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Results from monotherapy dose escalation of MDNA11, a long-acting IL-2 superkine, in a phase 1/2 trial show evidence of single-agent activity in advanced solid tumors Atkinson, Victoria G.; Antras, Jesus F.; Bedard, Philippe; Brenner, Warren; Brown, Jacqueline; Lemech, Charlotte R.; Lloyd, Peter; Margolin, Kim; Mathew, Matthen; Park, John J.; Thomas, Sajeve; Twardowski, Przemyslaw; Gardner, Humphrey; Prawira, Amy; Coello, Melissa; Ebrahimimizadeh, Walead; To, Minh D.; Merchant, Rosemina; Karanam, Sudhir Madduri; Yavari, Arash; Siu, Lillian L.; Tawbi, Hussein A.; Ascierto, Paolo A. 分享 收藏
Biopsy analysis of trial S1616: Ipilimumab plus nivolumab versus ipilimumab alone in patients with anti-PD-1 refractory melanoma Campbell, Katie M.; Bustami, Zaid; Chen, Daniel G.; Medina, Egmidio; Gonzalez, Cynthia R.; Aldeen, Nataly Naser; Baselga-Carretero, Ignacio; Vega-Crespo, Agustin; Maxey, Jessica; Chen, Jia M.; Kuklinski, Lawrence F.; Kendra, Kari L.; Chmielowski, Bartosz; Thach-Giao Truong; Khushalani, Nikhil I.; Collichio, Frances; Ikeguchi, Alexandra; Victor, Adrienne I.; Margolin, Kim; Sosman, Jeffrey A.; Patel, Sapna P.; Hu-Lieskovan, Siwen; Moon, James; Bellasea, Shay; Wells, Daniel K.; Spencer, Christine N.; Thompson, Marshall A.; Wu, Michael; Scumpia, Philip O.; VanderWalde, Ari; Ribas, Antoni 分享 收藏
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Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases In, Gino K.; Ribeiro, Jennifer R.; Yin, Jun; Xiu, Joanne; Bustos, Matias A.; Ito, Fumito; Chow, Frances; Zada, Gabriel; Hwang, Lindsay; Salama, April K. S.; Park, Soo J.; Moser, Justin C.; Darabi, Sourat; Domingo-Musibay, Evidio; Ascierto, Maria L.; Margolin, Kim; Lutzky, Jose; Gibney, Geoffrey T.; Atkins, Michael B.; Izar, Benjamin; Hoon, Dave S. B.; Vanderwalde, Ari M. 分享 收藏
Comparison of intracranial (IC) response assessment criteria in patients (pts) with melanoma brain metastases (MBM) treated with combination nivolumab (NIVO) plus ipilimumab (IPI) in CheckMate 204 Huang, R.; Youssef, G.; Nelson, T.; Wen, P.; Forsyth, P.; Hodi, F. S.; Margolin, K. A.; Algazi, A. P.; Hamid, O.; Lao, C. D.; Ernstoff, M. S.; Moschos, S. J.; Atkins, M. B.; Postow, M.; Reardon, D. A.; Grootendorst, D. J.; Askelson, M.; Ritchings, C.; Tawbi, H. A. 分享 收藏
Ipilimumab with or without nivolumab in PD-1 or PD-L1 blockade refractory metastatic melanoma: a randomized phase 2 trial VanderWalde, Ari; Bellasea, Shay L.; Kendra, Kari L.; Khushalani, Nikhil I.; Campbell, Katie M.; Scumpia, Philip O.; Kuklinski, Lawrence F.; Collichio, Frances; Sosman, Jeffrey A.; Ikeguchi, Alexandra; Victor, Adrienne I.; Truong, Thach-Giao; Chmielowski, Bartosz; Portnoy, David C.; Chen, Yuanbin; Margolin, Kim; Bane, Charles; Dasanu, Constantin A.; Johnson, Douglas B.; Eroglu, Zeynep; Chandra, Sunandana; Medina, Egmidio; Gonzalez, Cynthia R.; Baselga-Carretero, Ignacio; Vega-Crespo, Agustin; Garcilazo, Ivan Perez; Sharon, Elad; Hu-Lieskovan, Siwen; Patel, Sapna P.; Grossmann, Kenneth F.; Moon, James; Wu, Michael C.; Ribas, Antoni 分享 收藏
Results from an expanded phase 1 trial of botensilimab (BOT), a multifunctional anti-CTLA-4, plus balstilimab (BAL; anti-PD-1) for metastatic heavily pretreated microsatellite stable colorectal cancer (MSS CRC) Bullock, A.; Fakih, M.; Gordon, M.; Tsimberidou, A.; El-Khoueiry, A.; Wilky, B.; Pimentel, A.; Margolin, K.; Mahadevan, D.; Balmanoukian, A.; Sanborn, R.; Schwartz, G.; Abou-Alfa, G.; Bockorny, B.; Moser, J.; Sharma, S.; Grossman, J.; Rosenthal, K.; O'Day, S.; Lenz, H.; Schlechter, B. 分享 收藏
