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Defining and therapeutically targeting a fusion-derived public neoantigen in desmoplastic small round cell tumor using T cell receptor gene therapy Banks, Lauren; Arkin, Hannah; Chandran, Smita; Slotkin, Emily; Espinosa-Cotton, Madelyn; Shukla, Neerav; Morris, Luc; Ladanyi, Marc; Kung, Andrew; Klatt, Martin; Klebanoff, Christopher 分享 收藏
AFNT-212: A TRAC-knocked-in KRASG12D-specific TCR-T cell product enhanced with CD8αß and a chimeric cytokine receptor for treatment of solid cancers Drain, Allison; Rouillard, Nicholas; Swanson, Nathaniel; Canestraro, Martina; Narayan, Santosh; Warner, Tyler; Danek, Nicole; Gareau, Ken; Liang, Jinsheng; Shen, Luhua; Tetrault, Tanya; Priyata, Iqraa; Vidyasagar, Sarah; Riggins-Walker, Taylor; Liu, Hui-Wen; Pechhold, Klaus; Brown, Lauren; Francis, Joshua; He, Xingyue; Browne, Patrick; Lamothe, Rebecca; Storlie, Meghan; Cost, Gregory; Schmitt, Thomas M.; Greenberg, Philip D.; Chandran, Smita S.; Klebanoff, Christopher A.; Lam, Hubert; Gupta, Ankit; Hallet, Damien; Shapiro, Gary; Nguyen, Kim; Vincent, Loic 分享 收藏
Persistence but not antitumor efficacy of CAR-engineered lymphocytes is governed by a FAS/FAS ligand auto-regulatory circuit Yi, Fei; Cohen, Tal; Zumbo, Paul; Eltilib, Razan; Arkin, Hannah; Gormally, Michael; Hackett, Christopher S.; Kropp, Korbinian; Chandran, Smita; Park, Jae H.; Betel, Doron; Klebanoff, Christopher A. 分享 收藏
Non-viral engineered T cell therapy specific for the hotspot mutation p53 R175H that integrates signal 1 (TCR), signal 2 ( co-stimulation) and signal 3 (cytokine) and co-opts FasL-dependent apoptosis to achieve a coordinated antitumor CD4/8 T cell response Narayan, Santosh; Gareau, Ken; Gupta, Ankit; Ferrell, Josh; Rouillard, Nicholas; Warner, Tyler; Liang, Jinsheng; Shen, Luhua; Tetrault, Tanya; Francis, Joshua; He, Xingyue; Browne, Patrick J.; Lamothe, Rebecca; Storlie, Meghan D.; Cost, Gregory J.; Schmitt, Thomas M.; Greenberg, Philip D.; Chandran, Smita S.; Hallet, Damien; Gormally, Michael; Klebanoff, Chistopher A.; Shapiro, Gary; Nguyen, Kim; Vincent, Loic 分享 收藏
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Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA 源自突变PIK3CA的公共新抗原的免疫原性和治疗靶向性 Chandran, Smita S.; Ma, Jiaqi; Klatt, Martin G.; Dundar, Friederike; Bandlamudi, Chaitanya; Razavi, Pedram; Wen, Hannah Y.; Weigelt, Britta; Zumbo, Paul; Fu, Si Ning; Banks, Lauren B.; Yi, Fei; Vercher, Enric; Etxeberria, Inaki; Bestman, Watchain D.; Da Cruz Paula, Arnaud; Aricescu, Ilinca S.; Drilon, Alexander; Betel, Doron; Scheinberg, David A.; Baker, Brian M.; Klebanoff, Christopher A. 分享 收藏
T cell receptor gene therapy for a public neoantigen derived from mutated PIK3CA, a dominant driver oncogene in breast and endometrial cancers Chandran, Smita; Ma, Jiaqi; Klatt, Martin G.; Dundar, Friederike; Zumbo, Paul; Femia, Matthew R.; Betel, Doron; Scheinberg, David A.; Baker, Brian M.; Klebanoff, Christopher A. 分享 收藏
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Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy Klebanoff, Christopher A.; Crompton, Joseph G.; Leonardi, Anthony J.; Yamamoto, Tori N.; Chandran, Smita S.; Eil, Robert L.; Sukumar, Madhusudhanan; Vodnala, Suman K.; Hu, Jinhui; Ji, Yun; Clever, David; Black, Mary A.; Gurusamy, Devikala; Kruhlak, Michael J.; Jin, Ping; Stroncek, David F.; Gattinoni, Luca; Feldman, Steven A.; Restifo, Nicholas P. 分享 收藏
Identification of an Immunogenic Subset of Metastatic Uveal Melanoma Rothermel, Luke D.; Sabesan, Arvind C.; Stephens, Daniel J.; Chandran, Smita S.; Paria, Biman C.; Srivastava, Abhishek K.; Somerville, Robert; Wunderlich, John R.; Lee, Chyi-Chia R.; Xi, Liqiang; Pham, Trinh H.; Raffeld, Mark; Jailwala, Parthav; Kasoji, Manjula; Kammula, Udai S. 分享 收藏
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Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma Beane, Joal D.; Lee, Gary; Zheng, Zhili; Mendel, Matthew; Abate-Daga, Daniel; Bharathan, Mini; Black, Mary; Gandhi, Nimisha; Yu, Zhiya; Chandran, Smita; Giedlin, Martin; Ando, Dale; Miller, Jeff; Paschon, David; Guschin, Dmitry; Rebar, Edward J.; Reik, Andreas; Holmes, Michael C.; Gregory, Philip D.; Restifo, Nicholas P.; Rosenberg, Steven A.; Morgan, Richard A.; Feldman, Steven A. 分享 收藏
Clinical Scale Zinc Finger Nuclease (ZFN)-Driven Gene-Editing of PD-1 in Tumor Infiltrating Lymphocytes (TIL) for the Potential Treatment of Metastatic Melanoma Beane, Joal D.; Lee, Gary; Zheng, Zhili; Gandhi, Nimisha; Abate-Daga, Daniel; Bharathan, Mini; Black, Mary; Mendel, Matthew; Yu, Zhiya; Kassim, Sadik H.; Chandran, Smita; Giedlin, Martin A.; Ando, Dale; Rebar, Ed; Reik, Andreas; Holmes, Michael C.; Gregory, Philip D.; Restifo, Nicholas P.; Rosenberg, Steven A.; Morgan, Richard A.; Feldman, Steven A. 分享 收藏
Persistence of CTL Clones Targeting Melanocyte Differentiation Antigens Was Insufficient to Mediate Significant Melanoma Regression in Humans Chandran, Smita S.; Paria, Biman C.; Srivastava, Abhishek K.; Rothermel, Luke D.; Stephens, Daniel J.; Dudley, Mark E.; Somerville, Robert; Wunderlich, John R.; Sherry, Richard M.; Yang, James C.; Rosenberg, Steven A.; Kammula, Udai S. 分享 收藏
The Stoichiometric Production of IL-2 and IFN-γ mRNA Defines Memory T Cells That Can Self-Renew After Adoptive Transfer in Humans Wang, Anran; Chandran, Smita; Shah, Syed A.; Chiu, Yu; Paria, Biman C.; Aghamolla, Tamara; Alvarez-Downing, Melissa M.; Lee, Chyi-Chia Richard; Singh, Sanmeet; Li, Thomas; Dudley, Mark E.; Restifo, Nicholas P.; Rosenberg, Steven A.; Kammula, Udai S. 分享 收藏
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