John H. Brumell - Publications, H-index & Citations

John H. Brumell

Hospital for Sick Children

75H指数

219论文数

3.1W被引数

收录论文 96

发表时间

Listeria promotes systemic infection by targeting the host deubiquitinase CYLD 李斯特菌通过靶向宿主脱泛素化酶CYLD促进系统性感染

Nature Communications

IF15.7

2026-08-31

OAAI

Dustin A. Ammendolia; Cara J. Ellison; Yuelin Zheng; Etienne Coyaud; Estelle M. N. Laurent; Bing-Ru Yan; Bri Manning; Anna K. Waldmann; Joel M. J. Tan; Scott Frendo-Cumbo; Carina Lyons; Ji-Young Youn; Brian Raught; Keith Ireton; Darren E. Higgins; Paul R. Elliott; John H. Brumell

A pore-forming toxin initiates ABI1 complex switching to promote bacterial cell-to-cell spread 成孔毒素通过诱导ABI1复合物转换来促进细菌细胞间传播

Nature Communications

IF15.7

2026-04-13

OAAI

He Sun; Arlon Wizzard; John H. Brumell; Darren E. Higgins

Proximity labelling reveals VPS13C as a regulator of Salmonella-containing vacuole fission (vol 21, e1013507, 2025)邻近标记技术揭示VPS13C为Salmonella-containing vacuole fission的调节因子（卷21，e1013507，2025）

PLoS Pathogens

IF4.9

2025-12-30

OAAI

Waldmann, Anna K.; Ammendolia, Dustin A.; Sydor, Andrew M.; Li, Ren; St-Germain, Jonathan; Raught, Brian; Brumell, John H.

The primate-specific Nedd4-1(NE) localizes to late endosomes in response to amino acids to suppress autophagy 灵长类特异性的Nedd4-1(NE)在氨基酸的刺激下定位于晚期内体，以抑制自噬。

NATURE COMMUNICATIONS

IF15.7

2025-03-18

OAAI

Kefalas, G.; Priya, A.; Astori, A.; Persaud, A.; Jing, L.; Sydor, A. M.; Yao, H. H. Y.; Warner, N.; Zhang, Y.; Brumell, J. H.; Muise, A. M.; Sari, S.; Su, H. C.; Lenardo, M. J.; Kahr, W. H. A.; Raught, B.; Rotin, D.

IL-1β Induces LDL Transcytosis by a Novel Pathway Involving LDLR and Rab27a

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IF7.4

2024-09-01

PREAI

Jang, Erika; Ho, Tse Wing Winnie; Brumell, John H.; Lefebvre, Francois; Wang, Changsen; Lee, Warren L.

Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy MARTX弧菌毒素的加工和细胞毒性效应对细胞Rab GTPases的降解使毛虫变得松软

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-06-11

OAAI

Herrera, Alfa; Packer, Megan M.; Lemus, Monica Rosas-; Minasov, George; Chen, Jiexi; Brumell, John H.; Satchell, Karla J. F.

Salmonella exploits membrane reservoirs for invasion of host cells

NATURE COMMUNICATIONS

IF15.7

2024-04-10

OAAI

Zhu, Hongxian; Sydor, Andrew M.; Boddy, Kirsten C.; Coyaud, Etienne; Laurent, Estelle M. N.; Au, Aaron; Tan, Joel M. J.; Yan, Bing-Ru; Moffat, Jason; Muise, Aleixo M.; Yip, Christopher M.; Grinstein, Sergio; Raught, Brian; Brumell, John H.

Loss of functional peroxisomes leads to increased mitochondrial biogenesis and reduced autophagy that preserve mitochondrial function

CELLULAR AND MOLECULAR LIFE SCIENCES

IF6.2

2023-06-20

OAAI

Chi, Lijun; Lee, Dorothy; Leung, Sharon; Hu, Guanlan; Wen, Bijun; Delgado-Olguin, Paul; Vissa, Miluska; Li, Ren; Brumell, John H.; Kim, Peter K.; Bandsma, Robert H. J.

SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing

LIFE SCIENCE ALLIANCE

IF2.9

2023-06-13

OAAI

Bhosle, Vikrant K.; Tan, Joel M. J.; Li, Taoyingnan; Hua, Rong; Kwon, Hyunwoo; Li, Zhubing; Patel, Sajedabanu; Tessier-Lavigne, Marc; Robinson, Lisa A.; Kim, Peter K.; Brumell, John H.