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Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma 新辅助-辅助或仅辅助的Pembrolizumab治疗晚期黑色素瘤 Patel, Sapna P.; Othus, Megan; Chen, Yuanbin; Wright, G. Paul; Yost, Kathleen J.; Hyngstrom, John R.; Hu-Lieskovan, Siwen; Lao, Christopher D.; Fecher, Leslie A.; Truong, Thach-Giao; Eisenstein, Jennifer L.; Chandra, Sunandana; Sosman, Jeffrey A.; Kendra, Kari L.; Wu, Richard C.; Devoe, Craig E.; Deutsch, Gary B.; Hegde, Aparna; Khalil, Maya; Mangla, Ankit; Reese, Amy M.; Ross, Merrick I.; Poklepovic, Andrew S.; Phan, Giao Q.; Onitilo, Adedayo A.; Yasar, Demet G.; Powers, Benjamin C.; Doolittle, Gary C.; In, Gino K.; Kokot, Niels; Gibney, Geoffrey T.; Atkins, Michael B.; Shaheen, Montaser; Warneke, James A.; Ikeguchi, Alexandra; Najera, Jose E.; Chmielowski, Bartosz; Crompton, Joseph G.; Floyd, Justin D.; Hsueh, Eddy; Margolin, Kim A.; Chow, Warren A.; Grossmann, Kenneth F.; Dietrich, Eliana; Prieto, Victor G.; Lowe, Michael C.; Buchbinder, Elizabeth I.; Kirkwood, John M.; Korde, Larissa; Moon, James; Sharon, Elad; Sondak, Vernon K.; Ribas, Antoni 分享 收藏
Intratumoral oncolytic virus V937 plus ipilimumab in patients with advanced melanoma: the phase 1b MITCI study 肿瘤内溶瘤病毒V937联合ipilimumab治疗晚期黑色素瘤: MITCI 1b期研究 Curti, Brendan D.; Richards, Jon; Hyngstrom, John R.; Daniels, Gregory A.; Faries, Mark; Feun, Lynn; Margolin, Kim A.; Hallmeyer, Sigrun; Grose, Mark; Zhang, Yiwei; Li, Anlong; Andtbacka, Robert H., I 分享 收藏
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Vidutolimod plus pembrolizumab as 2L+treatment in patients with antiePD-1erefractory melanoma and adrenal insufficiency: Subgroup analyses of a phase Ib study Kirkwood, J. M.; Zakharia, Y.; Davar, D.; Buchbinder, E.; Medina, T.; Daud, A.; Ribas, A.; Chmielowski, B.; Niu, J. J.; Gibney, G. T.; Margolin, K. A.; Olszanski, A. J.; Mehmi, I.; Sato, T.; Shaheen, M.; Zhao, L.; Bobilev, D.; Krieg, A. M.; Wooldridge, J.; Milhem, M. 分享 收藏
Botensilimab, a novel innate/adaptive immune activator, plus balstilimab (anti-PD-1) for metastatic heavily pretreated microsatellite stable colorectal cancer Bullock, A.; Grossman, J.; Fakih, M.; Lenz, H.; Gordon, M.; Margolin, K.; Wilky, B.; Mahadevan, D.; Trent, J.; Bockorny, B.; Moser, J.; Balmanoukian, A.; Schlechter, B.; Feliu, W. Ortuzar; Rosenthal, K.; Bullock, B.; Stebbing, J.; Godwin, J.; O'Day, S.; Tsimberidou, A.; El-Khoueiry, A. 分享 收藏
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Tumor-infiltrating exhausted CD8+ T cells dictate reduced survival in premenopausal estrogen receptor-positive breast cancer Egelston, Colt A.; Guo, Weihua; Tan, Jiayi; Avalos, Christian; Simons, Diana L.; Lim, Min Hui; Huang, Yinghui J.; Nelson, Michael S.; Chowdhury, Arnab; Schmolze, Daniel B.; Yim, John H.; Kruper, Laura; Melstrom, Laleh; Margolin, Kim; Mortimer, Joanne E.; Yuan, Yuan; Waisman, James R.; Lee, Peter P. 分享 收藏
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Cardiovascular adverse events are associated with usage of immune checkpoint inhibitors in real-world clinical data across the United States (vol 6, 100252, 2021) Jain, P.; Bugarin, J. Gutierrez; Guha, A.; Jain, C.; Patil, N.; Shen, T.; Stanevich, I.; Nikore, V.; Margolin, K.; Ernstoff, M.; Velcheti, V.; Barnholtz-Sloan, J.; Dowlati, A. 分享 收藏
Cardiovascular adverse events are associated with usage of immune checkpoint inhibitors in real-world clinical data across the United States Jain, P.; Bugarin, J. Gutierrez; Guha, A.; Jain, C.; Patil, N.; Shen, T.; Stanevich, I.; Nikore, V.; Margolin, K.; Ernstoff, M.; Velcheti, V.; Barnholtz-Sloan, J.; Dowlati, A. 分享 收藏
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