Xiao‐chen Bai

University of Texas Southwestern Medical Center

56H指数

186论文数

1.5W被引数

收录论文 64

发表时间

Mechanism of Kch activation by Zn2+Zn2+介导的Kch通道激活机制

PNAS Nexus

IF3.8

2026-08-31

OAAI

Brian Morote-Costas; Yaping Pan; Lie Wang; Xiaochen Bai; Steve Lockless; Ming Zhou; null

Mechanisms of VEGFR2 activation by VEGF; neuropilin; and heparin VEGFR2由VEGF、神经纤毛蛋白和肝素激活的机制

Science Advances

IF12.5

2026-07-15

OAAI

Lianqi Chen; Zhichen Sun; Jian Qiao; Xiao-chen Bai; Xuewu Zhang

Structural insights into the activation of the chicken ROS1 receptor by the NEL/NICOL ligand complex 关于NEL/NICOL配体复合物激活鸡ROS1受体的结构见解

Nature Communications

IF15.7

2026-02-24

OAAI

Weidong An; Xuewu Zhang; Xiao-chen Bai

Publisher Correction: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling Publisher Correction: PtdIns(3,5)P2 是先天免疫信号通路中 STING 的内源性配体

Nature

IF48.5

2026-02-20

PREAI

Jay Xiaojun Tan; Bo Lv; Jie Li; Tuo Li; Fenghe Du; Xiang Chen; Xuewu Zhang; Xiao-chen Bai; Zhijian J. Chen

Regulation of STING activation by phosphoinositide and cholesterol 磷酸肌醇和胆固醇对STING活化的调节

Nature

IF48.5

2026-02-04

PREAI

Jie Li; Jay Xiaojun Tan; Zhijian J. Chen; Xuewu Zhang; Xiao-chen Bai

PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling 期刊名称：Nature；作者：JX Tan；发表日期：2026；DOI：10.1038/s41586-025-10084-0；引用ID：CR7

Nature

IF48.5

2026-02-01

PREAI

Tan, Jay Xiaojun; Lv, Bo; Li, Jie; Li, Tuo; Du, Fenghe; Chen, Xiang; Zhang, Xuewu; Bai, Xiao-chen; Chen, Zhijian J.

Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells IDH1-R132H的棕榈酰化自调节其在癌细胞中的新生物活性

Nature Chemical Biology

IF13.7

2026-01-13

PREAI

Lu Hu; Jinyu Lin; Liping Sun; Alison M. Berezuk; Katharine S. Tuttle; Xing Zhu; Hyuk-Soo Seo; Sirano Dhe-Paganon; Pan Li; Yang Sun; Lisheng Ni; Jianan Zhang; Dazhi Tan; Hiroaki Wakimoto; Daniel P. Cahill; Xiaochen Bai; Xuelian Luo; John M. Asara; Sriram Subramaniam; Yibing Shan; Xu Wu

Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramer IL-17受体异源四聚体诱导的ACT1寡聚化的结构基础

Nature Communications

IF15.7

2025-12-16

OAAI

Hui Zhang; Xiao-chen Bai; Xuewu Zhang

Structure and activation of the Drosophila insulin receptor by three Drosophila insulin-like peptides 果蝇胰岛素受体的结构及其通过三种果蝇胰岛素样肽的激活

Nature Communications

IF15.7

2025-10-28

OAAI

Kai Cai; Michelle Ng; Rochele R. Yamamoto; Mohammed Akhter Hossain; Catherine Hall; John D. Wade; Marc Tatar; Eunhee Choi; Xiao-chen Bai

Tuning insulin receptor signaling using de novo-designed agonists 使用从头设计的激动剂调节胰岛素受体信号传导

Molecular Cell

IF16.6

2025-10-13

OAAI

Xinru Wang; Sarah Cardoso; Kai Cai; Preetham Venkatesh; Albert Hung; Michelle Ng; Catherine Hall; Brian Coventry; David S. Lee; Rishabh Chowhan; Stacey Gerben; Jie Li; Weidong An; Mara Hon; Michael Gao; Ya-Cheng Liao; Domenico Accili; Eunhee Choi; Xiao-chen Bai; David Baker

Profiling antigen-binding affinity of B cell repertoires in tumors by deep learning predicts immune-checkpoint inhibitor treatment outcomes 通过深度学习分析肿瘤中B细胞库的抗原结合亲和力，可预测免疫检查点抑制剂治疗结局

