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收藏Novel translational mouse models of metabolic dysfunction-associated steatotic liver disease comparable to human MASLD with severe obesity与人类MASLD相当的代谢功能障碍相关脂肪性肝病的新型翻译小鼠模型
Hupa-Breier, Katharina L.; Schenk, Heiko; Campos-Murguia, Alejandro; Wellhoener, Freya; Heidrich, Benjamin; Dywicki, Janine; Hartleben, Bjoern; Boeker, Clara; Mall, Julian; Terkamp, Christoph; Wilkens, Ludwig; Becker, Friedrich; Rudolph, Karl Lenhard; Manns, Michael Peter; Mederacke, Young-Seon; Marhenke, Silke; Redeker, Hanna; Lieber, Maren; Iordanidis, Konstantinos; Taubert, Richard; Wedemeyer, Heiner; Noyan, Fatih; Hardtke-Wolenski, Matthias; Jaeckel, Elmar 分享 收藏 分享 收藏 The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo (vol 6, pg 275, 2005)端粒功能障碍的细胞水平决定体内衰老或凋亡的诱导 (第6卷，275页，2005)Lechel, Andre; Ande, Satyanarayana; Ju, Zhenyu; Plentz, Ruben R.; Schaetzlein, Sonja; Rudolph, Cornelia; Wilkens, Ludwig; Wiemann, Stefanie U.; Saretzki, Gabriele; Malek, Nisar P.; Manns, Michael P.; Buer, Jan; Rudolph, K. Lenhard 分享 收藏 分享 收藏 IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regenerationOmrani, Omid; Krepelova, Anna; Rasa, Seyed Mohammad Mahdi; Syrvinskas, Dovydas; Lu, Jing; Annunziata, Francesco; Garside, George; Bajwa, Seerat; Reinhardt, Susanne; Adam, Lisa; Kaeppel, Sandra; Ducano, Nadia; Donna, Daniela; Ori, Alessandro; Oliviero, Salvatore; Rudolph, Karl Lenhard; Neri, Francesco 分享 收藏 分享 收藏 Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signalingSatyanarayana, A; Greenberg, RA; Schaetzlein, S; Buer, J; Masutomi, K; Hahn, WC; Zimmermann, S; Martens, U; Manns, MP; Rudolph, KL 分享 收藏 Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction炎症是由先天免疫受体和全身性干扰素信号的上调驱动的，并通过饮食限制得到改善Rasa, Seyed Mohammad Mahdi; Annunziata, Francesco; Krepelova, Anna; Nunna, Suneetha; Omrani, Omid; Gebert, Nadja; Adam, Lisa; Kappel, Sandra; Hohn, Sven; Donati, Giacomo; Jurkowski, Tomasz Piotr; Rudolph, Karl Lenhard; Ori, Alessandro; Neri, Francesco 分享 收藏 PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signalingPI(18:1/18:1) 是一种限制应激信号的SCD1-derived脂因子Thuermer, Maria; Gollowitzer, Andre; Pein, Helmut; Neukirch, Konstantin; Gelmez, Elif; Waltl, Lorenz; Wielsch, Natalie; Winkler, Rene; Loeser, Konstantin; Grander, Julia; Hotze, Madlen; Harder, Sonke; Doeding, Annika; Messner, Martina; Troisi, Fabiana; Ardelt, Maximilian; Schlueter, Hartmut; Pachmayr, Johanna; Gutierrez-Gutierrez, Oscar; Rudolph, Karl Lenhard; Thedieck, Kathrin; Schulze-Spaete, Ulrike; Gonzalez-Estevez, Cristina; Kosan, Christian; Svatos, Ales; Kwiatkowski, Marcel; Koeberle, Andreas 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction (vol 14, pg 73, 2011)Sperka, Tobias; Song, Zhangfa; Morita, Yohei; Nalapareddy, Kodandaramireddy; Guachalla, Luis Miguel; Lechel, Andre; Begus-Nahrmann, Yvonne; Burkhalter, Martin D.; Mach, Monika; Schlaudraff, Falk; Liss, Birgit; Ju, Zhenyu; Speicher, Michael R.; Rudolph, K. Lenhard 分享 收藏 分享 收藏 Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging (vol 213, pg 535, 2016)Tang, Duozhuang; Tao, Si; Chen, Zhiyang; Koliesnik, Ievgen Oleksandrovich; Calmes, Philip Gerald; Hoerr, Verena; Han, Bing; Gebert, Nadja; Zoernig, Martin; Loeffler, Bettina; Morita, Yohei; Rudolph, Karl Lenhard 分享 收藏 分享 收藏 Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation (vol 39, pg 99, 2007)Choudhury, Aaheli Roy; Ju, Zhenyu; Djojosubroto, Meta W.; Schienke, Andrea; Lechel, Andre; Schaetzlein, Sonja; Jiang, Hong; Stepczynska, Anna; Wang, Chunfang; Buer, Jan; Lee, Han-Woong; von Zglinicki, Thomas; Ganser, Arnold; Schirmacher, Peter; Nakauchi, Hiromitsu; Rudolph, K. Lenhard 分享 收藏 Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary RestrictionGebert, Nadja; Cheng, Chia-Wei; Kirkpatrick, Joanna M.; Di Fraia, Domenico; Yun, Jina; Schaedel, Patrick; Pace, Simona; Garside, George B.; Werz, Oliver; Rudolph, K. Lenhard; Jasper, Henri; Yilmaz, Omer H.; Ori, Alessandro 分享 收藏 Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice (vol 1, pg 303, 2009)Guachalla, Luis Miguel; Ju, Zhenyu; Koziel, Rafal; von Figura, Guido; Song, Zhangfa; Fusser, Markus; Epe, Bernd; Jansen-Durr, Pidder; Rudolph, K. Lenhard 分享 收藏 
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