James D. Brenton

cancer research uk cambridge institute

H指数:77

被引数:3.8万

个人简介

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教育背景

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Germline homologous recombination deficiency influences TP53-mutant clonal hematopoiesis fitness during platinum and PARP inhibitor treatment

生殖系同源重组缺陷影响铂类和PARP抑制剂治疗期间TP53突变克隆性造血的适应性

Nature Genetics

IF29

2026-09-280

OAAI

Jeremy T. Baeten; Irenaeus C. C. Chan; Lea Moukarzel; Giulia E. M. Petrone; Jie Liu; Duc Tran; Jacob Tabs; Imene Tabet; Sumedha Agashe; Elaheh Nasrollahzadeh; Ankush Vasireddy; Amber Carter; Minal Patel; Konrad H. Stopsack; Philip W. Kantoff; Weiyin Zhou; Armel L. Batchi-Bouyou; J. Scott Beeler; Griffen Mustion; Paul Pharoah; James Brenton; Kenneth Offit; Ethan Barnett; Bob Li; Wassim Abida; Alison M. Schram; Britta Weigelt; David Mutch; Alessandro Vindigni; Mary Mullen; Carlos Cruchaga; Howard Scher; Ross Levine; Elli Papaemmanuil; Mitchell J. Machiela; Karen Cadoo; Daniel C. Link; Kelly L. Bolton

Rethinking ovarian cancer III: the past decade and future directions

重新思考卵巢癌III：过去十年及未来方向

Nature Reviews Cancer

IF66.8

2026-04-130

PRE

Frances R. Balkwill; Céline M. Laumont; Nikki Burdett; Olivia Le Saux; Dale W. Garsed; Whitney R. Grither; Anke M. Nijhuis; Maria S. Recouvreux; Ziqi Kang; Rugang Zhang; Katherine B. Chiappinelli; Jason S. Lee; Denarda Dangaj Laniti; Iain McNeish; Ahmed A. Ahmed; Robert Rottapel; Jose R. Conejo-Garcia; Kunle Odunsi; Paul D. P. Pharoah; Dmitriy Zamarin; Charles A. Ishak; Christina Fotopoulou; Ronald J. Buckanovich; Intidhar Labidi-Galy; James D. Brenton; Ernst Lengyel; David P. Cook; Sophia H. L. George; Stephanie Lheureux; Ronny Drapkin; Kenneth P. Nephew; Sarah Adams; Shailja Pathania; Brad H. Nelson; Anniina Färkkilä; Katherine Fuh; Benjamin G. Neel; David D. Bowtell

Clinicopathologic and molecular predictors of survival in BRCA-deficient tubo-ovarian high-grade serous carcinoma