Nature Cancer

IF28.5

2025-06-27

PREAI

Bing Song; Kaiwen Wang; Saiyang Na; Jia Yao; Farjana J. Fattah; Alexandra L. Martin; Mitchell S. von Itzstein; Donghan M. Yang; Jialiang Liu; Yaming Xue; Chaoying Liang; Yuzhi Guo; Indu Raman; Chengsong Zhu; Jonathan E. Dowell; Jade Homsi; Sawsan Rashdan; Shengjie Yang; Mary E. Gwin; Tuoqi Wu; David Hsiehchen; Yvonne Gloria-McCutchen; Catherine Pei-ju Lu; Prithvi Raj; Xiao-chen Bai; Jun Wang; Jose Conejo-Garcia; Yang Xie; Junzhou Huang; David E. Gerber; Tao Wang

Structural insights into the ubiquitin- independent midnolin- proteasome pathway 结构洞察：泛素非依赖性midnolin-蛋白酶体通路

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2025-05-08

OAAI

Peddada, Nagesh; Zhong, Xue; Yin, Yan; Lazaro, Danielle Renee; Wang, Jianhui; Lyon, Stephen; Choi, Jin Huk; Bai, Xiao-Chen; Moresco, Eva Marie Y.; Beutler, Bruce

Structural basis for Retriever-SNX17 assembly and endosomal sorting

NATURE COMMUNICATIONS

IF15.7

2024-11-25

OAAI

Singla, Amika; Boesch, Daniel J.; Fung, Ho Yee Joyce; Ngoka, Chigozie; Enriquez, Avery S.; Song, Ran; Kramer, Daniel A.; Han, Yan; Banarer, Esther; Lemoff, Andrew; Juneja, Puneet; Billadeau, Daniel D.; Bai, Xiaochen; Chen, Zhe; Turer, Emre E.; Burstein, Ezra; Chen, Baoyu

Polydopamine-coated polycaprolactone/carbon nanotube fibrous scaffolds loaded with basic fibroblast growth factor for wound healing

MATERIALS TODAY BIO

IF10.2

2024-10-01

OAAI

Cui, Dapeng; Guo, Wei; Chang, Jing; Fan, Shuang; Bai, Xiaochen; Li, Lei; Yang, Chen; Wang, Chuanlin; Li, Ming; Fei, Jiandong

Activation of the insulin receptor by insulin-like growth factor 2

NATURE COMMUNICATIONS

IF15.7

2024-03-23

OAAI

An, Weidong; Hall, Catherine; Li, Jie; Hung, Albert; Wu, Jiayi; Park, Junhee; Wang, Liwei; Bai, Xiao-chen; Choi, Eunhee

Applications of cryo-EM in drug development for STING

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2024-02-01

OAAI

Bai, Xiao-chen; Zhang, Xuewu

Challenges and opportunities in macromolecular structure determination

NATURE REVIEWS MOLECULAR CELL BIOLOGY

IF90.2

2023-10-17

PREAI

Bai, Xiao-chen; Gonen, Tamir; Gronenborn, Angela M.; Perrakis, Anastassis; Thorn, Andrea; Yang, Jianyi

Activation of human STING by a molecular glue-like compound 通过分子胶样化合物激活人类STING

NATURE CHEMICAL BIOLOGY

IF13.7

2023-10-12

OAAI

Li, Jie; Canham, Stephen M.; Wu, Hua; Henault, Martin; Chen, Lihao; Liu, Guoxun; Chen, Yu; Yu, Gary; Miller, Howard R.; Hornak, Viktor; Brittain, Scott M.; Michaud, Gregory A.; Tutter, Antonin; Broom, Wendy; Digan, Mary Ellen; Mcwhirter, Sarah M.; Sivick, Kelsey E.; Pham, Helen T.; Chen, Christine H.; Tria, George S.; Mckenna, Jeffery M.; Schirle, Markus; Mao, Xiaohong; Nicholson, Thomas B.; Wang, Yuan; Jenkins, Jeremy L.; Jain, Rishi K.; Tallarico, John A.; Patel, Sejal J.; Zheng, Lianxing; Ross, Nathan T.; Cho, Charles Y.; Zhang, Xuewu; Bai, Xiao-Chen; Feng, Yan

Structural basis of insulin fibrillation

SCIENCE ADVANCES

IF12.5

2023-09-15

OAAI

Wang, Liwei; Hall, Catherine E.; Uchikawa, Emiko; Chen, Dailu; Choi, Eunhee; Zhang, Xuewu; Bai, Xiao-chen

CTCF and R-loops are boundaries of cohesin-mediated DNA looping CTCF和R环是cohesin介导的DNA成环的边界

MOLECULAR CELL

IF16.6

2023-08-01

OAAI

Zhang, Hongshan; Shi, Zhubing; Banigan, Edward J.; Kim, Yoori; Yu, Hongtao; Bai, Xiao-chen; Finkelstein, Ilya J.

研究方向