Phillip K. Darcy - Publications, H-index & Citations

Phillip K. Darcy

Peter MacCallum Cancer Centre

77H指数

536论文数

2.2W被引数

收录论文 144

发表时间

Rewiring immunity with in vivo CAR T cell engineering 通过体内CAR T细胞工程重塑免疫

Nature Cancer

IF28.5

2026-08-21

PREAI

Clare Y. Slaney; Rachel Xu; Shiyi Wu; Kevin Sek; Colin W. Pouton; Michael Dickinson; Michael H. Kershaw; Phillip K. Darcy

Ironing out a metabolic barrier to durable CAR T cell therapy 阐明CAR T细胞疗法持久性的代谢障碍

Cell Research

IF25.9

2026-07-30

PREAI

Clare Y. Slaney; Rachel Xu; Phillip K. Darcy

Cytokine armored CAR T cells for cancer immunotherapy 细胞因子装甲型CAR-T细胞用于癌症免疫治疗

immunology & cell biology

IF0

2026-04-05

OAAI

Kevin Sek; Kah Min Yap; Woon Xuan Hong; Phillip K. Darcy

Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes Flt3L-mediated肿瘤cDC1扩增通过引发淋巴结中的干细胞样cd8t 细胞来增强免疫治疗

Nature Immunology

IF27.6

2026-02-10

PREAI

Junyun Lai; Cheok Weng Chan; Jesse D. Armitage; Katherine M. Audsley; Yu-Kuan Huang; Emily B. Derrick; Laura S. Carstensen; Christina M. Scheffler; Matt E. Jones; Kevin Sek; Nicola Principe; Joelle S. Kim; Imran G. House; Amanda X. Y. Chen; Kah Min Yap; Jim Middelburg; Isabelle Munoz; Dat Nguyen; Junming Tong; Thang X. Hoang; Kirsten L. Todd; Maximilien Evrard; Jonathan Chee; Laura K. Mackay; Alistair R. R. Forrest; Ian A. Parish; Anthony Bosco; Jason Waithman; Paul A. Beavis; Phillip K. Darcy

A novel switch receptor enhances CAR-T cell fitness in TGF-β-enriched solid tumors

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Qin, Mengfei; Thio, Niko; Ong, Xiaojing; Wang, Xuan; Darcy, Phillip K.; D'souza, Criselle; Zhu, Joe Jiang; Neeson, Paul J.

Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models 靶向PTPN2增强人CAR T细胞在异种移植模型中的功效及长期记忆的发育

Science Translational Medicine

IF14.6

2025-10-29

PREAI

Xin Du; Pei K. Goh; Chenkai Ma; Eamon Coughlan; Spencer Greatorex; Laura H. Porter; Brendan Russ; Katherine D. Cummins; Kevin Sek; Clare Y. Slaney; Andrew M. Scott; Jane Oliaro; Paul J. Neeson; Gail P. Risbridger; Renea A. Taylor; Joseph A. Trapani; Stephen J. Turner; Phillip K. Darcy; Florian Wiede; Tony Tiganis

Transcriptional regulator SATB1 limits CD8+ T cell population expansion and effector differentiation in chronic infection and cancer 转录因子SATB1限制CD8+ T细胞群体扩增和效应分化，这在慢性感染和癌症中尤为明显。

Nature Immunology

IF27.6

2025-10-27

PREAI

Leonie Heyden; Lisa Rausch; Michael H. Shannon; Lachlan Dryburgh; Marcela L. Moreira; Aleksej Frolov; Christina M. Scheffler; Marit J. van Elsas; Junming Tong; Olivia Hidajat; Sharanya K. M. Wijesinghe; Sining Li; Helena Horvatic; Nhat Truong Huynh-Anh; Catarina Gago da Graça; Carlson Tsui; Maren Köhne; Daniel Sommer; F. Thomas Wunderlich; Bianca von Scheidt; Simone L. Park; Laura K. Mackay; Daniel T. Utzschneider; Jan Schröder; Stephen J. Turner; Phillip K. Darcy; Marc D. Beyer; Zeinab Abdullah; Axel Kallies

Parity and lactation induce T cell mediated breast cancer protection 同源性和哺乳诱导T细胞介导的乳腺癌保护作用

