未登录 Determination of Ligand-Binding Affinity (K d) Using Transverse Relaxation Rate (R 2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery Liu, Manjuan; Mirza, Amin; McAndrew, P. Craig; Thapaliya, Arjun; Pierrat, Olivier A.; Stubbs, Mark; Hahner, Tamas; Chessum, Nicola E. A.; Innocenti, Paolo; Caldwell, John; Cheeseman, Matthew D.; Bellenie, Benjamin R.; van Montfort, Rob L. M.; Newton, Gary K.; Burke, Rosemary; Collins, Ian; Hoelder, Swen 分享 收藏
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Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancer Gavory, Gerald; Fasching, Bernhard; Bonenfant, Debora; Sadok, Amine; Singh, Ambika; Schillo, Martin; Massafra, Vittoria; d'Alessandro, Anne-Cecile; Castle, John; Ghandi, Mahmoud; Chicas, Agustin; Delobel, Frederic; Flohr, Alexander; Ottaviani, Giorgio; Ryckmans, Thomas; Laine, Anne-Laure; Eidam, Oliv; Wang, Hannah; Bernett, Ilona; Chan, Laura; Gorrini, Chiara; Roumiliotis, Theo; Choudhary, Jyoti; LeBihan, Yann-Vai; Cabry, Marc; Stubbs, Mark; Burke, Rosemary; Van Montfort, Rob; Caldwell, John; Chopra, Rajesh; Collins, Ian; Buonamici, Silvia 分享 收藏
Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease Colombano, Giampiero; Caldwell, John J.; Matthews, Thomas P.; Bhatia, Chitra; Joshi, Amar; McHardy, Tatiana; Mok, Ngai Yi; Newbatt, Yvette; Pickard, Lisa; Strover, Jade; Hedayat, Somaieh; Walton, Michael I.; Myers, Stephanie M.; Jones, Alan M.; Saville, Harry; McAndrew, Craig; Burke, Rosemary; Eccles, Suzanne A.; Davies, Faith E.; Bayliss, Richard; Collins, Ian 分享 收藏
Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin Sharp, Swee Y.; Chessum, Nicola E.; Caldwell, John J.; Powers, Marissa V.; Pasqua, A. Elisa; Wilding, Birgit; Collins, Ian; Ozer, Bugra; Rowlands, Martin; Stubbs, Mark; Burke, Rosemary; van Montfort, Rob L.; Cheeseman, Matthew D.; Clarke, Paul A.; Workman, Paul; Jones, Keith 分享 收藏
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766) Chessum, Nicola E. A.; Sharp, Swee Y.; Caldwell, John J.; Pasqua, A. Elisa; Wilding, Birgit; Colombano, Giampiero; Collins, Ian; Ozer, Bugra; Richards, Meirion; Rowlands, Martin; Stubbs, Mark; Burke, Rosemary; McAndrew, P. Craig; Clarke, Paul A.; Workman, Paul; Cheeseman, Matthew D.; Jones, Keith 分享 收藏
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Synthesis and Evaluation of a 2,11-Cembranoid-Inspired Library Welford, Amanda J.; Caldwell, John J.; Liu, Manjuan; Richards, Meirion; Brown, Nathan; Lomas, Cara; Tizzard, Graham J.; Pitak, Mateusz B.; Coles, Simon J.; Eccles, Suzanne A.; Raynaud, Florence I.; Collins, Ian 分享 收藏
Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis Sadok, Amine; McCarthy, Afshan; Caldwell, John; Collins, Ian; Garrett, Michelle D.; Yeo, Maggie; Hooper, Steven; Sahai, Erik; Kuemper, Sandra; Mardakheh, Faraz K.; Marshall, Christopher J. 分享 收藏
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Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930 Yap, Timothy A.; Walton, Mike I.; Hunter, Lisa-Jane K.; Valenti, Melanie; Brandon, Alexis de Haven; Eve, Paul D.; Ruddle, Ruth; Heaton, Simon P.; Henley, Alan; Pickard, Lisa; Vijayaraghavan, Gowri; Caldwell, John J.; Thompson, Neil T.; Aherne, Wynne; Raynaud, Florence I.; Eccles, Suzanne A.; Workman, Paul; Collins, Ian; Garrett, Michelle D. 分享 收藏
CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors Anderson, Victoria E.; Walton, Michael I.; Eve, Paul D.; Boxall, Katherine J.; Antoni, Laurent; Caldwell, John J.; Aherne, Wynne; Pearl, Laurence H.; Oliver, Antony W.; Collins, Ian; Garrett, Michelle D. 分享 收藏
Structure-Based Design of Potent and Selective 2-(Quinazolin-2-yl)phenol Inhibitors of Checkpoint Kinase 2 Caldwell, John J.; Welsh, Emma J.; Matijssen, Cornelis; Anderson, Victoria E.; Antoni, Laurent; Boxall, Kathy; Urban, Frederique; Hayes, Angela; Raynaud, Florence I.; Rigoreau, Laurent J. M.; Raynham, Tony; Aherne, G. Wynne; Pearl, Laurence H.; Oliver, Antony W.; Garrett, Michelle D.; Collins, Ian 分享 收藏
Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2 (vol 18, pg 707, 2010) Hilton, Stephen; Naud, Sebastien; Caldwell, John J.; Boxall, Kathy; Burns, Samantha; Anderson, Victoria E.; Antoni, Laurent; Allen, Charlotte E.; Pearl, Laurence H.; Oliver, Antony W.; Aherne, G. Wynne; Garrett, Michelle D.; Collins, Ian 分享 收藏
Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt) McHardy, Tatiana; Caldwell, John J.; Cheung, Kwai-Ming; Hunter, Lisa J.; Taylor, Kevin; Rowlands, Martin; Ruddle, Ruth; Henley, Alan; Brandon, Alexis de Haven; Valenti, Melanie; Davies, Thomas G.; Fazal, Lynsey; Seavers, Lisa; Raynaud, Florence I.; Eccles, Suzanne A.; Aherne, G. Wynne; Garrett, Michelle D.; Collins, Ian 分享 收藏
Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2 检查点激酶2的2-氨基吡啶抑制剂的鉴定和表征 Hilton, Stephen; Naud, Sebastien; Caldwell, John J.; Boxall, Kathy; Burns, Samantha; Anderson, Victoria E.; Antoni, Laurent; Allen, Charlotte E.; Pearl, Laurence H.; Oliver, Antony W.; Aherne, G. Wynne; Garrett, Michelle D.; Collins, Ian 分享 收藏
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Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration Caldwell, John J.; Davies, Thomas G.; Doiiald, Alastai R. R.; McHardy, Tatiana; Rowlands, Martin G.; Aherne, G. Wynne; HLinter, Lisa K.; Taylor, Kevin; Ruddle, Ruth; Raynaud, Florence I.; Verdonk, Marcel; Workman, Paul; Garrett, Michelle D.; Collins, Ian 分享 收藏
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Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B 基于结构的isoquinoline-5-sulfonamide蛋白激酶B抑制剂的设计 Collins, I; Caldwell, J; Fonseca, T; Donald, A; Bavetsias, V; Hunter, LJK; Garrett, MD; Rowlands, MG; Aherne, GW; Davies, TG; Berdini, V; Woodhead, SJ; Davis, D; Seavers, LCA; Wyatt, PG; Workman, P; McDonald, E 分享 收藏
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