未登录 Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite Plasmodium falciparum 基于细胞模型的螺吲哚啉表型活性化合物的优化鉴定出对人类疟原虫 *Plasmodium falciparum* 具有不同寄生虫学特征的化合物 Dam, Jean; Boyle, Grant A.; Horatscheck, Andre; Woodland, John G.; Le Manach, Claire; Kaur, Gurminder; Taylor, Dale; Krugmann, Liezl; Njoroge, Mathew; Lawrence, Nina; Brunschwig, Christel; Zdorichenko, Victor; Cox, Brian; Wittlin, Sergio; von Geldern, Thomas W.; Smith, Dennis; Duffy, James; Basarab, Gregory S. 分享 收藏
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead 欧洲药物化学和化学生物学联合会 (EFMC) 最佳实践倡议: 领先 Quancard, Jean; Bach, Anders; Borsari, Chiara; Craft, Russell; Gnamm, Christian; Gueret, Stephanie M.; Hartung, Ingo V.; Koolman, Hannes F.; Laufer, Stefan; Lepri, Susan; Messinger, Josef; Ritter, Kurt; Sbardella, Gianluca; Lopez, Andrea Unzue; Willwacher, Marina K.; Cox, Brian; Young, Robert J. 分享 收藏
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit Generation Quancard, Jean; Vulpetti, Anna; Bach, Anders; Cox, Brian; Gueret, Stephanie M.; Hartung, Ingo V.; Koolman, Hannes F.; Laufer, Stefan; Messinger, Josef; Sbardella, Gianluca; Craft, Russell 分享 收藏
Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease Le Grand, Darren; Gosling, Martin; Baettig, Urs; Bahra, Parmjit; Bala, Kamlesh; Brocklehurst, Cara; Budd, Emma; Butler, Rebecca; Cheung, Atwood K.; Choudhury, Hedaythul; Collingwood, Stephen P.; Cox, Brian; Danahay, Henry; Edwards, Lee; Everatt, Brian; Glaenzel, Ulrike; Glotin, Anne-Lise; Groot-Kormelink, Paul; Hall, Edward; Hatto, Julia; Howsham, Catherine; Hughes, Glyn; King, Anna; Koehler, Julia; Kulkarni, Swarupa; Lightfoot, Megan; Nicholls, Ian; Page, Christopher; Pergl-Wilson, Giles; Popa, Mariana Oana; Robinson, Richard; Rowlands, David; Sharp, Tom; Spendiff, Matthew; Stanley, Emily; Steward, Oliver; Taylor, Roger J.; Tranter, Pamela; Wagner, Trixie; Watson, Hazel; Williams, Gareth; Wright, Penny; Young, Alice; Sandham, David A. 分享 收藏
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery Quancard, Jean; Bach, Anders; Cox, Brian; Craft, Russell; Finsinger, Dirk; Gueret, Stephanie M.; Hartung, Ingo V.; Laufer, Stefan; Messinger, Josef; Sbardella, Gianluca; Koolman, Hannes F. 分享 收藏
Structural and Electronic Control of the Bidentate 1-(2-pyridyl)benzotriazole Ligand in Copper Chemistry with Application to Catalysis in the A3 Coupling Reaction Sampani, Stavroula I.; Zdorichenko, Victor; Devonport, Jack; Rossini, Gioia; Leech, Matthew C.; Lam, Kevin; Cox, Brian; Abdul-Sada, Alaa; Vargas, Alfredo; Kostakis, George E. 分享 收藏
Escaping from Flatland: Antimalarial Activity of sp3-Rich Bridged Pyrrolidine Derivatives Cox, Brian; Duffy, James; Zdorichenko, Victor; Bellanger, Corentin; Hurcum, Jessica; Laleu, Benoit; Booker-Milburn, Kevin, I; Elliott, Luke D.; Robertson-Ralph, Michael; Swain, Christopher J.; Bishop, Stephen J.; Hallyburton, Irene; Anderson, Mark 分享 收藏
The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes Quancard, Jean; Cox, Brian; Finsinger, Dirk; Gueret, Stephanie M.; Hartung, Ingo, V; Koolman, Hannes F.; Messinger, Josef; Sbardella, Gianluca; Laufer, Stefan 分享 收藏
