Maarten van Lohuizen - Publications, H-index & Citations

Maarten van Lohuizen

netherlands cancer institute

80H指数

283论文数

2.5W被引数

收录论文 81

发表时间

PRC2 loss impairs small cell lung cancer tumorigenesis and enhances sensitivity to G9a/GLP inhibition PRC2缺失抑制小细胞肺癌肿瘤发生并增强对G9a/GLP抑制的敏感性

Communications Biology

IF5.1

2026-02-21

OAAI

Jawahar Kopparam; Gayathri Chandrasekaran; Danielle Hulsman; Liesa-Marie Pilger; Karen Stevers; Ji-Ying Song; Miguel Hernandez-Quiles; Jelmer Dijkstra; Jitendra Badhai; Nick Landman; Michiel Vermeulen; Maarten van Lohuizen

Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma

BRITISH JOURNAL OF CANCER

IF6.8

2024-03-22

OAAI

Landman, Nick; Hulsman, Danielle; Badhai, Jitendra; Kopparam, Jawahar; Puppe, Julian; Pandey, Gaurav Kumar; van Lohuizen, Maarten

Retinoids and EZH2 inhibitors cooperate to orchestrate anti-oncogenic effects on bladder cancer cells

CANCER GENE THERAPY

IF5

2024-01-17

PREAI

Ozgun, Gizem; Yaras, Tutku; Akman, Burcu; Ozden-Yilmaz, Guelden; Landman, Nick; Karakulah, Gokhan; van Lohuizen, Maarten; Senturk, Serif; Erkek-Ozhan, Serap

Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: Indication for separate Pc-G complexes

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

120

OAAI

van Lohuizen, M; Tijms, M; Voncken, JW; Schumacher, A; Magnuson, T; Wientjens, E

Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Kranc, KR; Bamforth, SD; Bragança, J; Norbury, C; van Lohuizen, M; Bhattacharya, S

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

436

OAAI

Itahana, K; Zou, Y; Itahana, Y; Martinez, JL; Beausejour, C; Jacobs, JJL; van Lohuizen, M; Band, V; Campisi, J; Dimri, GP

Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

172

OAAI

Hernández-Muñoz, I; Taghavi, P; Kuijl, C; Neefjes, J; van Lohuizen, M

BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

241

OAAI

Ginjala, Vasudeva; Nacerddine, Karim; Kulkarni, Atul; Oza, Jay; Hill, Sarah J.; Yao, Ming; Citterio, Elisabetta; van Lohuizen, Maarten; Ganesan, Shridar

Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma

CELL REPORTS MEDICINE

IF10.6

2023-02-01

OAAI

Pandey, Gaurav Kumar; Landman, Nick; Neikes, Hannah K.; Hulsman, Danielle; Lieftink, Cor; Beijersbergen, Roderick; Kolluri, Krishna Kalyan; Janes, Sam M.; Vermeulen, Michiel; Badhai, Jitendra; van Lohuizen, Maarten

Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer EZH2和ATM的联合抑制在BRCA1-deficient乳腺癌中是合成致死的

BREAST CANCER RESEARCH

IF5.6

2022-06-17

OAAI

Ratz, Leonie; Brambillasca, Chiara; Bartke, Leandra; Huetzen, Maxim A.; Goergens, Jonas; Leidecker, Orsolya; Jachimowicz, Ron D.; van de Ven, Marieke; Proost, Natalie; Siteur, Bjorn; de Korte-Grimmerink, Renske; Bouwman, Peter; Pulver, Emilia M.; de Bruijn, Roebi; Isensee, Joerg; Hucho, Tim; Pandey, Gaurav; van Lohuizen, Maarten; Mallmann, Peter; Reinhardt, Hans Christian; Jonkers, Jos; Puppe, Julian

Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2020-04-09

OAAI

Badhai, Jitendra; Pandey, Gaurav Kumar; Song, Ji-Ying; Krijgsman, Oscar; Bhaskaran, Rajith; Chandrasekaran, Gayathri; Kwon, Min-chul; Bombardelli, Lorenzo; Monkhorst, Kim; Grasso, Cristoforo; Zevenhoven, John; van der Vliet, Jan; Cozijnsen, Miranda; Krimpenfort, Paul; Peeper, Daniel; van Lohuizen, Maarten; Berns, Anton

Multiplexed Cas9 targeting reveals genomic location effects and gRNA-based staggered breaks influencing mutation efficiency

NATURE COMMUNICATIONS

IF15.7

2019-04-08

OAAI

Gisler, Santiago; Goncalves, Joana P.; Akhtar, Waseem; de Jong, Johann; Pindyurin, Alexey V.; Wessels, Lodewyk F. A.; van Lohuizen, Maarten

Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells

GASTROENTEROLOGY

IF25.1

2016-10-01

PREAI

Koppens, Martijn A. J.; Bounova, Gergana; Gargiulo, Gaetano; Tanger, Ellen; Janssen, Hans; Cornelissen-Steijger, Paulien; Blom, Marleen; Song, Ji-Ying; Wessels, Lodewyk F. A.; van Lohuizen, Maarten

Neoadjuvant Ezh2 inhibition amplifies an inflammatory program and sensitizes Kras-driven NSCLC to anti-NF-κB inhibition

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Serresi, Michela; Siteur, Bjorn; Cesaroni, Matteo; Proost, Natalie; Hulsman, Danielle; van Lohuizen, Maarten; Gargiulo, Gaetano

TRIM28 is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming TRIM28是诱导多能干细胞重编程的表观遗传屏障

Stem Cells

IF3.6

2016-07-06

OAAI

Miles, Denise Catherine; de Vries, Nienke Alexandra; Gisler, Santiago; Lieftink, Cor; Akhtar, Waseem; Gogola, Ewa; Pawlitzky, Inka; Hulsman, Danielle; Tanger, Ellen; Koppens, Martijn; Beijersbergen, Roderick Leonardus; van Lohuizen, Maarten

Context-dependent actions of Polycomb repressors in cancer

ONCOGENE

IF7.3

2015-06-08

OAAI

Koppens, M.; van Lohuizen, M.

Using TRIP for genome-wide position effect analysis in cultured cells (vol 9, pg 1255, 2014)

NATURE PROTOCOLS

IF16

2015-03-26

OAAI

Akhtar, Waseem; Pindyurin, Alexey V.; de Jong, Johann; Pagie, Ludo; ten Hoeve, Jelle; Berns, Anton; Wessels, Lodewyk F. A.; van Steensel, Bas; van Lohuizen, Maarten

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression 胶质母细胞瘤中长时间的Ezh2耗竭会导致细胞命运的强烈转变，从而导致肿瘤进展

CELL REPORTS

IF6.9

2015-01-01

OAAI

de Vries, Nienke A.; Hulsman, Danielle; Akhtar, Waseem; de Jong, Johann; Miles, Denise C.; Blom, Marleen; van Tellingen, Olaf; Jonkers, Jos; van Lohuizen, Maarten

In vivo shRNA screens in solid tumors

NATURE PROTOCOLS

IF16

2014-11-20

PREAI

Gargiulo, Gaetano; Serresi, Michela; Cesaroni, Matteo; Hulsman, Danielle; van Lohuizen, Maarten

Unexpected results of prolonged EZH2 inhibition in an in vivo model for glioblastoma

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

van Lohuizen, Maarten

研究方向