John S. Lazo - Publications, H-index & Citations

John S. Lazo

University of Virginia

67H指数

640论文数

1.7W被引数

收录论文 129

发表时间

The PTP4A3 inhibitor KVX-053 reduces Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virulence, inflammation, and development of acute lung injury in K18-hACE2 mice PTP4A3抑制剂KVX-053可降低K18-hACE2小鼠中严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的致病性、炎症以及急性肺损伤的发生发展。

Respiratory Research

IF5

2025-10-30

OAAI

Ruben M. L. Colunga-Biancatelli; Pavel A. Solopov; Caitlin M. Woodson; Irving Coy Allen; Ivan Akhrymuk; Maryna Akhrymuk; Brittany N. Heath; Hannah M. Ivester; Tierney Day; Dan E. Austin; Kylene Kehn-Hall; John S. Lazo; Elizabeth R. Sharlow; John D. Catravas

KVX-053, a protein tyrosine phosphatase 4A3 inhibitor, ameliorates SARS-CoV-2 spike protein subunit 1-induced acute lung injury in mice

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2025-03-01

OAAI

Solopov, Pavel A.; Biancatelli, Ruben Manuel Luciano Colunga; Day, Tierney; Gregory, Betsy; Sharlow, Elizabeth R.; Lazo, John S.; Catravas, John D.

Deletion of PTP4A3 phosphatase in high-grade serous ovarian cancer cells decreases tumorigenicity and produces marked changes in intracellular signaling pathways and cytokine release

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2025-01-01

OAAI

Lazo, John S.; Isbell, Kelly N.; Vasa, Sai Ashish; Llaneza, Danielle C.; Mingledorff, Garnett A.; Sharlow, Elizabeth R.

Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells

NATURE MEDICINE

IF50

2024-08-02

PREAI

Chokshi, Chirayu R.; Shaikh, Muhammad Vaseem; Brakel, Benjamin; Rossotti, Martin A.; Tieu, David; Maich, William; Anand, Alisha; Chafe, Shawn C.; Zhai, Kui; Suk, Yujin; Kieliszek, Agata M.; Miletic, Petar; Mikolajewicz, Nicholas; Chen, David; Mcnicol, Jamie D.; Chan, Katherine; Tong, Amy H. Y.; Kuhlmann, Laura; Liu, Lina; Alizada, Zahra; Mobilio, Daniel; Tatari, Nazanin; Savage, Neil; Aghaei, Nikoo; Grewal, Shan; Puri, Anish; Subapanditha, Minomi; Mckenna, Dillon; Ignatchenko, Vladimir; Salamoun, Joseph M.; Kwiecien, Jacek M.; Wipf, Peter; Sharlow, Elizabeth R.; Provias, John P.; Lu, Jian-Qiang; Lazo, John S.; Kislinger, Thomas; Lu, Yu; Brown, Kevin R.; Venugopal, Chitra; Henry, Kevin A.; Moffat, Jason; Singh, Sheila K.

Functional mapping of glioblastoma recurrence reveals targetable dependencies in an axonal guidance pathway in highly invasive brain cancers

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Singh, Sheila Kumari; Chokshi, Chirayu; Shaikh, Vaseem; Brakel, Benjamin; Anand, Alisha; Venugopal, Chitra; Kislinger, Thomas; Henry, Kevin; Rossotti, Martin; Brown, Kevin; Lazo, John; Moffat, Jason

Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations

FEBS JOURNAL

IF4.2

2023-07-17

PREAI

Sharlow, Elizabeth R. R.; Llaneza, Danielle C. C.; Tewari, Bhanu P. P.; Mingledorff, Garnett A. A.; Mendelson, Anna J. J.; Sontheimer, Harald; Bloom, George S. S.; Lazo, John S. S.

Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2023-03-01

PREAI

Lazo, John S.; Isbell, Kelly N.; Vasa, Sai Ashish; Llaneza, Danielle C.; Rastelli, Ettore J.; Wipf, Peter; Sharlow, Elizabeth R.

