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Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings 锌转运蛋白SLC39A5的遗传失活可改善致肥胖环境中的肝功能和高血糖 Chim, Shek Man; Howell, Kristen; Dronzek, John; Wu, Weizhen; Van Hout, Cristopher; Ferreira, Manuel A. R.; Ye, Bin; Li, Alexander; Brydges, Susannah; Arunachalam, Vinayagam; Marcketta, Anthony; Locke, Adam E.; Bovijn, Jonas; Verweij, Niek; De, Tanima; Lotta, Luca; Mitnaul, Lyndon; LeBlanc, Michelle; Carey, David J.; Melander, Olle; Shuldiner, Alan; Karalis, Katia; Economides, Aris N.; Nistala, Harikiran 分享 收藏
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Joint testing of rare variant burden scores using non-negative least squares 使用非负最小二乘法对罕见变异负担评分进行联合检验 Ziyatdinov, Andrey; Mbatchou, Joelle; Marcketta, Anthony; Backman, Joshua; Gaynor, Sheila; Zou, Yuxin; Joseph, Tyler; Geraghty, Benjamin; Herman, Joseph; Watanabe, Kyoko; Ghosh, Arkopravo; Kosmicki, Jack; Locke, Adam; Thornton, Timothy; Kang, Hyun Min; Ferreira, Manuel; Baras, Aris; Abecasis, Goncalo; Marchini, Jonathan 分享 收藏
Genetic risk factors for COVID-19 and influenza are largely distinct Kosmicki, Jack A.; Marcketta, Anthony; Sharma, Deepika; Di Gioia, Silvio Alessandro; Batista, Samantha; Yang, Xiao-Man; Tzoneva, Gannie; Martinez, Hector; Sidore, Carlo; Kessler, Michael D.; Horowitz, Julie E.; Roberts, Genevieve H. L.; Justice, Anne E.; Banerjee, Nilanjana; Coignet, Marie V.; Leader, Joseph B.; Park, Danny S.; Lanche, Rouel; Maxwell, Evan; Knight, Spencer C.; Bai, Xiaodong; Guturu, Harendra; Baltzell, Asher; Girshick, Ahna R.; McCurdy, Shannon R.; Partha, Raghavendran; Mansfield, Adam J.; Turissini, David A.; Zhang, Miao; Mbatchou, Joelle; Watanabe, Kyoko; Verma, Anurag; Sirugo, Giorgio; Ritchie, Marylyn D.; Salerno, William J.; Shuldiner, Alan R.; Rader, Daniel J.; Mirshahi, Tooraj; Marchini, Jonathan; Overton, John D.; Carey, David J.; Habegger, Lukas; Reid, Jeffrey G.; Economides, Aris; Kyratsous, Christos; Karalis, Katia; Baum, Alina; Cantor, Michael N.; Rand, Kristin A.; Hong, Eurie L.; Ball, Catherine A.; Siminovitch, Katherine; Baras, Aris; Abecasis, Goncalo R.; Ferreira, Manuel A. R. 分享 收藏
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target 全基因组关联荟萃分析确定腹主动脉瘤的风险位点，并强调PCSK9作为治疗靶点 Roychowdhury, Tanmoy; Klarin, Derek; Levin, Michael G.; Spin, Joshua M.; Rhee, Yae Hyun; Deng, Alicia; Headley, Colwyn A.; Tsao, Noah L.; Gellatly, Corry; Zuber, Verena; Shen, Fred; Hornsby, Whitney E.; Laursen, Ina Holst; Verma, Shefali S.; Locke, Adam E.; Einarsson, Gudmundur; Thorleifsson, Gudmar; Graham, Sarah E.; Dikilitas, Ozan; Pattee, Jack W.; Judy, Renae L.; Pauls-Verges, Ferran; Nielsen, Jonas B.; Wolford, Brooke N.; Brumpton, Ben M.; Dilme, Jaume; Peypoch, Olga; Juscafresa, Laura Calsina; Edwards, Todd L.; Li, Dadong; Banasik, Karina; Brunak, Soren; Jacobsen, Rikke L.; Garcia-Barrio, Minerva T.; Zhang, Jifeng; Rasmussen, Lars M.; Lee, Regent; Handa, Ashok; Wanhainen, Anders; Mani, Kevin; Lindholt, Jes S.; Obel, Lasse M.; Strauss, Ewa; Oszkinis, Grzegorz; Nelson, Christopher P.; Saxby, Katie L.; van Herwaarden, Joost A.; van der Laan, Sander W.; van