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Polygenic risk score adds to a clinical risk score in the prediction of cardiovascular disease in a clinical setting Samani, Nilesh J.; Beeston, Emma; Greengrass, Chris; Riveros-McKay, Fernando; Debiec, Radoslaw; Lawday, Daniel; Wang, Qingning; Budgeon, Charley A.; Braund, Peter S.; Bramley, Richard; Kharodia, Shireen; Newton, Michelle; Marshall, Andrea; Krzeminski, Andre; Zafar, Azhar; Chahal, Anuj; Heer, Amadeeep; Khunti, Kamlesh; Joshi, Nitin; Lakhani, Mayur; Farooqi, Azhar; Plagnol, Vincent; Donnelly, Peter; Weale, Michael E.; Nelson, Christopher P. 分享 收藏
A polygenic risk score added to a QRISK®2 cardiovascular disease risk calculator demonstrated robust clinical acceptance and clinical utility in the primary care setting 添加到qri确定的多基因风险评分®2心血管疾病风险计算器在初级保健环境中显示出强大的临床接受度和临床实用性 Fuat, Ahmet; Adlen, Ella; Monane, Mark; Coll, Ruth; Groves, Sarah; Little, Elizabeth; Wild, Jonathan; Kamali, Farzan J.; Soni, Yusuf; Haining, Shona; Riding, Helen; Riveros-Mckay, Fernando; Peneva, Iliana; Lachapelle, Alexander; Giner-Delgado, Carla; Weale, Michael E.; Plagnol, Vincent; Harrison, Seamus; Donnelly, Peter 分享 收藏
Patient and Primary Care Provider Experiences From an Implementation Study of a Risk Prediction Tool Integrating a Polygenic Risk Score and the QRISK2 Cardiovascular Risk Calculator Fuat, Professor Ahmet; Adlen, Ella; Monane, Mark; Coll, Ruth; Little, Elizabeth; Wild, Jonathan; Kamali, Farzan; Soni, Yusuf; Haining, Shona; Riding, Helen; Delgado, Carla Giner; Weale, Michael E. 分享 收藏
Analysis of subcellular RNA fractions demonstrates significant genetic regulation of gene expression in human brain post-transcriptionally D'Sa, Karishma; Guelfi, Sebastian; Vandrovcova, Jana; Reynolds, Regina H.; Zhang, David; Hardy, John; Botia, Juan A.; Weale, Michael E.; Taliun, Sarah A. Gagliano; Small, Kerrin S.; Ryten, Mina 分享 收藏
Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture Bird, Nancy; Ormond, Louise; Awah, Paschal; Caldwell, Elizabeth F.; Connell, Bruce; Elamin, Mohamed; Fadlelmola, Faisal M.; Fomine, Forka Leypey Matthew; Lopez, Saioa; MacEachern, Scott; Monino, Yves; Morris, Sam; Nasanen-Gilmore, Pieta; Nketsia, V. Nana Kobina; Veeramah, Krishna; Weale, Michael E.; Zeitlyn, David; Thomas, Mark G.; Bradman, Neil; Hellenthal, Garrett 分享 收藏
Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction Riveros-Mckay, Fernando; Weale, Michael E.; Moore, Rachel; Selzam, Saskia; Krapohl, Eva; Sivley, R. Michael; Tarran, William A.; Sorensen, Peter; Lachapelle, Alexander S.; Griffiths, Jonathan A.; Saffari, Ayden; Deanfield, John; Spencer, Chris C. A.; Hippisley-Cox, Julia; Hunter, David J.; O'Sullivan, Jack W.; Ashley, Euan A.; Plagnol, Vincent; Donnelly, Peter 分享 收藏
Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information Guelfi, Sebastian; D'Sa, Karishma; Botia, Juan A.; Vandrovcova, Jana; Reynolds, Regina H.; Zhang, David; Trabzuni, Daniah; Collado-Torres, Leonardo; Thomason, Andrew; Leyton, Pedro Quijada; Taliun, Sarah A. Gagliano; Nalls, Mike A.; Small, Kerrin S.; Smith, Colin; Ramasamy, Adaikalavan; Hardy, John; Weale, Michael E.; Ryten, Mina 分享 收藏
Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals Genomic Precision Medicine May Dispense With Ethnicity Iniesta, Raquel; Campbell, Desmond; Venturini, Cristina; Faconti, Luca; Singh, Sonal; Irvin, Marguerite R.; Cooper-DeHoff, Rhonda M.; Johnson, Julie A.; Turner, Stephen T.; Arnett, Donna K.; Weale, Michael E.; Warren, Helen; Munroe, Patricia B.; Cruickshank, Kennedy; Padmanabhan, Sandosh; Lewis, Cathryn; Chowienczyk, Phil 分享 收藏
The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population Stapleton, Caragh P.; Heinzel, Andreas; Guan, Weihua; van der Most, Peter J.; van Setten, Jessica; Lord, Graham M.; Keating, Brendan J.; Israni, Ajay K.; de Borst, Martin H.; Bakker, Stephan J. L.; Snieder, Harold; Weale, Michael E.; Delaney, Florence; Hernandez-Fuentes, Maria P.; Reindl-Schwaighofer, Roman; Oberbauer, Rainer; Jacobson, Pamala A.; Mark, Patrick B.; Chapman, Fiona A.; Phelan, Paul J.; Kennedy, Claire; Sexton, Donal; Murray, Susan; Jardine, Alan; Traynor, Jamie P.; McKnight, Amy Jayne; McKnight, Alexander P.; Smyth, Laura J.; Oetting, William S.; Matas, Arthur J.; Mannon, Roslyn B.; Schladt, David P.; Ikle, David N.; Cavalleri, Gianpiero L.; Conlon, Peter J.; Franklin, Christopher; Rebollo-Mesa, Irene; Mollon, Jennifer; Perucha, Esperanza; Borrows, Richard; Byrne, Catherine; Clarke, Brendan; Clatworthy, Menna; Feehally, John; Fuggle, Susan; Gagliano, Sarah A.; Griffin, Sian; Hammad, Abdul; Higgins, Robert; Keogan, Mary; Leach, Timothy; MacPhee, Iain; Marsh, James; Maxwell, Peter; McKane, William; McLean, Adam; Newstead, Charles; Augustine, Titus; Powis, Steve; Rowe, Peter; Sheerin, Neil; Solomon, Ellen; Stephens, Henry; Thuraisingham, Raj; Trembath, Richard; Topham, Peter; Sacks, Steven H.; Conlon, Peter; Opelz, Gerhard; Soranzo, Nicole; Cecka, J. Michael; Connett, John; Cosio, Fernando G.; Gaston, Robert; Gourishankar, Sita; Grande, Joseph P.; Hunsicker, Lawrence; Kasiske, Bertram; Rush, David 分享 收藏
Transcriptomic and genetic analyses reveal potential causal drivers for intractable partial epilepsy Guelfi, Sebastian; Botia, Juan A.; Thom, Maria; Ramasamy, Adaikalavan; Perona, Marina; Stanyer, Lee; Martinian, Lillian; Trabzuni, Daniah; Smith, Colin; Walker, Robert; Ryten, Mina; Reimers, Mark; Weale, Michael E.; Hardy, John; Matarin, Mar 分享 收藏
Phenome-wide association studies across large population cohorts support drug target validation 跨大人群队列的全表型组关联研究支持药物靶标验证 Diogo, Dorothee; Tian, Chao; Franklin, Christopher S.; Alanne-Kinnunen, Mervi; March, Michael; Spencer, Chris C. A.; Vangjeli, Ciara; Weale, Michael E.; Mattsson, Hannele; Kilpelainen, Elina; Sleiman, Patrick M. A.; Reilly, Dermot F.; McElwee, Joshua; Maranville, Joseph C.; Chatterjee, Arnaub K.; Bhandari, Aman; Nguyen, Khanh-Dung H.; Estrada, Karol; Reeve, Mary-Pat; Hutz, Janna; Bing, Nan; John, Sally; Macarthur, Daniel G.; Salomaa, Veikko; Ripatti, Samuli; Hakonarson, Hakon; Daly, Mark J.; Palotie, Aarno; Hinds, David A.; Donnelly, Peter; Fox, Caroline S.; Day-Williams, Aaron G.; Plenge, Robert M.; Runz, Heiko 分享 收藏