BRCA缺陷性输卵管卵巢高级别浆液性癌的生存临床病理及分子预测因子

Nature Communications

IF15.7

2026-04-010

OAAI

Tibor A. Zwimpfer; Sian Fereday; Ahwan Pandey; Dinuka Ariyaratne; Madawa W. Jayawardana; Laura Twomey; Céline M. Laumont; Catherine J. Kennedy; Adelyn Bolithon; Nicola S. Meagher; Katy Milne; Phineas Hamilton; Jennifer Alsop; Antonis C. Antoniou; George Au-Yeung; Matthias W. Beckmann; Amy Berrington de Gonzalez; Christiani Bisinotto; Freya Blome; Clara Bodelon; Jessica Boros; Alison H. Brand; Michael E. Carney; Alicia Cazorla-Jiménez; Derek S. Chiu; Elizabeth L. Christie; Anita Chudecka-Głaz; Penny Coulson; Kara L. Cushing-Haugen; Cezary Cybulski; Kathleen M. Darcy; Cath David; Trent Davidson; Arif B. Ekici; Esther Elishaev; Julius Emons; Tobias Engler; Rhonda Farrell; Anna Fischer; Montserrat García-Closas; Aleksandra Gentry-Maharaj; Prafull Ghatage; Rosalind Glasspool; Philipp Harter; Andreas D. Hartkopf; Arndt Hartmann; Sebastian Heikaus; Brenda Y. Hernandez; Anusha Hettiaratchi; Sabine Heublein; David G. Huntsman; Mercedes Jimenez-Linan; Michael E. Jones; Eunyoung Kang; Ewa Kaznowska; Tomasz Kluz; Felix K. F. Kommoss; Gottfried Konecny; Roy F. P. M. Kruitwagen; Jessica Kwon; Diether Lambrechts; Cheng-Han Lee; Jenny Lester; Samuel C. Y. Leung; Yee Leung; Anna Linder; Jolanta Lissowska; Liselore Loverix; Jan Lubiński; Constantina Mateoiu; Iain A. McNeish; Malak Moubarak; Gregg S. Nelson; Nikilyn Nevins; Alexander B. Olawaiye; Siel Olbrecht; Sandra Orsulic; Ana Osorio; Carmel M. Quinn; Ganendra Raj Mohan; Isabelle Ray-Coquard; Cristina Rodríguez-Antona; Patricia Roxburgh; Matthias Ruebner; Stuart G. Salfinger; Spinder Samra; Minouk J. Schoemaker; Hans-Peter Sinn; Gabe S. Sonke; Linda Steele; Colin J. R. Stewart; Aline Talhouk; Adeline Tan; Christopher M. Tarney; Sarah E. Taylor; Koen K. Van de Vijver; Maaike A. van der Aa; Toon Van Gorp; Els Van Nieuwenhuysen; Lilian Van-Wagensveld; Andrea E. Wahner-Hendrickson; Christina Walter; Chen Wang; Julia Welz; Nicolas Wentzensen; Lynne R. Wilkens; Stacey J. Winham; Boris Winterhoff; Michael S. Anglesio; Andrew Berchuck; Francisco J. Candido dos Reis; Paul A. Cohen; Thomas P. Conrads; Philip Crowe; Jennifer A. Doherty; Peter A. Fasching; Renée T. Fortner; María J. García; Simon A. Gayther; Marc T. Goodman; Jacek Gronwald; Holly R. Harris; Florian Heitz; Hugo M. Horlings; Beth Y. Karlan; Linda E. Kelemen; G. Larry Maxwell; Usha Menon; Francesmary Modugno; Susan L. Neuhausen; Joellen M. Schildkraut; Annette Staebler; Karin Sundfeldt; Anthony J. Swerdlow; Ignace Vergote; Anna H. Wu; James D. Brenton; Paul D. P. Pharoah; Celeste Leigh Pearce; Malcolm C. Pike; Ellen L. Goode; Susan J. Ramus; Martin Köbel; Brad H. Nelson; Anna DeFazio; Michael L. Friedlander; David D. L. Bowtell; Dale W. Garsed

Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome

肺癌和卵巢癌对铂类化疗的治疗耐药性是由可靶向的tgf β 衰老分泌蛋白驱动的

Nature Aging

IF19.4

2026-02-030

OAAI

Estela González-Gualda; Marika A. V. Reinius; David Macias; Samir Morsli; Jianfeng Ge; Ioana Olan; José Ezequiel Martín; Hui-Ling Ou; Muhamad Hartono; María Pilar Puerto-Camacho; Mary Denholm; Rosalind Kieran; Reuben Hoffmann; Mark Dane; Dimitris Veroutis; Guillermo Medrano; Francisca Mulero; Mercedes Jimenez-Linan; Ljiljana Fruk; Carla P. Martins; Mariano Barbacid; Vassilis Gorgoulis; James E. Korkola; Doris M. Rassl; Gary J. Doherty; Robert C. Rintoul; Masashi Narita; James D. Brenton; Daniel Muñoz-Espín