Setten, Jessica; Camacho, Mercedes; Davis, Frank M.; Wasikowski, Rachael; Tsoi, Lam C.; Gudjonsson, Johann E.; Eliason, Jonathan L.; Coleman, Dawn M.; Henke, Peter K.; Ganesh, Santhi K.; Chen, Y. Eugene; Guan, Weihua; Pankow, James S.; Pankratz, Nathan; Pedersen, Ole B.; Erikstrup, Christian; Tang, Weihong; Hveem, Kristian; Gudbjartsson, Daniel; Gretarsdottir, Solveig; Thorsteinsdottir, Unnur; Holm, Hilma; Stefansson, Kari; Ferreira, Manuel A.; Baras, Aris; Kullo, Iftikhar J.; Ritchie, Marylyn D.; Christensen, Alex H.; Iversen, Kasper K.; Eldrup, Nikolaj; Sillesen, Henrik; Ostrowski, Sisse R.; Bundgaard, Henning; Ullum, Henrik; Burgess, Stephen; Gill, Dipender; Gallagher, Katherine; Sabater-Lleal, Maria; Surakka, Ida; Jones, Gregory T.; Bown, Matthew J.; Tsao, Philip S.; Willer, Cristen J.; Damrauer, Scott M. 分享 收藏
Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis Zhou, Sirui; Sosina, Olukayode A.; Bovijn, Jonas; Laurent, Laetitia; Sharma, Vasundhara; Akbari, Parsa; Forgetta, Vincenzo; Jiang, Lai; Kosmicki, Jack A.; Banerjee, Nilanjana; Morris, John A.; Oerton, Erin; Jones, Marcus; LeBlanc, Michelle G.; Idone, Vincent; Overton, John D.; Reid, Jeffrey G.; Cantor, Michael; Abecasis, Goncalo R.; Goltzman, David; Greenwood, Celia M. T.; Langenberg, Claudia; Baras, Aris; Economides, Aris N.; Ferreira, Manuel A. R.; Hatsell, Sarah; Ohlsson, Claes; Richards, J. Brent; Lotta, Luca A. 分享 收藏
An international genome-wide meta- analysis of primary biliary cholangitis: Novel risk loci and candidate drugs (vol 75, pg 572, 2021) Cordell, Heather J.; Fryett, James J.; Ueno, Kazuko; Darlay, Rebecca; Aiba., Yoshihiro; Hitomi., Yuki; Kawashima, Minae.; Nishida, Nao; Khor, Seik-Soon; Gervais, Olivier; Kawai, Yosuke; Nagasaki, Masao; Tokunaga, Katsushi; Tang, Ruqi; Shi, Yongyong; Li, Zhiqiang; Juran, Brian D.; Atkinson, Elizabeth J.; Gerussi, Alessio; Carbone, Marco; Asselta, Rosanna; Cheung, Angela; de Andrade, Mariza; Baras, Aris; Horowitz, Julie; Ferreira, Manuel A. R.; Sun, Dylan; Jones, David E.; Flack, Steven; Spicer, Ann; Mulcahy, Victoria L.; Byan, Jinyoung; Han, Younghun; Sandford, Richard N.; Lazaridis, Konstantinos N.; Amos, Christopher I.; Hirschfield, Gideon M.; Seldin, Michael F.; Invernizzi, Pietro; Siminovitch, Katherine A.; Ma, Xiong; Nakamura, Minoru; Mells, George F. 分享 收藏
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma Jackman, Janet K.; Stockwell, Amy; Choy, David F.; Xie, Markus M.; Lu, Peipei; Jia, Guiquan; Li, Hong; Abbas, Alexander R.; Bronson, Paola G.; Lin, Wei-Yu; Chiu, Cecilia P. C.; Maun, Henry R.; Roose-Girma, Merone; Tam, Lucinda; Zhang, Juan; Modrusan, Zora; Graham, Robert R.; Behrens, Timothy W.; White, Steven R.; Naureckas, Ted; Ober, Carole; Ferreira, Manuel; Sedlacek, Radislav; Wu, Jiansheng; Lee, Wyne P.; Lazarus, Robert A.; Koerber, James T.; Arron, Joseph R.; Yaspan, Brian L.; Yi, Tangsheng 分享 收藏