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Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study Hernandez-Fuentes, Maria P.; Franklin, Christopher; Rebollo-Mesa, Irene; Mollon, Jennifer; Delaney, Florence; Perucha, Esperanza; Stapleton, Caragh; Borrows, Richard; Byrne, Catherine; Cavalleri, Gianpiero; Clarke, Brendan; Clatworthy, Menna; Feehally, John; Fuggle, Susan; Gagliano, Sarah A.; Griffin, Sian; Hammad, Abdul; Higgins, Robert; Jardine, Alan; Keogan, Mary; Leach, Timothy; MacPhee, Iain; Mark, Patrick B.; Marsh, James; Maxwell, Peter; McKane, William; McLean, Adam; Newstead, Charles; Augustine, Titus; Phelan, Paul; Powis, Steve; Rowe, Peter; Sheerin, Neil; Solomon, Ellen; Stephens, Henry; Thuraisingham, Raj; Trembath, Richard; Topham, Peter; Vaughan, Robert; Sacks, Steven H.; Conlon, Peter; Opelz, Gerhard; Soranzo, Nicole; Weale, Michael E.; Lord, Graham M. 分享 收藏
ARHGEF26 is a Novel Genetic Risk Factor for Vascular Inflammation and Coronary Artery Disease Zhu, Qiuyu M.; Klarin, Derek; Emdin, Connor A.; Chaffin, Mark; Horner, Steven; McMillan, Brian; Leed, Alison; Weale, Michael E.; Spencer, Chris C.; Aguet, Francois; Segre, Ayellet V.; Ardlie, Kristin G.; Khera, Amit V.; Kaushik, Virendar K.; Natarajan, Pradeep; Kathiresan, Sekar 分享 收藏
The Genetic Legacy of Zoroastrianism in Iran and India: Insights into Population Structure, Gene Flow, and Selection Lopez, Saioa; Thomas, Mark G.; van Dorp, Lucy; Ansari-Pour, Naser; Stewart, Sarah; Jones, Abigail L.; Jelinek, Erik; Chikhi, Lounes; Parfitt, Tudor; Bradman, Neil; Weale, Michael E.; Hellenthal, Garrett 分享 收藏
Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease Klarin, Derek; Zhu, Qiuyu Martin; Emdin, Connor A.; Chaffin, Mark; Horner, Steven; McMillan, Brian J.; Leed, Alison; Weale, Michael E.; Spencer, Chris C. A.; Aguet, Francois; Segre, Ayellet V.; Ardlie, Kristin G.; Khera, Amit V.; Kaushik, Virendar K.; Natarajan, Pradeep; Kathiresan, Sekar 分享 收藏
Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis Smith, Bradley N.; Topp, Simon D.; Fallini, Claudia; Shibata, Hideki; Chen, Han-Jou; Troakes, Claire; King, Andrew; Ticozzi, Nicola; Kenna, Kevin P.; Soragia-Gkazi, Athina; Miller, Jack W.; Sato, Akane; Dias, Diana Marques; Jeon, Maryangel; Vance, Caroline; Wong, Chun Hao; de Majo, Martina; Kattuah, Wejdan; Mitchell, Jacqueline C.; Scotter, Emma L.; Parkin, Nicholas W.; Sapp, Peter C.; Nolan, Matthew; Nestor, Peter J.; Simpson, Michael; Weale, Michael; Lek, Monkel; Baas, Frank; de Jong, J. M. Vianney; ten Asbroek, Anneloor L. M. A.; Garcia Redondo, Alberto; Esteban-Perez, Jesus; Tiloca, Cinzia; Verde, Federico; Duga, Stefano; Leigh, Nigel; Pall, Hardev; Morrison, Karen E.; Al-Chalabi, Ammar; Shaw, Pamela J.; Kirby, Janine; Turner, Martin R.; Talbot, Kevin; Hardiman, Orla; Glass, Jonathan D.; de Belleroche, Jacqueline; Maki, Masatoshi; Moss, Stephen E.; Miller, Christopher; Gellera, Cinzia; Ratti, Antonia; Al-Sarraj, Safa; Brown, Robert H., Jr.; Silani, Vincenzo; Landers, John E.; Shaw, Christopher E. 分享 收藏
Identification, Regulation and Characterisation of Transcribed Intergenic Regions in Human Substantia Nigra and Putamen Ryten, Mina; Guelfi, Sebastian; D'Sa, Karishma; Botia, Juan; Vandrocova, Jana; Trabzuni, Daniah; Ramasamy, Adaikalavan; Smith, Colin; Hardy, John; Weale, Michael 分享 收藏