Somatic evolution following cancer treatment in normal tissue

正常组织中癌症治疗后的体细胞进化

Nature

IF48.5

2025-12-100

Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer

398,238名女性的全基因组关联研究揭示了七个与高级别浆液性卵巢癌相关的位点

npj Genomic Medicine

IF4.8

2025-11-200

OAAI

Daniel R. Barnes; Jonathan P. Tyrer; Joe Dennis; Goska Leslie; Manjeet K. Bolla; Michael Lush; Amber M. Aeilts; Kristiina Aittomäki; Nadine Andrieu; Irene L. Andrulis; Hoda Anton-Culver; Adalgeir Arason; Banu K. Arun; Judith Balmaña; Elisa V. Bandera; Rosa B. Barkardottir; Lieke P. V. Berger; Amy Berrington de Gonzalez; Pascaline Berthet; Katarzyna Białkowska; Line Bjørge; Amie M. Blanco; Marinus J. Blok; Kristie A. Bobolis; Natalia V. Bogdanova; James D. Brenton; Henriett Butz; Saundra S. Buys; Maria A. Caligo; Ian Campbell; Carmen Castillo; Kathleen B. M. Claes; Sarah V. Colonna; Linda S. Cook; Mary B. Daly; Agnieszka Dansonka-Mieszkowska; Miguel de la Hoya; Anna deFazio; Allison DePersia; Yuan Chun Ding; Jennifer A. Doherty; Susan M. Domchek; Thilo Dörk; Zakaria Einbeigi; Christoph Engel; D. Gareth Evans; Lenka Foretova; Renée T. Fortner; Florentia Fostira; Maria Cristina Foti; Eitan Friedman; Megan N. Frone; Patricia A. Ganz; Aleksandra Gentry-Maharaj; Gord Glendon; Andrew K. Godwin; Anna González-Neira; Mark H. Greene; Jacek Gronwald; Aliana Guerrieri-Gonzaga; Ute Hamann; Thomas V. O. Hansen; Holly R. Harris; Jan Hauke; Florian Heitz; Frans B. L. Hogervorst; Maartje J. Hooning; John L. Hopper; Chad D. Huff; David G. Huntsman; Evgeny N. Imyanitov; Louise Izatt; Anna Jakubowska; Paul A. James; Ramunas Janavicius; Esther M. John; Siddhartha Kar; Beth Y. Karlan; Catherine J. Kennedy; Lambertus A.L.M. Kiemeney; Irene Konstantopoulou; Jolanta Kupryjanczyk; Yael Laitman; Ofer Lavie; Kate Lawrenson; Jenny Lester; Fabienne Lesueur; Carlos Lopez-Pleguezuelos; Phuong L. Mai; Siranoush Manoukian; Taymaa May; Iain A. McNeish; Usha Menon; Roger L. Milne; Francesmary Modugno; Jennifer M. Mongiovi; Marco Montagna; Kirsten B. Moysich; Susan L. Neuhausen; Finn C. Nielsen; Catherine Noguès; Edit Oláh; Olufunmilayo I. Olopade; Ana Osorio; Laura Papi; Harsh Pathak; Celeste L. Pearce; Inge S. Pedersen; Ana Peixoto; Tanja Pejovic; Pei-Chen Peng; Beth N. Peshkin; Paolo Peterlongo; C. Bethan Powell; Darya Prokofyeva; Miquel Angel Pujana; Paolo Radice; Muhammad U. Rashid; Gad Rennert; George Richenberg; Dale P. Sandler; Naoko Sasamoto; Veronica W. Setiawan; Priyanka Sharma; Weiva Sieh; Christian F. Singer; Katie Snape; Anna P. Sokolenko; Penny Soucy; Melissa C. Southey; Dominique Stoppa-Lyonnet; Rebecca Sutphen; Christian Sutter; Yen Y. Tan; Manuel R. Teixeira; Kathryn L. Terry; Liv Cecilie V. Thomsen; Marc Tischkowitz; Amanda E. Toland; Toon Van Gorp; Ana Vega; Digna R. Velez Edwards; Penelope M. Webb; Jeffrey N. Weitzel; Nicolas Wentzensen; Alice S. Whittemore; Stacey J. Winham; Anna H. Wu; Siddhartha Yadav; Yao Yu; Argyrios Ziogas; Andrew Berchuck; Fergus J. Couch; Ellen L. Goode; Marc T. Goodman; Alvaro N. Monteiro; Kenneth Offit; Susan J. Ramus; Harvey A. Risch; Joellen M. Schildkraut; Mads Thomassen; Jacques Simard; Douglas F. Easton; Michelle R. Jones; Georgia Chenevix-Trench; Simon A. Gayther; Antonis C. Antoniou; Paul D. P. Pharoah