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility 大规模测序鉴定与克罗恩病易感性相关的多个基因和罕见变异 Sazonovs, Aleksejs; Stevens, Christine R.; Venkataraman, Guhan R.; Yuan, Kai; Avila, Brandon; Abreu, Maria T.; Ahmad, Tariq; Allez, Matthieu; Ananthakrishnan, Ashwin N.; Atzmon, Gil; Baras, Aris; Barrett, Jeffrey C.; Barzilai, Nir; Beaugerie, Laurent; Beecham, Ashley; Bernstein, Charles N.; Bitton, Alain; Bokemeyer, Bernd; Chan, Andrew; Chung, Daniel; Cleynen, Isabelle; Cosnes, Jacques; Cutler, David J.; Daly, Allan; Damas, Oriana M.; Datta, Lisa W.; Dawany, Noor; Devoto, Marcella; Dodge, Sheila; Ellinghaus, Eva; Fachal, Laura; Farkkila, Martti; Faubion, William; Ferreira, Manuel; Franchimont, Denis; Gabriel, Stacey B.; Ge, Tian; Georges, Michel; Gettler, Kyle; Giri, Mamta; Glaser, Benjamin; Goerg, Siegfried; Goyette, Philippe; Graham, Daniel; Hamalainen, Eija; Haritunians, Talin; Heap, Graham A.; Hiltunen, Mikko; Hoeppner, Marc; Horowitz, Julie E.; Irving, Peter; Iyer, Vivek; Jalas, Chaim; Kelsen, Judith; Khalili, Hamed; Kirschner, Barbara S.; Kontula, Kimmo; Koskela, Jukka T.; Kugathasan, Subra; Kupcinskas, Juozas; Lamb, Christopher A.; Laudes, Matthias; Levesque, Chloe; Levine, Adam P.; Lewis, James D.; Liefferinckx, Claire; Loescher, Britt-Sabina; Louis, Edouard; Mansfield, John; May, Sandra; McCauley, Jacob L.; Mengesha, Emebet; Mni, Myriam; Moayyedi, Paul; Moran, Christopher J.; Newberry, Rodney D.; O'Charoen, Sirimon; Okou, David T.; Oldenburg, Bas; Ostrer, Harry; Palotie, Aarno; Paquette, Jean; Pekow, Joel; Peter, Inga; Pierik, Marieke J.; Ponsioen, Cyriel Y.; Pontikos, Nikolas; Prescott, Natalie; Pulver, Ann E.; Rahmouni, Souad; Rice, Daniel L.; Saavalainen, Paivi; Sands, Bruce; Sartor, R. Balfour; Schiff, Elena R.; Schreiber, Stefan; Schumm, L. Philip; Segal, Anthony W.; Seksik, Philippe; Shawky, Rasha; Sheikh, Shehzad Z.; Silverberg, Mark S.; Simmons, Alison; Skeiceviciene, Jurgita; Sokol, Harry; Solomonson, Matthew; Somineni, Hari; Sun, Dylan; Targan, Stephan; Turner, Dan; Uhlig, Holm H.; van der Meulen, Andrea E.; Vermeire, Severine; Verstockt, Sare; Voskuil, Michiel D.; Winter, Harland S.; Young, Justine; Duerr, Richard H.; Franke, Andre; Brant, Steven R.; Cho, Judy; Weersma, Rinse K.; Parkes, Miles; Xavier, Ramnik J.; Rivas, Manuel A.; Rioux, John D.; McGovern, Dermot P. B.; Huang, Hailiang; Anderson, Carl A.; Daly, Mark J. 分享 收藏
Germline Mutations in CIDEB and Protection against Liver Disease CIDEB的种系突变和对肝脏疾病的保护 Verweij, N.; Haas, M. E.; Nielsen, J. B.; Sosina, O. A.; Kim, M.; Akbari, P.; De, T.; Hindy, G.; Bovijn, J.; Persaud, T.; Miloscio, L.; Germino, M.; Panagis, L.; Watanabe, K.; Mbatchou, J.; Jones, M.; LeBlanc, M.; Balasubramanian, S.; Lammert, C.; Enhorning, S.; Melander, O.; Carey, D. J.; Still, C. D.; Mirshahi, T.; Rader, D. J.; Parasoglou, P.; Walls, J. R.; Overton, J. D.; Reid, J. G.; Economides, A.; Cantor, M. N.; Zambrowicz, B.; Murphy, A. J.; Abecasis, G. R.; Ferreira, M. A. R.; Smagris, E.; Gusarova, V; Sleeman, M.; Yancopoulos, G. D.; Marchini, J.; Kang, H. M.; Karalis, K.; Shuldiner, A. R.; Della Gatta, G.; Locke, A. E.; Baras, A.; Lotta, L. A. 分享 收藏
