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M

Michael B. Kastan

Duke University School of Medicine

85H指数
295论文数
4.9W被引数
收录论文 75
发表时间
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Phase 1a clinical trial of XRD-0394, a first-in-class dual ATM/DNA-PK inhibitor, in combination with palliative radiotherapyXRD-0394（一种首创的ATM/DNA-PK双抑制剂）与姑息性放疗联合治疗的1a期临床试验
errInternational Journal of Radiation Oncology Biology Physics
IF6.5
err2026-09-11
err0
PREAI
errChristopher T Chen; Michael F Gensheimer; Tona M. Gilmer; Jennifer Stanley; Deborah Smith; Lei Fang; Michael B. Kastan; Quynh-Thu Le; Simon N. Powell; David G. Kirsch; Steven H. Lin; Jonathan T. Yang; Paul Romesser
err分享
err收藏
Enhanced Response to Radiopharmaceutical Therapy in Preclinical Tumor Models with XRD-0394, a Dual Inhibitor of ATM Kinase and DNA-PKcsXRD-0394（一种ATM激酶和DNA-PKcs的双抑制剂）在预临床肿瘤模型中增强对放射性药物治疗的响应
errRadiation Research
IF2.7
err2026-05-01
err0
PREAI
errKerr, Caroline P.; Jin, Won Jong; Onate, Alejandro J.; Kwon, Ohyun; Rojas, Hansel Comas; Clark, Paul A.; Hyun, Meredith; Ferreira, Carolina A.; Idrissou, Malick Bio; Rahman, Md Mahfuzur; Wang, Yujuan; Sheehan-Klenk, Julia; Chen, Tessa; Jagodinsky, Justin C.; Nystuen, Erin; Zangl, Luke M.; Pinchuk, Anatoly N.; Kim, KyungMann; Hernandez, Reinier; Bednarz, Bryan P.; Weichert, Jamey P.; Kastan, Michael B.; Gilmer, Tona M.; Morris, Zachary S.
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err收藏
A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2024-04-08
err9
errOAAI
errGilmer, Tona M.; Lai, Chun-Hsiang; Guo, Kexiao; Deland, Katherine; Ashcraft, Kathleen A.; Stewart, Amy E.; Wang, Yaode; Fu, Jianmin; Wood, Kris C.; Kirsch, David G.; Kastan, Michael B.
err分享
err收藏
First disclosure of XRD-0394, a novel dual ATM/DNA-PK inhibitor, that potently radiosensitizes and potentiates PARP and topoisomerase inhibitors
errCANCER RESEARCH
IF16.6
err2024-04-05
err1
PREAI
errGilmer, Tona M.; Lai, Chun-Hsiang; Guo, Kexiao; Deland, Katherine; Ashcraft, Kathleen A.; Stewart, Amy E.; Wang, Yaode; Fu, Jianmin; Wood, Kris C.; Smith, Deborah A.; Yang, Jonathan T.; Chen, Christopher T.; Gensheimer, Michael F.; Romesser, Paul B.; Lin, Steven H.; Kirsch, David G.; Kastan, Michael B.
err分享
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Fragments of ATM which have dominant-negative or complementing activity
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err158
errOAAI
errMorgan, SE; Lovly, C; Pandita, TK; Shiloh, Y; Kastan, MB
err分享
err收藏
Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err349
errOAAI
errKoumenis, C; Alarcon, R; Hammond, E; Sutphin, P; Hoffman, W; Murphy, M; Derr, J; Taya, Y; Lowe, SW; Kastan, M; Giaccia, A
err分享
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Two molecularly distinct G2/M checkpoints are induced by ionizing irradiation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err485
errOAAI
errXu, B; Kim, ST; Lim, DS; Kastan, MB
err分享
err收藏
Involvement of Brca1 in S-phase and G2-phase checkpoints after ionizing irradiation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err549
errOAAI
errXu, B; Kim, ST; Kastan, MB
err分享
err收藏
BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err129
errOAAI
errArlt, MF; Xu, B; Durkin, SG; Casper, AM; Kastan, MB; Glover, TW
err分享
err收藏
NAD+ modulates p53 DNA binding specificity and function
