Robert Tycko

national institutes of health

H指数:91

被引数:3.6万

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Polymorphic structures of rapidly twisting 40-residue amyloid-β fibrils

快速扭曲的40残基淀粉样β纤维的多晶型结构

Biophysical Journal

IF3.1

2026-08-070

PRE

Brain-seeded 42-residue Amyloid-β Fibrils That Resemble Fibrils Directly Extracted From Alzheimer's Disease Brain Tissue

脑源42残基淀粉样蛋白-β纤维，其与直接从阿尔茨海默病脑组织中提取的纤维相似

Journal of Molecular Biology

IF4.5

2026-08-010

PRE

Effects of Nanopore Confinement on the Conformational; Dynamical; and Self-Assembly Properties of an FG-Repeat Peptide

纳米孔限域效应对FG-重复肽构象、动力学及自组装性质的影响

The Journal of Physical Chemistry B

IF2.9

2025-12-040

PRE

The evolving role of solid state nuclear magnetic resonance methods in studies of amyloid fibrils

固态核磁共振方法在淀粉样纤维研究中的演变作用

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2025-06-010

PRE

Conformations of a low-complexity protein in homogeneous and phase-separated frozen solutions

BIOPHYSICAL JOURNAL

IF3.1

2024-12-010

OAAI

Micron-scale magnetic resonance imaging based on low temperatures and dynamic nuclear polarization

基于低温和动态核极化的微米级磁共振成像

Progress in Nuclear Magnetic Resonance Spectroscopy

IF8.2

2023-11-011

PRE

Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice

EMBO REPORTS

IF6.2

2023-07-105

PRE

Early events in amyloid-β self-assembly probed by time-resolved solid state NMR and light scattering

NATURE COMMUNICATIONS

IF15.7

2023-05-2322

OAAI

Structures of brain-derived 42-residue amyloid-β fibril polymorphs with unusual molecular conformations and intermolecular interactions

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-03-0920

OAAI

Millisecond Time-Resolved Solid-State NMR Initiated by Rapid Inverse Temperature Jumps

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2022-05-2611

Enhanced spatial resolution in magnetic resonance imaging by dynamic nuclear polarization at 5 K

通过5 k的动态核极化增强磁共振成像的空间分辨率

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-05-239

OAAI

Time-resolved DEER EPR and solid-state NMR afford kinetic and structural elucidation of substrate binding to Ca2+-ligated calmodulin

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-02-0131

OAAI

Structural differences in amyloid-β fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients

非痴呆老年人和阿尔茨海默氏病患者大脑中淀粉样 β 纤维的结构差异

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-11-0126

Constraints on the Structure of Fibrils Formed by a Racemic Mixture of Amyloid-β Peptides from Solid-State NMR, Electron Microscopy, and Theory

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2021-08-1019

OAAI

Automated picking of amyloid fibrils from cryo-EM images for helical reconstruction with RELION

从cryo-em图像中自动拾取淀粉样蛋白原纤维，以使用RELION进行螺旋重建

JOURNAL OF STRUCTURAL BIOLOGY

IF5.1

2021-06-017

OAAI

Transiently structured head domains control intermediate filament assembly

瞬态结构化头域控制中间丝组装

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-02-1537

OAAI

Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer's disease brain tissue

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-01-11126

Millisecond Time-Resolved Solid-State NMR Reveals a Two-Stage Molecular Mechanism for Formation of Complexes between Calmodulin and a Target Peptide from Myosin Light Chain Kinase

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2020-12-0729

OAAI

Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS

NATURE COMMUNICATIONS

IF15.7

2020-11-1271

OAAI

Effects of an HIV-1 maturation inhibitor on the structure and dynamics of CA-SP1 junction helices in virus-like particles

HIV-1成熟抑制剂对病毒样颗粒中CA-SP1连接螺旋的结构和动力学的影响

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-04-2720

Robert Tycko

个人简介

教育背景

工作经历

荣誉奖项

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