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Yasuhiko Izumi

Kobe Pharmaceutical University

32H指数
114论文数
2.8K被引数
收录论文 48
发表时间
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PNU-120596, an α7 nicotinic acetylcholine receptor positive allosteric modulator, attenuates microglial activation and protects dopaminergic neurons from inflammatory injury independently of canonical α7 nicotinic acetylcholine receptor signalingPNU-120596，一种α7烟碱型乙酰胆碱受体正向别构调节剂，可减轻小胶质细胞活化并独立于经典α7烟碱型乙酰胆碱受体信号通路保护多巴胺能神经元免受炎症损伤
errEuropean Journal of Pharmacology
IF4.7
err2026-07-01
err0
PREAI
errIzumi, Yasuhiko; Niwa, Kenta; Kamei, Yuichi; Akaike, Akinori; Koyama, Yutaka; Kume, Toshiaki
err分享
err收藏
Endothelin-1 induces Zfp36 family RNA binding proteins and restrains cytokine and chemokine production in reactive astrocytes内皮素-1诱导Zfp36家族RNA结合蛋白，并抑制反应性星形胶质细胞中细胞因子和趋化因子的产生。
errJournal of Biological Chemistry
IF3.9
err2026-04-02
err0
errOAAI
errYutaka Koyama; Aina Nishiuma; Nagi Takahashi; Eri Izumikawa; Chisato Hamada; Yasuhiko Izumi; Shigeru Hishinuma; Shotaro Michinaga
err分享
err收藏
In Vivo and in Vitro Characterization of the Anti-inflammatory and Neuroprotective Effects of TPNA10168体内和体外TPNA10168的抗炎和神经保护作用表征
errBIOLOGICAL & PHARMACEUTICAL BULLETIN
IF1.7
err2026-01-01
err0
PREAI
errIzumi, Yasuhiko; Hirai, Kana; Moro, Sayuka; Inoue, Sonoka; Nonaka, Mari; Ikawa, Saori; Yamaki, Kouya; Takeda, Norihiko; Yamada, Takahiro; Ueda, Masafumi; Kume, Toshiaki; Koyama, Yutaka
err分享
err收藏
Screening and identification of covalent Nrf2 activators with α,β-unsaturated imide structures筛选和鉴定具有α,β-不饱和亚胺结构的共价Nrf2激活剂
errBioorganic & Medicinal Chemistry
IF3
err2025-10-19
err0
PREAI
errYasuhiko Izumi; Norihiko Takeda; Shuzo Nishimoto; Honoka Niimi; Sayuri Ishizu; Natsumi Muneyasu; Yuto Takamatsu; Emi Mishiro-Sato; Keiko Kano; Kouya Yamaki; Takahiro Yamada; Yutaka Koyama; Masafumi Ueda
err分享
err收藏
Evaluation of the deep learning-based detection of dopaminergic neurons in primary culture: A practical alternative to manual counting基于深度学习的多巴胺能神经元原代培养物检测评估：一种替代人工计数的实用方法
errJournal of Neuroscience Methods
IF2.3
err2025-08-15
err0
PREAI
errYasuhiko Izumi; Saori Ikawa; Kouya Yamaki; Toshiaki Kume; Yutaka Koyama
err分享
err收藏
Perilla-derived chalcone inhibits α-synuclein fibrillization and prevents aggregate-induced disruption of intracellular α-synuclein conformation in neuronal cells迷迭香来源的查尔酮抑制α-突触核蛋白纤维化，并防止聚集诱导的神经元细胞内α-突触核蛋白构象破坏
errBiochemical and Biophysical Research Communications
IF2.2
err2025-08-06
err0
PREAI
errYasuhiko Izumi; Naoto Kondo; Akinori Akaike; Yutaka Koyama; Toshiaki Kume
err分享
err收藏
TPNA10168, an Nrf2 activator, attenuates LPS-induced inflammation in microglia through modulation of MAPK and NF-κB pathwaysTPNA10168，一种Nrf2激活剂，通过调节MAPK和NF-κB通路来减轻LPS诱导的小胶质细胞炎症。
errJournal of Pharmacological Sciences
IF2.9
err2025-07-03
err0
errOAAI
errYasuhiko Izumi; Eri Koide; Fumika Kobayashi; Saori Ikawa; Midai Takayama; Kouya Yamaki; Norihiko Takeda; Takahiro Yamada; Masafumi Ueda; Toshiaki Kume; Yutaka Koyama
err分享
err收藏
Nrf2-Independent Anti-Inflammatory Effects of Dimethyl Fumarate: Challenges and Prospects in Developing Electrophilic Nrf2 Activators for Neurodegenerative Diseases
errANTIOXIDANTS
IF6.6
err2024-12-13
err0
errOAAI
errIzumi, Yasuhiko; Koyama, Yutaka
err分享
err收藏
Endothelin-1 increases Na+-K+-2Cl- cotransporter-1 expression in cultured astrocytes and in traumatic brain injury model: An involvement of HIF1α activation
