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The role of MLH1, MSH2 and MSH6 in the development of colorectal cancer in Uganda MLH1、MSH2和MSH6在乌干达结直肠癌发展中的作用 Wismayer, Richard; Matthews, Rosie; Whalley, Celina; Kiwanuka, Julius; Kakembo, Fredrick Elishama; Thorn, Steve; Wabinga, Henry; Odida, Michael; Tomlinson, Ian 分享 收藏
Tumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis 基于深度学习的结直肠癌肿瘤纯度评估及其对分子分析的影响 Schoenpflug, Lydia A.; Chatzipli, Aikaterini; Sirinukunwattana, Korsuk; Richman, Susan; Blake, Andrew; Robineau, James; Mertz, Kirsten D.; Verrill, Clare; Leedham, Simon J.; Hardy, Claire; Whalley, Celina; Redmond, Keara; Dunne, Philip; Walker, Steven; Beggs, Andrew D.; Mcdermott, Ultan; Murray, Graeme, I; Samuel, Leslie M.; Seymour, Matthew; Tomlinson, Ian; Quirke, Philip; S CORT Consortium, Jens; Rittscher, Jens; Maughan, Tim; Domingo, Enric; Koelzer, Viktor H. 分享 收藏
Germline copy number variants and endometrial cancer risk 生殖细胞拷贝数变异与子宫内膜癌风险 Stylianou, Cassie E.; Wiggins, George A. R.; Lau, Vanessa L.; Dennis, Joe; Shelling, Andrew N.; Wilson, Michelle; Sykes, Peter; Amant, Frederic; Annibali, Daniela; De Wispelaere, Wout; Easton, Douglas F.; Fasching, Peter A.; Glubb, Dylan M.; Goode, Ellen L.; Lambrechts, Diether; Pharoah, Paul D. P.; Scott, Rodney J.; Tham, Emma; Tomlinson, Ian; Bolla, Manjeet K.; Couch, Fergus J.; Czene, Kamila; Doerk, Thilo; Dunning, Alison M.; Fletcher, Olivia; Garcia-Closas, Montserrat; Hoppe, Reiner; Jernstrom, Helena; Kaaks, Rudolf; Michailidou, Kyriaki; Obi, Nadia; Southey, Melissa C.; Stone, Jennifer; Wang, Qin; Spurdle, Amanda B.; O'Mara, Traacy A.; Pearson, John; Walker, Logan C. 分享 收藏
Determination of the frequency and distribution of APC, PIK3CA, and SMAD4 gene mutations in Ugandan patients with colorectal cancer Wismayer, Richard; Matthews, Rosie; Whalley, Celina; Kiwanuka, Julius; Kakembo, Fredrick Elishama; Thorn, Steve; Wabinga, Henry; Odida, Michael; Tomlinson, Ian 分享 收藏
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes 包括254,000多名东亚和欧洲后代的精细图谱分析确定了136个推定的结直肠癌易感基因 Chen, Zhishan; Guo, Xingyi; Tao, Ran; Huyghe, Jeroen R.; Law, Philip J.; Fernandez-Rozadilla, Ceres; Ping, Jie; Jia, Guochong; Long, Jirong; Li, Chao; Shen, Quanhu; Xie, Yuhan; Timofeeva, Maria N.; Thomas, Minta; Schmit, Stephanie L.; Diez-Obrero, Virginia; Devall, Matthew; Moratalla-Navarro, Ferran; Fernandez-Tajes, Juan; Palles, Claire; Sherwood, Kitty; Briggs, Sarah E. W.; Svinti, Victoria; Donnelly, Kevin; Farrington, Susan M.; Blackmur, James; Vaughan-Shaw, Peter G.; Shu, Xiao-Ou; Lu, Yingchang; Broderick, Peter; Studd, James; Harrison, Tabitha A.; Conti, David V.; Schumacher, Fredrick R.; Melas, Marilena; Rennert, Gad; Obon-Santacana, Mireia; Martin-Sanchez, Vicente; Oh, Jae Hwan; Kim, Jeongseon; Jee, Sun Ha; Jung, Keum