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Disease coverage of human genome-wide association studies and pharmaceutical research and development 疾病覆盖人类全基因组关联研究与药物研发 Gordillo-Maranon, Maria; Schmidt, Amand F.; Warwick, Alasdair; Tomlinson, Chris; Ytsma, Cai; Engmann, Jorgen; Torralbo, Ana; Maclean, Rory; Sofat, Reecha; Langenberg, Claudia; Shah, Anoop D.; Denaxas, Spiros; Pirmohamed, Munir; Hemingway, Harry; Hingorani, Aroon D.; Finan, Chris 分享 收藏
Communicating exploratory unsupervised machine learning analysis in age clustering for paediatric disease 在儿科疾病的年龄聚类中进行探索性无监督机器学习分析 Spear, Joshua William; Pissaridou, Eleni; Bowyer, Stuart; Bryant, William A.; Key, Daniel; Booth, John; Spiridou, Anastasia; Denaxas, Spiros; Pope, Rebecca; Taylor, Andrew M.; Hemingway, Harry; Sebire, Neil J. 分享 收藏
Proteomic signatures improve risk prediction for common and rare diseases 蛋白质组学特征改善了常见和罕见疾病的风险预测 Carrasco-Zanini, Julia; Pietzner, Maik; Davitte, Jonathan; Surendran, Praveen; Croteau-Chonka, Damien C.; Robins, Chloe; Torralbo, Ana; Tomlinson, Christopher; Gruenschlaeger, Florian; Fitzpatrick, Natalie; Ytsma, Cai; Kanno, Tokuwa; Gade, Stephan; Freitag, Daniel; Ziebell, Frederik; Haas, Simon; Denaxas, Spiros; Betts, Joanna C.; Wareham, Nicholas J.; Hemingway, Harry; Scott, Robert A.; Langenberg, Claudia 分享 收藏
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Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats 病史可预测整个表型组的疾病发作，并能够对新出现的健康威胁做出快速反应 Steinfeldt, Jakob; Wild, Benjamin; Buergel, Thore; Pietzner, Maik; Upmeier zu Belzen, Julius; Vauvelle, Andre; Hegselmann, Stefan; Denaxas, Spiros; Hemingway, Harry; Langenberg, Claudia; Landmesser, Ulf; Deanfield, John; Eils, Roland 分享 收藏
Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog 多基因风险评分在筛查、预测和风险分层中的表现: 多基因评分目录中数据的二次分析 Hingorani, Aroon D.; Gratton, Jasmine; Finan, Chris; Schmidt, A. Floriaan; Patel, Riyaz; Sofat, Reecha; Kuan, Valerie; Langenberg, Claudia; Hemingway, Harry; Morris, Joan K.; Wald, Nicholas J. 分享 收藏
ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon ADRA2A和IRX1是雷诺现象的假定风险基因 Hartmann, Sylvia; Yasmeen, Summaira; Jacobs, Benjamin M.; Denaxas, Spiros; Pirmohamed, Munir; Gamazon, Eric R.; Caulfield, Mark J.; Hemingway, Harry; Pietzner, Maik; Langenberg, Claudia 分享 收藏
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Identifying subtypes of heart failure from three electronic health record sources with machine learning: an external, prognostic, and genetic validation study 使用机器学习从三种电子健康记录来源识别心力衰竭的亚型: 一项外部，预后和遗传验证研究 Banerjee, Amitava; Dashtban, Ashkan; Chen, Suliang; Pasea, Laura; Thygesen, Johan H.; Fatemifar, Ghazaleh; Tyl, Benoit; Dyszynski, Tomasz; Asselbergs, Folkert W.; Lund, Lars H.; Lumbers, Tom; Denaxas, Spiros; Hemingway, Harry 分享 收藏
Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study 确定英国初级保健中无原因胸痛患者的心血管风险: 一项电子健康记录研究 Jordan, Kelvin P.; Rathod-Mistry, Trishna; van der Windt, Danielle A.; Bailey, James; Chen, Ying; Clarson, Lorna; Denaxas, Spiros; Hayward, Richard A.; Hemingway, Harry; Kyriacou, Theocharis; Mamas, Mamas A. 分享 收藏