errGLIA
IF5.1
err2024-08-21
err0
PREAI
errKoyama, Yutaka; Hamada, Yasuhiro; Fukui, Yura; Hosogi, Nami; Fujimoto, Rina; Hishinuma, Shigeru; Ogawa, Yasuhiro; Takahashi, Kenta; Izumi, Yasuhiko; Michinaga, Shotaro
err分享
err收藏
TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway
errJOURNAL OF PHARMACOLOGICAL SCIENCES
IF2.9
err2022-05-01
err3
errOAAI
errIzumi, Yasuhiko; Tatsumoto, Ai; Horiuchi, Naoko; Arifuku, Monami; Uegomori, Momoko; Kume, Toshiaki; Koyama, Yutaka
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Establishing a high throughput drug screening system for cerebral ischemia using zebrafish larvae
errJOURNAL OF PHARMACOLOGICAL SCIENCES
IF2.9
err2021-09-01
err9
errOAAI
errMatsumoto, Mami; Miyamoto, Moeri; Sawahata, Masahito; Izumi, Yasuhiko; Takada-Takatori, Yuki; Kume, Toshiaki
err分享
err收藏
In vivo brain ischemia-reperfusion model induced by hypoxia-reoxygenation using zebrafish larvae
errBRAIN RESEARCH BULLETIN
IF3.7
err2021-08-01
err8
PREAI
errSawahata, Masahito; Izumi, Yasuhiko; Akaike, Akinori; Kume, Toshiaki
err分享
err收藏
α-Synuclein oligomers mediate the aberrant form of spike-induced calcium release from IP3 receptor
errSCIENTIFIC REPORTS
IF3.9
err2019-11-04
err9
errOAAI
errYamamoto, Kenji; Izumi, Yasuhiko; Arifuku, Monami; Kume, Toshiaki; Sawada, Hideyuki
err分享
err收藏
Effects of 2′-3′-dihydroxy-4′,6′-dimethoxychalcone derived from green perilla on auricle thickness in chronic contact dermatitis model mice
errJOURNAL OF PHARMACOLOGICAL SCIENCES
IF2.9
err2019-09-01
err2
errOAAI
errTakada-Takatori, Yuki; Takeda, Yuka; Imai, Risa; Izumi, Yasuhiko; Akaike, Akinori; Tsuchida, Katsuharu; Kume, Toshiaki
err分享
err收藏
Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons
errSCIENTIFIC REPORTS
IF3.9
err2019-08-15
err24
errOAAI
errTakada-Takatori, Yuki; Nakagawa, Shota; Kimata, Riko; Nao, Yousuke; Mizukawa, Yumiko; Urushidani, Tetsuro; Izumi, Yasuhiko; Akaike, Akinori; Tsuchida, Katsuharu; Kume, Toshiaki
err分享
err收藏
Inhibitory effect of the gut microbial linoleic acid metabolites, 10-oxo-trans-11-octadecenoic acid and 10-hydroxy-cis-12-octadecenoic acid, on BV-2 microglial cell activation
errJOURNAL OF PHARMACOLOGICAL SCIENCES
IF2.9
err2018-09-01
err30
errOAAI
errIkeguchi, Shiori; Izumi, Yasuhiko; Kitamura, Nahoko; Kishino, Shigenobu; Ogawa, Jun; Akaike, Akinori; Kume, Toshiaki
err分享
err收藏
Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons
errEUROPEAN JOURNAL OF PHARMACOLOGY
IF4.7
err2018-01-01
err23
errOAAI
errIzumi, Yasuhiko; Kataoka, Harue; Inose, Yuri; Akaike, Akinori; Koyama, Yutaka; Kume, Toshiaki
err分享
err收藏
PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2017-06-08
err41
PREAI
errOkuda, Michiaki; Fujita, Yuki; Hijikuro, Ichiro; Wada, Mei; Uemura, Takuya; Kobayashi, Yukako; Waku, Tomonori; Tanaka, Naoki; Nishimoto, Takaaki; Izumi, Yasuhiko; Kume, Toshiaki; Akaike, Akinori; Takahashi, Takashi; Sugimoto, Hachiro
err分享
err收藏
Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes
errJOURNAL OF PHARMACOLOGICAL SCIENCES
IF2.9
err2017-05-01
err22
errOAAI
errMakitani, Kouki; Nakagawa, Shota; Izumi, Yasuhiko; Akaike, Akinori; Kume, Toshiaki
err分享
err收藏
Protective effect of Nrf2 ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model
errEUROPEAN JOURNAL OF PHARMACOLOGY
IF4.7
err2017-03-01
err38
PREAI
errMasaki, Yuta; Izumi, Yasuhiko; Matsumura, Atsuko; Akaike, Akinori; Kume, Toshiaki
err分享
err收藏

研究方向

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