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M

Michael Hölzel

university hospital bonn

47H指数
346论文数
1.0W被引数
收录论文 95
发表时间
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Beyond dose escalation in glioblastoma: Lessons learned from INTRAGO-II and the case for targeting tumor biology超越剂量递增在胶质母细胞瘤中的应用：来自INTRAGO-II试验的经验教训及靶向肿瘤生物学的依据
errNeuro-Oncology
IF13.4
err2026-09-19
err0
errOAAI
errJulian Philipp Layer; Matthias Schneider; Michael Hölzel; Ulrich Herrlinger; Frank Winkler
err分享
err收藏
AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteinsAI赋能的靶向癌细胞表面蛋白的迷你结合物的发现与生化优化
errNature Communications
IF15.7
err2026-08-20
err0
errOAAI
errBianca Broske; Benjamin A. McEnroe; Sophie C. Frechen; Tim N. Kempchen; Caroline I. Fandrey; Elisabeth Tan; Dominic Ferber; Michelle C. R. Yong; Marie Kleinert; Julia M. Messmer; Peter Konopka; Alexander Hoch; Katja Blumenstock; Jan M. P. Tödtmann; Johannes Oldenburg; Heiko Rühl; Alexander Semaan; Marieta I. Toma; Kristina Markova; Sebastian Kobold; Tim Rollenske; Matthias Geyer; Stephan Menzel; Tobias Bald; Jonathan L. Schmid-Burgk; Gregor Hagelueken; Michael Hölzel
err分享
err收藏
Semantic Segmentation for Histopathology using Learned Regularization based on Global Proportions基于全局比例学习的正则化用于组织病理学语义分割
errInternational Journal of Computer Vision
IF9.3
err2026-05-26
err0
errOAAI
errYangping Li; Thomas Pinetz; Michael Hölzel; Marieta Toma; Alexander Effland
err分享
err收藏
L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial基于L-RNA适配体的CXCL12抑制联合放射治疗和贝伐珠单抗在 newly-diagnosed glioblastoma 中的研究：扩展I/II期GLORIA试验
errNature Communications
IF15.7
err2026-04-08
err0
errOAAI
errFrank A. Giordano; Julian P. Layer; Roberta Turiello; Lea L. Friker; Oriol Mirallas; Barbara E. F. Pregler; Anna-Laura Potthoff; Thomas Zeyen; Johannes Weller; Elena Sperk; Katharina Sahm; Christoph Oster; Sied Kebir; Peter Hambsch; Niklas Schäfer; Sebastian Kadzik; Mirjam Renovanz; Torsten Pietsch; Sotirios Bisdas; Juan Manuel Sepúlveda-Sánchez; Diego Gómez-Puerto; Maria Vieito; Michael Platten; Eleni Gkika; Oliver M. Grauer; Ghazaleh Tabatabai; Matthias Schneider; Martin Glas; Clemens Seidel; Ulrich Herrlinger; Michael Hölzel
err分享
err收藏
High-salt diet induces immune-independent re-differentiation, metabolic shut down and cell cycle arrest of melanoma高盐饮食诱导黑色素瘤发生免疫非依赖性再分化、代谢关闭和细胞周期停滞。
errCell Death & Disease
IF9.6
err2025-12-20
err0
errOAAI
errClivia Lisowski; Natascha E. Stumpf; Katarzyna Jobin; Daniela Klaus; Melanie Eichler; Ann-Kathrin Baumgart; Olena Babyak; Mirjam Meißner; Agnes Schröder; Patrick Neubert; Vanessa Schmitt; Marcel Michla; Süleyman Bozkurt; Jelena Zurkovic; Daniel Hinze; Jana Liebing; Matthias Eckhardt; Christoph Heuser; Lea Seep; Annkristin Heine; Janine Becker-Gotot; Christoph Thiele; Christian Münch; Thomas Becker; Jonathan Jantsch; Christoph Wilhelm; Michael Hölzel; Christian Kurts
err分享
err收藏
Histological and molecular characterization of endolymphatic sac tumor reveals key differences from its primary differential diagnosis, choroid plexus papilloma内淋巴囊肿瘤的组织学及分子学特征揭示其与主要鉴别诊断——脉络丛乳头状瘤存在关键差异。
errHISTOLOGY AND HISTOPATHOLOGY
IF2
err2025-12-01
err0
PREAI
errFriker, Lea L.; Klein, Rebecca; Clauberg, Ralf; Goschzik, Tobias; Layer, Julian P.; Gies, Ursula; Holzel, Michael; Herrlinger, Ulrich; Waha, Andreas; Pietsch, Torsten; Gielen, Gerrit H.
