杜嘉木 (Jiamu Du)

southern university of science and technology教授邮箱:dujm@sustech.edu.cn

H指数:37

被引数:7,608

个人简介

"研究领域杜嘉木教授主要从事植物表观遗传调控的分子机制研究，重点研究了植物如何通过对表观遗传标记的特异性识别和动态互作来调控重要植物生物学过程的科学问题，在植物花期转变的表观遗传调控机制和植物DNA甲基化的分子调控机理方面取得了一系列突破性研究成果。教学本科生《生物化学I（生物大分子）》研究生《Advanced Biological Sciences》学术成果查看更多 Xie, G#, Du, X#, Hu, H#, Li, S, Cao, X, Jacobsen, S.E, and Du, J. Structure and mechanism of the plant RNA polymerase V. Science. 2023, adf8231. Du X, Yang Z, Xie G, Wang C, Zhang L, Yan K, Yang M, Li S, Zhu JK, Du J. Molecular basis of the plant ROS1-mediated active DNA demethylation. Nat Plants. 2023, 9: 271-279. Zhang J#, Yuan J#, Lin J#, Chen L, You LY, Chen S, Peng L, Wang CH, Du J*, Duan CG*. Molecular basis of locus-specific H3K9 methylation catalyzed by SUVH6 in plants. Proc Natl Acad Sci U S A. 2023, 120: e2208525120. Leichter SM, Du J, Zhong X. Structure and Mechanism of Plant DNA Methyltransferases. Adv Exp Med Biol. 2022, 1389: 137-157. Zhou X#, Wei M#, Nie W#, Xi Y, Peng L, Zheng Q, Tang K, Satheesh V, Wang Y, Luo J, Du X, Liu R, Yang Z, La H, Zhong Y, Yang Y, Zhu JK, Du J*, Lei M*.The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis. J Integr Plant Biol. 2022, 64: 2385-2395. Du J*, Patel DJ*. Cofactor-assisted dicing: insights from structural snapshots. Cell Res. 2022 32: 965-966. Li S*, Du J*. Making a 6mA demethylase. Nat Chem Biol. 2022, 18: 683-684. Wang Q#, Xue Y#, Zhang L#, Zhong Z, Feng S, Wang C, Xiao L, Yang Z, Harris JC, Wu Z, Zhai J, Yang M, Li S*, Jacobsen SE*, Du J*. A SYBR Gold-based Label-free in vitro Dicing Assay. Bio Protoc. 2022, 12: e4382. Hu H, Du J*. Structure and mechanism of histone methylation dynamics in Arabidopsis. Curr Opin Plant Biol. 2022, 67:102211. Du X#, Yang Z#, Ariza AJF, Wang Q, Xie G, Li S, Du J*. Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production. Plant Cell. 2022, 34: 2140-2149. Zeng X#, Lv X#, Liu R, He H, Liang S, Chen L, Zhang F, Chen L, He Y*, Du J*. Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation. J Integr Plant Biol. 2022, 64: 731-740. Wang Q#, Xue Y#, Zhang L#, Zhong Z, Feng S, Wang C, Xiao L, Yang Z, Harris CJ, Wu Z, Zhai J, Yang M, Li S*, Jacobsen SE*, Du J*. Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science. 2021, 374: 1152-1157 Hu H#, Tian S#, Xie G, Liu R, Wang N, Li S, He Y*, Du J*. TEM1 combinatorially binds to FLOWERING LOCUS T and recruits a Polycomb factor to repress the floral transition in Arabidopsis. Proc Natl Acad Sci U S A. 2021, 118: e2103895118 Wang Y#, Zhou X#, Luo J, Lv S, Liu R, Du X, Jia B, Yuan F, Zhang H, Du J*. Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2. J Integr Plant Biol. 2021, 63: 1091-1096. Niu Q#, Song Z#, Tang K, Chen L, Wang L, Ban T, Guo Z, Kim C, Zhang H, Duan CG, Zhang H, Zhu JK, Du J*, Lang Z*. A histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation. Nat Commun. 2021, 12: 3367. Lv X, Zeng X, Hu H, Chen L, Zhang F, Liu R, Liu Y, Zhou X, Wang C, Wu Z, Kim C, He Y, Du J*. Structural insights into the multivalent binding of the Arabidopsis FLOWERING LOCUS T promoter by the CO-NF-Y master transcription factor complex. Plant Cell. 2021, 33: 1182-1195. Zhang YZ#, Yuan J#, Zhang L#, Chen C, Wang Y, Zhang G, Peng L, Xie SS, Jiang J, Zhu JK*, Du J*, Duan CG*.. Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis. Nat Commun. 2020, 11: 6212. Tan LM#, Liu R#, Gu BW, Zhang CJ, Luo J, Guo J, Wang Y, Chen L, Du X, Li S, Shao CR, Su YN, Cai XW, Lin RN, Li L, Chen S, Du J*, He XJ*. Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis. Plant Cell. 2020, 32: 2178-2195. Tao Z#, Hu H#, Luo X#, Jia B, Du J*, He Y*. Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis. Nature Plants 2019, 5: 424-435. Zheng S, Hu H, Ren H, Yang Z, Qiu Q, Qi W, Liu X, Chen X, Cui X, Li S, Zhou B, Sun D*, Cao X*, Du J*. The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor. Nat Commun. 2019 10: 1303. Harris CJ#, Scheibe M#, Wongpalee SP, Liu W, Cornett EM, Vaughan RM, Li X, Chen W, Xue Y, Zhong Z, Yen L, Barshop WD, Rayatpisheh S, Gallego-Bartolome J, Groth M, Wang Z, Wohlschlegel JA, Du J, Rothbart SB, Butter F*, Jacobsen SE*. A DNA methylation reader complex that enhances gene transcription. Science 2018; 362: 1182-1186. Zhang C#, Du X#, Tang K#, Yang Z, Pan L, Zhu P, Luo J, Jiang Y, Zhang H, Wan H, Wang X, Wu F, Tao WA, He XJ, Zhang H, Bressan RA, Du J*, Zhu JK*. Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin. Nat Commun. 2018b; 9: 4547. (* co-corresponding authors) Li X#, Harris CJ#, Zhong Z, Chen W, Liu R, Jia B, Wang Z, Li S, Jacobsen SE*, Du J*. Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context biased non-CG DNA methylation. Proc Natl Acad Sci U S A. 2018; 115: E8793-E8802. (* co-corresponding authors) Yang Z#, Qian S#, Scheid RN, Lu L, Chen X, Liu R, Du X, Lv X, Boersma MD, Scalf M, Smith LM, Denu JM, Du J*, Zhong X*. EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis. Nat Genet. 2018; 50: 1247-1253. (* co-corresponding authors) Qian S#, Lv X#, Scheid RN#, Lu L, Yang Z, Chen W, Liu R, Boersma MD, Denu JM, Zhong X*, Du J*. Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL. Nat Commun. 2018; 9: 2425. (* co-corresponding authors) Yang Z, Qiu Q, Chen W, Jia B, Chen X, Hu H, He K, Deng X, Li S, Tao WA, Cao X*, Du J*. Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases. Plant Cell. 2018; 30: 167-177. (* co-corresponding authors) Liu R#, Li X#, Chen W, Du J*. Structure and mechanism of plant histo"