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Alejandra Bruna

University of Cambridge
H指数:41
被引数:8,982

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Real-time cell viability monitoring for high-throughput drug screening using tumor xenograft-derived cells

利用肿瘤异种移植来源细胞进行高通量药物筛选的实时细胞活力监测

Cell Reports Methods
IF4.5
2026-05-270
OAAI
Elham Esmaeilishirazifard; Daniel Guerrero-Romero; Allan J.W. Lui; Abigail Shea; Long V. Nguyen; Maurizio Callari; Riccardo Masina; Kevin Tu; Richard Baird; Paul Edwards; Wendy Greenwood; Steve Fuller; Claire Crafter; Mandy Lawson; Alejandra Bruna; Oscar M. Rueda; Carlos Caldas
Genetic interactions, synthetic lethality and complexity in cancer vulnerability mapping-Insights and perspectives from the 2nd EuroDepMap symposium

癌症易感性图谱中的遗传相互作用、合成致死性与复杂性——第二届EuroDepMap研讨会的见解与展望

FEBS Letters
IF3
2026-02-010
PRE
Proietti, Ludovica; Beltrao, Pedro; Bruna, Alejandra; Cortes-Ciriano, Isidro; Garnett, Mathew J.; Goncalves, Emanuel; Herranz-Ors, Carmen; Kaulich, Manuel; Lord, Christopher J.; Petsalaki, Evangelia; Rad, Roland; Ryan, Colm J.; Savino, Aurora; Sesia, Debora; Wessels, Lodewyk; Iorio, Francesco
Fitness and transcriptional plasticity of human breast cancer single-cell-derived clones

人类乳腺癌单细胞来源克隆的适应性及转录组可塑性

CELL REPORTS
IF6.9
2025-05-010
OA
Nguyen, Long V.; Eyal-Lubling, Yaniv; Guerrero-Romero, Daniel; Kronheim, Sarah; Chin, Suet-Feung; Garcia, Raquel Manzano; Sammut, Stephen-John; Lerda, Giulia; Lui, Allan J. W.; Bardwell, Helen A.; Greenwood, Wendy; Shin, Hee Jin; Masina, Riccardo; Kania, Katarzyna; Bruna, Alejandra; Esmaeilishirazifard, Elham; Kolyvas, Emily A.; Aparicio, Samuel; Rueda, Oscar M.; Caldas, Carlos
Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer
NATURE METABOLISM
IF20.8
2023-11-0912
OAAI
Kreuzaler, Peter; Inglese, Paolo; Ghanate, Avinash; Gjelaj, Ersa; Wu, Vincen; Panina, Yulia; Mendez-Lucas, Andres; MacLachlan, Catherine; Patani, Neill; Hubert, Catherine B.; Huang, Helen; Greenidge, Gina; Rueda, Oscar M.; Taylor, Adam J.; Karali, Evdoxia; Kazanc, Emine; Spicer, Amy; Dexter, Alex; Lin, Wei; Thompson, Daria; Dos Santos, Mariana Silva; Calvani, Enrica; Legrave, Nathalie; Ellis, James K.; Greenwood, Wendy; Green, Mary; Nye, Emma; Still, Emma; Barry, Simon; Goodwin, Richard J. A.; Bruna, Alejandra; Caldas, Carlos; MacRae, James; de Carvalho, Luiz Pedro Sorio; Poulogiannis, George; McMahon, Greg; Takats, Zoltan; Bunch, Josephine; Yuneva, Mariia
RANK is a poor prognosis marker and a therapeutic target in ER-negative postmenopausal breast cancer

