Philipp J. Kahle - Publications, H-index & Citations

Philipp J. Kahle

bc children's hospital research institute

63H指数

173论文数

1.5W被引数

收录论文 81

发表时间

Loss of epigenetic adaptation to a high-fat diet in alpha-synuclein transgenic mice 高脂饮食下α-突触核蛋白转基因小鼠表观遗传适应性的丧失

Frontiers in Cellular Neuroscience

IF4

2026-08-01

PREAI

Hoof, Vivien; Schaffner, Samantha L.; Dever, Kristy; MacIsaac, Julie; Rotermund, Carola; Kobor, Michael S.; Kahle, Philipp J.; Hentrich, Thomas; Schulze-Hentrich, Julia M.

The PET tracer [11C]MODAG-005 targets alpha-synuclein aggregates in the brain PET示踪剂[11C]MODAG-005靶向大脑中的α-突触核蛋白聚集物

Science Translational Medicine

IF14.6

2026-05-27

PREAI

Ran Sing Saw; Sabrina Haas; Felix Schmidt; Sergey Ryazanov; Andrei Leonov; Daniel Bleher; Ann-Kathrin Grotegerd; Laura Kuebler; Benjamin Roeben; Fabian Schmidt; Matthias Reimold; Federica Bonanno; Viktoria C. Ruf; Bernadette Dahl; Christine M. Sandiego; Kelly E. Henry; Ioannis Papadopoulos; Martin Schaller; Philipp J. Kahle; Johannes Levin; Thomas Gasser; Kathrin Brockmann; Gerald Reischl; Christian la Fougère; Bernd J. Pichler; Andreas Maurer; Christian Griesinger; Armin Giese; Kristina Herfert

Interactions of Oligodendrocyte Precursor Cells and Dopaminergic Neurons in the Mouse Substantia Nigra 少突胶质前体细胞和多巴胺能神经元在小鼠黑质中的相互作用

JOURNAL OF NEUROCHEMISTRY

IF4

2025-01-27

OAAI

Fitzgerald, Julia C.; Sun, Ying; Reinecke, Frederek; Bauer, Elisabeth; Garaschuk, Olga; Kahle, Philipp J.

Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors 功能筛选揭示了非典型畸形性横纹肌样瘤的遗传依赖性和不同的细胞周期控制

GENOME BIOLOGY

IF9.4

2024-12-02

OAAI

Merk, Daniel J.; Tsiami, Foteini; Hirsch, Sophie; Walter, Bianca; Haeusser, Lara A.; Maile, Jens D.; Stahl, Aaron; Jarboui, Mohamed A.; Lechado-Terradas, Anna; Klose, Franziska; Babaei, Sepideh; Admard, Jakob; Casadei, Nicolas; Roggia, Cristiana; Spohn, Michael; Schittenhelm, Jens; Singer, Stephan; Schueller, Ulrich; Piccioni, Federica; Persky, Nicole S.; Claassen, Manfred; Tatagiba, Marcos; Kahle, Philipp J.; Root, David E.; Templin, Markus; Tabatabai, Ghazaleh

A Novel PINK1 p.F385S Loss-of-Function Mutation in an Indian Family with Parkinson's Disease

MOVEMENT DISORDERS

IF7.6

2024-04-08

OAAI

Sharma, Karan; Kishore, Asha; Lechado-Terradas, Anna; Passannanti, Raffaele; Raimondi, Francesco; Sturm, Marc; Sreelatha, Ashwin Ashok Kumar; Puthenveedu, Divya Kalikavila; Sarma, Gangadhara; Casadei, Nicolas; Krueger, Rejko; Gasser, Thomas; Kahle, Philipp; Riess, Olaf; Fitzgerald, Julia C.; Sharma, Manu

Proteomics elucidating physiological and pathological functions of TDP-43

PROTEOMICS

IF3.9

2023-09-06

OAAI

Garcia Morato, Jorge; Gloeckner, Christian Johannes; Kahle, Philipp J.

Regulation of mitochondrial cargo-selective autophagy by posttranslational modifications (vol 297, 101339, 2021)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-08-01

OAAI

Terradas, Anna Lechado; Zittlau, Katharina I.; Macek, Boris; Fraiberg, Milana; Elazar, Zvulun; Kahle, Philipp J.

Failure of diet-induced transcriptional adaptations in alpha-synuclein transgenic mice

HUMAN MOLECULAR GENETICS

IF3.2

2022-08-24

OAAI

Kilzheimer, Alexander; Hentrich, Thomas; Rotermund, Carola; Kahle, Philipp J.; Schulze-Hentrich, Julia M.

Signatures of glial activity can be detected in the CSF proteome

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-06-06

OAAI

Eninger, Timo; Mueller, Stephan A.; Bacioglu, Mehtap; Schweighauser, Manuel; Lambert, Marius; Maia, Luis F.; Neher, Jonas J.; Hornfeck, Sarah M.; Obermueller, Ulrike; Kleinberger, Gernot; Haass, Christian; Kahle, Philipp J.; Staufenbiel, Matthias; Ping, Lingyan; Duong, Duc M.; Levey, Allan, I; Seyfried, Nicholas T.; Lichtenthaler, Stefan F.; Jucker, Mathias; Kaeser, Stephan A.

Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43

NATURE COMMUNICATIONS

IF15.7

2022-03-09

OAAI

Morato, Jorge Garcia; Hans, Friederike; von Zweydorf, Felix; Feederle, Regina; Elsasser, Simon J.; Skodras, Angelos A.; Gloeckner, Christian Johannes; Buratti, Emanuele; Neumann, Manuela; Kahle, Philipp J.

Temporal Analysis of Protein Ubiquitylation and Phosphorylation During Parkin-Dependent Mitophagy

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2022-02-01

OAAI

Zittlau, Katharina I.; Lechado-Terradas, Anna; Nalpas, Nicolas; Geisler, Sven; Kahle, Philipp J.; Macek, Boris

Regulation of mitochondrial cargo-selective autophagy by posttranslational modifications (vol 297, 101339, 2021 )

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-11-01

OAAI

Terradas, Anna Lechado; Zittlau, Katharina I.; Macek, Boris; Fraiberg, Milana; Elazar, Zvulun; Kahle, Philipp J.

Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction

NEUROBIOLOGY OF AGING

IF3.5

2021-10-01

PREAI

Gentzel, Renee C.; Toolan, Dawn; Jinn, Sarah; Schachter, Joel B.; Ma, Lei; Kahle, Philipp J.; Smith, Sean M.; Marcus, Jacob N.

Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures 在长期脑片培养中，神经元 α-突触核蛋白损伤后小胶质细胞内含物和神经丝轻链释放

MOLECULAR NEURODEGENERATION

IF17.5

2021-08-11

OAAI

Barth, Melanie; Bacioglu, Mehtap; Schwarz, Niklas; Novotny, Renata; Brandes, Janine; Welzer, Marc; Mazzitelli, Sonia; Haesler, Lisa M.; Schweighauser, Manuel; Wuttke, Thomas, V; Kronenberg-Versteeg, Deborah; Fog, Karina; Ambjorn, Malene; Alik, Ania; Melki, Ronald; Kahle, Philipp J.; Shimshek, Derya R.; Koch, Henner; Jucker, Mathias; Tanrioever, Gaye

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies LAG3在人和鼠神经元中不表达，并且不调节 α-突触核蛋白病

EMBO MOLECULAR MEDICINE

IF8.3

2021-07-26

OAAI

Emmenegger, Marc; De Cecco, Elena; Hruska-Plochan, Marian; Eninger, Timo; Schneider, Matthias M.; Barth, Melanie; Tantardini, Elena; de Rossi, Pierre; Bacioglu, Mehtap; Langston, Rebekah G.; Kaganovich, Alice; Bengoa-Vergniory, Nora; Gonzalez-Guerra, Andres; Avar, Merve; Heinzer, Daniel; Reimann, Regina; Haesler, Lisa M.; Herling, Therese W.; Matharu, Naunehal S.; Landeck, Natalie; Luk, Kelvin; Melki, Ronald; Kahle, Philipp J.; Hornemann, Simone; Knowles, Tuomas P. J.; Cookson, Mark R.; Polymenidou, Magdalini; Jucker, Mathias; Aguzzi, Adriano

Chronic-Progressive Dopaminergic Deficiency Does Not Induce Midbrain Neurogenesis

CELLS

IF5.2

2021-03-31

OAAI

Fauser, Mareike; Pan-Montojo, Francisco; Richter, Christian; Kahle, Philipp J.; Schwarz, Sigrid C.; Schwarz, Johannes; Storch, Alexander; Hermann, Andreas

Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice Medin聚集导致衰老野生型小鼠的脑血管功能障碍

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-09-08

OAAI

Degenhardt, Karoline; Wagner, Jessica; Skodras, Angelos; Candlish, Michael; Koppelmann, Anna Julia; Wild, Katleen; Maxwell, Rusheka; Rotermund, Carola; von Zweydorf, Felix; Gloeckner, Christian Johannes; Davies, Hannah A.; Madine, Jillian; Del Turco, Domenico; Feederle, Regina; Lashley, Tammaryn; Deller, Thomas; Kahle, Philipp; Hefendehl, Jasmin K.; Jucker, Mathias; Neher, Jonas J.

Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2020-08-12

OAAI

Tanrioever, Gaye; Bacioglu, Mehtap; Schweighauser, Manuel; Mahler, Jasmin; Wegenast-Braun, Bettina M.; Skodras, Angelos; Obermueller, Ulrike; Barth, Melanie; Kronenberg-Versteeg, Deborah; Nilsson, K. Peter R.; Shimshek, Derya R.; Kahle, Philipp J.; Eisele, Yvonne S.; Jucker, Mathias

Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2020-01-17

OAAI

Hans, Friederike; Glasebach, Hanna; Kahle, Philipp J.

Ubiquitin-specific protease USP36 knockdown impairs Parkin-dependent mitophagy via downregulation of Beclin-1-associated autophagy-related ATG14L

EXPERIMENTAL CELL RESEARCH

IF3.5

2019-11-01

PREAI

Geisler, Sven; Jaeger, Lea; Golombek, Sonia; Nakanishi, Etsuro; Hans, Friederike; Casadei, Nicolas; Terradas, Anna Lechado; Linnemann, Caren; Kahle, Philipp J.

研究方向