未登录A single-chain variable fragment-based bispecific T-cell activating antibody against CD117 enables T-cell mediated lysis of acute myeloid leukemia and hematopoietic stem and progenitor cells
Volta, Laura; Myburgh, Renier; Hofstetter, Mara; Koch, Christian; Kiefer, Jonathan D.; Gobbi, Celeste; Manfredi, Francesco; Zimmermann, Kathrin; Kaufmann, Philipp; Fazio, Serena; Pellegrino, Christian; Russkamp, Norman F.; Villars, Danielle; Matasci, Mattia; Maurer, Monique; Mueller, Jan; Schneiter, Florin; Buschl, Paul; Harrer, Niclas; Mock, Jacqueline; Balabanov, Stefan; Nombela-Arrieta, Cesar; Schroeder, Timm; Neri, Dario; Manz, Markus G. .png)
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收藏Efficient combinatorial adaptor-mediated targeting of acute myeloid leukemia with CAR T-cellsVolta, Laura; Myburgh, Renier; Pellegrino, Christian; Koch, Christian; Maurer, Monique; Manfredi, Francesco; Hofstetter, Mara; Kaiser, Anne; Schneiter, Florin; Muller, Jan; Buehler, Marco M.; De Luca, Roberto; Favalli, Nicholas; Magnani, Chiara F.; Schroeder, Timm; Neri, Dario; Manz, Markus G. 分享 收藏 Identification of an embryonic differentiation stage marked by Sox1 and FoxA2 co-expression using combined cell tracking and high dimensional protein imagingArekatla, Geethika; Skylaki, Stavroula; Suarez, David Corredor; Jackson, Hartland; Schapiro, Denis; Engler, Stefanie; Auler, Markus; Ortega, German Camargo; Hastreiter, Simon; Reimann, Andreas; Loeffler, Dirk; Bodenmiller, Bernd; Schroeder, Timm 分享 收藏 IL-1 3 promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cellsRai, Shivam; Zhang, Yang; Grockowiak, Elodie; Kimmerlin, Quentin; Hansen, Nils; Stoll, Cedric B.; Usart, Marc; Paz, Damien Luque; Hao-Shen, Hui; Zhu, Yexuan; Roux, Julien; Bader, Michael S.; Dirnhofer, Stefan; Farady, Christopher J.; Schroeder, Timm; Mendez-Ferrer, Simon; Skoda, Radek C. 分享 收藏 Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells靶向甲羟戊酸或Wnt途径以克服TP53-mutant AML细胞中的CAR T细胞抗性Mueller, Jan; Schimmer, Roman R.; Koch, Christian; Schneiter, Florin; Fullin, Jonas; Lysenko, Veronika; Pellegrino, Christian; Klemm, Nancy; Russkamp, Norman; Myburgh, Renier; Volta, Laura; Theocharides, Alexandre P. A.; Kurppa, Kari J.; Ebert, Benjamin L.; Schroeder, Timm; Manz, Markus G.; Boettcher, Steffen 分享 收藏 分享 收藏 分享 收藏 Open-source personal pipetting robots with live-cell incubation and microscopy compatibilityDettinger, Philip; Kull, Tobias; Arekatla, Geethika; Ahmed, Nouraiz; Zhang, Yang; Schneiter, Florin; Wehling, Arne; Schirmacher, Daniel; Kawamura, Shunsuke; Loeffler, Dirk; Schroeder, Timm 分享 收藏 分享 收藏 An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic ProgressionScheidmann, Manuel C.; Castro-Giner, Francesc; Strittmatter, Karin; Krol, Ilona; Paasinen-Sohns, Aino; Scherrer, Ramona; Donato, Cinzia; Gkountela, Sofia; Szczerba, Barbara M.; Diamantopoulou, Zoi; Muenst, Simone; Vlajnic, Tatjana; Kunz, Leo; Vetter, Marcus; Rochlitz, Christoph; Taylor, Verdon; Giachino, Claudio; Schroeder, Timm; Platt, Randall J.; Aceto, Nicola 分享 收藏 分享 收藏 Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulationAhmed, Nouraiz; Etzrodt, Martin; Dettinger, Philip; Kull, Tobias; Loeffler, Dirk; Hoppe, Philipp