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D

David L. Spector

Cold Spring Harbor Laboratory
H指数:92
被引数:3.9万

个人简介

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教育背景

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工作经历

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荣誉奖项

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A dependency map enhanced with next-generation 3D cancer models

一张融合了新一代3D癌症模型的药物靶点互作图

Nature
IF48.5
2026-08-050
OA
James V. Neiswender; Samuel Maffa; Lisa Brenan; Dina ElHarouni; Yejie Yun; Isabella Boyle; Kirsty Wienand; Haider Inam; Tate Bertea; Ashley Anderson; Megan Wong; Matias Enriquez; Evan Lenz; Beatriz Villafranca; Nora Shanks; Mary Hager; Nia Lloyd; Hannah Shadmany; Sarah J. Wie; Harry Liang; Konnor Yunghans; Xiaomeng Zhang; Lauren Golden; Hannah Harris; Serena Day; Philip Montgomery; Samantha Stokes; Ross M. Giglio; Cynthia Hajal; James R. Whittle; Guadalupe Garcia; Caitlin E. Mills; Mehdi Touat; Kristine Pelton; Hongyu Li; Prem Sai Prabhakar; Sonja Herter; Zoe Hoffmann Kamrat; Dan Gui; Julien Dilly; Chen Khuan Wong; Jimmy A. Guo; Sangita Pal; Yossef Baidi; Ryan Johnston; Daniel D. Brown; Sonam Bhatia; Peter S. Winter; Srivatsan Raghavan; Rameen Beroukhim; Eva Colas; David L. Spector; Adam J. Bass; Peter K. Sorger; Yu Chen; Sarah J. Hill; Steffi Oesterreich; Adrian V. Lee; Himisha Beltran; Jesse S. Boehm; Yuen-Yi Tseng; David E. Root; William C. Hahn; Andrew J. Aguirre; Catarina D. Campbell; Keith L. Ligon; Joshua M. Dempster; Tsukasa Shibue; Francisca Vazquez
A compendium of next-generation patient-derived models for diverse cancers

用于多种癌症的下一代患者来源模型汇编

Nature
IF48.5
2026-08-050
OA
Dina ElHarouni; Mushriq Al-Jazrawe; Seongmin Choi; Merve Dede; Toshinori Hinoue; Sean A. Misek; Heeju Noh; Luca Zanella; Yuen-Yi Tseng; Hayley E. Francies; Dennis Plenker; Cindy W. Kyi; Julyann Perez-Mayoral; Megan J. Stine; Eva Tonsing-Carter; Rachana Agarwal; Jean Claude Zenklusen; James M. Clinton; Jennifer M. Shelton; Timothy R. Chu; William F. Hooper; Xavi Loinaz; Paula Keskula; Jordan Tagle; Peyton C. Kuhlers; Bahar Tercan; Sylvia F. Boj; Alessandro Vasciaveo; Lorenzo Tomassoni; James M. Crawford; Shawna Walsh; Claire Sinai; Sonam Bhatia; Priya Sridevi; Hardik Patel; Maria Antonietta Cerone; Kyle Ellrott; Calvin J. Kuo; Olivier Elemento; Semir Beyaz; Vincenzo Corbo; David L. Spector; Rameen Beroukhim; Martin L. Ferguson; Andrew D. Cherniack; Peter W. Laird; Nicolas Robine; Andrew McPherson; Katherine A. Hoadley; Mathew J. Garnett; David A. Tuveson; Andrea Califano; Paul T. Spellman; Keith L. Ligon; Daniela S. Gerhard; Louis M. Staudt; Jesse S. Boehm
A genetic platform to deconvolve efficacy and toxicity reveals the on-target effects of CDK11 inhibition in vivo

一个用于解析功效和毒性的遗传平台揭示了CDK11抑制在体内的靶向效应

Nature Communications
IF15.7
2026-01-010
OAAI
Linda Julian; Lisa Crozier; Devon A. Lukow; Aditi Swamy; Sanat Mishra; Ryan A. Hagenson; Peter C. Sennhenn; Erin L. Sausville; Amy J. S. McGeoch; Sarah L. Thompson; Brianna E. Mendelson; Claudio E. Chuaqui; Lu Qiao; Anand Vasudevan; Kuan-Ting Lin; Sonam Bhatia; Thierry Bertomeu; Andrew Chatr‐aryamontri; Li Zhang; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Timothy Nottoli; Suxia Bai; Jayalakshmi Lakshmipathi; Viswanathan Muthusamy; Jonathan G. Van Vranken; Gregory Gauthier-Coles; Steven P. Gygi; Joan C. Smith; Kendall L. Anderson; Sanjana Shah; Ranjit S. Bindra; Martin Akerman; David L. Spector; Basil J. Greber; Adrian R. Krainer; Jason M. Sheltzer
Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors

