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Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy p38α介导的磷酸化与PRMT1介导的精氨酸甲基化在驱动TDP-43蛋白病中的对立作用 Aikio, Mari; Odeh, Hana M.; Wobst, Heike J.; Lee, Bo Lim; Chan, Una; Mauna, Jocelyn C.; Mack, Korrie L.; Class, Bradley; Ollerhead, Thomas A.; Ford, Alice F.; Barbieri, Edward M.; Cupo, Ryan R.; Drake, Lauren E.; Smalley, Joshua L.; Lin, Yuan-Ta; Lam, Stephanie; Thomas, Reuben; Castello, Nicholas; Baral, Ashmita; Beyer, Jenna N.; Najar, Mohd A.; Dunlop, John; Gitler, Aaron D.; Javaherian, Ashkan; Kaye, Julia A.; Burslem, George M.; Brown, Dean G.; Donnelly, Christopher J.; Finkbeiner, Steven; Moss, Stephen J.; Brandon, Nicholas J.; Shorter, James 分享 收藏
SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine Wobst, Heike J.; Viader, Andreu; Muncipinto, Giovanni; Hollibaugh, Ryan; van Kalken, Daniel; Burkhart, Christopher T.; Cantin, Susan M.; Bates, Rachel M.; Regimbald-Dumas, Yannik; Gross, Liam; Antalek, Mitchell T.; Zweig, Joshua E.; Wu, Frank; Rettenmaier, T. Justin; Labenski, Matthew T.; Pullen, Nicholas; Blanchette, Heather S.; Henderson, Jaclyn L.; Weng, Haoling H.; Vaughn, Toby A.; Brown, Dean G.; Throup, John P.; Barrish, Joel C. 分享 收藏
Novel Corrector for Variants of SLC6A8: A Therapeutic Opportunity for Creatine Transporter Deficiency Gechijian, Lara N.; Muncipinto, Giovanni; Rettenmaier, T. Justin; Labenski, Matthew T.; Rusu, Victor; Rosskamp, Lea; Conway, Leslie; van Kalken, Daniel; Gross, Liam; Iantosca, Gianna; Crotty, William; Mathis, Robert; Park, Hyejin; Rabin, Benjamin; Westgate, Christina; Lyons, Matthew; Deshusses, Chloe; Brandon, Nicholas; Brown, Dean G.; Blanchette, Heather S.; Pullen, Nicholas; Jones, Lyn H.; Barrish, Joel C. 分享 收藏
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JNT-517, a first-in-class SLC6A19 inhibitor for the treatment of phenylketonuria, enhances urinary excretion of phenylalanine in healthy volunteers Viader, Andreu; Throup, John; Wobst, Heike; Blanchette, Heather; Nix, Darrell; Pullen, Nicholas; Brown, Dean; Barrish, Joel; Vaughn, Tobias; Weng, Haoling; Longo, Nicola; Harding, Cary 分享 收藏
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Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors Heitmann, Tyler; Liao, Gangling; de Leon, Pablo; Ernst, Glen; Buchler, Ingrid; Wei, Huijun; Shlevkov, Evgeny; Brown, Dean; Fitzek, Martina; Collier, Matthew; Smith, David M.; Barrow, James C. 分享 收藏
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A SMALL MOLECULE SLC6A19 INHIBITOR INCREASES URINARY PHENYLALANINE EXCRETION AND REDUCES ITS PATHOGENIC PLASMA ACCUMULATION IN A PHENYLKETONURIA MOUSE MODEL Wobst, Heike; Hollibaugh, Ryan; Muncipinto, Giovanni; Burkhart, Christopher; van Kalken, Daniel; Viader, Andreu; Blanchette, Heather; Brown, Dean; Pullen, Nick; Throup, John; Barrish, Joel 分享 收藏
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Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition Kennedy, Amanda J.; Sundstrom, Linda; Geschwindner, Stefan; Poon, Eunice K. Y.; Jiang, Yuhong; Chen, Rongfeng; Cooke, Rob; Johnstone, Shawn; Madin, Andrew; Lim, Junxian; Liu, Qingqi; Lohman, Rink-Jan; Nordqvist, Anneli; Friden-Saxin, Maria; Yang, Wenzhen; Brown, Dean G.; Fairlie, David P.; Dekker, Niek 分享 收藏
Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons Silva, M. Catarina; Nandi, Ghata A.; Tentarelli, Sharon; Gurrell, Ian K.; Jamier, Tanguy; Lucente, Diane; Dickerson, Bradford C.; Brown, Dean G.; Brandon, Nicholas J.; Haggarty, Stephen J. 分享 收藏
Axl receptor tyrosine kinase is a regulator of apolipoprotein E Zhao, Wenchen; Fan, Jianjia; Kulic, Iva; Koh, Cheryl; Clark, Amanda; Meuller, Johan; Engkvist, Ola; Barichievy, Samantha; Raynoschek, Carina; Hicks, Ryan; Maresca, Marcello; Wang, Qi; Brown, Dean G.; Lok, Alvin; Parro, Cameron; Robert, Jerome; Chou, Hsien-Ya; Zuhl, Andrea M.; Wood, Michael W.; Brandon, Nicholas J.; Wellington, Cheryl L. 分享 收藏
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