Paul J. Brindley - Publications, H-index & Citations

Paul J. Brindley

George Washington University

70H指数

543论文数

2.1W被引数

收录论文 167

发表时间

Toward transgenic multicellular parasites: CRISPR-Cas12a germline editing of Schistosoma mansoni eggs as key to success 构建转基因多细胞寄生虫：利用CRISPR-Cas12a对埃及血吸虫卵进行生殖系编辑是实现成功的关键

Science Advances

IF12.5

2026-09-30

OAAI

Max F. Moescheid; Prapakorn Wisitpongpun; Vanessa Gross; Victoria H. Mann; Thomas Quack; Anne Rognon; Christoph Grunau; Wannaporn Ittiprasert; Paul J. Brindley; Christoph G. Grevelding

Heritable transgenic schistosomes as a living platform for SARS-CoV-2 neutralizing antibody secretion 可遗传转基因血吸虫作为SARS-CoV-2中和抗体分泌的活体平台

Nature Communications

IF15.7

2026-08-26

OAAI

Wannaporn Ittiprasert; Michael J. Smout; Victoria H. Mann; Matthew Moyle; Sean M. Kinahan; Daniel N. Ackerman; Danielle N. Rivera; Joshua L. Santarpia; Eric C. Carnes; Margaret M. Mentink-Kane; Marina Reis Costa; Cornelis H. Hokke; Meta Roestenberg; Maria Elena Bottazzi; Bethany K. Bracken; Bruce A. Rosa; Sergej Djuranovic; Darren A. Pickering; Paul R. Giacomin; Daniel Watterson; Naphak Modhiran; Max F. Moescheid; Christoph G. Grevelding; Makedonka Mitreva; Alex Loukas; Paul J. Brindley

Transgenic hookworm secretes anti-tetrodotoxin human single chain antibody 转基因钩虫分泌抗河豚毒素人单链抗体

Nature Communications

IF15.7

2026-06-03

OAAI

Kumar Sachin Singh; Suman Bharti; Bruce A. Rosa; Mahdiyeh Bigham; Samuel C. Uzoechi; Young-Jun Choi; John C. Martin; Danielle Kemper; Slavica Pavlovic Djuranovic; Darren A. Pickering; Rachael Ryan; Bethany K. Bracken; Maria Elena Bottazzi; Eric C. Carnes; Wannaporn Ittiprasert; Matthew Moyle; Paul J. Brindley; Alex Loukas; Sergej Djuranovic; Makedonka Mitreva

Tumor-suppressor pathways in Schistosoma mansoni support a novel hypothesis on neodermatan flatworm origins 曼氏血吸虫中的肿瘤抑制通路支持关于新皮层扁虫起源的新假说

Trends in Parasitology

IF6.6

2026-03-11

PREAI

Paul J. Brindley

Gene Editing of a Carcinogenic Liver Fluke Tetraspanin Impairs Parasite Surface Biogenesis and Extracellular Vesicle Uptake by Human Host Cells 致癌肝吸虫四跨膜蛋白的基因编辑破坏了寄生虫表面生物发生和人类宿主细胞对细胞外囊泡的摄取

JOURNAL OF INFECTIOUS DISEASES

IF4.5

2025-09-01

OAAI

Chaiyadet, Sujittra; Ittiprasert, Wannaporn; Smout, Michael J.; Khowawisetsut, Ladawan; Ruangsuwast, Apisit; Brindley, Paul J.; Loukas, Alex; Laha, Thewarach

CRISPR/Cas genome editing, functional genomics, and diagnostics for parasitic helminths CRISPR/Cas基因组编辑、功能基因组学以及寄生虫线虫的诊断技术

International Journal for Parasitology

IF3.2

2025-05-08

PREAI

Akito Koike; Paul J. Brindley

Anti-Fibrotic Effect of Oleamide Identified from the Moringa oleifera Lam. Leaves via Inhibition of TGF-β1-Induced SMAD2/3 Signaling Pathway 从Moringa oleifera Lam.叶片中鉴定出的oleamide的抗纤维化作用，通过抑制TGF-β1诱导的SMAD2/3信号通路。

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IF4.9

2025-04-04

OAAI

Khongpiroon, Chavisa; Buakaew, Watunyoo; Brindley, Paul J.; Potikanond, Saranyapin; Daowtak, Krai; Thongsri, Yordhathai; Potup, Pachuen; Usuwanthim, Kanchana

Gut Microbiome and Bile Acid Interactions Mechanistic Implications for Cholangiocarcinoma Development, Immune Resistance, and Therapy 肠道微生物组与胆汁酸相互作用的机制意义：胆管癌发展、免疫抵抗和治疗

AMERICAN JOURNAL OF PATHOLOGY

IF3.6

2025-03-01

PREAI

Wu, N; Bayatpour, S; Hylemon, PB; Aseem, SO; Brindley, PJ; Zhou, HP

Revisiting What Constitutes a Neglected Tropical Disease?

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2025-02-20

OAAI

Brindley, Paul J.; Hotez, Peter J.; Kamhawi, Shaden

Proteomic characterization and comparison of the infective and adult life stage secretomes from Necator americanus and Ancylostoma ceylanicum

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2025-01-20

OAAI

Wong, Yide; Rosa, Bruce A.; Becker, Luke; Camberis, Mali; Legros, Graham; Zhan, Bin; Bottazzi, Maria Elena; Fujiwara, Ricardo T.; Ritmejeryte, Edita; Laha, Thewarach; Chaiyadet, Sujittra; Taweethavonsawat, Piyanan; Brindley, Paul J.; Bracken, Bethany K.; Giacomin, Paul R.; Mitreva, Makedonka; Loukas, Alex

Mechanistic insights into liver-fluke-induced bile-duct cancer

Trends in Parasitology

IF6.6

2024-12-01

PREAI

Smout, Michael J.; Laha, Thewarach; Chaiyadet, Sujittra; Brindley, Paul J.; Loukas, Alex

CRISPR-based functional genomics for schistosomes and related flatworms

Trends in Parasitology

IF6.6

2024-11-01

PREAI

Ittiprasert, Wannaporn; Brindley, Paul J.

