Jonathan M. Brotchie - Publications, H-index & Citations

Jonathan M. Brotchie

atuka

72H指数

275论文数

1.6W被引数

收录论文 111

发表时间

A small molecule reduces both parkinsonism and l-dopa–induced dyskinesia in animal models of Parkinson’s disease 一种小分子在帕金森病动物模型中同时降低帕金森症状和左旋多巴诱导的运动障碍

Science Translational Medicine

IF14.6

2026-07-15

PREAI

Aarash Bordbar; Bernard Bloem; Colton Lloyd; Tom H. Johnston; Jay S. Schneider; Erwan Bezard; Elsa Pioli; Qin Li; Caesar Tawfeeq; Nathan Vu Pham; Gary Huber; Jian Wu; Michael P. Hill; Jonathan M. Brotchie; J. Andrew McCammon; Friedrich W. Herberg; Susan Taylor; David M. Weiner; Kalpana Merchant; Iman Famili

Low β predicts motor output and cell degeneration in the A53T Parkinson's disease rat model 低β预测A53T帕金森病大鼠模型中的运动输出和细胞变性

BRAIN

IF11.7

2025-08-01

OAAI

Hofman, Katarina; Chen, Jiazhi; Sil, Tanmoy; Pellegrini, Franziska; Haufe, Stefan; Pozzi, Nicolo; Palmisano, Chiara; Isaias, Ioannis U.; Koprich, James B.; Brotchie, Jonathan M.; Kuehn, Andrea A.; Matthies, Cordula; Reich, Martin M.; Muthuraman, Muthuraman; Volkmann, Jens; Ip, Chi Wang

Deep brain stimulation halts Parkinson's disease-related immune dysregulation in the brain and peripheral blood 深部脑刺激可阻止大脑和外周血中与帕金森氏病相关的免疫失调

BRAIN BEHAVIOR AND IMMUNITY

IF7.6

2025-01-01

OAAI

McFleder, Rhonda L.; Musacchio, Thomas; Keller, Johanna; Knorr, Susanne; Petschner, Tobias; Chen, Jia Zhi; Muthuraman, Muthuraman; Badr, Mohammad; Harder-Rauschenberger, Lisa; Kremer, Fabian; Asci, Selin; Steinhauser, Sophie; Karl, Ann-Kathrin; Brotchie, Jonathan M.; Koprich, James B.; Volkmann, Jens; Ip, Chi Wang

Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson's disease

JOURNAL OF NEUROINFLAMMATION

IF10.1

2023-03-21

OAAI

Grotemeyer, Alexander; Fischer, Judith F.; Koprich, James B.; Brotchie, Jonathan M.; Blum, Robert; Volkmann, Jens; Ip, Chi Wang

Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson's disease mice

JOURNAL OF NEUROINFLAMMATION

IF10.1

2022-12-31

OAAI

Badr, Mohammad; McFleder, Rhonda L.; Wu, Jingjing; Knorr, Susanne; Koprich, James B.; Huenig, Thomas; Brotchie, Jonathan M.; Volkmann, Jens; Lutz, Manfred B.; Ip, Chi Wang

Toward in vivo proof of binding of 18F-labeled inhibitor [18F]TRACK to peripheral tropomyosin receptor kinases

EJNMMI RESEARCH

IF3

2022-07-30

OAAI

Wuest, Melinda; Bailey, Justin J.; Dufour, Jennifer; Glubrecht, Darryl; Omana, Vanessa; Johnston, Tom H.; Brotchie, Jonathan M.; Schirrmacher, Ralf

P2B001 (Extended Release Pramipexole and Rasagiline): A New Treatment Option in Development for Parkinson's Disease P2B001 (缓释普拉克索和雷沙吉兰): 帕金森病的新治疗选择

ADVANCES IN THERAPY

IF4

2022-03-10

OAAI

Hauser, Robert A.; Giladi, Nir; Poewe, Werner; Brotchie, Jonathan; Friedman, Hadas; Oren, Sheila; Litman, Pninit

Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson's disease mice

BRAIN BEHAVIOR AND IMMUNITY

IF7.6

2022-03-01

OAAI

Karikari, Akua A.; McFleder, Rhonda L.; Ribechini, Eliana; Blum, Robert; Bruttel, Valentin; Knorr, Susanne; Gehmeyr, Mona; Volkmann, Jens; Brotchie, Jonathan M.; Ahsan, Fadhil; Haack, Beatrice; Monoranu, Camelia-Maria; Keber, Ursula; Yeghiazaryan, Rima; Pagenstecher, Axel; Heckel, Tobias; Bischler, Thorsten; Wischhusen, Joerg; Koprich, James B.; Lutz, Manfred B.; Ip, Chi Wang