RANK是ER阴性绝经后乳腺癌的不良预后标志物和治疗靶点

EMBO MOLECULAR MEDICINE
IF8.3
2023-03-073
OAAI
Ciscar, Marina; Trinidad, Eva M.; Perez-Chacon, Gema; Alsaleem, Mansour; Jimenez, Maria; Jimenez-Santos, Maria J.; Perez-Montoyo, Hector; Sanz-Moreno, Adrian; Vethencourt, Andrea; Toss, Michael; Petit, Anna; Soler-Monso, Maria T.; Lopez, Victor; Gomez-Miragaya, Jorge; Gomez-Aleza, Clara; Dobrolecki, Lacey E.; Lewis, Michael T.; Bruna, Alejandra; Mouron, Silvana; Quintela-Fandino, Miguel; Al-Shahrour, Fatima; Martinez-Aranda, Antonio; Sierra, Angels; Green, Andrew R.; Rakha, Emad; Gonzalez-Suarez, Eva
MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer

MiR-182-3p靶向TRF2并损害三阴性乳腺癌的肿瘤生长

EMBO MOLECULAR MEDICINE
IF8.3
2022-11-2519
OAAI
Dinami, Roberto; Pompili, Luca; Petti, Eleonora; Porru, Manuela; D'Angelo, Carmen; Di Vito, Serena; Rizzo, Angela; Campani, Virginia; De Rosa, Giuseppe; Bruna, Alejandra; Serra, Violeta; Mano, Miguel; Giacca, Mauro; Leonetti, Carlo; Ciliberto, Gennaro; Tarsounas, Madalena; Stoppacciaro, Antonella; Schoeftner, Stefan; Biroccio, Annamaria
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer (September, 10.1038/s41467-022-32828-6, 2022)

高p16表达和杂合RB1丢失是ER乳腺癌中CDK4/6抑制剂抗性的生物标志物 (9月，10.1038/s41467-022-32828-6，2022)

NATURE COMMUNICATIONS
IF15.7
2022-11-140
OAAI
Palafox, Marta; Monserrat, Laia; Bellet, Meritxell; Villacampa, Guillermo; Gonzalez-Perez, Abel; Oliveira, Mafalda; Braso-Maristany, Fara; Ibrahimi, Nusaibah; Kannan, Srinivasaraghavan; Mina, Leonardo; Herrera-Abreu, Maria Teresa; Odena, Andreu; Sanchez-Guixe, Monica; Capelan, Marta; Azaro, Analia; Bruna, Alejandra; Rodriguez, Olga; Guzman, Marta; Grueso, Judit; Viaplana, Cristina; Hernandez, Javier; Su, Faye; Lin, Kui; Clarke, Robert B.; Caldas, Carlos; Arribas, Joaquin; Michiels, Stefan; Garcia-Sanz, Alicia; Turner, Nicholas C.; Prat, Aleix; Nuciforo, Paolo; Dienstmann, Rodrigo; Verma, Chandra S.; Lopez-Bigas, Nuria; Scaltriti, Maurizio; Arnedos, Monica; Saura, Cristina; Serra, Violeta
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer

高p16表达和杂合RB1缺失是ER乳腺癌中CDK4/6抑制剂耐药的生物标志物

NATURE COMMUNICATIONS
IF15.7
2022-09-0747
OAAI
Palafox, Marta; Monserrat, Laia; Bellet, Meritxell; Villacampa, Guillermo; Gonzalez-Perez, Abel; Oliveira, Mafalda; Braso-Maristany, Fara; Ibrahimi, Nusaibah; Kannan, Srinivasaraghavan; Mina, Leonardo; Herrera-Abreu, Maria Teresa; Odena, Andreu; Sanchez-Guixe, Monica; Capelan, Marta; Azaro, Analia; Bruna, Alejandra; Rodriguez, Olga; Guzman, Marta; Grueso, Judit; Viaplana, Cristina; Hernandez, Javier; Su, Faye; Lin, Kui; Clarke, Robert B.; Caldas, Carlos; Arribas, Joaquin; Michiels, Stefan; Garcia-Sanz, Alicia; Turner, Nicholas C.; Prat, Aleix; Nuciforo, Paolo; Dienstmann, Rodrigo; Verma, Chandra S.; Lopez-Bigas, Nuria; Scaltriti, Maurizio; Arnedos, Monica; Saura, Cristina; Serra, Violeta
Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance

确定对WEE1或ATR抑制有反应的乳腺癌和卵巢癌模型的分子定义子集，克服PARP抑制剂耐药性

CLINICAL CANCER RESEARCH
IF10.2
2022-08-0327
OAAI
Serra, Violeta; Wang, Anderson T.; Castroviejo-Bermejo, Marta; Polanska, Urszula M.; Palafox, Marta; Herencia-Ropero, Andrea; Jones, Gemma N.; Lai, Zhongwu; Armenia, Joshua; Michopoulos, Filippos; Llop-Guevara, Alba; Brough, Rachel; Gulati, Aditi; Pettitt, Stephen J.; Bulusu, Krishna C.; Nikkila, Jenni; Wilson, Zena; Hughes, Adina; Wijnhoven, Paul W. G.; Ahmed, Ambar; Bruna, Alejandra; Gris-Oliver, Albert; Guzman, Marta; Rodriguez, Olga; Grueso, Judit; Arribas, Joaquin; Cortes, Javier; Saura, Cristina; Lau, Alan; Critchlow, Susan; Dougherty, Brian; Caldas, Carlos; Mills, Gordon B.; Barrett, J. Carl; Forment, Josep V.; Cadogan, Elaine; Lord, Christopher J.; Cruz, Cristina; Balmana, Judith; O'Connor, Mark J.
DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

1538乳腺癌的DNA甲基化景观揭示了与复制相关的时钟，表观基因组不稳定性和顺式调节

NATURE COMMUNICATIONS
IF15.7
2021-09-1332
OAAI
Batra, Rajbir Nath; Lifshitz, Aviezer; Vidakovic, Ana Tufegdzic; Chin, Suet-Feung; Sati-Batra, Ankita; Sammut, Stephen-John; Provenzano, Elena; Ali, H. Raza; Dariush, Ali; Bruna, Alejandra; Murphy, Leigh; Purushotham, Arnie; Ellis, Ian; Green, Andrew; Garrett-Bakelman, Francine E.; Mason, Chris; Melnick, Ari; Aparicio, Samuel A. J. R.; Rueda, Oscar M.; Tanay, Amos; Caldas, Carlos
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

乳腺癌异种移植细胞表型多样性及其对药物反应的影响

NATURE COMMUNICATIONS
IF15.7
2021-03-3137
OAAI
Georgopoulou, Dimitra; Callari, Maurizio; Rueda, Oscar M.; Shea, Abigail; Martin, Alistair; Giovannetti, Agnese; Qosaj, Fatime; Dariush, Ali; Chin, Suet-Feung; Carnevalli, Larissa S.; Provenzano, Elena; Greenwood, Wendy; Lerda, Giulia; Esmaeilishirazifard, Elham; O'Reilly, Martin; Serra, Violeta; Bressan, Dario; Mills, Gordon B.; Ali, H. R.; Cosulich, Sabina S.; Hannon, Gregory J.; Bruna, Alejandra; Caldas, Carlos; Alon, S.; Al Sa'd, M.; Aparicio, S.; Battistoni, G.; Balasubramanian, S.; Becker, R.; Bodenmiller, B.; Boyden, E. S.; Burger, Marcel; Cannell, I. G.; Casbolt, H.; Chornay, N.; Cui, Y.; Dariush, A.; Dinh, K.; Emenari, A.; Eyal-Lubling, Y.; Fan, J.; Fatemi, A.; Fisher, E.; Gonzalez-Solares, E. A.; Gonzalez-Fernandez, C.; Goodwin, D.; Greenwood, W.; Grimaldi, F.; Hannon, G. J.; Harris, O.; Harris, S.; Jauset, C.; Joyce, J. A.; Karagiannis, E. D.; Kovacevic, T.; Kuett, L.; Kunes, R.; Kupcu, Yoldas A.; Lai, D.; Laks, E.; Lee, H.; Lee, M.; Lerda, G.; Li, Y.; McPherson, A.; Millar, N.; Mulvey, C. M.; Nugent, F.; O'Flanagan, C. H.; Paez-Ribes, M.; Pearsall, I.; Qosaj, F.; Roth, A. J.; Rueda, O. M.; Ruiz, T.; Sawicka, K.; Sepulveda, L. A.; Shah, S. P.; Shea, A.; Sinha, A.; Smith, A.; Tavare, S.; Tietscher, S.; Vazquez-Garcia, I.; Vogl, S. L.; Walton, N. A.; Wassie, A. T.; Watson, S. S.; Weselak, J.; Wild, S. A.; Williams, E.; Windhager, J.; Whitmarsh, T.; Xia, C.; Zheng, P.; Zhuang, X.
PI3K activation promotes resistance to eribulin in HER2-negative breast cancer