Novel genetic loci associated with hippocampal volume 与海马体积相关的新遗传位点 Hibar, Derrek P.; Adams, Hieab H. H.; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L.; Hofer, Edith; Renteria, Miguel E.; Bis, Joshua C.; Arias-Vasquez, Alejandro; Ikram, M. Kamran; Desrivieres, Sylvane; Vernooij, Meike W.; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S.; Armstrong, Nicola J.; Athanasiu, Lavinia; Axelsson, Tomas; Beecham, Ashley H.; Beiser, Alexa; Bernard, Manon; Blanton, Susan H.; Bohlken, Marc M.; Boks, Marco P.; Bralten, Janita; Brickman, Adam M.; Carmichael, Owen; Chakravarty, M. Mallar; Chen, Qiang; Ching, Christopher R. K.; Chouraki, Vincent; Cuellar-Partida, Gabriel; Crivello, Fabrice; Den Braber, Anouk; Nhat Trung Doan; Ehrlich, Stefan; Giddaluru, Sudheer; Goldman, Aaron L.; Gottesman, Rebecca F.; Grimm, Oliver; Griswold, Michael E.; Guadalupe, Tulio; Gutman, Boris A.; Hass, Johanna; Haukvik, Unn K.; Hoehn, David; Holmes, Avram J.; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Jorgensen, Kjetil N.; Karbalai, Nazanin; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H.; Liewald, David C. M.; Lopez, Lorna M.; Luciano, Michelle; Macare, Christine; Marquand, Andre F.; Matarin, Mar; Mather, Karen A.; Mattheisen, Manuel; McKay, David R.; Milaneschi, Yuri; Maniega, Susana Munoz; Nho, Kwangsik; Nugent, Allison C.; Nyquist, Paul; Loohuis, Loes M. Olde; Oosterlaan, Jaap; Papmeyer, Martina; Pirpamer, Lukas; Puetz, Benno; Ramasamy, Adaikalavan; Richards, Jennifer S.; Risacher, Shannon L.; Roiz-Santianez, Roberto; Rommelse, Nanda; Ropele, Stefan; Rose, Emma J.; Royle, Natalie A.; Rundek, Tatjana; Saemann, Philipp G.; Saremi, Arvin; Satizabal, Claudia L.; Schmaal, Lianne; Schork, Andrew J.; Shen, Li; Shin, Jean; Shumskaya, Elena; Smith, Albert V.; Sprooten, Emma; Strike, Lachlan T.; Teumer, Alexander; Tordesillas-Gutierrez, Diana; Toro, Roberto; Trabzuni, Daniah; Trompet, Stella; Vaidya, Dhananjay; Van der Grond, Jeroen; Van der Lee, Sven J.; Van der Meer, Dennis; Van Donkelaar, Marjolein M. J.; Van Eijk, Kristel R.; Van Erp, Theo G. M.; Van Rooij, Daan; Walton, Esther; Westlye, Lars T.; Whelan, Christopher D.; Windham, Beverly G.; Winkler, Anderson M.; Wittfeld, Katharina; Woldehawariat, Girma; Wolf, Christiane; Wolfers, Thomas; Yanek, Lisa R.; Yang, Jingyun; Zijdenbos, Alex; Zwiers, Marcel P.; Agartz, Ingrid; Almasy, Laura; Ames, David; Amouyel, Philippe; Andreassen, Ole A.; Arepalli, Sampath; Assareh, Amelia A.; Barral, Sandra; Bastin, Mark E.; Becker, Diane M.; Becker, James T.; Bennett, David A.; Blangero, John; van Bokhoven, Hans; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Brunner, Han G.; Buckner, Randy L.; Buitelaar, Jan K.; Bulayeva, Kazima B.; Cahn, Wiepke; Calhoun, Vince D.; Cannon, Dara M.; Cavalleri, Gianpiero L.; Cheng, Ching-Yu; Cichon, Sven; Cookson, Mark R.; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Czisch, Michael; Dale, Anders M.; Davies, Gareth E.; De Craen, Anton J. M.; De Geus, Eco J. C.; De Jager, Philip L.; De Zubicaray, Greig I.; Deary, Ian