A Protein Tyrosine Phosphatase 4A3 (PTP4A3) inhibitor prevents and repairs pulmonary endothelial barrier dysfunction and ameliorates acute lung injury provoked by the SARS-CoV-2 Spike protein subunit 1 in k18-hACE2 transgenic mice

FASEB JOURNAL

IF4.2

2022-05-13

OAAI

Biancatelli, Ruben Manuel Luciano Colunga; Solopov, Pavel; Dimitropoulou, Christiana; Lazo, John; Sharlow, Elizabeth; Catravas, John

Deactivation of STAT3 and ERK and Activation of p38 in Ovarian Cancer Cells Treated with a Small Molecule Inhibitor of PTP4A3 Phosphatase

FASEB JOURNAL

IF4.2

2022-05-13

OAAI

Lazo, John S.; Isbell, Kelly N.; Rastelli, Ettore J.; Wipf, Peter; Sharlow, Elizabeth R.

The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in K18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IF3.5

2021-08-01

OAAI

Biancatelli, Ruben M. L. Colunga; Solopov, Pavel A.; Sharlow, Elizabeth R.; Lazo, John S.; Marik, Paul E.; Catravas, John D.

Single intratracheal exposure to SARS-CoV-2 S1 spike protein induces acute lung injury in K18-hACE2 transgenic mice

FASEB JOURNAL

IF4.2

2021-05-14

OAAI

Solopov, Pavel; Biancatelli, Ruben Colunga; Sharlow, Elizabeth; Lazo, John; Catravas, John

Accelerated Maturation of Non-cycling Human Induced Pluripotent Stem Cell-derived neurons for High Content Screening

FASEB JOURNAL

IF4.2

2021-05-14

PREAI

Sharlow, Elizabeth; Mendelson, Anna; Llaneza, Danielle; Porterfield, Veronica; Bloom, George; Lazo, John

Combination of Subtherapeutic Doses of Tretazicar and Liposomal Amphotericin B Suppresses and Cures Leishmania major-Induced Cutaneous Lesions in Murine Models

ACS INFECTIOUS DISEASES

IF3.8

2021-02-02

PREAI

Caridha, Diana; Sciotti, Richard J.; Sousa, Jason; Vesely, Brian; Teshome, Tesfaye; Bonkoungou, Gustave; Chau Vuong; Leed, Susan; Khraiwesh, Mozna; Penn, Erica; Kreishman-Deitrick, Mara; Lee, Patricia; Pybus, Brandon; Lazo, John S.; Sharlow, Elizabeth R.

Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin

MOLECULAR PHARMACOLOGY

IF3

2020-12-01

OAAI

Czub, Mateusz P.; Boulton, Adam M.; Rastelli, Ettore J.; Tasker, Nikhil R.; Maskrey, Taber S.; Blanco, Isabella K.; McQueeney, Kelley E.; Bushweller, John H.; Minor, Wladek; Wipf, Peter; Sharlow, Elizabeth R.; Lazo, John S.

A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype

NEUROBIOLOGY OF AGING

IF3.5

2020-06-01

OAAI

Porterfield, Veronica; Khan, Shahzad S.; Foff, Erin P.; Koseoglu, Mehmet Murat; Blanco, Isabella K.; Jayaraman, Sruthi; Lien, Eric; McConnell, Michael J.; Bloom, George S.; Lazo, John S.; Sharlow, Elizabeth R.

Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2019-12-01

OAAI

Lazo, John S.; Blanco, Isabella K.; Tasker, Nikhil R.; Rastelli, Ettore J.; Burnett, James C.; Garrott, Sharon R.; Hart, Duncan J.; McCloud, Rebecca L.; Hsu, Ku-Lung; Wipf, Peter; Sharlow, Elizabeth R.

Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer's Disease and Brain Insulin Resistance, and Its Relation to Cancer

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2019-01-08

OAAI

Koseoglu, Mehmet Murat; Norambuena, Andres; Sharlow, Elizabeth R.; Lazo, John S.; Bloom, George S.

A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion

CANCER RESEARCH

IF16.6

2018-07-01

PREAI

McQueeney, Kelley E.; Salamoun, Joseph M.; Ahn, Jennifer; Pekic, Paula; Blanco, Isabella K.; Struckman, Heather; Sharlow, Elizabeth R.; Wipf, Peter; Lazo, John S.

A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion

FASEB JOURNAL

IF4.2

2018-05-10

OAAI

McQueeney, Kelley E.; Salamoun, Joseph M.; Ahn, Jennifer G.; Pekic, Paula; Blanco, Isabella K.; Struckman, Heather L.; Sharlow, Elizabeth R.; Wipf, Peter; Lazo, John S.

Small molecule targeting of PTPs in cancer

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IF2.8

2018-03-01

PREAI

Lazo, John S.; McQueeney, Kelley E.; Burnett, James C.; Wipf, Peter; Sharlow, Elizabeth R.

研究方向