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P

Paul Lyons

cambridge biomedical campus
H指数:74
被引数:2.4万

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Multiomic analysis identifies glutaminolysis-dependent metabolic enhancement of immune memory utilised for vaccine development

多组学分析识别谷氨酰胺分解依赖的代谢增强，该增强被用于疫苗开发以利用免疫记忆

Nature Communications
IF15.7
2026-06-260
OAAI
J. M. Sowerby; P. Kotagiri; S. Clare; D. Griffiths; O. Knight; I. Cuthbertson; K. Harcourt; P. Pereyra Gerber; I. Pshenichnaya; C. Connor; A. Denton; G. A. Stoll; C. Matara; C. Keel; G. Manferrari; T. Birkle; P. Naydenova; H. Peck; P. A. Lyons; I. Barr; Y. Modis; G. Dougan; N. J. Matheson; K. G. C. Smith; E. F. McKinney
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals

禽源甲型流感病毒在哺乳动物中耐受高热性体温。

Science
IF45.8
2025-11-270
PRE
Matthew L. Turnbull; Yingxue Wang; Simon Clare; Gauthier Lieber; Stephanie L. Williams; Marko Noerenberg; Akira J. T. Alexander; Sara Clohisey Hendry; Douglas G. Stewart; Joseph Hughes; Simon Swingler; Spyros Lytras; Emma L. Davies; Katherine Harcourt; Katherine Smollett; Rute M. Pinto; Hui-Min Lee; Eleanor R. Gaunt; Colin Loney; Johanna S. Jung; Paul A. Lyons; Darrell R. Kapczynski; Edward Hutchinson; Ana da Silva Filipe; Jeffery K. Taubenberger; Suzannah J. Rihn; J. Kenneth Baillie; Ervin Fodor; Alfredo Castello; Kenneth G. C. Smith; Paul Digard; Sam J. Wilson
Anti-tumor necrosis factor treatment from diagnosis is more effective and less costly than conventional step-up care for patients with active Crohn's disease: a cost-effectiveness analysis from the PROFILE trial

从诊断开始使用抗肿瘤坏死因子治疗，比常规逐步升级治疗对活动性克罗恩病患者的效果更好且成本更低：PROFILE试验的成本效益分析

JOURNAL OF CROHNS & COLITIS
IF8.7
2025-09-010
OAAI
Noor, Nurulamin M.; Davies, Neil; Tahir, Warda; Bond, Simon; Dowling, Francis; Patel, Kamal, V; Lyons, Paul A.; McKinney, Eoin F.; Smith, Kenneth G. C.; Lee, James C.; Buchanan, Vanessa; Parkes, Miles
Assessment of PredictSURE IBD Assay in a Multinational Cohort of Patients With Inflammatory Bowel Disease

评估PredictSURE IBD检测在跨国炎症性肠病患者队列中的应用

United European Gastroenterology Journal
IF6.7
2025-07-110
OAAI
Dahham Alsoud; Nurulamin M. Noor; Lea Ann Chen; Vivian Abadom; Simon H. C. Anderson; Lediona Ardolli; Jordan Axelrad; Peter Bossuyt; Kenneth Croitoru; Oriana M. Damas; Lily Deng; Parakkal Deepak; Juan De La Revilla Negro; Shanika de Silva; Marc Ferrante; Karen Hills; Peter M. Irving; James O. Lindsay; Dana J. Lukin; Paul A. Lyons; Eoin F. McKinney; Maria Oliva-Hemker; Caterina Oneto; Roohi Patel; Miles Parkes; Lieven Pouillon; João Sabino; Lawrence J. Saubermann; Jenny S. Sauk; Sarah Sheibani; Kenneth G. C. Smith; Keith S. Sultan; Tony C. Tham; Sare Verstockt; Raluca Vrabie; Melissa Weidner; Huimin Yu; Bram Verstockt; James C. Lee; Séverine Vermeire
Disease-specific B cell clones are shared between patients with Crohn's disease

克罗恩病患者的疾病特异性B细胞克隆存在共享现象。

NATURE COMMUNICATIONS
IF15.7
2025-04-170
OA
Kotagiri, Prasanti; Rae, William M.; Bergamaschi, Laura; Pombal, Diana; Lee, Ji-Yeun; Noor, Nurulamin M.; Sojwal, Raoul S.; Rubin, Samuel J. S.; Unger, Lukas W.; Tolmeijer, Sofie H.; Manferrari, Giulia; Bashford-Rogers, Rachael J. M.; Bingham, David B.; Stift, Anton; Rogalla, Stephan; Gubatan, John; Lee, James C.; Smith, Kenneth G. C.; Mckinney, Eoin F.; Boyd, Scott D.; Lyons, Paul A.
Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11

