未登录 Multiplex immunofluorescence microscopy assays for pharmacodynamic assessment of MET tyrosine kinase activation in the plasma membrane and nucleus 多重免疫荧光显微镜检测方法用于评估MET酪氨酸激酶在质膜和细胞核中的药效动力学激活 Navas, Tony; Srivastava, Apurva K.; Lawrence, Scott M.; Hollingshead, Melinda G.; Alcoser, Sergio Y.; Miller, Sarah B.; Kinders, Robert J.; Bottaro, Donald P.; Linehan, W. Marston; Kummar, Shivaani; Doroshow, James H.; Parchment, Ralph E. 分享 收藏
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A PHASE 1/2 TRIAL OF FOG-001, A FIRST-IN-CLASS DIRECT β-CATENIN:TCF4 INHIBITOR: SAFETY AND PRELIMINARY ANTITUMOR ACTIVITY IN ADAMANTINOMATOUS CRANIOPHARYNGIOMA (ACP) PATIENTS I期/II期FOG-001试验：一种首创的、直接作用于β-CATENIN:TCF4的抑制剂，在成釉细胞瘤性颅咽管瘤（ACP）患者中的安全性及初步抗肿瘤活性研究 Papadopoulos, Kyriakos P.; Brastianos, Priscilla K.; Cecchini, Michael; Khushman, Moh'd; Kummar, Shivaani; Pelster, Meredith; Rodon, Jordi; Sharma, Sunil; Yaeger, Rona; Rojo, Jonathan; Wells, Amber L.; Tipps, Megan; Berry, Wade; Garofalo, Amanda; Akella, Lalith; Yu, Ziyang; Ramos, Jorge D.; Nguyen, Marie Huong; Orford, Keith; Klempner, Samuel J. 分享 收藏
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Myeloid targeting antibodies PY159 and PY314 for platinum-resistant ovarian cancer 髓系靶向抗体PY159和PY314用于铂耐药性卵巢癌 Yeku, Oladapo O.; Barve, Minal; Tan, Winston W.; Wang, Judy; Patnaik, Amita; Lorusso, Patricia; Richardson, Debra L.; Naqash, Abdul Rafeh; Lynam, Sarah K.; Fu, Siqing; Gordon, Michael; Hubbard, Joleen; Kummar, Shivaani; Kyriakopoulos, Christos; Dowlati, Afshin; Chamberlain, Marc; Winer, Ira 分享 收藏
The ESMO Tumour-Agnostic Classifier and Screener (ETAC-S): a tool for assessing tumour-agnostic potential of molecularly guided therapies and for steering drug development ESMO肿瘤不可知分类器和筛选器 (etac-s): 一种评估分子引导疗法的肿瘤不可知潜力和指导药物开发的工具 Westphalen, C. B.; Martins-Branco, D.; Beal, J. R.; Cardone, C.; Coleman, N.; Schram, A. M.; Halabi, S.; Michiels, S.; Yap, C.; Andre, F.; Bibeau, F.; Curigliano, G.; Garralda, E.; Kummar, S.; Kurzrock, R.; Limaye, S.; Loges, S.; Marabelle, A.; Marchio, C.; Mateo, J.; Rodon, J.; Spanic, T.; Pentheroudakis, G.; Subbiah, V. 分享 收藏
Efficacy, safety and PKPD of 23ME-00610, a first-in-class anti-CD200R1 antibody, in patients with tumor mutational burden-high (TMB-H) and/or microsatellite instability-high (MSI-H) cancers: Results from an expansion cohort 23ME-00610（一种首创抗CD200R1抗体）在肿瘤突变负荷高（TMB-H）和/或微卫星不稳定性高（MSI-H）癌症患者中的疗效、安全性和PKPD：扩展队列的研究结果 Naing, A.; Khaki, A. R.; Kummar, S.; Al-Hallak, M. N.; Razak, A. R. Abdul; Diep, A. N.; Schmidt, M.; Maslyar, D.; Vold, R.; Hwang, C. C.; Glatt, D. M. 分享 收藏
Uncovering therapeutic targets for macrophage-mediated T cell suppression and PD-L1 therapy sensitization Kumar, Sushil; Tailor, Dhanir; Dheeraj, Arpit; Li, Wenqi; Stefan, Kirsten; Lee, Jee Min; Nelson, Dylan; Keefe, Bailey F.; Schedin, Pepper; Kummar, Shivaani; Coussens, Lisa M.; V. Malhotra, Sanjay 分享 收藏