PI3K激活促进HER2-negative乳腺癌对eribulin的耐药性

BRITISH JOURNAL OF CANCER
IF6.8
2021-03-1513
OAAI
Gris-Oliver, Albert; Ibrahim, Yasir H.; Rivas, Martin A.; Garcia-Garcia, Celina; Sanchez-Guixe, Monica; Ruiz-Pace, Fiorella; Viaplana, Cristina; Perez-Garcia, Jose M.; Llombart-Cussac, Antonio; Grueso, Judit; Pares, Mireia; Guzman, Marta; Rodriguez, Olga; Anton, Pilar; Cozar, Patricia; Calvo, Maria Teresa; Bruna, Alejandra; Arribas, Joaquin; Caldas, Carlos; Dienstmann, Rodrigo; Nuciforo, Paolo; Oliveira, Mafalda; Cortes, Javier; Serra, Violeta
The EurOPDX Research Infrastructure: Supporting European and worldwide cancer research with patient-derived xenografts
CANCER RESEARCH
IF16.6
2020-08-150
PRE
Vinolo, Emilie; Arribas, Joaquin; Bertotti, Andrea; Bruna, Alejandra; Byrne, Annette T.; Clarke, Robert B.; Conte, Nathalie; de Jong, Steven; Decaudin, Didier; Dudova, Zdenka; Jonkers, Jos; Krasser, Daniela; Krenek, Ales; Lanfrancone, Luisa; Leucci, Eleonora; Marangoni, Elisabetta; Maelandsmo, Gunhild Mari; Mayrhofer, Michaela Th; Meehan, Terrence F.; Norum, Jens Henrik; Palmer, Hector G.; Gimenez, Alejandro Piris; Price, Leo; Roman-Roman, Sergio; Sarno, Francesca; Serra, Violeta; Soucek, Laura; Trusolino, Livio; van de Ven, Marieke; Vezzadini, Luca; Villanueva, Alberto; Wutte, Andrea; Medico, Enzo

研究方向

暂未获取到该数据
C
Carlos Caldas
H 指数:158论文数:1,383被引数:12.8万
O
Oscar M. Rueda
H 指数:56论文数:339被引数:2.5万
V
Violeta Serra
H 指数:71论文数:872被引数:2.1万
J
Joaquı́n Arribas
H 指数:61论文数:560被引数:1.4万
W
Wendy Greenwood
H 指数:15论文数:44被引数:3,233
A
Ankita Sati Batra
H 指数:13论文数:26被引数:1,045
S
Suet‐Feung Chin
H 指数:76论文数:366被引数:4.7万
C
Cristina Saura
H 指数:61论文数:740被引数:1.9万
J
Judith Balmañà
H 指数:66论文数:599被引数:1.9万
P
Paolo Nucíforo
H 指数:70论文数:840被引数:1.9万