BPTF的缺失恢复了雌激素反应并抑制了乳腺肿瘤的转移

Nature Communications
IF15.7
2025-10-150
OAAI
Michael F. Ciccone; Dhivyaa Anandan; Deeptiman Chatterjee; Chen Chen; Marygrace C. Trousdell; Rebecca Anderson; Steven M. Lewis; Mackenzie K. Callaway; Chris Z. Zhao; Amritha Varshini Hanasoge Somasundara; Suzanne Russo; Shih-Ting Yang; Yixin Zhao; Julie Ostrander; John E. Wilkinson; William C. K. Pomerantz; Adam Siepel; David L. Spector; Jessica Tollkuhn; Camila O. dos Santos
MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer
CANCER DISCOVERY
IF33.3
2024-07-250
OAAI
Klingbeil, Olaf; Skopelitis, Damianos; Tonelli, Claudia; Yoshimoto, Toyoki; Alpsoy, Aktan; Panepinto, Maria C.; Minicozzi, Francesca; Merrill, Joseph R.; Cafiero, Amanda M.; Aggarwal, Disha; Russo, Suzanne; Ha, Taehoon; Demerdash, Osama E.; Wee, Tse-Luen; Spector, David L.; Lyons, Scott K.; Tuveson, David A.; Cifani, Paolo; Vakoc, Christopher R.
Long non-coding RNAs: definitions, functions, challenges and recommendations

长链非编码rna: 定义、功能、挑战和建议

NATURE REVIEWS MOLECULAR CELL BIOLOGY
IF90.2
2023-01-03711
OA
Mattick, John S. S.; Amaral, Paulo P. P.; Carninci, Piero; Carpenter, Susan; Chang, Howard Y. Y.; Chen, Ling-Ling; Chen, Runsheng; Dean, Caroline; Dinger, Marcel E. E.; Fitzgerald, Katherine A. A.; Gingeras, Thomas R. R.; Guttman, Mitchell; Hirose, Tetsuro; Huarte, Maite; Johnson, Rory; Kanduri, Chandrasekhar; Kapranov, Philipp; Lawrence, Jeanne B. B.; Lee, Jeannie T. T.; Mendell, Joshua T. T.; Mercer, Timothy R. R.; Moore, Kathryn J. J.; Nakagawa, Shinichi; Rinn, John L. L.; Spector, David L. L.; Ulitsky, Igor; Wan, Yue; Wilusz, Jeremy E. E.; Wu, Mian
Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics

患者来源的三阴性乳腺癌类器官提供了强大的模型系统，可以概括肿瘤的内在特征

CANCER RESEARCH
IF16.6
2022-02-1831
OA
Bhatia, Sonam; Kramer, Melissa; Russo, Suzanne; Naik, Payal; Arun, Gayatri; Brophy, Kyle; Andrews, Peter; Fan, Cheng; Perou, Charles M.; Preall, Jonathan; Ha, Taehoon; Plenker, Dennis; Tuveson, David A.; Rishi, Arvind; Wilkinson, John E.; McCombie, W. Richard; Kostroff, Karen; Spector, David L.
Noncoding RNAs: biology and applications-a Keystone Symposia report

非编码rna: 生物学和应用-Keystone专题讨论会报告

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
IF4.8
2021-11-1716
OA
Cable, Jennifer; Heard, Edith; Hirose, Tetsuro; Prasanth, Kannanganattu, V; Chen, Ling-Ling; Henninger, Jonathan E.; Quinodoz, Sofia A.; Spector, David L.; Diermeier, Sarah D.; Porman, Allison M.; Kumar, Dhiraj; Feinberg, Mark W.; Shen, Xiaohua; Unfried, Juan Pablo; Johnson, Rory; Chen, Chun-Kan; Wilusz, Jeremy E.; Lempradl, Adelheid; McGeary, Sean E.; Wahba, Lamia; Pyle, Anna Marie; Hargrove, Amanda E.; Simon, Matthew D.; Marcia, Marco; Przanowska, Roza K.; Chang, Howard Y.; Jaffrey, Samie R.; Contreras, Lydia M.; Chen, Qi; Shi, Junchao; Mendell, Joshua T.; He, Lin; Song, Erwei; Rinn, John L.; Lalwani, Mukesh Kumar; Kalem, Murat Can; Chuong, Edward B.; Maquat, Lynne E.; Liu, Xuhang

研究方向

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T
Tom Misteli
H 指数:94论文数:297被引数:3.7万
K
Kannanganattu V. Prasanth
H 指数:44论文数:148被引数:1.1万
G
Gayatri Arun
H 指数:12论文数:43被引数:4,716
R
Roland Eils
H 指数:138论文数:1,082被引数:11.5万
S
Sarah D. Diermeier
H 指数:21论文数:46被引数:2,679
S
Sonam Bhatia
H 指数:11论文数:61被引数:707
Y
Yuda Fang
H 指数:21论文数:41被引数:2,364
M
Mélanie Eckersley-Maslin
H 指数:18论文数:64被引数:3,045
F
Frank Rigo
H 指数:66论文数:247被引数:1.9万
J
Jan H. Bergmann
H 指数:16论文数:39被引数:1,944