic analogs of glutamate and a-ketoglutarate on Escherichia coli metabolism

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-10-01

OAAI

Giovannercole, Fabio; Goncalves, Luis Gafeira; Armengaud, Jean; Coelho, Ana Varela; Khomutov, Alex; De Biase, Daniela

Organophosphorus S-adenosyl-L-methionine mimetics: synthesis, stability, and substrate properties

FRONTIERS IN CHEMISTRY

IF4.2

2024-08-01

OAAI

Rudenko, Alexander Yu; Mariasina, Sofia S.; Bolikhova, Anastasiia K.; Nikulin, Maxim V.; Ozhiganov, Ratislav M.; Vasil'ev, Vasiliy G.; Ikhalaynen, Yuri A.; Khandazhinskaya, Anastasia L.; Khomutov, Maxim A.; Sergiev, Peter V.; Khomutov, Alex R.; Polshakov, Vladimir I.

Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle

CELLS

IF5.2

2024-06-14

OAAI

Zakirova, Natalia F.; Khomich, Olga A.; Smirnova, Olga A.; Molle, Jennifer; Duponchel, Sarah; Yanvarev, Dmitry V.; Valuev-Elliston, Vladimir T.; Monnier, Lea; Grigorov, Boyan; Ivanova, Olga N.; Karpenko, Inna L.; Golikov, Mikhail V.; Bovet, Cedric; Rindlisbacher, Barbara; Khomutov, Alex R.; Kochetkov, Sergey N.; Bartosch, Birke; Ivanov, Alexander V.

Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome

EMBO MOLECULAR MEDICINE

IF8.3

2023-09-13

OAAI

Stewart, Tracy Murray; Foley, Jackson R.; Holbert, Cassandra E.; Khomutov, Maxim; Rastkari, Noushin; Tao, Xianzun; Khomutov, Alex R.; Zhai, R. Grace; Casero Jr, Robert A.

In search for structural targets for engineering D-amino acid transaminase: modulation of pH optimum and substrate specificity

BIOCHEMICAL JOURNAL

IF4.3

2023-08-23

OAAI

Shilova, Sofia A.; Matyuta, Ilya O.; Khrenova, Maria G.; Nikolaeva, Alena Y.; Klyachko, Natalia L.; Minyaev, Mikhail E.; Khomutov, Alex R.; Boyko, Konstantin M.; Popov, Vladimir O.; Bezsudnova, Ekaterina Yu.

Antibacterial Activity of Peptide Derivatives of Phosphinothricin against Multidrug-Resistant Klebsiella pneumoniae 膦丝菌素肽衍生物对多重耐药肺炎克雷伯菌的抗菌活性

MOLECULES

IF4.6

2023-01-27

OAAI

Demiankova, Marija V.; Giovannercole, Fabio; Khomutov, Maxim A.; Salikhov, Arthur I.; Onillon, Laura; Valuev-Elliston, Vladimir T.; Vasilieva, Byazilya F.; Khurs, Elena N.; Gabrielyan, Nina I.; Kochetkov, Sergey N.; Efremenkova, Olga V.; De Biase, Daniela; Khomutov, Alex R.

Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group

COMMUNICATIONS CHEMISTRY

IF6.2

2020-09-02

OAAI

De Biase, Daniela; Cappadocio, Francesca; Pennacchietti, Eugenia; Giovannercole, Fabio; Coluccia, Antonio; Vepsalainen, Jouko; Khomutov, Alex

Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-11-25

OAAI

Khomutov, Maxim; Hyvonen, Mervi T.; Simonian, Alina; Formanovsky, Andrey A.; Mikhura, Irina V.; Chizhov, Alexander O.; Kochetkov, Sergey N.; Alhonen, Leena; Vepsalainen, Jouko; Keinanen, Tuomo A.; Khomutov, Alex R.

Activation of Polyamine Catabolism by N1,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype

CELLS

IF5.2

2018-12-18

OAAI

Ivanova, Olga N.; Snezhkina, Anastasiya, V; Krasnov, George S.; Valuev-Elliston, Vladimir T.; Khomich, Olga A.; Khomutov, Alexey R.; Keinanen, Tuomo A.; Alhonen, Leena; Bartosch, Birke; Kudryavtseva, Anna, V; Kochetkov, Sergey N.; Ivanov, Alexander, V

Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators

BIOSCIENCE REPORTS

IF4.7

2018-08-29

OAAI

Keinanen, Tuomo A.; Grigorenko, Nikolay; Khomutov, Alex R.; Huang, Qingqiu; Uimari, Anne; Alhonen, Leena; Hyvonen, Mervi T.; Vepsalainen, Jouko

On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge

MOLECULES

IF4.6

2017-06-23

OAAI

Khomich, Olga A.; Yanvarev, Dmitry V.; Novikov, Roman A.; Kornev, Alexey B.; Puljulla, Elina; Vepsalainen, Jouko; Khomutov, Alex R.; Kochetkov, Sergey N.

Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation

BIOCHEMICAL JOURNAL

IF4.3

2016-05-11

PREAI

Hyvonen, Mervi T.; Ucal, Sebahat; Pasanen, Markku; Peraniemi, Sirpa; Weisell, Janne; Khomutov, Maxim; Khomutov, Alex R.; Vepsalainen, Jouko; Alhonen, Leena; Keinanen, Tuomo A.

Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport

ACS CHEMICAL BIOLOGY

IF3.8

2015-02-27

PREAI

Hyvonen, Mervi T.; Khomutov, Maxim; Petit, Marine; Weisell, Janne; Kochetkov, Sergey N.; Alhonen, Leena; Vepsalainen, Jouko; Khomutov, Alex R.; Keinanen, Tuomo A.

Aminooxy analog of histamine is an efficient inhibitor of mammalian l-histidine decarboxylase: combined in silico and experimental evidence 组胺的氨基氧类似物是哺乳动物l-组氨酸脱羧酶的有效抑制剂: 结合计算机和实验证据

AMINO ACIDS

IF2.4

2013-10-10

PREAI

Castro-Oropeza, R.; Pino-Angeles, A.; Khomutov, M. A.; Urdiales, J. L.; Moya-Garcia, A. A.; Vepsalainen, J.; Persson, L.; Sarabia, F.; Khomutov, A.; Sanchez-Jimenez, F.

Selective regulation of polyamine metabolism with methylated polyamine analogues

AMINO ACIDS

IF2.4

2013-09-11

PREAI

Keinanen, Tuomo A.; Hyvonen, Mervi T.; Alhonen, Leena; Vepsalainen, Jouko; Khomutov, Alex R.

研究方向