err分享
err收藏
The GLIOSCREEN trial: Feasibility, genomic landscape, and clinical impact of prospective comprehensive molecular profiling in newly diagnosed gliomaGLIOSCREEN试验：前瞻性全面分子分型在 newly diagnosed glioma 中的可行性、基因组景观及临床影响
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errZeyen, Thomas; Friker, Lea L.; Duffy, Cathrina; Gielen, Gerrit H.; Ebrahimi, Azadeh; Schaefer, Niklas; Weller, Johannes; Schneider, Matthias; Potthoff, Anna-Laura; Layer, Julian P.; Doerner, Evelyn; Klein, Rebecca; Goschzik, Tobias; Hoelzel, Michael; Pietsch, Torsten; Waha, Andreas; Herrlinger, Ulrich
err分享
err收藏
Core2Edge: A human glioblastoma organoid and brain slice co-culture model capturing tumor infiltration and transcriptional heterogeneity from core to single-cell dispersionCore2Edge: 一种人类胶质母细胞瘤类器官与脑片共培养模型，可捕捉从核心到单细胞分散的肿瘤浸润和转录异质性
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errPotthoff, Anna-Laura; Melhem, Ahmad; Pregler, Barbara E. F.; Rodriguez-Gatica, Juan Eduardo; Friker, Lea L.; Thomas, Jake; Borger, Valeri; Toma, Marieta, I; Westhoff, Mike-Andrew; Ravi, Vidhya M.; Heiland, Dieter Henrik; Schlitzer, Andreas; Pietsch, Torsten; Holzel, Michael; Waha, Andreas; Vatter, Hartmut; Schwarz, Martin K.; Herrlinger, Ulrich; Kubitscheck, Ulrich; Schneider, Matthias
err分享
err收藏
Can NaCl predict or even enhance responses to immunotherapy in cancer?NaCl能否预测或甚至增强癌症免疫治疗反应？
errEuropean Journal of Cancer
IF7.1
err2025-10-18
err0
errOAAI
errJonas Saal; Michael Hölzel; Niklas Klümper
err分享
err收藏
P01.24.B CORE2EDGE: A HUMAN GLIOBLASTOMA ORGANOID AND BRAIN SLICE CO-CULTURE MODEL CAPTURING TUMOR INFILTRATION AND TRANSCRIPTIONAL HETEROGENEITY FROM CORE TO SINGLE-CELL DISPERSIONP01.24.B CORE2EDGE：一种人类胶质母细胞瘤类器官和脑片共培养模型，捕获从肿瘤核心到单细胞分散的肿瘤浸润和转录异质性
errNEURO-ONCOLOGY
IF13.4
err2025-10-01
err0
errOAAI
errSchneider, M.; Potthoff, A.; Melhem, A.; Pregler, B. E.; Rodriguez-Gatica, J. E.; Thomas, J.; Friker, L. L.; Westhoff, M.; Ravi, V. M.; Heiland, D. H.; Schlitzer, A.; Pietsch, T.; Holzel, M.; Waha, A.; Vatter, H.; Schwarz, M. K.; Kubitscheck, U.; Herrlinger, U.
