Markus A. Rüegg - Publications, H-index & Citations

Markus A. Rüegg

University of Basel

77H指数

269论文数

2.6W被引数

收录论文 104

发表时间

Dual AAV gene therapy using laminin-linking proteins ameliorates muscle and nerve defects in LAMA2-related muscular dystrophy

Molecular Therapy

IF12

2026-02-02

OAAI

Judith R. Reinhard; Shuo Lin; Eleonora Maino; Daniel J. Ham; Markus A. Rüegg

Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy 细胞自主分泌的层粘连蛋白-α2的丢失驱动LAMA2相关肌营养不良症中肌肉干细胞的功能障碍

Nature Communications

IF15.7

2025-11-27

OAAI

Timothy J. McGowan; Judith R. Reinhard; Nicolas Lewerenz; Marta Białobrzeska; Shuo Lin; Jacek Stępniewski; Krzysztof Szade; Józef Dulak; Markus A. Rüegg

AAV capsids target muscle-resident cells with different efficiencies-A comparative study between AAV8, AAVMYO, and AAVMYO2 AAV衣壳以不同效率靶向肌肉驻留细胞—AAV8、AAVMYO和AAVMYO2的比较研究

MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT

IF4.7

2025-06-01

OAAI

Timothy J. McGowan; Nicolas Lewerenz; Eleonora Maino; Marco Thürkauf; Lena Jörin; Markus A. Rüegg

Muscle fiber Myc is dispensable for muscle growth and its forced expression severely perturbs homeostasis 肌纤维Myc对于肌肉生长并非必需，且其强制表达严重扰乱了稳态。

NATURE COMMUNICATIONS

IF15.7

2025-04-03

OAAI

Ham, Daniel J.; Semeraro, Michelangelo; Berger, Bianca M.; McGowan, Timothy J.; Lin, Shuo; Maino, Eleonora; Oliveri, Filippo; Ruegg, Markus A.

Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice

NPJ REGENERATIVE MEDICINE

IF6.5

2024-09-19

OAAI

Mittal, Nitish; Ataman, Meric; Tintignac, Lionel; Ham, Daniel J.; Jorin, Lena; Schmidt, Alexander; Sinnreich, Michael; Ruegg, Markus A.; Zavolan, Mihaela

Calorie restriction and rapamycin distinctly mitigate aging-associated protein phosphorylation changes in mouse muscles

COMMUNICATIONS BIOLOGY

IF5.1

2024-08-10

OAAI

Ataman, Meric; Mittal, Nitish; Tintignac, Lionel; Schmidt, Alexander; Ham, Daniel J.; Gonzalez, Asier; Ruegg, Markus A.; Zavolan, Mihaela

Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9 使用aav-crispr/Cas9在成年小鼠骨骼肌纤维中快速，多重和有效的体细胞基因缺失

NATURE COMMUNICATIONS

IF15.7

2023-09-30

OAAI

Thurkauf, Marco; Lin, Shuo; Oliveri, Filippo; Grimm, Dirk; Platt, Randall J.; Ruegg, Markus A.

Raptor levels are critical for 13-cell adaptation to a high-fat diet in male mice

MOLECULAR METABOLISM

IF6.6

2023-09-01

OAAI

Blandino-Rosano, Manuel; Louzada, Ruy Andrade; Werneck-De-Castro, Joao Pedro; Lubaczeuski, Camila; Almaca, Joana; Ruegg, Markus A.; Hall, Michael N.; Leibowitz, Gil; Bernal-Mizrachi, Ernesto

The TSC-mTOR Pathway Mediates Translational Activation of TOP mRNAs by Insulin Largely in a Raptor- or Rictor-Independent Manner

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

128

OAAI

Patursky-Polischuk, Ilona; Stolovich-Rain, Miri; Hausner-Hanochi, Mirit; Kasir, Judith; Cybulski, Nadine; Avruch, Joseph; Rueegg, Markus A.; Hall, Michael N.; Meyuhas, Oded

Defective Mitochondrial Morphology and Bioenergetic Function in Mice Lacking the Transcription Factor Yin Yang 1 in Skeletal Muscle

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Blaettler, Sharon M.; Verdeguer, Francisco; Liesa, Marc; Cunningham, John T.; Vogel, Rutger O.; Chim, Helen; Liu, Huifei; Romanino, Klaas; Shirihai, Orian S.; Vazquez, Francisca; Rueegg, Markus A.; Shi, Yang; Puigserver, Pere

mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation mTORC1通过控制前成骨细胞分化在骨骼发育中发挥重要作用

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-17

OAAI

Fitter, Stephen; Matthews, Mary P.; Martin, Sally K.; Xie, Jianling; Ooi, Soo Siang; Walkley, Carl R.; Codrington, John D.; Ruegg, Markus A.; Hall, Michael N.; Proud, Christopher G.; Gronthos, Stan; Zannettino, Andrew C. W.