Targeted insertion and reporter transgene activity at a gene safe harbor of the human blood fluke, Schistosoma mansoni

CELL REPORTS METHODS

IF4.5

2023-07-01

OAAI

Ittiprasert, Wannaporn; Moescheid, Max F.; Chaparro, Cristian; Mann, Victoria H.; Quack, Thomas; Rodpai, Rutchanee; Miller, Andre; Wisitpongpun, Prapakorn; Buakaew, Watunyoo; Mentink-Kane, Margaret; Schmid, Sarah; Popratiloff, Anastas; Grevelding, Christoph G.; Grunau, Christoph; Brindley, Paul J.

Excretory/Secretory Proteome of Females and Males of the Hookworm Ancylostoma ceylanicum

PATHOGENS

IF3.3

2023-01-06

OAAI

Uzoechi, Samuel C.; Rosa, Bruce A.; Singh, Kumar Sachin; Choi, Young-Jun; Bracken, Bethany K.; Brindley, Paul J.; Townsend, R. Reid; Sprung, Robert; Zhan, Bin; Bottazzi, Maria-Elena; Hawdon, John M.; Wong, Yide; Loukas, Alex; Djuranovic, Sergej; Mitreva, Makedonka

Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility

JOURNAL OF EXTRACELLULAR VESICLES

IF14.5

2023-01-05

OAAI

White, Ruby; Sotillo, Javier; Ancarola, Maria Eugenia; Borup, Anne; Boysen, Anders Toftegaard; Brindley, Paul J.; Buzas, Edit, I; Cavallero, Serena; Chaiyadet, Sujittra; Chalmers, Iain W.; Cucher, Marcela A.; Dagenais, Maude; Davis, Chelsea N.; Devaney, Eileen; Duque-Correa, Maria A.; Eichenberger, Ramon Marc; Fontenla, Santiago; Gasan, Thomas A.; Hokke, Cornelis H.; Kosanovic, Maja; Kuipers, Marije E.; Laha, Thewarach; Loukas, Alex; Maizels, Rick M.; Marcilla, Antonio; Mazanec, Hynek; Morphew, Russell M.; Neophytou, Kyriaki; Nguyen, Linh Thuy; Nolte-'t Hoen, Esther; Povelones, Michael; Robinson, Mark W.; Rojas, Alicia; Schabussova, Irma; Smits, Hermelijn H.; Sungpradit, Sivapong; Tritten, Lucienne; Whitehead, Bradley; Zakeri, Amin; Nejsum, Peter; Buck, Amy H.; Hoffmann, Karl F.

Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini

PLOS PATHOGENS

IF4.9

2022-09-22

OAAI

Chaiyadet, Sujittra; Tangkawattana, Sirikachorn; Smout, Michael J.; Ittiprasert, Wannaporn; Mann, Victoria H.; Deenonpoe, Raksawan; Arunsan, Patpicha; Loukas, Alex; Brindley, Paul J.; Laha, Thewarach

Transgenesis in parasitic helminths: a brief history and prospects for the future

PARASITES & VECTORS

IF3.5

2022-03-28

OAAI

Quinzo, M. J.; Perteguer, M. J.; Brindley, P. J.; Loukas, A.; Sotillo, J.

Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation

PLOS PATHOGENS

IF4.9

2022-02-15

OAAI

Stroehlein, Andreas J.; Korhonen, Pasi K.; Lee, V. Vern; Ralph, Stuart A.; Mentink-Kane, Margaret; You, Hong; McManus, Donald P.; Tchuente, Louis-Albert Tchuem; Stothard, J. Russell; Kaur, Parwinder; Dudchenko, Olga; Aiden, Erez Lieberman; Yang, Bicheng; Yang, Huanming; Emery, Aidan M.; Webster, Bonnie L.; Brindley, Paul J.; Rollinson, David; Chang, Bill C. H.; Gasser, Robin B.; Young, Neil D.

MIxS-SA: a MIxS extension defining the minimum information standard for sequence data from symbiont-associated micro-organisms

ISME COMMUNICATIONS

IF6.1

2022-02-01

OAAI

Jorge, Fatima; Brealey, Jaelle C.; Brindley, Paul J.; Buysse, Marie; Cantacessi, Cinzia; Duron, Olivier; Fichorova, Raina; Fitzpatrick, Connor R.; Hahn, Megan; Hunter, Christopher; Herve, Vincent; Knoll, Laura J.; Kohl, Kevin D.; Lalle, Marco; Lukes, Julius; Martinez, Joaquin Martinez; Perkins, Susan L.; Poulin, Robert; Rosario, Karyna; Schneider, Adam C.; Schriml, Lynn M.; Thompson, Luke R.; Walls, Ramona L.; Dheilly, Nolwenn M.

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

PLOS PATHOGENS

IF4.9

2022-01-13

OAAI

Hulme, Benjamin J.; Geyer, Kathrin K.; Forde-Thomas, Josephine E.; Padalino, Gilda; Phillips, Dylan W.; Ittiprasert, Wannaporn; Karinshak, Shannon E.; Mann, Victoria H.; Chalmers, Iain W.; Brindley, Paul J.; Hokke, Cornelis H.; Hoffmann, Karl F.

研究方向