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease

SCIENTIFIC REPORTS

IF3.9

2022-02-24

OAAI

Matschke, Lina A.; Komadowski, Marlene A.; Stoehr, Annette; Lee, Bolam; Henrich, Martin T.; Griesbach, Markus; Rinne, Susanne; Geibl, Fanni F.; Chiu, Wei-Hua; Koprich, James B.; Brotchie, Jonathan M.; Kiper, Aytug K.; Dolga, Amalia M.; Oertel, Wolfgang H.; Decher, Niels

α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms

SCIENCE ADVANCES

IF12.5

2021-03-12

OAAI

Chiu, Wei-Hua; Kovacheva, Lora; Musgrove, Ruth E.; Arien-Zakay, Hadar; Koprich, James B.; Brotchie, Jonathan M.; Yaka, Rami; Ben-Zvi, Danny; Hanani, Menachem; Roeper, Jochen; Goldberg, Joshua A.

Exosome markers of LRRK2 kinase inhibition

NPJ PARKINSONS DISEASE

IF8.2

2020-11-13

OAAI

Wang, Shijie; Kelly, Kaela; Brotchie, Jonathan M.; Koprich, James B.; West, Andrew B.

The selective 5-HT1A receptor agonist, NLX-112, exerts anti-dyskinetic effects in MPTP-treated macaques

PARKINSONISM & RELATED DISORDERS

IF3.4

2020-09-01

PREAI

Depoortere, R.; Johnston, T. H.; Fox, S. H.; Brotchie, J. M.; Newman-Tancredi, A.

The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson's Disease

CELLS

IF5.2

2020-03-31

OAAI

Titze-de-Almeida, Simoneide S.; Soto-Sanchez, Cristina; Fernandez, Eduardo; Koprich, James B.; Brotchie, Jonathan M.; Titze-de-Almeida, Ricardo

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein 由 α-突触核蛋白引起的多巴胺能神经元中泛素-蛋白酶体系统的早发性损伤

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2020-02-14

101

OAAI

McKinnon, Chris; De Snoo, Mitchell L.; Gondard, Elise; Neudorfer, Clemens; Chau, Hien; Ngana, Sophie G.; O'Hara, Darren M.; Brotchie, Jonathan M.; Koprich, James B.; Lozano, Andres M.; Kalia, Lorraine, V; Kalia, Suneil K.

NYX-458 improves cognitive performance in a primate Parkinson's disease model

MOVEMENT DISORDERS

IF7.6

2020-01-22

PREAI

Barth, A. L.; Schneider, J. S.; Johnston, T. H.; Hill, M. P.; Brotchie, J. M.; Moskal, J. R.; Cearley, Cassia N.

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson's Disease

SCIENTIFIC REPORTS

IF3.9

2019-06-10

OAAI

Schneider, Jay S.; Aras, Radha; Williams, Courtney K.; Koprich, James B.; Brotchie, Jonathan M.; Singh, Vikrant

Beneficial Effects of Trehalose on Striatal Dopaminergic Deficits in Rodent and Primate Models of Synucleinopathy in Parkinson's Disease

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2019-06-01

OAAI

Howson, Patrick A.; Johnston, Tom H.; Ravenscroft, Paula; Hill, Michael P.; Su, Jin; Brotchie, Jonathan M.; Koprich, James B.

Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques

MOVEMENT DISORDERS

IF7.6

2018-12-21

PREAI

Johnston, Tom H.; Geva, Michal; Steiner, Lilach; Orbach, Aric; Papapetropoulos, Spyros; Savola, Juha-Matti; Reynolds, Ian J.; Ravenscroft, Paula; Hill, Michael; Fox, Susan H.; Brotchie, Jonathan M.; Laufer, Ralph; Hayden, Michael R.

Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2018-11-01

OAAI

Brigham, Elizabeth F.; Johnston, Tom H.; Brown, Carl; Holt, Jonathon D. S.; Fox, Susan H.; Hill, Michael P.; Howson, Patrick A.; Brotchie, Jonathan M.; Nguyen, Jack T.

Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism (vol 106, pg 133, 2018)

NEUROBIOLOGY OF DISEASE

IF5.6

2018-08-01

PREAI

Gleave, Jacqueline A.; Arathoon, Lindsay R.; Trinh, Dennison; Lizal, Kristin E.; Giguere, Nicolas; Barber, James E. M.; Najarali, Zainab; Khan, M. Hassan; Thiele, Sherri L.; Semmen, Mahin S.; Koprich, James B.; Brotchie, Jonathan M.; Eubanks, James H.; Trudeau, Louis-Eric; Nash, Joanne E.

研究方向