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Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL 网络分析揭示了14q32簇mirna在确定IGHV突变和未突变CLL之间的转录差异中的主要作用 Bryant, Dean; Smith, Lindsay; Rogers-Broadway, Karly Rai; Karydis, Laura; Woo, Jeongmin; Blunt, Matthew D.; Forconi, Francesco; Stevenson, Freda K.; Goodnow, Christopher; Russell, Amanda; Humburg, Peter; Packham, Graham; Steele, Andrew J.; Strefford, Jonathan C. 分享 收藏
High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL 高表面IgM水平与CLL患者对ibrutinib和BTK旁路的较短反应相关 Chiodin, Giorgia; Drennan, Samantha; Martino, Enrica A.; Ondrisova, Laura; Henderson, Isla; del Rio, Luis; Tracy, Ian; D'Avola, Annalisa; Parker, Helen; Bonfiglio, Silvia; Scarfo, Lydia; Sutton, Lesley-Ann; Strefford, Jonathan C.; Forster, Jade; Brake, Oliver; Potter, Kathleen N.; Sale, Benjamin; Lanham, Stuart; Mraz, Marek; Ghia, Paolo; Stevenson, Freda K.; Forconi, Francesco 分享 收藏
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B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells B细胞受体信号通过MEK1/2和mTORC1诱导恶性b细胞中PDCD4的蛋白酶体降解 Taylor, Joe; Wilmore, Sarah; Marriot, Sophie; Rogers-Broadway, Karly-Rai; Fell, Rachel; Minton, Annabel R.; Branch, Tom; Ashton-Key, Meg; Coldwell, Mark; Stevenson, Freda K.; Forconi, Francesco; Steele, Andrew J.; Packham, Graham; Yeomans, Alison 分享 收藏
Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells 靶向抑制eIF4A抑制b细胞受体诱导的慢性淋巴细胞白血病细胞中MYC和MCL1的翻译和表达 Wilmore, Sarah; Rogers-Broadway, Karly-Rai; Taylor, Joe; Lemm, Elizabeth; Fell, Rachel; Stevenson, Freda K.; Forconi, Francesco; Steele, Andrew J.; Coldwell, Mark; Packham, Graham; Yeomans, Alison 分享 收藏
DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity 滤泡性淋巴瘤中dc-sign与甘露糖基化b细胞受体的结合下调了受体的信号传导能力 Valle-Argos, Beatriz; Chiodin, Giorgia; Bryant, Dean J.; Taylor, Joe; Lemm, Elizabeth; Duriez, Patrick J.; Rock, Philip J.; Strefford, Jonathan C.; Forconi, Francesco; Burack, Richard W.; Packham, Graham; Stevenson, Freda K. 分享 收藏
Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells Lemm, Elizabeth A.; Valle-Argos, Beatriz; Smith, Lindsay D.; Richter, Johanna; Gebreselassie, Yohannes; Carter, Matthew J.; Karolova, Jana; Svaton, Michael; Helman, Karel; Weston-Bell, Nicola J.; Karydis, Laura; Williamson, Chris T.; Lenz, Georg; Pettigrew, Jeremy; Harwig, Curtis; Stevenson, Freda K.; Cragg, Mark; Forconi, Francesco; Steele, Andrew J.; Cross, Jennifer; Mackenzie, Lloyd; Klener, Pavel; Packham, Graham 分享 收藏
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BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia BCR信号通路在慢性淋巴细胞白血病自噬调节中的作用 Smith, Lindsay D.; Minton, Annabel R.; Blunt, Matthew D.; Karydis, Laura I.; Dutton, David A.; Rogers-Broadway, Karly-Rai; Dobson, Rachel; Liu, Rena; Norster, Faith; Hogg, Elizabeth; Ashton-Key, Margaret; Strefford, Jonathan C.; Jia, Li; Efremov, Dimitar G.; Helgason, G. Vignir; Johnson, Peter W. M.; Stevenson, Freda K.; Forconi, Francesco; Cragg, Mark S.; Tumbarello, David A.; Packham, Graham; Steele, Andrew J. 分享 收藏
Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic Lymphocytic Leukemia Patients Ibrutinib疗法从慢性淋巴细胞白血病患者的抗原驱动中释放白血病表面IgM Drennan, Samantha; Chiodin, Giorgia; D'Avola, Annalisa; Tracy, Ian; Johnson, Peter W.; Trentin, Livio; Steele, Andrew J.; Packham, Graham; Stevenson, Freda K.; Forconi, Francesco 分享 收藏
Development of pelorol analogues to activate the SHIP1 lipid phosphatase; a novel paradigm to suppress B-cell receptor signaling in human B-cell cancers Packham, Graham; Lemm, Elizabeth; Valle-Argos, Beatriz; Smith, Lindsay; Weston-Bell, Nichola; Stevenson, Freda; Carter, Matthew J.; Cragg, Mark S.; Forconi, Francesco; Steele, Andrew J.; Cross, Jennifer; Harwig, Curtis; Lenz, Georg; Mackenzie, Lloyd; Klener, Pavel 分享 收藏
The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia Blunt, Matthew D.; Koehrer, Stefan; Dobson, Rachel C.; Larrayoz, Marta; Wilmore, Sarah; Hayman, Alice; Parnell, Jack; Smith, Lindsay D.; Davies, Andrew; Johnson, Peter W. M.; Conley, Pamela B.; Pandey, Anjali; Strefford, Jonathan C.; Stevenson, Freda K.; Packham, Graham; Forconi, Francesco; Coffey, Greg P.; Burger, Jan A.; Steele, Andrew J. 分享 收藏
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IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus Drennan, S.; D'Avola, A.; Gao, Y.; Weigel, C.; Chrysostomou, E.; Steele, A. J.; Zenz, T.; Plass, C.; Johnson, P. W.; Williams, A. P.; Packham, G.; Stevenson, F. K.; Oakes, C. C.; Forconi, F. 分享 收藏
Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes McCann, Katy J.; Mander, Ann; Cazaly, Angelica; Chudley, Lindsey; Stasakova, Jana; Thirdborough, Stephen M.; King, Andrew; Lloyd-Evans, Paul; Buxton, Emily; Edwards, Ceri; Halford, Sarah; Bateman, Andrew; O'Callaghan, Ann; Clive, Sally; Anthoney, Alan; Jodrell, Duncan I.; Weinschenk, Toni; Simon, Petra; Sahin, Ugur; Thomas, Gareth J.; Stevenson, Freda K.; Ottensmeier, Christian H. 分享 收藏
A plant-expressed conjugate vaccine breaks CD4+ tolerance and induces potent immunity against metastatic Her2+ breast cancer Chotprakaikiat, Warayut; Allen, Alex; Bui-Minh, Duc; Harden, Elena; Jobsri, Jantipa; Cavallo, Federica; Gleba, Yuri; Stevenson, Freda K.; Ottensmeier, Christian; Klimyuk, Victor; Savelyeva, Natalia 分享 收藏
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