Efficacy and Safety of Sarilumab in Hospitalized Patients With Coronavirus Disease 2019: A Randomized Clinical Trial Sarilumab在冠状病毒疾病住院患者中的疗效和安全性2019: 一项随机临床试验 Sivapalasingam, Sumathi; Lederer, David J.; Bhore, Rafia; Hajizadeh, Negin; Criner, Gerard; Hosain, Romana; Mahmood, Adnan; Giannelou, Angeliki; Somersan-Karakaya, Selin; O'Brien, Meagan P.; Boyapati, Anita; Parrino, Janie; Musser, Bret J.; Labriola-Tompkins, Emily; Ramesh, Divya; Purcell, Lisa A.; Gulabani, Daya; Kampman, Wendy; Waldron, Alpana; Ng Gong, Michelle; Saggar, Suraj; Sperber, Steven J.; Menon, Vidya; Stein, David K.; Sobieszczyk, Magdalena E.; Park, William; Aberg, Judith A.; Brown, Samuel M.; Kosmicki, Jack A.; Horowitz, Julie E.; Ferreira, Manuel A.; Baras, Aris; Kowal, Bari; Thomas DiCioccio, A.; Akinlade, Bolanle; Nivens, Michael C.; Braunstein, Ned; Herman, Gary A.; Yancopoulos, George D.; Weinreich, David M. 分享 收藏
Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma Werder, Rhiannon B.; Ullah, Md Ashik; Rahman, Muhammed Mahfuzur; Simpson, Jennifer; Lynch, Jason P.; Collinson, Natasha; Rittchen, Sonja; Rashid, Ridwan B.; Sikder, Md Al Amin; Handoko, Herlina Y.; Curren, Bodie F.; Sebina, Ismail; Hartel, Gunter; Bissell, Alec; Ngo, Sylvia; Yarlagadda, Tejasri; Hasnain, Sumaira Z.; Lu, Wenying; Sohal, Sukhwinder S.; Martin, Megan; Bowler, Simon; Burr, Lucy D.; Martinez, Laurent O.; Robaye, Bernard; Spann, Kirsten; Ferreira, Manuel A. R.; Phipps, Simon 分享 收藏
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs (vol 75, pg 572, 2021) 原发性胆汁性胆管炎的国际全基因组荟萃分析: 新的风险位点和候选药物 (第75卷，572页，2021) Cordell, Heather J.; Fryett, James J.; Ueno, Kazuko; Darlay, Rebecca; Aiba, Yoshihiro; Hitomi, Yuki; Kawashima, Minae; Nishida, Nao; Khor, Seik-Soon; Gervais, Olivier; Kawai, Yosuke; Nagasaki, Masao; Tokunaga, Katsushi; Tang, Ruqi; Shi, Yongyong; Li, Zhiqiang; Juran, Brian D.; Atkinson, Elizabeth J.; Gerussi, Alessio; Carbone, Marco; Asselta, Rosanna; Cheung, Angela; de Andrade, Mariza; Baras, Aris; Horowitz, Julie; Ferreira, Manuel A. R.; Sun, Dylan; Jones, David E.; Flack, Steven; Spicer, Ann; Mulcahy, Victoria L.; Byun, Jinyoung; Han, Younghun; Sandford, Richard N.; Lazaridis, Konstantinos N.; Amos, Christopher I.; Hirsch, Gideon M.; Seldin, Michael F.; Invernizzi, Pietro; Siminovitch, Katherine A.; Ma, Xiong; Nakamura, Minoru; Mells, George F. 分享 收藏
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4 Grosche, Sarah; Marenholz, Ingo; Esparza-Gordillo, Jorge; Arnau-Soler, Aleix; Pairo-Castineira, Erola; Rueschendorf, Franz; Ahluwalia, Tarunveer S.; Almqvist, Catarina; Arnold, Andreas; Baurecht, Hansjoerg; Bisgaard, Hans; Bonnelykke, Klaus; Brown, Sara J.; Bustamante, Mariona; Curtin, John A.; Custovic, Adnan; Dharmage, Shyamali C.; Esplugues, Ana; Falchi, Mario; Fernandez-Orth, Dietmar; Ferreira, Manuel A. R.; Franke, Andre; Gerdes, Sascha; Gieger, Christian; Hakonarson, Hakon; Holt, Patrick G.; Homuth, Georg; Hubner, Norbert; Hysi, Pirro G.; Jarvelin, Marjo-Riitta; Karlsson, Robert; Koppelman, Gerard H.; Lau, Susanne; Lutz, Manuel; Magnusson, Patrik K. E.; Marks, Guy B.; Mueller-Nurasyid, Martina; Noethen, Markus M.; Paternoster, Lavinia; Pennell, Craig E.; Peters, Annette; Rawlik, Konrad; Robertson, Colin F.; Rodriguez, Elke; Sebert, Sylvain; Simpson, Angela; Sleiman, Patrick M. A.; Standl, Marie; Stoelzl, Dora; Strauch, Konstantin; Szwajda, Agnieszka; Tenesa, Albert; Thompson, Philip J.; Ullemar, Vilhelmina; Visconti, Alessia; Vonk, Judith M.; Wang, Carol A.; Weidinger, Stephan; Wielscher, Matthias; Worth, Catherine L.; Xu, Chen-Jian; Lee, Young-Ae 分享 收藏
ERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers Gelfman, Sahar; Monnet, Dominique; Ligocki, Ann J.; Tabary, Thierry; Moscati, Arden; Bai, Xiaodong; Freudenberg, Jan; Cooper, Blerta; Kosmicki, Jack A.; Wolf, Sarah; Ferreira, Manuel A. R.; Overton, John; Weyne, Jonathan; Stahl, Eli A.; Baras, Aris; Romano, Carmelo; Cohen, Jacques H. M.; Coppola, Giovanni; Brezin, Antoine 分享 收藏
Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial Rabe, Klaus F.; Celli, Bartolome R.; Wechsler, Michael E.; Abdulai, Raolat M.; Luo, Xiaodong; Boomsma, Maarten M.; Staudinger, Heribert; Horowitz, Julie E.; Baras, Aris; Ferreira, Manuel A.; Ruddy, Marcella K.; Nivens, Michael C.; Amin, Nikhil; Weinreich, David M.; Yancopoulos, George D.; Goulaouic, Helene 分享 收藏
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs 原发性胆汁性胆管炎的国际全基因组荟萃分析: 新的风险位点及候选药物 Cordell, Heather J.; Fryett, James J.; Ueno, Kazuko; Darlay, Rebecca; Aiba, Yoshihiro; Hitomi, Yuki; Kawashima, Minae; Nishida, Nao; Khor, Seik-Soon; Gervais, Olivier; Kawai, Yosuke; Nagasaki, Masao; Tokunaga, Katsushi; Tang, Ruqi; Shi, Yongyong; Li, Zhiqiang; Juran, Brian D.; Atkinson, Elizabeth J.; Gerussi, Alessio; Carbone, Marco; Asselta, Rosanna; Cheung, Angela; de Andrade, Mariza; Baras, Aris; Horowitz, Julie; Ferreira, Manuel A. R.; Sun, Dylan; Jones, David E.; Flack, Steven; Spicer, Ann; Mulcahy, Victoria L.; Byan, Jinyoung; Han, Younghun; Sandford, Richard N.; Lazaridis, Konstantinos N.; Amos, Christopher, I; Hirschfield, Gideon M.; Seldin, Michael F.; Invernizzi, Pietro; Siminovitch, Katherine A.; Ma, Xiong; Nakamura, Minoru; Mells, George F. 分享 收藏
Computationally efficient whole-genome regression for quantitative and binary traits 用于定量和二元性状的计算有效的全基因组回归 Mbatchou, Joelle; Barnard, Leland; Backman, Joshua; Marcketta, Anthony; Kosmicki, Jack A.; Ziyatdinov, Andrey; Benner, Christian; O'Dushlaine, Colm; Barber, Mathew; Boutkov, Boris; Habegger, Lukas; Ferreira, Manuel; Baras, Aris; Reid, Jeffrey; Abecasis, Goncalo; Maxwell, Evan; Marchini, Jonathan 分享 收藏
Exome-wide evaluation of rare coding variants using electronic health records identifies new gene-phenotype associations 使用电子健康记录对罕见编码变异进行全外显子组评估可识别新的基因-表型关联 Park, Joseph; Lucas, Anastasia M.; Zhang, Xinyuan; Chaudhary, Kumardeep; Cho, Judy H.; Nadkarni, Girish; Dobbyn, Amanda; Chittoor, Geetha; Josyula, Navya S.; Katz, Nathan; Breeyear, Joseph H.; Ahmadmehrabi, Shadi; Drivas, Theodore G.; Chavali, Venkata R. M.; Fasolino, Maria; Sawada, Hisashi; Daugherty, Alan; Li, Yanming; Zhang, Chen; Bradford, Yuki; Weaver, JoEllen; Verma, Anurag; Judy, Renae L.; Kember, Rachel L.; Overton, John D.; Reid, Jeffrey G.; Ferreira, Manuel A. R.; Li, Alexander H.; Baras, Aris; LeMaire, Scott A.; Shen, Ying H.; Naji, Ali; Kaestner, Klaus H.; Vahedi, Golnaz; Edwards, Todd L.; Chen, Jinbo; Damrauer, Scott M.; Justice, Anne E.; Do, Ron; Ritchie, Marylyn D.; Rader, Daniel J. 分享 收藏
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