Identifying subtypes of chronic kidney disease with machine learning: development, internal validation and prognostic validation using linked electronic health records in 350,067 individuals 用机器学习识别慢性肾脏病的亚型: 在350,067个人中使用链接的电子健康记录进行开发，内部验证和预后验证 Dashtban, Ashkan; Mizani, Mehrdad A.; Pasea, Laura; Denaxas, Spiros; Corbett, Richard; Mamza, Jil B.; Gao, He; Morris, Tamsin; Hemingway, Harry; Banerjee, Amitava 分享 收藏
Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry 聚集测试确定了不同血统人群中与乳腺癌的新基因关联 Mueller, Stefanie H.; Lai, Alvina G.; Valkovskaya, Maria; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Lush, Michael; Abu-Ful, Zomoruda; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Augustinsson, Annelie; Baert, Thais; Freeman, Laura E. Beane; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Bogdanova, Natalia, V; Bojesen, Stig E.; Bonanni, Bernardo; Brenner, Hermann; Brucker, Sara Y.; Buys, Saundra S.; Castelao, Jose E.; Chan, Tsun L.; Chang-Claude, Jenny; Chanock, Stephen J.; Choi, Ji-Yeob; Chung, Wendy K.; Colonna, Sarah, V; Cornelissen, Sten; Couch, Fergus J.; Czene, Kamila; Daly, Mary B.; Devilee, Peter; Dork, Thilo; Dossus, Laure; Dwek, Miriam; Eccles, Diana M.; Ekici, Arif B.; Eliassen, A. Heather; Engel, Christoph; Evans, D. Gareth; Fasching, Peter A.; Fletcher, Olivia; Flyger, Henrik; Gago-Dominguez, Manuela; Gao, Yu-Tang; Garcia-Closas, Montserrat; Garcia-Saenz, Jose A.; Genkinger, Jeanine; Gentry-Maharaj, Aleksandra; Grassmann, Felix; Guenel, Pascal; Gundert, Melanie; Haeberle, Lothar; Hahnen, Eric; Haiman, Christopher A.; Hakansson, Niclas; Hall, Per; Harkness, Elaine F.; Harrington, Patricia A.; Hartikainen, Jaana M.; Hartman, Mikael; Hein, Alexander; Ho, Weang-Kee; Hooning, Maartje J.; Hoppe, Reiner; Hopper, John L.; Houlston, Richard S.; Howell, Anthony; Hunter, David J.; Huo, Dezheng; Investigators, Abctb; Ito, Hidemi; Iwasaki, Motoki; Jakubowska, Anna; Janni, Wolfgang; John, Esther M.; Jones, Michael E.; Jung, Audrey; Kaaks, Rudolf; Kang, Daehee; Khusnutdinova, Elza K.; Kim, Sung-Won; Kitahara, Cari M.; Koutros, Stella; Kraft, Peter; Kristensen, Vessela N.; Kubelka-Sabit, Katerina; Kurian, Allison W.; Kwong, Ava; Lacey, James, V; Lambrechts, Diether; Le Marchand, Loic; Li, Jingmei; Linet, Martha; Lo, Wing-Yee; Long, Jirong; Lophatananon, Artitaya; Mannermaa, Arto; Manoochehri, Mehdi; Margolin, Sara; Matsuo, Keitaro; Mavroudis, Dimitrios; Menon, Usha; Muir, Kenneth; Murphy, Rachel A.; Nevanlinna, Heli; Newman, William G.; Niederacher, Dieter; O'Brien, Katie M.; Obi, Nadia; Offit, Kenneth; Olopade, Olufunmilayo, I; Olshan, Andrew F.; Olsson, Hakan; Park, Sue K.; Patel, Alpa, V; Patel, Achal; Perou, Charles M.; Peto, Julian; Pharoah, Paul D. P.; Plaseska-Karanfilska, Dijana; Presneau, Nadege; Rack, Brigitte; Radice, Paolo; Ramachandran, Dhanya; Rashid, Muhammad U.; Rennert, Gad; Romero, Atocha; Ruddy, Kathryn J.; Ruebner, Matthias; Saloustros, Emmanouil; Sandler, Dale P.; Sawyer, Elinor J.; Schmidt, Marjanka K.; Schmutzler, Rita K.; Schneider, Michael O.; Scott, Christopher; Shah, Mitul; Sharma, Priyanka; Shen, Chen-Yang; Shu, Xiao-Ou; Simard, Jacques; Surowy, Harald; Tamimi, Rulla M.; Tapper, William J.; Taylor, Jack A.; Teo, Soo Hwang; Teras, Lauren R.; Toland, Amanda E.; Tollenaar, Rob A. E. M.; Torres, Diana; Torres-Mejia, Gabriela; Troester, Melissa A.; Truong, Therese; Vachon, Celine M.; Vijai, Joseph; Weinberg, Clarice R.; Wendt, Camilla; Winqvist, Robert; Wolk, Alicja; Wu, Anna H.; Yamaji, Taiki; Yang, Xiaohong R.; Yu, Jyh-Cherng; Zheng, Wei; Ziogas, Argyrios; Ziv, Elad; Dunning, Alison M.; Easton, Douglas F.; Hemingway, Harry; Hamann, Ute; Kuchenbaecker, Karoline B. 分享 收藏
Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study 识别和可视化英国国家卫生服务中患者的多发病和合并症模式: 一项基于人群的研究 Kuan, Valerie; Denaxas, Spiros; Patalay, Praveetha; Nitsch, Dorothea; Mathur, Rohini; Gonzalez-Izquierdo, Arturo; Sofat, Reecha; Partridge, Linda; Roberts, Amanda; Wong, Ian C. K.; Hingorani, Melanie; Chaturvedi, Nishi; Hemingway, Harry; Hingorani, Aroon; MMTRC 分享 收藏
Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19-a data-driven retrospective cohort study 使用国家电子健康记录进行大流行准备: 验证COVID-19-a数据驱动的回顾性队列研究中预测超额死亡的简约模型 Mizani, Mehrdad A.; Dashtban, Ashkan; Pasea, Laura; Lai, Alvina G.; Thygesen, Johan; Tomlinson, Chris; Handy, Alex; Mamza, Jil B.; Morris, Tamsin; Khalid, Sara; Zaccardi, Francesco; Macleod, Mary Joan; Torabi, Fatemeh; Canoy, Dexter; Akbari, Ashley; Berry, Colin; Bolton, Thomas; Nolan, John; Khunti, Kamlesh; Denaxas, Spiros; Hemingway, Harry; Sudlow, Cathie; Banerjee, Amitava; CVD COVID UK Consortium, C. V. D. C. O. V. I. D. U. K. Consortium 分享 收藏
Rare and common genetic determinants of metabolic individuality and their effects on human health 代谢个性的罕见和常见遗传决定因素及其对人类健康的影响 Surendran, Praveen; Stewart, Isobel D.; Yeung, Victoria P. W. Au; Pietzner, Maik; Raffler, Johannes; Worheide, Maria A.; Li, Chen; Smith, Rebecca F.; Wittemans, Laura B. L.; Bomba, Lorenzo; Menni, Cristina; Zierer, Jonas; Rossi, Niccolo; Sheridan, Patricia A.; Watkins, Nicholas A.; Mangino, Massimo; Hysi, Pirro G.; Di Angelantonio, Emanuele; Falchi, Mario; Spector, Tim D.; Soranzo, Nicole; Michelotti, Gregory A.; Arlt, Wiebke; Lotta, Luca A.; Denaxas, Spiros; Hemingway, Harry; Gamazon, Eric R.; Howson, Joanna M. M.; Wood, Angela M.; Danesh, John; Wareham, Nicholas J.; Kastenmueller, Gabi; Fauman, Eric B.; Suhre, Karsten; Butterworth, Adam S.; Langenberg, Claudia 分享 收藏
CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research Kotecha, Dipak; Asselbergs, Folkert W.; Achenbach, Stephan; Anker, Stefan D.; Atar, Dan; Baigent, Colin; Banerjee, Amitava; Beger, Birgit; Brobert, Gunnar; Casadei, Barbara; Ceccarelli, Cinzia; Cowie, Martin R.; Crea, Filippo; Cronin, Maureen; Denaxas, Spiros; Derix, Andrea; Fitzsimons, Donna; Fredriksson, Martin; Gale, Chris P.; Gkoutos, Georgios, V; Goettsch, Wim; Hemingway, Harry; Ingvar, Martin; Jonas, Adrian; Kazmierski, Robert; Logstrup, Susanne; Lumbers, R. Thomas; Luescher, Thomas F.; McGreavy, Paul; Pina, Ileana L.; Roessig, Lothar; Steinbeisser, Carl; Sundgren, Mats; Tyl, Benoit; van Thiel, Ghislaine; van Bochove, Kees; Vardas, Panos E.; Villanueva, Tiago; Vrana, Marilena; Weber, Wim; Weidinger, Franz; Windecker, Stephan; Wood, Angela; Grobbee, Diederick E. 分享 收藏
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