Ji; Kweon, Sun-Seog; Shin, Min-Ho; Shin, Aesun; Ahn, Yoon-Ok; Kim, Dong-Hyun; Oze, Isao; Wen, Wanqing; Matsuo, Keitaro; Matsuda, Koichi; Tanikawa, Chizu; Ren, Zefang; Gao, Yu-Tang; Jia, Wei-Hua; Hopper, John L.; Jenkins, Mark A.; Win, Aung Ko; Pai, Rish K.; Figueiredo, Jane C.; Haile, Robert W.; Gallinger, Steven; Woods, Michael O.; Newcomb, Polly A.; Duggan, David; Cheadle, Jeremy P.; Kaplan, Richard; Kerr, Rachel; Kerr, David; Kirac, Iva; Bohm, Jan; Mecklin, Jukka-Pekka; Jousilahti, Pekka; Knekt, Paul; Aaltonen, Lauri A.; Rissanen, Harri; Pukkala, Eero; Eriksson, Johan G.; Cajuso, Tatiana; Hanninen, Ulrika; Kondelin, Johanna; Palin, Kimmo; Tanskanen, Tomas; Renkonen-Sinisalo, Laura; Mannisto, Satu; Albanes, Demetrius; Weinstein, Stephanie J.; Ruiz-Narvaez, Edward; Palmer, Julie R.; Buchanan, Daniel D.; Platz, Elizabeth A.; Visvanathan, Kala; Ulrich, Cornelia M.; Siegel, Erin; Brezina, Stefanie; Gsur, Andrea; Campbell, Peter T.; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Slattery, Martha L.; Potter, John D.; Tsilidis, Kostas K.; Schulze, Matthias B.; Gunter, Marc J.; Murphy, Neil; Castells, Antoni; Castellvi-Bel, Sergi; Moreira, Leticia; Arndt, Volker; Shcherbina, Anna; Bishop, D. Timothy; Giles, Graham G.; Southey, Melissa C.; Idos, Gregory E.; McDonnell, Kevin J.; Abu-Ful, Zomoroda; Greenson, Joel K.; Shulman, Katerina; Lejbkowicz, Flavio; Offit, Kenneth; Su, Yu-Ru; Steinfelder, Robert; Keku, Temitope O.; van Guelpen, Bethany; Hudson, Thomas J.; Hampel, Heather; Pearlman, Rachel; Berndt, Sonja I.; Hayes, Richard B.; Martinez, Marie Elena; Thomas, Sushma S.; Pharoah, Paul D. P.; Larsson, Susanna C.; Yen, Yun; Lenz, Heinz-Josef; White, Emily; Li, Li; Doheny, Kimberly F.; Pugh, Elizabeth; Shelford, Tameka; Chan, Andrew T.; Cruz-Correa, Marcia; Lindblom, Annika; Hunter, David J.; Joshi, Amit D.; Schafmayer, Clemens; Scacheri, Peter C.; Kundaje, Anshul; Schoen, Robert E.; Hampe, Jochen; Stadler, Zsofia K.; Vodicka, Pavel; Vodickova, Ludmila; Vymetalkova, Veronika; Edlund, Christopher K.; Gauderman, W. James; Shibata, David; Toland, Amanda; Markowitz, Sanford; Kim, Andre; Chanock, Stephen J.; van Duijnhoven, Franzel; Feskens, Edith J. M.; Sakoda, Lori C.; Gago-Dominguez, Manuela; Wolk, Alicja; Pardini, Barbara; FitzGerald, Liesel M.; Lee, Soo Chin; Ogino, Shuji; Bien, Stephanie A.; Kooperberg, Charles; Li, Christopher I.; Lin, Yi; Prentice, Ross; Qu, Conghui; Bezieau, Stephane; Yamaji, Taiki; Sawada, Norie; Iwasaki, Motoki; Le Marchand, Loic; Wu, Anna H.; Qu, Chenxu; McNeil, Caroline E.; Coetzee, Gerhard; Hayward, Caroline; Deary, Ian J.; Harris, Sarah E.; Theodoratou, Evropi; Reid, Stuart; Walker, Marion; Ooi, Li Yin; Lau, Ken S.; Zhao, Hongyu; Hsu, Li; Cai, Qiuyin; Dunlop, Malcolm G.; Gruber, Stephen B.; Houlston, Richard S.; Moreno, Victor; Casey, Graham; Peters, Ulrike; Tomlinson, Ian; Zheng, Wei 分享 收藏