S.; Chavez, James S.; Zhang, Yang; Camargo Ortega, German; Hilsenbeck, Oliver; Nakajima, Hideaki; Pietras, Eric M.; Schroeder, Timm 分享 收藏 TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fateGarcia-Prat, Laura; Kaufmann, Kerstin B.; Schneiter, Florin; Voisin, Veronique; Murison, Alex; Chen, Jocelyn; Chan-Seng-Yue, Michelle; Gan, Olga, I; McLeod, Jessica L.; Smith, Sabrina A.; Shoong, Michelle C.; Parris, Darrien; Pan, Kristele; Zeng, Andy G. X.; Krivdova, Gabriela; Gupta, Kinam; Takayanagi, Shin-Ichiro; Wagenblast, Elvin; Wang, Weijia; Lupien, Mathieu; Schroeder, Timm; Xie, Stephanie Z.; Dick, John E. 分享 收藏 Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNFHausmann, Annika; Felmy, Boas; Kunz, Leo; Kroon, Sanne; Berthold, Dorothee Lisa; Ganz, Giverny; Sandu, Ioana; Nakamura, Toshihiro; Zangger, Nathan Sebastien; Zhang, Yang; Dolowschiak, Tamas; Fattinger, Stefan Alexander; Furter, Markus; Mueller-Hauser, Anna Angelika; Barthel, Manja; Vlantis, Katerina; Wachsmuth, Laurens; Kisielow, Jan; Tortola, Luigi; Heide, Danijela; Heikenwaelder, Mathias; Oxenius, Annette; Kopf, Manfred; Schroeder, Timm; Pasparakis, Manolis; Sellin, Mikael Erik; Hardt, Wolf-Dietrich 分享 收藏 分享 收藏 GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasisGPR182是一种内皮特异性非典型趋化因子受体，可维持造血干细胞稳态Le Mercier, Alan; Bonnavion, Remy; Yu, Weijia; Alnouri, Mohamad Wessam; Ramas, Sophie; Zhang, Yang; Jaeger, Yannick; Roquid, Kenneth Anthony; Jeong, Hyun-Woo; Sivaraj, Kishor Kumar; Cho, Haaglim; Chen, Xinyi; Strilic, Boris; Sijmonsma, Tjeerd; Adams, Ralf; Schroeder, Timm; Rieger, Michael A.; Offemanns, Stefan 分享 收藏 PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stressPU.1在炎症应激期间强制静止并限制造血干细胞扩增Chavez, James S.; Rabe, Jennifer L.; Loeffler, Dirk; Higa, Kelly C.; Hernandez, Giovanny; Mills, Taylor S.; Ahmed, Nouraiz; Gessner, Rachel L.; Ke, Zhonghe; Idler, Beau M.; Nino, Katia E.; Kim, Hyunmin; Myers, Jason R.; Stevens, Brett M.; Davizon-Castillo, Pavel; Jordan, Craig T.; Nakajima, Hideaki; Ashton, John; Welner, Robert S.; Schroeder, Timm; DeGregori, James; Pietras, Eric M. 分享 收藏 分享 收藏 E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fatesWanet, Anais; Bassal, Mahmoud A.; Patel, Sweta B.; Marchi, Francisco; Mariani, Samanta A.; Ahmed, Nouraiz; Zhang, Haoran; Borchiellini, Marta; Chen, Sisi; Zhang, Junyan; Di Ruscio, Annalisa; Miyake, Kensuke; Tsai, Mindy; Paranjape, Anuya; Park, Shin-Young; Karasuyama, Hajime; Schroeder, Timm; Dzierzak, Elaine; Galli, Stephen J.; Tenen, Daniel G.; Welner, Robert S. 分享 收藏 Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote DifferentiationXie, Stephanie Z.; Kaufmann, Kerstin B.; Wang, Weijia; Chan-Seng-Yue, Michelle; Gan, Olga, I; Laurenti, Elisa; Garcia-Prat, Laura; Takayanagi, Shin-Ichiro; Ng, Stanley W. K.; Xu, ChangJiang; Zeng, Andy G. X.; Jin, Liqing; McLeod, Jessica; Wagenblast, Elvin; Mitchell, Amanda; Kennedy, James A.; Liu, Qiang; Boutzen, Helena; Kleinau, Melissa; Jargstorf, Joseph; Holmes, Gareth; Zhang, Yang; Voisin, Veronique; Bader, Gary D.; Wang, Jean C. Y.; Hannun, Yusuf A.; Luberto, Chiara; Schroeder, Timm; Minden, Mark D.; Dick, John E. 分享 收藏 
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