err分享
err收藏
IL-17A-producing NKp44(-) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue产生IL-17A的NKp44(-)组3先天淋巴样细胞在家族性腺瘤性息肉病十二指肠组织中积聚
errNATURE COMMUNICATIONS
IF15.7
err2025-04-25
err0
errOAAI
errKaiser, Kim M.; Raabe, Jan; ToVinh, Michael; Hack, Gudrun; Ahmad, Sarah; Mueller, Niko; Cassella, Julia; Walravens, Sofia I.; Alfaro, Paula; Garcia, Lauren Arias; Kaczmarek, Dominik J.; Marwitz, Tim; Goeser, Felix; Nischalke, Hans Dieter; Lutz, Philipp; Sommer, Nils; Vilz, Tim; Toma, Marieta; Steiner, Susanne; Hommerding, Oliver; Oldenburg, Johannes; Hoelzel, Michael; Kadzik, Sebastian; Maas, Alexander; Eckrich, Jonas; Zumfelde, Philipp; Shakeri, Farhad; Nesic, Svetozar; Buness, Andreas; De Caro, Emilia; Becker, Matthias; Beyer, Marc D.; Ulas, Thomas; Aschenbrenner, Anna C.; Steinheuer, Lisa M.; Thurley, Kevin; Kroh, Sandy; Uecker, Ralf; Hauser, Anja E.; Gohr, Florian N.; Schmidt, Florian I.; Wang, Danni; Held, Kathrin; Baranov, Olga; Geldmacher, Christof; Strassburg, Christian P.; Hueneburg, Robert; Kraemer, Benjamin; Nattermann, Jacob
err分享
err收藏
MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade gliomaMSH2、MSH6、MLH1和PMS2免疫组化作为儿科高级别胶质瘤中DNA错配修复缺陷综合征的高敏感性筛查方法
errACTA NEUROPATHOLOGICA
IF9.3
err2025-02-02
err0
errOAAI
errFriker, LL; Perwein, T; Waha, A; Dörner, E; Klein, R; Blattner-Johnson, M; Layer, JP; Sturm, D; Nussbaumer, G; Kwiecien, R; Spier, I; Aretz, S; Kerl, K; Hennewig, U; Rohde, M; Karow, A; Bluemcke, I; Schmitz, AK; Reinhard, H; Driever, PH; Wendt, S; Weiser, A; Stücklin, ASG; Gerber, NU; von Bueren, AO; Khurana, C; Jorch, N; Wiese, M; Kratz, CP; Eyrich, M; Karremann, M; Herrlinger, U; Hölzel, M; Jones, DTW; Hoffmann, M; Pietsch, T; Gielen, GH; Kramm, CM
err分享
err收藏
C-Reactive Protein Facilitates Premetastatic Niche Formation in the Lungs
errCANCER RESEARCH
IF16.6
err2024-12-16
err0
PREAI
errSaal, Jonas; Kluemper, Niklas; Hoelzel, Michael
err分享
err收藏
The Role of Microsatellite Instability/DNA Mismatch Repair Deficiency and Tumor Mutational Burden as Biomarkers in Predicting Response to Immunotherapy in Castration-resistant Prostate Cancer
errEUROPEAN UROLOGY
IF25.2
err2024-11-01
err0
PREAI
errKluemper, Niklas; Gruenwald, Viktor; Hartmann, Arndt; Hoelzel, Michael; Eckstein, Markus
err分享
err收藏
Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer
errNATURE REVIEWS UROLOGY
IF14.6
err2024-10-29
err0
PREAI
errKluemper, Niklas; Cox, Alexander; Sjoedahl, Gottfrid; Roghmann, Florian; Bolenz, Christian; Hartmann, Arndt; Gruenwald, Viktor; Faltas, Bishoy M.; Hoelzel, Michael; Eckstein, Markus
err分享
err收藏
HLA-G expression associates with immune evasion muscle-invasive urothelial cancer and drives prognostic relevanceHla-g表达与免疫逃避肌肉浸润性尿路上皮癌相关并驱动预后相关性
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2024-10-14
err0
errOAAI