J.; Debette, Stephanie; DeCarli, Charles; Delanty, Norman; Depondt, Chantal; DeStefano, Anita; Dillman, Allissa; Djurovic, Srdjan; Donohoe, Gary; Drevets, Wayne C.; Duggirala, Ravi; Dyer, Thomas D.; Enzinger, Christian; Erk, Susanne; Espeseth, Thomas; Fedko, Iryna O.; Fernandez, Guillen; Ferrucci, Luigi; Fisher, Simon E.; Fleischman, Debra A.; Ford, Ian; Fornage, Myriam; Foroud, Tatiana M.; Fox, Peter T.; Francks, Clyde; Fukunaga, Masaki; Gibbs, J. Raphael; Glahn, David C.; Gollub, Randy L.; Goring, Harald H. H.; Green, Robert C.; Gruber, Oliver; Gudnason, Vilmundur; Guelfi, Sebastian; Haberg, Asta K.; Hansell, Narelle K.; Hardy, John; Hartman, Catharina A.; Hashimoto, Ryota; Hegenscheid, Katrin; Heinz, Andreas; Le Hellard, Stephanie; Hernandez, Dena G.; Heslenfeld, Dirk J.; Ho, Beng-Choon; Hoekstra, Pieter J.; Hoffmann, Wolfgang; Hofman, Albert; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Hottenga, Jouke-Jan; Huentelman, Matthew; Pol, Hilleke E. Hulshoff; Ikeda, Masashi; Jack, Clifford R., Jr.; Jenkinson, Mark; Johnson, Robert; Joensson, Erik G.; Jukema, J. Wouter; Kahn, Rene S.; Kanai, Ryota; Kloszewska, Iwona; Knopman, David S.; Kochunov, Peter; Kwok, John B.; Lawrie, Stephen M.; Lemaitre, Herve; Liu, Xinmin; Longo, Dan L.; Lopez, Oscar L.; Lovestone, Simon; Martinez, Oliver; Martinot, Jean-Luc; Mattay, Venkata S.; McDonald, Colm; McIntosh, Andrew M.; McMahon, Francis J.; McMahon, Katie L.; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Mohnke, Sebastian; Montgomery, Grant W.; Morris, Derek W.; Mosley, Thomas H.; Muhleisen, Thomas W.; Mueller-Myhsok, Bertram; Nalls, Michael A.; Nauck, Matthias; Nichols, Thomas E.; Niessen, Wiro J.; Nothen, Markus M.; Nyberg, Lars; Ohi, Kazutaka; Olvera, Rene L.; Ophoff, Roel A.; Pandolfo, Massimo; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W. J. H.; Pike, G. Bruce; Potkin, Steven G.; Psaty, Bruce M.; Reppermund, Simone; Rietschel, Marcella; Roffman, Joshua L.; Romanczuk-Seiferth, Nina; Rotter, Jerome I.; Ryten, Mina; Sacco, Ralph L.; Sachdev, Perminder S.; Saykin, Andrew J.; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter R.; Sigursson, Sigurdur; Simmons, Andrew; Singleton, Andrew; Sisodiya, Sanjay M.; Smith, Colin; Smoller, Jordan W.; Soininen, Hilkka; Steen, Vidar M.; Stott, David J.; Sussmann, Jessika E.; Thalamuthu, Anbupalam; Toga, Arthur W.; Traynor, Bryan J.; Troncoso, Juan; Tsolaki, Magda; Tzourio, Christophe; Uitterlinden, Andre G.; Hernandez, Maria C. Valdes; Van der Brug, Marcel; van der Lugt, Aad; van der Wee, Nic J. A.; Van Haren, Neeltje E. M.; van't Ent, Dennis; Van Tol, Marie-Jose; Vardarajan, Badri N.; Vellas, Bruno; Veltman, Dick J.; Voelzke, Henry; Walter, Henrik; Wardlaw, Joanna M.; Wassink, Thomas H.; Weale, Michael E.; Weinberger, Daniel R.; Weiner, Michael W.; Wen, Wei; Westman, Eric; White, Tonya; Wong, Tien Y.; Wright, Clinton B.; Zielke, Ronald H.; Zonderman, Alan B.; Martin, Nicholas G.; Van Duijn, Cornelia M.; Wright, Margaret J.; Longstreth, W. T.; Schumann, Gunter; Grabe, Hans J.; Franke, Barbara; Launer, Lenore J.; Medland, Sarah E.; Seshadri, Sudha; Thompson, Paul M.; Ikram, M. Arfan 分享 收藏
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