Nerve pathology is prevented by linker proteins in mouse models for LAMA2-related muscular dystrophy

PNAS NEXUS

IF3.8

2023-03-15

OAAI

Reinhard, Judith R.; Porrello, Emanuela; Lin, Shuo; Pelczar, Pawel; Previtali, Stefano C.; Ruegg, Markus A.

Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis

COMMUNICATIONS BIOLOGY

IF5.1

2022-10-27

OAAI

Kaiser, Marco S.; Milan, Giulia; Ham, Daniel J.; Lin, Shuo; Oliveri, Filippo; Chojnowska, Kathrin; Tintignac, Lionel A.; Mittal, Nitish; Zimmerli, Christian E.; Glass, David J.; Zavolan, Mihaela; Rueegg, Markus A.

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle (vol 13, 2025, 2022)

NATURE COMMUNICATIONS

IF15.7

2022-04-27

OAAI

Ham, Daniel J.; Borsch, Anastasiya; Chojnowska, Kathrin; Lin, Shuo; Leuchtmann, Aurel B.; Ham, Alexander S.; Thurkauf, Marco; Delezie, Julien; Furrer, Regula; Burri, Dominik; Sinnreich, Michael; Handschin, Christoph; Tintignac, Lionel A.; Zavolan, Mihaela; Mittal, Nitish; Ruegg, Markus A.

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

NATURE COMMUNICATIONS

IF15.7

2022-04-19

OAAI

Ham, Daniel J.; Boersch, Anastasiya; Chojnowska, Kathrin; Lin, Shuo; Leuchtman, Aurel B.; Ham, Alexander S.; Thuerkauf, Marco; Delezie, Julien; Furrer, Regula; Burri, Dominik; Sinnreich, Michael; Handschin, Christoph; Tintignac, Lionel A.; Zavolan, Mihaela; Mittal, Nitish; Rueegg, Markus A.

Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia 啮齿动物模型的分子和表型分析揭示了人类肌肉减少症的保守和物种特异性调节剂

COMMUNICATIONS BIOLOGY

IF5.1

2021-02-12

OAAI

Borsch, Anastasiya; Ham, Daniel J.; Mittal, Nitish; Tintignac, Lionel A.; Migliavacca, Eugenia; Feige, Jerome N.; Ruegg, Markus A.; Zavolan, Mihaela

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

NATURE COMMUNICATIONS

IF15.7

2020-09-09

111

OAAI

Ham, Daniel J.; Borsch, Anastasiya; Lin, Shuo; Thurkauf, Marco; Weihrauch, Martin; Reinhard, Judith R.; Delezie, Julien; Battilana, Fabienne; Wang, Xueyong; Kaiser, Marco S.; Guridi, Maitea; Sinnreich, Michael; Rich, Mark M.; Mittal, Nitish; Tintignac, Lionel A.; Handschin, Christoph; Zavolan, Mihaela; Ruegg, Markus A.

The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player?

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2020-08-28

OAAI

Castets, Perrine; Ham, Daniel J.; Rueegg, Markus A.

Mice carrying an analogous heterozygous dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy

HUMAN MOLECULAR GENETICS

IF3.2

2020-03-04

OAAI

Pereira, Jorge A.; Gerber, Joanne; Ghidinelli, Monica; Gerber, Daniel; Tortola, Luigi; Ommer, Andrea; Bachofner, Sven; Santarella, Francesco; Tinelli, Elisa; Lin, Shuo; Rueegg, Markus A.; Kopf, Manfred; Toyka, Klaus, V; Suter, Ueli

Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation 表皮哺乳动物雷帕霉素靶蛋白复合物2在表皮屏障形成中控制脂质合成和成丝蛋白加工

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IF11.2

2020-01-01

OAAI

Ding, Xiaolei; Willenborg, Sebastian; Bloch, Wilhelm; Wickstroem, Sara A.; Wagle, Prerana; Brodesser, Susanne; Roers, Axel; Jais, Alexander; Bruening, Jens C.; Hall, Michael N.; Rueegg, Markus A.; Eming, Sabine A.

研究方向