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Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer Tsimberidou, Apostolia M.; Alayli, Farah A.; Okrah, Kwame; Drakaki, Alexandra; Khalil, Danny N.; Kummar, Shivaani; Khan, Saad A.; Hodi, F. Stephen; Oh, David Y.; Cabanski, Christopher R.; Gautam, Shikha; Meier, Stefanie L.; Amouzgar, Meelad; Pfeiffer, Shannon M.; Kageyama, Robin; Yang, Enjun; Spasic, Marko; Tetzlaff, Michael T.; Foo, Wai Chin; Hollmann, Travis J.; Li, Yanyun; Adamow, Matthew; Wong, Phillip; Moore, Jonni S.; Velichko, Sharlene; Chen, Richard O.; Kumar, Dinesh; Bucktrout, Samantha; Ibrahim, Ramy; Dugan, Ute; Salvador, Lisa; Hubbard-Lucey, Vanessa M.; O'Donnell-Tormey, Jill; Santulli-Marotto, Sandra; Butterfield, Lisa H.; Da Silva, Diane M.; Fairchild, Justin; Lavallee, Theresa M.; Padron, Lacey J.; Sharma, Padmanee 分享 收藏
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Phase 1 trial of bortezomib and clofarabine combination in adults with refractory solid tumors De Souza, Andre L.; Takebe, Naoko; Chen, Alice P.; Doroshow, James H.; Parchment, Ralph E.; Srivastava, Apurva K.; Rubistein, Lawrence; Wilsker, Deborah; Miller, Brandon L.; Hogu, Murielle; Coney, Geraldine O. Sullivan; Kummar, Shivaani; Govindharajulu, Jeevan; Meehan, Robert; Herrick, William G.; Dull, Angie; Ketchum, Donna; Li, Shaowei; Ji, Jiuping; Piekarz, Richard 分享 收藏
A first-in-human, open-label, multi-center phase 1 study of TST003, a GREM 1 inhibitor, in subjects with locally advanced or metastatic solid tumors Rivera, Ismael Rodriguez; Shen, Lin; Kummar, Shivaani; Barve, Minal; Germa, Caroline; Qi, Chuan; Chen, Lei; Milata, Jenny; Yao, Jenny; Shen, Li; Zhu, Xuelian 分享 收藏
Intratumoral (ITu) delivery of mRNA-2752 encoding human OX40L/IL-23/IL-36γ in combination with durvalumab induces an immunostimulatory effect within the tumor microenvironment (TME) of patients with advanced solid tumors Abadier, Michael; Sullivan, Ryan J.; Chow, Jacky; Sehgal, Vasudha; Sweis, Randy F.; Daud, Adil; Shapira-Frommer, Ronnie; Perets, Ruth; Kummar, Shivaani; McKean, Meredith; Geva, Ravit; Patel, Manish R.; Khattak, Adnan; Fernandez-Penas, Pablo; Zacharek, Sima; Wahl, Natalia; Walker, Russell M.; Linh Van; Aanur, Praveen; Ward, Jim; Do, Khanh T.; Long, Georgina V. 分享 收藏
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Efficacy and safety of larotrectinib in a pooled analysis of patients (Pts) with tropomyosin receptor kinase (TRK) fusion cancer Drilon, A.; Shen, L.; van Tilburg, C.; Doz, F.; Tan, D. S. W.; Lin, J. J.; Kummar, S.; Lassen, U. N.; McDermott, R. S.; Dierselhuis, M. P.; Albert, C. M.; Nagasubramanian, R.; Watt, T.; Patil, T.; Burcoveanu, D-I.; Norenberg, R.; Brega, N.; Laetsch, T. W.; Xu, R-H.; Hong, D. S. 分享 收藏
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