空间蛋白质组学鉴定了一种依赖CRTC的病毒信号通路，该通路能刺激白介素-11的产生。

CELL REPORTS
IF6.9
2025-02-010
OAAI
Ravenhill, Benjamin J.; Oliveira, Marisa; Wood, George; Di, Ying; Kite, Joanne; Wang, Xinyue; Davies, Colin T. R.; Lu, Yongxu; Antrobus, Robin; Elliott, Gill; Irigoyen, Nerea; Hughes, David J.; Lyons, Paul A.; Chung, Betty; Borner, Georg H. H.; Weekes, Michael P.
Characterization of Genetic Landscape and Novel Inflammatory Biomarkers in Patients With Adult-Onset Still's Disease

成人斯蒂尔病患者的遗传景观和新型炎症生物标志物的表征

ARTHRITIS & RHEUMATOLOGY
IF10.9
2024-12-160
OAAI
Topping, Joanne; Chang, Leon; Nadat, Fatima; Poulter, James A.; Ibbotson, Alice; Lara-Reyna, Samuel; Watson, Christopher M.; Carter, Clive; Pournara, Linda P.; Zernicke, Jan; Ross, Rebecca L.; Cargo, Catherine; Lyons, Paul A.; Smith, Kenneth G. C.; Del Galdo, Francesco; Rech, Juergen; Fautrel, Bruno; Feist, Eugen; Mcdermott, Michael F.; Savic, Sinisa; ImmunAID Consortium
Early human lung immune cell development and its role in epithelial cell fate
EUROPEAN RESPIRATORY JOURNAL
IF21
2024-10-300
OA
Barnes, Josephine; Yoshida, Masahiro; He, Peng; Worlock, Kaylee; Lindeboom, Rik; Suo, Chenqu; Pett, J. Patrick; Wilbrey-Clark, Anna; Dann, Emma; Mamanova, Lira; Richardson, Laura; Polanski, Krzysztof; Pennycuick, Adam; Allen-Hytinnen, Jessica; Herczeg, Ivan; Arzili, Romina; Hynds, Robert; Teixeira, Vitor; Haniffa, Muzlifah; Lim, Kyungtae; Sun, Dawei; Rawlins, Emma; Oliver, Amanda; Lyons, Paul; Marioni, John; Ruhrberg, Christiana; Tuong, Zewen; Clatworthy, Menna; Reading, James; Janes, Sam; Teichmann, Sarah; Meyer, Kerstin; Nikolic, Marko
Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site
SCIENCE IMMUNOLOGY
IF16.3
2024-05-243
OAAI
Takahashi, Munetomo; So, Tsz Y.; Chamberlain-Evans, Vitalina; Hughes, Robert; Yam-Puc, Juan Carlos; Kania, Katarzyna; Ruhle, Michelle; Mann, Tiffeney; Schuijs, Martijn J.; Coupland, Paul; Naisbitt, Dean; Halim, Timotheus Y. F.; Lyons, Paul A.; Lio, Pietro; Roychoudhuri, Rahul; Okkenhaug, Klaus; Adams, David J.; Smith, Ken G. C.; Jodrell, Duncan I.; Chapman, Michael A.; Thaventhiran, James E. D.
A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial
LANCET GASTROENTEROLOGY & HEPATOLOGY
IF38.6
2024-05-0143
OAAI
Noor, Nurulamin M.; Lee, James C.; Bond, Simon; Dowling, Francis; Brezina, Biljana; Patel, Kamal, V; Ahmad, Tariq; Banim, Paul J.; Berrill, James W.; Cooney, Rachel; Negro, Juan De La Revilla; de Silva, Shanika; Din, Shahida; Durai, Dharmaraj; Gordon, John N.; Irving, Peter M.; Johnson, Matthew; Kent, Alexandra J.; Kok, Klaartje B.; Moran, Gordon W.; Mowat, Craig; Patel, Pritash; Probert, Chris S.; Raine, Tim; Saich, Rebecca; Seward, Abigail; Sharpstone, Dan; Smith, Melissa A.; Subramanian, Sreedhar; Upponi, Sara S.; Wiles, Alan; Williams, Horace R. T.; van den Brink, Gijs R.; Vermeire, Severine; Jairath, Vipul; D'Haens, Geert R.; McKinney, Eoin F.; Lyons, Paul A.; Lindsay, James; Kennedy, Nicholas A.; Smith, Kenneth G. C.; Parkes, Miles
Altered B-Cell Expansion and Maturation in Draining Mesenteric Lymph Nodes of Inflamed Gut in Crohn's Disease
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
IF7.4
2024-01-011
OAAI
Kappel-latif, Sonja; Kotagiri, Prasanti; Schlager, Lukas; Walterskirchen, Natalie; Schimek, Vanessa; Schuld, Gabor; Sewell, Gavin; Binder, Carina; Jobst, Johanna; Murthy, Supriya; Messner, Barbara; Dabsch, Stefanie; Kaser, Arthur; Lyons, Paul a.; Bergmann, Michael; Stift, Anton; Oehler, Rudolf; Unger, Lukas w.
Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis

靶向b细胞中的nf-κb信号传导作为ANCA相关血管炎的潜在新治疗方式

JOURNAL OF AUTOIMMUNITY
IF7
2024-01-013
OA
Merino-Vico, Ana; van Hamburg, Jan Piet; Tuijnenburg, Paul; Frazzei, Giulia; Al-Soudi, Aram; Bonasia, Carlo G.; Helder, Boy; Rutgers, Abraham; Abdulahad, Wayel H.; Stegeman, Coen A.; Sanders, Jan-Stephan; Bergamaschi, Laura; Lyons, Paul A.; Bijma, Theo; van Keep, Laura; Wesenhagen, Kirsten; Jongejan, Aldo; Olsson, Henric; de Vries, Niek; Kuijpers, Taco W.; Heeringa, Peter; Tas, Sander W.
Early human lung immune cell development and its role in epithelial cell fate
SCIENCE IMMUNOLOGY
IF16.3
2023-12-2214
OAAI
Barnes, Josephine L.; Yoshida, Masahiro; He, Peng; Worlock, Kaylee B.; Lindeboom, Rik G. H.; Suo, Chenqu; Pett, J. Patrick; Wilbrey-Clark, Anna; Dann, Emma; Mamanova, Lira; Richardson, Laura; Polanski, Krzysztof; Pennycuick, Adam; Allen-Hyttinen, Jessica; Herczeg, Ivan T.; Arzili, Romina; Hynds, Robert E.; Teixeira, Vitor H.; Haniffa, Muzlifah; Lim, Kyungtae; Sun, Dawei; Rawlins, Emma L.; Oliver, Amanda J.; Lyons, Paul A.; Marioni, John C.; Ruhrberg, Christiana; Tuong, Zewen Kelvin; Clatworthy, Menna R.; Reading, James L.; Janes, Sam M.; Teichmann, Sarah A.; Meyer, Kerstin B.; Nikolic, Marko Z.
Genotyping and population characteristics of the China Kadoorie Biobank

中国嘉道理生物银行的基因分型和种群特征

CELL GENOMICS
IF9
2023-08-0134
OAAI
Walters, Robin G.; Millwood, Iona Y.; Lin, Kuang; Valle, Dan Schmidt; McDonnell, Pandora; Hacker, Alex; Avery, Daniel; Edris, Ahmed; Fry, Hannah; Cai, Na; Kretzschmar, Warren W.; Ansari, M. Azim; Lyons, Paul A.; Collins, Rory; Donnelly, Peter; Hill, Michael; Peto, Richard; Shen, Hongbing; Jin, Xin; Nie, Chao; Xu, Xun; Guo, Yu; Yu, Canqing; Lv, Jun; Clarke, Robert J.; Li, Liming; Chen, Zhengming

研究方向

暂未获取到该数据
K
Kenneth G. C. Smith
H 指数:100论文数:488被引数:3.7万
E
Eoin McKinney
H 指数:32论文数:100被引数:6,547
L
Laura Bergamaschi
H 指数:23论文数:56被引数:6,069
M
Menna R. Clatworthy
H 指数:62论文数:334被引数:1.7万
J
James Lee
H 指数:90论文数:508被引数:4.2万
P
Prasanti Kotagiri
H 指数:13论文数:45被引数:1,686
J
John R. Bradley
H 指数:70论文数:356被引数:2.5万
F
Federica Mescia
H 指数:24论文数:94被引数:8,921
N
Nicholas J. Matheson
H 指数:41论文数:147被引数:1.3万
D
David Jayne
H 指数:130论文数:983被引数:7.8万