Population screening requires robust evidence-genomics is no exception 人口筛查需要强有力的证据-基因组学也不例外 Turnbull, Clare; Firth, Helen, V; Wilkie, Andrew O. M.; Newman, William; Raymond, F. Lucy; Tomlinson, Ian; Lachmann, Robin; Wright, Caroline F.; Wordsworth, Sarah; George, Angela; Mccartney, Margaret; Lucassen, Anneke 分享 收藏
Adult stem cell activity in naked mole rats for long-term tissue maintenance Montazid, Shamir; Bandyopadhyay, Sheila; Hart, Daniel W.; Gao, Nan; Johnson, Brian; Thrumurthy, Sri G.; Penn, Dustin J.; Wernisch, Bettina; Bansal, Mukesh; Altrock, Philipp M.; Rost, Fabian; Gazinska, Patrycja; Ziolkowski, Piotr; Hayee, Bu Hussain; Liu, Yue; Han, Jiangmeng; Tessitore, Annamaria; Koth, Jana; Bodmer, Walter F.; East, James E.; Bennett, Nigel C.; Tomlinson, Ian; Irshad, Shazia 分享 收藏
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations 结合亚洲和欧洲的结直肠癌全基因组关联研究可改善跨种族和民族人群的风险预测 Thomas, Minta; Su, Yu-Ru; Rosenthal, Elisabeth A.; Sakoda, Lori C.; Schmit, Stephanie L.; Timofeeva, Maria N.; Chen, Zhishan; Fernandez-Rozadilla, Ceres; Law, Philip J.; Murphy, Neil; Carreras-Torres, Robert; Diez-Obrero, Virginia; van Duijnhoven, Franzel J. B.; Jiang, Shangqing; Shin, Aesun; Wolk, Alicja; Phipps, Amanda I.; Burnett-Hartman, Andrea; Gsur, Andrea; Chan, Andrew T.; Zauber, Ann G.; Wu, Anna H.; Lindblom, Annika; Um, Caroline Y.; Tangen, Catherine M.; Gignoux, Chris; Newton, Christina; Haiman, Christopher A.; Qu, Conghui; Bishop, D. Timothy; Buchanan, Daniel D.; Crosslin, David R.; Conti, David V.; Kim, Dong-Hyun; Hauser, Elizabeth; White, Emily; Siegel, Erin; Schumacher, Fredrick R.; Rennert, Gad; Giles, Graham G.; Hampel, Heather; Brenner, Hermann; Oze, Isao; Oh, Jae Hwan; Lee, Jeffrey K.; Schneider, Jennifer L.; Chang-Claude, Jenny; Kim, Jeongseon; Huyghe, Jeroen R.; Zheng, Jiayin; Hampe, Jochen; Greenson, Joel; Hopper, John L.; Palmer, Julie R.; Visvanathan, Kala; Matsuo, Keitaro; Matsuda, Koichi; Jung, Keum Ji; Li, Li; Le Marchand, Loic; Vodickova, Ludmila; Bujanda, Luis; Gunter, Marc J.; Matejcic, Marco; Jenkins, Mark A.; Slattery, Martha L.; D'Amato, Mauro; Wang, Meilin; Hoffmeister, Michael; Woods, Michael O.; Kim, Michelle; Song, Mingyang; Iwasaki, Motoki; Du, Mulong; Udaltsova, Natalia; Sawada, Norie; Vodicka, Pavel; Campbell, Peter T.; Newcomb, Polly A.; Cai, Qiuyin; Pearlman, Rachel; Pai, Rish K.; Schoen, Robert E.; Steinfelder, Robert S.; Haile, Robert W.; Vandenputtelaar, Rosita; Prentice, Ross L.; Kuery, Sebastien; Castellvi-Bel, Sergi; Tsugane, Shoichiro; Berndt, Sonja I.; Lee, Soo Chin; Brezina, Stefanie; Weinstein, Stephanie J.; Chanock, Stephen J.; Jee, Sun Ha; Kweon, Sun-Seog; Vadaparampil, Susan; Harrison, Tabitha A.; Yamaji, Taiki; Keku, Temitope O.; Vymetalkova, Veronika; Arndt, Volker; Jia, Wei-Hua; Shu, Xiao-Ou; Lin, Yi; Ahn, Yoon-Ok; Stadler, Zsofia K.; Van Guelpen, Bethany; Ulrich, Cornelia M.; Platz, Elizabeth A.; Potter, John D.; Li, Christopher I.; Meester, Reinier; Moreno, Victor; Figueiredo, Jane C.; Casey, Graham; Lansdorp Vogelaar, Iris; Dunlop, Malcolm G.; Gruber, Stephen B.; Hayes, Richard B.; Pharoah, Paul D. P.; Houlston, Richard S.; Jarvik, Gail P.; Tomlinson, Ian P.; Zheng, Wei; Corley, Douglas A.; Peters, Ulrike; Hsu, Li 分享 收藏