The Syk protein tyrosine kinase is essential for Fcγ receptor signaling in macrophages and neutrophils

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

376

OAAI

Kiefer, F; Brumell, J; Al-Alawi, N; Latour, S; Cheng, A; Veillette, A; Grinstein, S; Pawson, T

Dynamic glucose uptake, storage, and release by human microvascular endothelial cells 人微血管内皮细胞的动态葡萄糖摄取，储存和释放

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2022-10-01

OAAI

Yazdani, Samaneh; Bilan, Philip J.; Jaldin-Fincati, Javier R.; Pang, Janice; Ceban, Felicia; Saran, Ekambir; Brumell, John H.; Freeman, Spencer A.; Klip, Amira

Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure

MICROBIOME

IF12.7

2022-08-15

OAAI

Zou, Angela; Nadeau, Kerry; Xiong, Xuejian; Wang, Pauline W.; Copeland, Julia K.; Lee, Jee Yeon; St Pierre, James; Ty, Maxine; Taj, Billy; Brumell, John H.; Guttman, David S.; Sharif, Shayan; Korver, Doug; Parkinson, John

The MCF Toxin of the Extracellular Pathogen Vibrio vulnificus is Activated by and Targets Host GTPases

FASEB JOURNAL

IF4.2

2022-05-13

PREAI

Herrera, Alfa; Packer, Megan M.; Brumell, John; Satchell, Karla

V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy

JOURNAL OF CELL BIOLOGY

IF6.4

2022-05-05

OAAI

Hooper, Kirsty M.; Jacquin, Elise; Li, Taoyingnan; Goodwin, Jonathan M.; Brumell, John H.; Durgan, Joanne; Florey, Oliver

Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase

NATURE CELL BIOLOGY

IF19.1

2022-04-28

OAAI

Walpole, Glenn F. W.; Pacheco, Jonathan; Chauhan, Neha; Clark, Jonathan; Anderson, Karen E.; Abbas, Yazan M.; Brabant-Kirwan, Danielle; Montano-Rendon, Fernando; Liu, Zetao; Zhu, Hongxian; Brumell, John H.; Deiters, Alexander; Stephens, Len R.; Hawkins, Phillip T.; Hammond, Gerald R., V; Grinstein, Sergio; Fairn, Gregory D.

Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn's disease

SCIENCE ADVANCES

IF12.5

2021-11-05

OAAI

Haq, Sabah; Wang, Huaqing; Grondin, Jensine; Banskota, Suhrid; Marshall, John K.; Khan, Irfan I.; Chauhan, Usha; Cote, Francine; Kwon, Yun Han; Philpott, Dana; Brumell, John H.; Surette, Michael; Steinberg, Gregory R.; Khan, Waliul, I

GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis GABARAP隔离flcn-fnip肿瘤抑制复合物，将自噬与溶酶体生物发生结合

SCIENCE ADVANCES

IF12.5

2021-10-01

OAAI

Goodwin, Jonathan M.; Walkup, Ward G.; Hooper, Kirsty; Li, Taoyingnan; Kishi-Itakura, Chieko; Ng, Aylwin; Lehmberg, Timothy; Jha, Archana; Kommineni, Sravya; Fletcher, Katherine; Garcia-Fortanet, Jorge; Fan, Yaya; Tang, Qing; Wei, Menghao; Agrawal, Asmita; Budhe, Sagar R.; Rouduri, Sreekanth R.; Baird, Dan; Saunders, Jeff; Kiselar, Janna; Chance, Mark R.; Ballabio, Andrea; Appleton, Brent A.; Brumell, John H.; Florey, Oliver; Murphy, Leon O.

Global Proximity Interactome of the Human Macroautophagy Pathway

AUTOPHAGY

IF14.3

2021-09-15

OAAI

Tu, Yi Xin (Iris); Sydor, Andrew M.; Coyaud, Etienne; Laurent, Estelle M. N.; Dyer, Diana; Mellouk, Nora; St-Germain, Jonathan; Vernon, Robert M.; Forman-Kay, Julie D.; Li, Taoyingnan; Hua, Rong; Zhao, Kexin; Ridgway, Neale D.; Kim, Peter K.; Raught, Brian; Brumell, John H.

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy

AUTOPHAGY

IF14.3

2021-08-25

OAAI

Yan, Bing-Ru; Li, Taoyingnan; Coyaud, Etienne; Laurent, Estelle M. N.; St-Germain, Jonathan; Zhou, Yuhuan; Kim, Peter K.; Raught, Brian; Brumell, John H.

Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes

NATURE COMMUNICATIONS

IF15.7

2021-08-17

OAAI

Tan, Joel M. J.; Garner, Monica E.; Regeimbal, James M.; Greene, Catherine J.; Marquez, Jorge D. Rojas; Ammendolia, Dustin A.; McCluggage, Adam R. R.; Li, Taoyingnan; Wu, Katherine J.; Cemma, Marija; Ostrowski, Philip P.; Raught, Brian; Diamond, Michael S.; Grinstein, Sergio; Yates, Robin M.; Higgins, Darren E.; Brumell, John H.

研究方向