Clinical validation of a DNA methylation biomarker associated with overall survival of relapsed ovarian cancer patients

复发性卵巢癌患者总生存期相关的DNA甲基化生物标志物的临床验证

INTERNATIONAL JOURNAL OF CANCER

IF4.7

2025-11-010

PRE

Transcript Identification Using Arrayed Hydrogels With TrapFISH (Adv. Mater. Technol. 18/2025)

阵列水凝胶结合TrapFISH的转录本识别 (Adv. Mater. Technol. 18/2025)

Advanced Materials Technologies

IF6.2

2025-09-170

PREAI

Multi-task deep learning for automatic image segmentation and treatment response assessment in metastatic ovarian cancer

多任务深度学习在自动图像分割和转移性卵巢癌治疗反应评估中的应用

INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY

IF2.3

2025-09-010

OAAI

Coordinated protein modules define DNA damage responses to carboplatin at single-cell resolution in human ovarian carcinoma models

协调的蛋白质模块在人类卵巢癌模型中定义了卡铂诱导的DNA损伤反应的单细胞分辨率。

Cell Reports Medicine

IF10.6

2025-08-220

OAAI

Predicting resistance to chemotherapy using chromosomal instability signatures

使用染色体不稳定性特征预测对化疗的抗性

Nature Genetics

IF0

2025-06-230

OAAI

Joe Sneath Thompson; Laura Madrid; Barbara Hernando; Carolin M. Sauer; Maria Vias; Maria Escobar-Rey; Wing-Kit Leung; Diego Garcia-Lopez; Jamie Huckstep; Magdalena Sekowska; Karen Hosking; Mercedes Jimenez-Linan; Marika A. V. Reinius; Abhipsa Roy; Omar Abdulle; Justina Pangonyte; Harry Dobson; Amy E. Cullen; Dilrini De Silva; David Gómez-Sánchez; Marina Torres; Ángel Fernández-Sanromán; Deborah Sanders; Filipe Correia Martins; Ionut-Gabriel Funingana; Giovanni Codacci-Pisanelli; Miguel Quintela-Fandino; Florian Markowetz; Jason Yip; James D. Brenton; Anna M. Piskorz; Geoff Macintyre

Transcript Identification Using Arrayed Hydrogels With TrapFISH

使用阵列水凝胶和TrapFISH进行转录本识别

Advanced Materials Technologies

IF6.2

2025-06-050

OAAI

Assessment of early response to neoadjuvant chemotherapy in multi-site high-grade serous ovarian cancer using hyperpolarized-13C MRI

多灶性高级别浆液性卵巢癌对新辅助化疗早期反应的评估：采用高极化-13C MRI技术

EJNMMI RESEARCH

IF3

2025-04-170

Beer, Lucian; Bura, Vlad; Ursprung, Stephan; Woitek, Ramona; Mclean, Mary A.; Ang, Joo Ern; Jimenez-Linan, Mercedes; Gill, Andrew B.; Kaggie, Joshua; Locke, Matthew; Frary, Amy; Field-Rayner, Johanna; Patterson, Ilse; Reinius, Marika; Graves, Martin J.; Deen, Surrin; Funingana, Gabriel; Rundo, Leonardo; Priest, Andrew; Aloj, Luigi; Manavaki, Roido; Mendichovszky, Iosif A.; Robb, Fraser; Schulte, Rolf F.; Couturier, Dominique-Laurent; D'Santos, Clive S.; Franklin, Valar; Kishore, Kamal; Allajbeu, Iris; Sauer, Carolin; Gallagher, Ferdia A.; Brindle, Kevin M.; Brenton, James D.; Sala, Evis