Nature

IF48.5

2025-10-20

PREAI

Balaji Virassamy; Franco Caramia; Peter Savas; Michael A. Harris; Jia-Wern Pan; Jianan Wang; Emmaline Brown; Megan M. R. O’Malley; Courtney T. van Geelen; Michael Hun; Thomas N. Burn; Sneha Sant; Jamieson D. Ballan; Jasmine Kay; Luis E. Lara Gonzalez; Kylie Clarke; Han Xian Aw Yeang; Rejhan Idrizi; Metta Jana; Damon J. Challice; Roberto Salgado; Heather Thorne; Cathie Poliness; Sophie Nightingale; Soo-Hwang Teo; Terence P. Speed; Jane Visvader; Paul J. Neeson; Phillip K. Darcy; Laura K. Mackay; Sherene Loi

Optimised modular anti-FLAG CAR T cells for solid tumor therapy 优化型模块化抗FLAG CAR T细胞用于实体瘤治疗

Clinical & Translational Immunology

IF3.8

2025-08-21

OAAI

Xiaomeng Zhang; Rachel Xu; Dmitry Zorin; Evan G Pappas; Jiawei Tang; Yuchen Bai; Vicky M Qin; Bianca von Scheidt; Ruihong Huang; Weronika Kulakowska; Charbel Darido; Phillip K Darcy; Michael H Kershaw; Clare Y Slaney

Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery 在CAR T细胞中重新连接内源性基因以进行肿瘤限制性有效载荷递送

Nature

IF48.5

2025-07-02

OAAI

Amanda X. Y. Chen; Kah Min Yap; Joelle S. Kim; Kevin Sek; Yu-Kuan Huang; Phoebe A. Dunbar; Volker Wiebking; Jesse D. Armitage; Isabelle Munoz; Kirsten L. Todd; Emily B. Derrick; Dat Nguyen; Junming Tong; Cheok Weng Chan; Thang X. Hoang; Katherine M. Audsley; Marit J. van Elsas; Jim Middelburg; Joel N. Lee; Maria N. de Menezes; Thomas J. Cole; Jasmine Li; Christina Scheffler; Andrew M. Scott; Laura K. Mackay; Jason Waithman; Jane Oliaro; Simon J. Harrison; Ian A. Parish; Junyun Lai; Matthew H. Porteus; Imran G. House; Phillip K. Darcy; Paul A. Beavis

Interleukin-4 modulates type I interferon to augment antitumor immunity 白细胞介素-4调节I型干扰素以增强抗肿瘤免疫。

SCIENCE ADVANCES

IF12.5

2025-05-16

PREAI

Newnes, Hannah V.; Armitage, Jesse D.; Buzzai, Anthony C.; de Jong, Emma; Audsley, Katherine M.; Barnes, Samantha A.; Srinivasan, Shamini; Serralha, Michael; Fear, Vanessa S.; Guo, Belinda B.; Jones, Matt E.; Forrest, Alistair R. R.; Foley, Bree; Darcy, Phil K.; Beavis, Paul A.; Bosco, Anthony; Waithman, Jason

CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity (vol 42, 113014, 2023)

CELL REPORTS

IF6.9

2024-02-01

OAAI

House, Imran G.; Derrick, Emily B.; Sek, Kevin; Chen, Amanda X. Y.; Li, Jasmine; Lai, Junyun; Todd, Kirsten L.; Munoz, Isabelle; Michie, Jessica; Chan, Cheok Weng; Huang, Yu-Kuan; Chan, Jack D.; Petley, Emma V.; Tong, Junming; Nguyen, Datminh; Engel, Sven; Savas, Peter; Hogg, Simon J.; Vervoort, Stephin J.; Kearney, Conor J.; Burr, Marian L.; Lam, Enid Y. N.; Gilan, Omer; Bedoui, Sammy; Johnstone, Ricky W.; Dawson, Mark A.; Loi, Sherene; Darcy, Phillip K.; Beavis, Paul A.

Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies

TRENDS IN IMMUNOLOGY

IF13.9

2023-12-01

OAAI

Nasir, Ibraheem; McGuinness, Conor; Poh, Ashleigh R.; Ernst, Matthias; Darcy, Phillip K.; Britt, Kara L.

A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses A2AR eGFP报告小鼠可以阐明抗肿瘤免疫反应过程中的A2AR表达动态

NATURE COMMUNICATIONS

IF15.7

2023-11-01

OAAI

Todd, Kirsten L.; Lai, Junyun; Sek, Kevin; Huang, Yu-Kuan; Newman, Dane M.; Derrick, Emily B.; Koay, Hui-Fern; Nguyen, Dat; Hoang, Thang X.; Petley, Emma V.; Chan, Cheok Weng; Munoz, Isabelle; House, Imran G.; Lee, Joel N.; Kim, Joelle S.; Li, Jasmine; Tong, Junming; N. de Menezes, Maria; Scheffler, Christina M.; Yap, Kah Min; Chen, Amanda X. Y.; Dunbar, Phoebe A.; Haugen, Brandon; Parish, Ian A.; Johnstone, Ricky W.; Darcy, Phillip K.; Beavis, Paul A.

