Frances M. Ashcroft - Publications, H-index & Citations

Frances M. Ashcroft

university of oxford

90H指数

396论文数

3.4W被引数

收录论文 167

发表时间

TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network TBL1X/TBL1XR1通过PAX6-containing基因调控网络控制 β 细胞身份

Nature Communications

IF15.7

2026-04-23

OAAI

Alina A. Walth-Hummel; Celine Jouffe; Peter Weber; Karsten Motzler; Julia Geppert; Michael Sterr; Wei Gan; Iwona Szczerbinska; Ann-Christine König; Stefanie M. Hauck; Raul Terron-Exposito; Daniela Hass; Congcong Wang; Kenneth A. Dyar; James G. Lyon; Heiko Lickert; Carina Ämmälä; Stephan Herzig; Frances M. Ashcroft; Mostafa Bakhti; Patrick E. MacDonald; Maria Rohm

Stephen Ashcroft, 27 January 1942–28 November 2025 Stephen Ashcroft，1942年1月27日–2025年11月28日

Diabetologia

IF10.2

2026-02-21

PREAI

Frances Ashcroft; Richard M. Denton; Patrik Rorsman; Guy A. Rutter

Residue 39 of Kir6.2 drives a difference in ATP sensitivity in human and canine beta-cell KATP channels Kir6.2的残基39驱动了人类和犬类β细胞KATP通道中ATP敏感性的差异。

Frontiers in Physiology

IF3.4

2025-10-17

OAAI

Natascia Vedovato; Frances M. Ashcroft; Brian Catchpole; Lucy J. Davison

Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes 1型糖尿病中 β 细胞与 δ 细胞的电偶联丧失是低血糖诱导的胰高血糖素分泌受损的基础

NATURE METABOLISM

IF20.8

2024-09-23

OAAI

Hill, Thomas G.; Gao, Rui; Benrick, Anna; Kothegala, Lakshmi; Rorsman, Nils; Santos, Cristiano; Acreman, Samuel; Briant, Linford J.; Dou, Haiqiang; Gandasi, Nikhil R.; Guida, Claudia; Haythorne, Elizabeth; Wallace, Marsha; Knudsen, Jakob G.; Miranda, Caroline; Tolo, Johan; Clark, Anne; Davison, Lucy; Storling, Joachim; Tarasov, Andrei; Ashcroft, Frances M.; Rorsman, Patrik; Zhang, Quan

KATP channel mutation disrupts hippocampal network activity and nocturnal gamma shifts

BRAIN

IF11.7

2024-05-15

PREAI

Burkart, Marie-Elisabeth; Kurzke, Josephine; Jacobi, Robert; Vera, Jorge; Ashcroft, Frances M.; Eilers, Jens; Lippmann, Kristina

A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life

DIABETOLOGIA

IF10.2

2024-02-17

OAAI

Vedovato, Natascia; Salguero, Maria V.; Greeley, Siri Atma W.; Yu, Christine H.; Philipson, Louis H.; Ashcroft, Frances M.

KATP Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture

DIABETES

IF7.5

2023-05-19

OAAI

Ashcroft, Frances M.

Glucokinase activity in diabetes: too much of a good thing?

TRENDS IN ENDOCRINOLOGY AND METABOLISM

IF12.6

2023-02-01

OAAI

Ashcroft, Frances M.; Lloyd, Matthew; Haythorne, Elizabeth A.

Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells 糖酵解改变触发糖尿病 β 细胞线粒体代谢受损和mTORC1激活

NATURE COMMUNICATIONS

IF15.7

2022-11-14

OAAI

Haythorne, Elizabeth; Lloyd, Matthew; Walsby-Tickle, John; Tarasov, Andrei, I; Sandbrink, Jonas; Portillo, Idoia; Exposito, Raul Terron; Sachse, Gregor; Cyranka, Malgorzata; Rohm, Maria; Rorsman, Patrik; McCullagh, James; Ashcroft, Frances M.

Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-07-26

OAAI

Koberstein, John N.; Stewart, Melissa L.; Smith, Chadwick B.; Tarasov, Andrei, I; Ashcroft, Frances M.; Stork, Philip J. S.; Goodman, Richard H.

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion

DIABETES

IF7.5

2021-02-10

OAAI

Sachse, Gregor; Haythorne, Elizabeth; Hill, Thomas; Proks, Peter; Joynson, Russell; Terron-Exposito, Raul; Bentley, Liz; Tucker, Stephen J.; Cox, Roger D.; Ashcroft, Frances M.

Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease

COMMUNICATIONS CHEMISTRY

IF6.2

2020-10-30

OAAI

Pipatpolkai, Tanadet; Corey, Robin A.; Proks, Peter; Ashcroft, Frances M.; Stansfeld, Phillip J.

New insights into KATP channel gene mutations and neonatal diabetes mellitus

nature reviews endocrinology

IF40

2020-05-06

PREAI

Pipatpolkai, Tanadet; Usher, Samuel; Stansfeld, Phillip J.; Ashcroft, Frances M.

Nucleotide inhibition of the pancreatic ATP-sensitive K plus channel explored with patch-clamp fluorometry

ELIFE

IF0

2020-01-07

OAAI

Usher, Samuel G.; Ashcroft, Frances M.; Puljung, Michael C.

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

NATURE COMMUNICATIONS

IF15.7

2019-06-06

248

OAAI

Haythorne, Elizabeth; Rohm, Maria; van de Bunt, Martijn; Brereton, Melissa F.; Tarasov, Andrei, I; Blacker, Thomas S.; SachseqF, Gregor; dos Santos, Mariana Silva; Exposito, Raul Terron; Davis, Simon; Baba, Otto; Fischer, Roman; Duchen, Michael R.; Rorsman, Patrik; MacRae, James, I; Ashcroft, Frances M.

Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes (vol 37, pg 3333, 2014)

DIABETES CARE

IF16.6

2019-05-21

OAAI

Myngheer, Nele; Allegaert, Karel; Hattersley, Andrew; McDonald, Tim; Kramer, Holger; Ashcroft, Frances M.; Verhaeghe, Johan; Mathieu, Chantal; Casteels, Kristina

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

ELIFE

IF0

2019-02-21

OAAI

Puljung, Michael; Vedovato, Natascia; Usher, Samuel; Ashcroft, Frances

Nucleotide Modulation of KATP Channels Disentangled with FRET

BIOPHYSICAL JOURNAL

IF3.1

2019-02-01

OAAI

Puljung, Michael C.; Usher, Samuel; Vedovato, Natascia; Ashcroft, Frances

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

NATURE COMMUNICATIONS

IF15.7

2019-01-11

137

OAAI

Vergari, Elisa; Knudsen, Jakob G.; Ramracheya, Reshma; Salehi, Albert; Zhang, Quan; Adam, Julie; Asterholm, Ingrid Wernstedt; Benrick, Anna; Briant, Linford J. B.; Chibalina, Margarita V.; Gribble, Fiona M.; Hamilton, Alexander; Hastoy, Benoit; Reimann, Frank; Rorsman, Nils J. G.; Spiliotis, Ioannis I.; Tarasov, Andrei; Wu, Yanling; Ashcroft, Frances M.; Rorsman, Patrik

Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+

DIABETOLOGIA

IF10.2

2018-11-13

OAAI

Kurstjens, Steef; de Baaij, Jeroen H. F.; Overmars-Bos, Caro; van den Munckhof, Inge C. L.; Garzero, Veronica; de Vries, Marijke A.; Burggraaf, Benjamin; van Diepen, Janna A.; Riksen, Niels P.; Rutten, Joost H. W.; Netea, Mihai G.; Cabezas, Manuel Castro; Bindels, Rene J. M.; Ashcroft, Frances M.; Tack, Cees J. J.; Hoenderop, Joost G. J.

研究方向