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Cancer-associated fibroblasts regulate DNA repair in pancreatic cancer through NDRG1-mediated R-loop processing 癌症相关成纤维细胞通过NDRG1介导的R环处理调控胰腺癌的DNA修复 Kozlova, Nina; Cruz, Kayla A.; Ruzette, Antoine A.; Doh, Hanna M.; Willis, Nicholas A.; Hong, Su Min; Gonzalez, Raul S.; Vyas, Monika; Selfors, Laura M.; Dreyer, Stephan; Upstill-Goddard, Rosie; Faia, Kerrie L.; Wenglowsky, Steve; Close, Josh; Beutel, Alica; Jutric, Zeljka; Oliphant, Michael U. J.; Poluben, Larysa; Thapa, Byanjana; Taylor, Martin S.; Mustonen, Venla; Mangalath, Pradeep; Halbrook, Christopher J.; Grossman, Joseph E.; Hwang, Rosa F.; Clohessy, John G.; Ruskamo, Salla; Kursula, Petri; Petrova, Boryana; Kanarek, Naama; Cole, Philip A.; Chang, David K.; Evans, Conor L.; Norrelykke, Simon F.; Scully, Ralph; Muranen, Taru 分享 收藏
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Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways Jorunnamycin A通过调节KRAS介导的存活途径诱导胰腺导管腺癌细胞，球体和患者来源的类器官凋亡 Khine, Hnin Ei Ei; Suriya, Utid; Rungrotmongkol, Thanyada; Chamni, Supakarn; Lu, Yanxi; Benard, Alan; Lan, Bin; Mukhopadhyay, Debabrata; Chang, David; Biankin, Andrew; Schneider-Stock, Regine; Gruetzmann, Robert; Sungthong, Rungroch; Pilarsky, Christian; Chaotham, Chatchai 分享 收藏
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nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer Hendley, Audrey M.; Ashe, Sudipta; Urano, Atsushi; Ng, Martin; Phu, Tuan A.; Peng, Xianlu Laura; Luan, Changfei; Finger, Anna-Marie; Jang, Gun Ho; Kerper, Natanya R.; Berrios, David I.; Jin, David; Lee, Jonghyun; Riahi, Irene R.; Gbenedio, Oghenekevwe M.; Chung, Christina; Roose, Jeroen P.; Yeh, Jen Jen; Gallinger, Steven; Biankin, Andrew V.; O'Kane, Grainne M.; Ntranos, Vasilis; Chang, David K.; Dawson, David W.; Kim, Grace E.; Weaver, Valerie M.; Raffai, Robert L.; Hebrok, Matthias 分享 收藏
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Identification of therapeutic vulnerabilities in the subset of pancreatic ductal adenocarcinoma (PDAC) with homologous recombination deficiency Tesson, Mathias; Kong, Kay; Repsicak, Peter; Bader, Aldo; Hsieh, Ya-Ching; Nourse, Craig; Kirschner, Kristina; Miller, Crispin; Roberts, Ed; Chang, David; Morton, Jen 分享 收藏
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Integrating metabolic profiling of pancreatic juice with transcriptomic analysis of pancreatic cancer tissue identifies distinct clinical subgroups Pulvirenti, Alessandra; Barbagallo, Marialuisa; Putignano, Anna Rita; Pea, Antonio; Polidori, Rebecca; Upstill-Goddard, Rosie; Cortese, Nina; Kunderfranco, Paolo; Brunelli, Laura; De Simone, Giulia; Pastorelli, Roberta; Spaggiari, Paola; Nappo, Gennaro; Jamieson, Nigel B.; Zerbi, Alessandro; Chang, David K.; Capretti, Giovanni; Marchesi, Federica 分享 收藏
Disruption of the pro-oncogenic c-RAF-PDE8A complex represents a differentiated approach to treating KRAS-c-RAF dependent PDAC Cooke, Sean F.; Wright, Thomas A.; Sin, Yuan Yan; Ling, Jiayue; Kyurkchieva, Elka; Phanthaphol, Nattaporn; Mcskimming, Thomas; Herbert, Katharine; Rebus, Selma; Biankin, Andrew V.; Chang, David K.; Baillie, George S.; Blair, Connor M. 分享 收藏
JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors Pennel, Kathryn A. F.; Hatthakarnkul, Phimmada; Wood, Colin S.; Lian, Guang-Yu; Al-Badran, Sara S. F.; Quinn, Jean A.; Legrini, Assya; Inthagard, Jitwadee; Alexander, Peter G.; van Wyk, Hester; Kurniawan, Ahmad; Hashmi, Umar; Gillespie, Michael A.; Mills, Megan; Ammar, Aula; Hay, Jennifer; Andersen, Ditte; Nixon, Colin; Rebus, Selma; Chang, David K.; Kelly, Caroline; Harkin, Andrea; Graham, Janet; Church, David; Tomlinson, Ian; Saunders, Mark; Iveson, Tim; Lannagan, Tamsin R. M.; Jackstadt, Rene; Maka, Noori; Horgan, Paul G.; Roxburgh, Campbell S. D.; Sansom, Owen J.; McMillan, Donald C.; Steele, Colin W.; Jamieson, Nigel B.; Park, James H.; Roseweir, Antonia K.; Edwards, Joanne 分享 收藏
nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma Hendley, Audrey M.; Urano, Atsushi; Peng, Xianlu L.; Ashe, Sudipta; Phu, Tuan A.; Ng, Martin; Kerper, Natanya R.; Berrios, David I.; Lee, Jonghyun; Jin, David; Jang, Gun H.; Gbenedio, Oghenekevwe M.; Roose, Jeroen P.; Yeh, Jen J.; Gallinger, Steven; Biankin, Andrew V.; Ntranos, Vasilis; Chang, David K.; Dawson, David W.; Kim, Grace E.; Weaver, Valerie M.; Raffai, Robert L.; Hebrok, Matthias 分享 收藏
Therapeutic development platform for pancreatic cancer in the UK national health service: Lessons learned and initial results from Precision-Panc Froeling, Fieke E. M.; Valle, Juan; Upstill-Goddard, Rosie; Grimwood, Paul; Westwood, Paul; Dreyer, Stephan B.; Kelly, Caroline; Duthie, Fraser; Dixon, Judith; Bradley, Sarah; Evans, T. R. Jeffry; Sansom, Owen J.; Biankin, Andrew V.; Chang, David K. 分享 收藏
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The Changing Indication and Outcomes of Patients Undergoing Pancreatectomy for Malignancy Jackson, S.; Dreyer, S.; Bryce, A.; Thomas, R.; Duthie, F.; Coats, M.; Carter, R.; Mckay, C.; Dickson, E.; Chang, D.; Holroyd, D.; Jamieson, N. 分享 收藏
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The relationship between heart rate variability and TNM stage, co-morbidity, systemic inflammation and survival in patients with primary operable colorectal cancer McGovern, Josh; Leadbitter, Stephen; Miller, Gillian; Hounat, Adam; Kamande, Irvine; Dolan, Ross D. D.; Horgan, Paul G. G.; Chang, David K. K.; Jamieson, Nigel B. B.; McMillan, Donald C. C. 分享 收藏
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