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err79
errOAAI
errMcLure, KG; Takagi, M; Kastan, MB
err分享
err收藏
A novel ATM-Dependent pathway regulates protein phosphatase 1 in response to DNA damage
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err74
errOAAI
errTang, Xi; Hui, Zhou-guang; Cui, Xiao-li; Garg, Renu; Kastan, Michael B.; Xu, Bo
err分享
err收藏
ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks
errMOLECULAR CANCER RESEARCH
IF4.7
err2022-12-05
err3
errOAAI
errBass, Thomas E.; Fleenor, Donald E.; Burrell, Paige E.; Kastan, Michael B.
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err收藏
Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness
errDIABETOLOGY & METABOLIC SYNDROME
IF3.9
err2019-07-29
err19
errOAAI
errMcGill, Janet B.; Johnson, Mariko; Hurst, Stacy; Cade, William T.; Yarasheski, Kevin E.; Ostlund, Richard E.; Schechtman, Kenneth B.; Razani, Babak; Kastan, Michael B.; McClain, Donald A.; de las Fuentes, Lisa; Davila-Roman, Victor G.; Ory, Daniel S.; Wickline, Samuel A.; Semenkovich, Clay F.
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Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers
errCANCER DISCOVERY
IF33.3
err2017-07-05
err70
errOAAI
errChen, Jing; Crutchley, John; Zhang, Dadong; Owzar, Kouros; Kastan, Michael B.
err分享
err收藏
Non-canonical aspects of ATM and p53 signaling pathways
errMOLECULAR CANCER RESEARCH
IF4.7
err2017-04-02
err0
PREAI
errKastan, Michael B.; Scarbrough, Peter; Chen, Jing; Brown, Adam; Crutchley, John; Fleenor, Donald
err分享
err收藏
Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells自我造成的DNA双链断裂维持了癌细胞的致瘤性和干细胞性
errCELL RESEARCH
IF25.9
err2017-03-24
err82
errOAAI
errLiu, Xinjian; Li, Fang; Huang, Qian; Zhang, Zhengxiang; Zhou, Ling; Deng, Yu; Zhou, Min; Fleenor, Donald E.; Wang, He; Kastan, Michael B.; Li, Chuan-Yuan
err分享
err收藏
Commentary on Participation of p53 Protein in the Cellular Response to DNA Damage
errCANCER RESEARCH
IF16.6
err2016-06-30
err5
PREAI
errKastan, Michael B.
err分享
err收藏
Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2016-02-03
err86
errOAAI
errLeBlanc, Amy K.; Breen, Matthew; Choyke, Peter; Dewhirst, Mark; Fan, Timothy M.; Gustafson, Daniel L.; Helman, Lee J.; Kastan, Michael B.; Knapp, Deborah W.; Levin, Wendy J.; London, Cheryl; Mason, Nicola; Mazcko, Christina; Olson, Patricia N.; Page, Rodney; Teicher, Beverly A.; Thamm, Douglas H.; Trent, Jeffrey M.; Vail, David M.; Khanna, Chand
err分享
err收藏
Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2016-01-12
err37
PREAI
errMin, Jaeki; Guo, Kexiao; Suryadevara, Praveen K.; Zhu, Fangyi; Holbrook, Gloria; Chen, Yizhe; Feau, Clementine; Young, Brandon M.; Lemoff, Andrew; Connelly, Michele C.; Kastan, Michael B.; Guy, Kiplin
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err收藏
Chromatin perturbations during the DNA damage response in higher eukaryotes
errDNA REPAIR
IF2.7
err2015-12-01
err52
errOAAI
errBakkenist, Christopher J.; Kastan, Michael B.
err分享
err收藏

研究方向

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合作学者
合作期刊
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B
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H 指数: 160 · 论文数: 1.4K
S
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H 指数: 156 · 论文数: 978
W
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H 指数: 141 · 论文数: 2.5K
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