errBranz, Annalena; Matek, Christian; Lange, Fabienne; Bahlinger, Veronika; Kluemper, Niklas; Hoelzel, Michael; Strissel, Pamela L.; Strick, Reiner; Sikic, Danijel; Wach, Sven; Taubert, Helge; Wullich, Bernd; Hartmann, Arndt; Seliger, Barbara; Eckstein, Markus
err分享
err收藏
IMMUNOHISTOCHEMISTRY REPRESENTS A HIGHLY SENSITIVE SCREENING METHOD FOR MISMATCH REPAIR DEFICIENCY SYNDROMES IN PEDIATRIC HIGH-GRADE GLIOMA
errNEURO-ONCOLOGY
IF13.4
err2024-06-18
err0
errOAAI
errFriker, Lea L.; Perwein, Thomas; Waha, Andreas; Doerner, Evelyn; Klein, Rebecca; Blattner-Johnson, Mirjam; Layer, Julian P.; Sturm, Dominik; Nussbaumer, Gunther; Kerl, Kornelius; Hennewig, Ulrike; Rohde, Marius; Karow, Axel; Bluemcke, Ingmar; Schmitz, Ann Kristin; Reinhard, Harald; Herz, Nina A.; Driever, Pablo Hernaiz; Wendt, Susanne; Weiser, Annette; Guerreiro Stuecklin, Ana S.; Gerber, Nicolas U.; von Bueren, Andre O.; Khurana, Claudia; Jorch, Norbert; Kratz, Christian P.; Eyrich, Matthias; Karremann, Michael; Hoelzel, Michael; Jones, David T. W.; Pietsch, Torsten; Gielen, Gerrit H.; Kramm, Christof M.
err分享
err收藏
High serum sodium predicts immunotherapy response in metastatic renal cell and urothelial carcinoma
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-06-01
err5
errOAAI
errKluemper, Niklas; Cox, Alexander; Eckstein, Markus; Kuppe, Christoph; Ritter, Manuel; Brossart, Peter; Luetkens, Julian; Holzel, Michael; Stein, Johannes; Saal, Jonas
err分享
err收藏
L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial新诊断的胶质母细胞瘤中基于l-rna适体的CXCL12抑制联合放疗: I/II期GLORIA试验的剂量递增
errNATURE COMMUNICATIONS
IF15.7
err2024-05-28
err5
errOAAI
errGiordano, Frank A.; Layer, Julian P.; Leonardelli, Sonia; Friker, Lea L.; Turiello, Roberta; Corvino, Dillon; Zeyen, Thomas; Schaub, Christina; Mueller, Wolf; Sperk, Elena; Schmeel, Leonard Christopher; Sahm, Katharina; Oster, Christoph; Kebir, Sied; Hambsch, Peter; Pietsch, Torsten; Bisdas, Sotirios; Platten, Michael; Glas, Martin; Seidel, Clemens; Herrlinger, Ulrich; Hoelzel, Michael
err分享
err收藏
Molecular Urothelial Tumor Cell Subtypes Remain Stable During Metastatic Evolution
errEUROPEAN UROLOGY
IF25.2
err2024-04-01
err7
errOAAI
errCox, Alexander; Kluemper, Niklas; Stein, Johannes; Sikic, Danijel; Breyer, Johannes; Bolenz, Christian; Roghmann, Florian; Erben, Philipp; Wirtz, Ralph M.; Wullich, Bernd; Ritter, Manuel; Hoelzel, Michael; Schwamborn, Kristina; Horn, Thomas; Gschwend, Juergen; Hartmann, Arndt; Weichert, Wilko; Erlmeier, Franziska; Eckstein, Markus
err分享
err收藏

研究方向

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合作学者
合作期刊
A
Aviv Regev
H 指数: 208 · 论文数: 965
D
Dirk Schadendorf
H 指数: 182 · 论文数: 2.4K
M
Mark J. Smyth
H 指数: 172 · 论文数: 1.4K
G
Georgina V. Long
H 指数: 169 · 论文数: 1.8K
M
Markus M. Nöthen
H 指数: 161 · 论文数: 2.0K
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