The impact of alterations in cancer driver genes and other potentially targetable mutations on progression and overall survival in patients with biliary tract cancer treated on the randomised phase III multicentre BILCAP clinical trial Crolley, V. E.; Guest, R.; Beggs, A. D.; Jaynes, E.; Thorn, S.; Herrero, J.; Tomlinson, I.; Valle, J. W.; Primrose, J. N.; Bridgewater, J. A. 分享 收藏
Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets Frei, Anja L.; McGuigan, Anthony; Sinha, Ritik R. A. K.; Glaire, Mark A.; Jabbar, Faiz; Gneo, Luciana; Tomasevic, Tijana; Harkin, Andrea; Iveson, Tim J.; Saunders, Mark; Oein, Karin; Maka, Noori; Pezella, Francesco; Campo, Leticia; Hay, Jennifer; Edwards, Joanne; Sansom, Owen J.; Kelly, Caroline; Tomlinson, Ian; Kildal, Wanja; Kerr, Rachel S.; Kerr, David J.; Danielsen, Havard E.; Domingo, Enric; TransSCOT Consortium, David N.; Church, David N.; Koelzer, Viktor H. 分享 收藏
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis Brown, Matthew; Leon, Alicia; Kedzierska, Katarzyna; Moore, Charlotte; Belnoue-Davis, Hayley L.; Flach, Susanne; Lydon, John P.; DeMayo, Francesco J.; Lewis, Annabelle; Bosse, Tjalling; Tomlinson, Ian; Church, David N. 分享 收藏
Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair (vol 14, 3636, 2023) Sherwood, Kitty; Ward, Joseph C.; Soriano, Ignacio; Martin, Lynn; Campbell, Archie; Rahbari, Raheleh; Kafetzopoulos, Ioannis; Sproul, Duncan; Green, Andrew; Sampson, Julian R.; Donaldson, Alan; Ong, Kai-Ren; Heinimann, Karl; Nielsen, Maartje; Thomas, Huw; Latchford, Andrew; Palles, Claire; Tomlinson, Ian 分享 收藏
Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair 由DNA修复缺陷引起的孟德尔癌症综合征家族中的种系从头突变 Sherwood, Kitty; Ward, Joseph C.; Soriano, Ignacio; Martin, Lynn; Campbell, Archie; Rahbari, Raheleh; Kafetzopoulos, Ioannis; Sproul, Duncan; Green, Andrew; Sampson, Julian R.; Donaldson, Alan; Ong, Kai-Ren; Heinimann, Karl; Nielsen, Maartje; Thomas, Huw; Latchford, Andrew; Palles, Claire; Tomlinson, Ian 分享 收藏
Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis Li, Wanxin; Zhou, Xuan; Yuan, Shuai; Wang, Lijuan; Yu, Lili; Sun, Jing; Chen, Jie; Xiao, Qian; Wan, Zhongxiao; Zheng, Ju-Sheng; Zhang, Cai-Xia; Larsson, Susanna C.; Farrington, Susan M.; Law, Philip; Houlston, Richard S.; Tomlinson, Ian; Ding, Ke-Feng; Dunlop, Malcolm G.; Theodoratou, Evropi; Li, Xue 分享 收藏
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