Exome sequencing identifies HELB as a novel susceptibility gene for non-mucinous, non-high-grade-serous epithelial ovarian cancer

EUROPEAN JOURNAL OF HUMAN GENETICS

IF4.6

2025-02-120

OAAI

Dicks, Ed M.; Tyrer, Jonthan P.; Ezquina, Suzana; Jones, Michelle; Baierl, John; Peng, Pei-Chen; Diaz, Michael; Goode, Ellen; Winham, Stacey J.; Doerk, Thilo; Gorp, Toon Van; Fazio, Anna; Bowtell, David D. L.; Garsed, Dale W.; Odunsi, Kunle; Moysich, Kirsten; Pavanello, Marina; Fostira, Florentia; Webb, Penelope M.; Soukupova, Jana; Cohen, Paul A.; Sieh, Weiva; Fortner, Renee Turzanski; Ricker, Charite; Karlan, Beth; Campbell, Ian; Brenton, James D.; Ramus, Susan J.; Gayther, Simon A.; Pharoah, Paul D. P.

Metabolic imaging distinguishes ovarian cancer subtypes and detects their early and variable responses to treatment

ONCOGENE

IF7.3

2024-12-060

OAAI

Novel immunotherapeutics against LGR5 to target multiple cancer types (vol 16, pg 2233, 2024)

EMBO MOLECULAR MEDICINE

IF8.3

2024-09-251

OAAI

Chen, Hung-Chang; Mueller, Nico; Stott, Katherine; Kapeni, Chrysa; Rivers, Eilidh; Sauer, Carolin M.; Beke, Flavio; Walsh, Stephen J.; Ashman, Nicola; O'Brien, Louise; Fard, Amir Rafati; Ghodsinia, Arman; Li, Changtai; Joud, Fadwa; Giger, Olivier; Zlobec, Inti; Olan, Ioana; Aitken, Sarah J.; Hoare, Matthew; Mair, Richard; Serrao, Eva; Brenton, James D.; Garcia-Gimenez, Alicia; Richardson, Simon E.; Huntly, Brian; Spring, David R.; Skjoedt, Mikkel-Ole; Skjodt, Karsten; de la Roche, Marc; de la Roche, Maike

Rare germline genetic variation in PAX8 transcription factor binding sites and susceptibility to epithelial ovarian cancer

PAX8转录因子结合位点罕见种系遗传变异与上皮性卵巢癌易感性

AMERICAN JOURNAL OF EPIDEMIOLOGY

IF4.8

2024-08-270

OAAI

PTEN Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma

CANCER RESEARCH

IF16.6

2024-08-260

OAAI

Novel immunotherapeutics against LGR5 to target multiple cancer types

EMBO MOLECULAR MEDICINE

IF8.3

2024-08-211

PRE

Chen, Hung-Chang; Mueller, Nico; Stott, Katherine; Kapeni, Chrysa; Rivers, Eilidh; Sauer, Carolin M.; Beke, Flavio; Walsh, Stephen J.; Ashman, Nicola; O'Brien, Louise; Rafati Fard, Amir; Godsinia, Arman; Li, Changtai; Joud, Fadwa; Giger, Olivier; Zlobec, Inti; Olan, Ioana; Aitken, Sarah J.; Hoare, Matthew; Mair, Richard; Serrao, Eva; Brenton, James D.; Garcia-Gimenez, Alicia; Richardson, Simon E.; Huntly, Brian; Spring, David R.; Skjoedt, Mikkel-Ole; Skjodt, Karsten; de la Roche, Marc; de la Roche, Maike

Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions

整合多组学分析以确定卵巢癌风险区域的遗传和功能机制

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2024-06-016

PRE

Dareng, Eileen O.; Coetzee, Simon G.; Tyrer, Jonathan P.; Peng, Pei-Chen; Rosenow, Will; Chen, Stephanie; Davis, Brian D.; Dezem, Felipe Segato; Seo, Ji-Heui; Nameki, Robbin; Reyes, Alberto L.; Aben, Katja K. H.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Aravantinos, Gerasimos; Bandera, Elisa V.; Freeman, Laura E. Beane; Beckmann, Matthias W.; Beeghly-Fadiel, Alicia; Benitez, Javier; Bernardini, Marcus Q.; Bjorge, Line; Black, Amanda; Bogdanova, Natalia V.; Bolton, Kelly L.; Brenton, James D.; Budzilowska, Agnieszka; Butzow, Ralf; Cai, Hui; Campbell, Ian; Cannioto, Rikki; Chang-Claude, Jenny; Chanock, Stephen J.; Chen, Kexin; Chenevix-Trench, Georgia; Chiew, Yoke-Eng; Cook, Linda S.; DeFazio, Anna; Dennis, Joe; Doherty, Jennifer A.; Doerk, Thilo; du Bois, Andreas; Duerst, Matthias; Eccles, Diana M.; Ene, Gabrielle; Fasching, Peter A.; Flanagan, James M.; Fortner, Renee T.; Fostira, Florentia; Gentry-Maharaj, Aleksandra; Giles, Graham G.; Goodman, Marc T.; Gronwald, Jacek; Haiman, Christopher A.; Hakansson, Niclas; Heitz, Florian; Hildebrandt, Michelle A. T.; Hogdall, Estrid; Hogdall, Claus K.; Huang, Ruea-Yea; Jensen, Allan; Jones, Michael E.; Kang, Daehee; Karlan, Beth Y.; Karnezis, Anthony N.; Kelemen, Linda E.; Kennedy, Catherine J.; Khusnutdinova, Elza K.; Kiemeney, Lambertus A.; Kjaer, Susanne K.; Kupryjanczyk, Jolanta; Labrie, Marilyne; Lambrechts, Diether; Larson, Melissa C.; Le, Nhu D.; Lester, Jenny; Li, Lian; Lubinski, Jan; Lush, Michael; Marks, Jeffrey R.; Matsuo, Keitaro; May, Taymaa; McLaughlin, John R.; McNeish, Iain A.; Menon, Usha; Missmer, Stacey; Modugno, Francesmary; Moffitt, Melissa; Monteiro, Alvaro N.; Moysich, Kirsten B.; Narod, Steven A.; Nguyen-Dumont, Tu; Odunsi, Kunle; Olsson, Hakan; Onland-Moret, N. Charlotte; Park, Sue K.; Pejovic, Tanja; Permuth, Jennifer B.; Piskorz, Anna; Prokofyeva, Darya; Riggan, Marjorie J.; Risch, Harvey A.; Rodriguez-Antona, Cristina; Rossing, Mary Anne; Sandler, Dale P.; Setiawan, V. Wendy; Shan, Kang; Song, Honglin; Southey, Melissa C.; Steed, Helen; Sutphen, Rebecca; Swerdlow, Anthony J.; Teo, Soo Hwang; Terry, Kathryn L.; Thompson, Pamela J.; Thomsen, Liv Cecilie Vestrheim; Titus, Linda; Trabert, Britton; Travis, Ruth; Tworoger, Shelley S.; Valen, Ellen; Van Nieuwenhuysen, Els; Edwards, Digna Velez; Vierkant, Robert A.; Webb, Penelope M.; Weinberg, Clarice R.; Weise, Rayna Matsuno; Wentzensen, Nicolas; White, Emily; Winham, Stacey J.; Wolk, Alicja; Woo, Yin-Ling; Wu, Anna H.; Yan, Li; Yannoukakos, Drakoulis; Zeinomar, Nur; Zheng, Wei; Ziogas, Argyrios; Berchuck, Andrew; Goode, Ellen L.; Huntsman, David G.; Pearce, Celeste L.; Ramus, Susan J.; Sellers, Thomas A.; Freedman, Matthew L.; Lawrenson, Kate; Schildkraut, Joellen M.; Hazelett, Dennis; Plummer, Jasmine T.; Kar, Siddhartha; Jones, Michelle R.; Pharoah, Paul D. P.; Gayther, Simon A.

James D. Brenton

个人简介

教育背景

工作经历

荣誉奖项

研究方向