Low-dose carboplatin modifies the tumor microenvironment to augment CAR T cell efficacy in human prostate cancer models

NATURE COMMUNICATIONS

IF15.7

2023-09-02

OAAI

Porter, L. H.; Zhu, J. J.; Lister, N. L.; Harrison, S. G.; Keerthikumar, S.; Goode, D. L.; Urban, R. Quezada; Byrne, D. J.; Azad, A.; Vela, I.; Hofman, M. S.; Neeson, P. J.; Darcy, P. K.; Trapani, J. A.; Taylor, R. A.; Risbridger, G. P.

Combined PARP and WEE1 inhibition triggers anti-tumor immune response in BRCA1/2 wildtype triple-negative breast cancer PARP和WEE1联合抑制触发BRCA1/2野生型三阴性乳腺癌的抗肿瘤免疫反应

NPJ BREAST CANCER

IF7.6

2023-08-15

OAAI

Teo, Zhi Ling; O'Connor, Mark J.; Versaci, Stephanie; Clarke, Kylie A.; Brown, Emmaline R.; Percy, Luke W.; Kuykhoven, Keilly; Mintoff, Christopher P.; Savas, Peter; Virassamy, Balaji; Luen, Stephen J.; Byrne, Ann; Sant, Sneha; Lindeman, Geoffrey J.; Darcy, Phillip K.; Loi, Sherene

CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity CRISPR-Cas9筛选确定了限制CXCL9表达和抗肿瘤免疫的IRF1-SOCS1-mediated负反馈回路

CELL REPORTS

IF6.9

2023-08-01

OAAI

House, Imran G.; Derrick, Emily B.; Sek, Kevin; Chen, Amanda X. Y.; Li, Jasmine; Lai, Junyun; Todd, Kirsten L.; Munoz, Isabelle; Michie, Jessica; Chan, Cheok Weng; Huang, Yu-Kuan; Chan, Jack D.; Petley, Emma, V; Tong, Junming; Nguyen, DatMinh; Engel, Sven; Savas, Peter; Hogg, Simon J.; Vervoort, Stephin J.; Kearney, Conor J.; Burr, Marian L.; Lam, Enid Y. N.; Gilan, Omer; Bedoui, Sammy; Johnstone, Ricky W.; Dawson, Mark A.; Loi, Sherene; Darcy, Phillip K.; Beavis, Paul A.

Tucatinib promotes immune activation and synergizes with programmed cell death-1 and programmed cell death-ligand 1 inhibition in HER2-positive breast cancer

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

IF7.2

2023-05-11

PREAI

Li, Ran; Sant, Sneha; Brown, Emmaline; Caramia, Franco; Nikolic, Bronte; Clarke, Kylie; Byrne, Ann; Gonzalez, Luis E. Lara; Savas, Peter; Luen, Stephen J.; Teo, Zhi Ling; Virassamy, Balaji; Neeson, Paul J.; Darcy, Phillip K.; Loi, Sherene

TSTEM-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models 在临床前模型中，与常规car-t细胞相比，TSTEM样car-t细胞表现出改善的持久性和肿瘤控制

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2023-04-05

PREAI

Meyran, Deborah; Zhu, Joe Jiang; Butler, Jeanne; Tantalo, Daniela; MacDonald, Sean; Nguyen, Thu Ngoc; Wang, Minyu; Thio, Niko; D'Souza, Criselle; Qin, Vicky Mengfei; Slaney, Clare; Harrison, Aaron; Sek, Kevin; Petrone, Pasquale; Thia, Kevin; Giuffrida, Lauren; Scott, Andrew M.; Terry, Rachael L.; Tran, Ben; Desai, Jayesh; Prince, H. Miles; Harrison, Simon J.; Beavis, Paul A.; Kershaw, Michael H.; Solomon, Ben; Ekert, Paul G.; Trapani, Joseph A.; Darcy, Phillip K.; Neeson, Paul J.

Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors 靶向蛋白酪氨酸磷酸酶22不增强嵌合抗原受体T细胞在实体瘤中的功效

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-02-27

OAAI

Du, Xin; Darcy, Phillip K.; Wiede, Florian; Tiganis, Tony

研究方向