Daniel Young

hospital for sick children (sickkids)

H指数:35

被引数:6,006

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A GENOME-WIDE IN VIVO CRISPR ACTIVATION SCREEN IDENTIFIES BACE1 AS A THERAPEUTIC VULNERABILITY OF LUNG CANCER BRAIN METASTASIS

全基因组体内CRISPR激活筛选确定了BACE1为肺癌脑转移的疗法易感性靶点

NEURO-ONCOLOGY

IF13.4

2025-11-010

OAAI

Chafe, Shawn; Zhai, Kui; Aghaei, Nikoo; Miletic, Petar; Huang, Zhi; Brown, Kevin; Mobilio, Daniel; Young, Daniel; Suk, Yujin; Grewal, Shan; Mckenna, Dillon; Alizada, Zahra; Kieliszek, Agata; Lam, Fred; Escudero, Laura; Huang, Qian; Huebner, Ariana; Lu, Jack; Ang, Patrick; Anand, Alisha; Custers, Stefan; Apel, Erika; Slassi, Sarah; Brakel, Benjamin; Kim, Jongmyung; Liu, James; Bassey-Archibong, Blessing; Abdo, Rober; Shargall, Yaron; Lu, Jian-Qiang; Cutz, Jean-Claude; Zhang, Qi; Li, Shawn; Venugopal, Chitra; Hynds, Robert; Dufour, Antoine; Moffat, Jason; Swanton, Charles; Bao, Shideng; Singh, Sheila

Proteolytic dysfunction in bovine digital dermatitis caused by Treponema spp. and the therapeutic use of non-antimicrobial matrix metalloproteinase inhibitors

由Treponema spp.引起的牛蹄皮炎中的蛋白酶功能障碍及非抗生素基质金属蛋白酶抑制剂的 therapeutic use

Communications Biology

IF5.1

2025-10-290

OAAI

A curcumin derivative metalloprotease inhibitor (CMC2.24) mitigates Brachyspira spp.-induced swine dysentery

一种姜黄素衍生物金属蛋白酶抑制剂（CMC2.24）可缓解布氏疏螺旋体引起的猪痢疾

International Immunopharmacology

IF4.7

2025-08-010

A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis

全基因组范围内的体内CRISPR激活筛选确定了BACE1作为肺癌脑转移的 therapeutic vulnerability。

Science Translational Medicine

IF14.6

2025-07-020

PRE

Shawn C. Chafe; Kui Zhai; Nikoo Aghaei; Petar Miletic; Zhi Huang; Kevin R. Brown; Daniel Mobilio; Daniel Young; Yujin Suk; Shan Grewal; Dillon McKenna; Zahra Alizada; Agata M. Kieliszek; Fred C. Lam; Laura Escudero; Qian Huang; Ariana Huebner; Jack Lu; Patrick Ang; Alisha Anand; Stefan Custers; Erika Apel; Sarah Slassi; Benjamin Brakel; Jongmyung Kim; James K. C. Liu; Blessing Iquo Bassey-Archibong; Rober Abdo; Yaron Shargall; Jian-Qiang Lu; Jean-Claude Cutz; Qi Zhang; Shawn Shun-Cheng Li; Chitra Venugopal; Robert E. Hynds; Antoine Dufour; Jason Moffat; Charles Swanton; Shideng Bao; Sheila K. Singh

N-terminomics and proteomics analysis of Calpain-2 reveal key proteolytic processing of metabolic and cell adhesion proteins

Calpain-2的N端组学和蛋白质组学分析揭示了代谢蛋白和细胞粘附蛋白的关键蛋白酶解加工。

PROTEIN SCIENCE

IF5.2

2025-04-250

OAAI

Identifying putative substrates of Calpain-15 in neurodevelopment

鉴定Calpain-15在神经发育中的潜在底物

PLOS ONE

IF2.6

2025-04-160