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Shedding light on the use of Cu(II)-salen complexes in the A3 coupling reaction Sampani, Stavroula I.; Zdorichenko, Victor; Danopoulou, Marianna; Leech, Matthew C.; Lam, Kevin; Abdul-Sada, Alaa; Cox, Brian; Tizzard, Graham J.; Coles, Simon J.; Tsipis, Athanassios; Kostakis, George E. 分享 收藏
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Synthesis of a Novel Type of 2,3′-BIMs via Platinum-Catalysed Reaction of Indolylallenes with Indoles 铂催化吲哚烯与吲哚的反应合成新型2,3 ′-BIMs Cooper, Lisa; Alonso, Jose Miguel; Eagling, Louise; Newson, Helen; Herath, Sachini; Thomson, Christopher; Lister, Andrew; Howsham, Catherine; Cox, Brian; Munoz, Maria Paz 分享 收藏
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Discovery of Fevipiprant (NVP-QAWO39), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma (vol 8, pg 582, 2017) Sandham, David A.; Barker, Lucy; Brown, Lyndon; Brown, Zarin; Budd, David; Charlton, Steven J.; Chatterjee, Devnandan; Cox, Brian; Dubois, Gerald; Duggan, Nicholas; Hall, Edward; Hatto, Julia; Leblanc, Catherine; Maas, Janet; Manini, Jodie; Profit, Rachael; Riddy, Darren; Ritchie, Catherine; Sohal, Bindi; Shaw, Duncan; Stringer, Rowan; Sykes, David A.; Thomas, Matthew; Turner, Katharine L.; Watson, Simon J.; West, Ryan; Willard, Elisabeth; Williams, Gareth; Willis, Jennifer 分享 收藏
Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma Sandham, David A.; Barker, Lucy; Brown, Lyndon; Brown, Zarin; Budd, David; Charlton, Steven J.; Chatterjee, Devnandan; Cox, Brian; Dubois, Gerald; Duggan, Nicholas; Hall, Edward; Hatto, Julia; Maas, Janet; Manini, Jodie; Profit, Rachael; Riddy, Darren; Ritchie, Catherine; Sohal, Bindi; Shaw, Duncan; Stringer, Rowan; Sykes, David A.; Thomas, Matthew; Turner, Katharine L.; Watson, Simon J.; West, Ryan; Willard, Elisabeth; Williams, Gareth; Willis, Jennifer 分享 收藏
Batch versus Flow Photochemistry: A Revealing Comparison of Yield and Productivity Elliott, Luke D.; Knowles, Jonathan P.; Koovits, Paul J.; Maskill, Katie G.; Ralph, Michael J.; Lejeune, Guillaume; Edwards, Lee J.; Robinson, Richard I.; Clemens, Ian R.; Cox, Brian; Pascoe, David D.; Koch, Guido; Eberle, Martin; Berry, Malcolm B.; Booker-Milburn, Kevin I. 分享 收藏
Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases Sandham, David A.; Arnold, Nicola; Aschauer, Heinrich; Bala, Kamlesh; Barker, Lucy; Brown, Lyndon; Brown, Zarin; Budd, David; Cox, Brian; Docx, Cerys; Dubois, Gerald; Duggan, Nicholas; England, Karen; Everatt, Brian; Furegati, Marcus; Hall, Edward; Kalthoff, Frank; King, Anna; Leblanc, Catherine J.; Manini, Jodie; Meingassner, Josef; Profit, Rachael; Schmidt, Alfred; Simmons, Jennifer; Sohal, Bindi; Stringer, Rowan; Thomas, Matthew; Turner, Katharine L.; Walker, Christoph; Watson, Simon J.; Westwick, John; Willis, Jennifer; Williams, Gareth; Wilson, Caroline 分享 收藏
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