未登录 Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness, and pathogenesis of SARS-CoV-2 nsp14-外切核酸酶活性的丧失损害了SARS-CoV-2的复制、校对、适应性和致病性 Anderson-Daniels, Jordan; Diefenbacher, Meghan V.; Yount, Boyd L.; Meganck, Rita M.; Tse, Longping V.; Burke, Kaitlyn N.; Miranda, Hector A.; Scobey, D. Trevor; Lu, Xiaotao; Stevens, Laura; Dinnon III, Kenneth H.; Chapman, Nathaniel S.; Pajon, Camryn; Powers, John M.; Nguyen, Cameron; Graham, Rachel L.; Heaton, Nicholas S.; Baric, Ralph S.; Denison, Mark R.; Sheahan, Timothy P. 分享 收藏
分享 收藏
Humanized mouse models for renal cell carcinoma research: evaluating immune checkpoint blockade Li, Li; Zhang, Xin; Maresh, Grace; Bhattarai, Amita; Moret, Ravan; Haupt, Carl; Ray, Alicia Nicole; Hobusch, Ashtian; Graham, Rachel; Latsis, Maria; Galwankar, Neeti; Bardot, Stephen F. 分享 收藏
MERS-CoV spike vaccine-induced N-terminal domain specific antibodies are more protective than receptor binding domain-specific antibodies- MERS-CoV刺突疫苗诱导的N端结构域特异性抗体比受体结合结构域特异性抗体具有更强的保护作用。 Abiona, Olubukola M.; Wang, Nianshuang; Leist, Sarah R.; Schafer, Alexandra; Cockrell, Adam S.; Wang, Lingshu; Bangaru, Sandhya; Stevens, Laura; Graham, Rachel L.; Kocher, Jacob F.; Tsybovsky, Yaroslav; Kanekiyo, Masaru; Kumar, Azad; Morabito, Kaitlyn M.; Rosen, Osnat; Shi, Wei; Werner, Anne; Zhang, Yi; Ziwawo, Cynthia; Dzuvor, Christian K. O.; Palandjian, Charis; Eastman, Connor; Matthews, Hannah R.; Chappell, James D.; Kong, Wing-Pui; Mascola, John R.; Ward, Andrew B.; Denison, Mark R.; Baric, Ralph; Mclellan, Jason S.; Graham, Barney S.; Corbett-Helaire, Kizzmekia S. 分享 收藏
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo Zhou, Nian E.; Tang, Su; Bian, Xuelin; Parai, Maloy K.; Krieger, Inna V.; Flores, Armando; Jaiswal, Pradeep K.; Bam, Radha; Wood, Jeremy L.; Shi, Zhe; Stevens, Laura J.; Scobey, Trevor; Diefenbacher, Meghan V.; Moreira, Fernando R.; Baric, Thomas J.; Acharya, Arjun; Shin, Joonyoung; Rathi, Manish M.; Wolff, Karen C.; Riva, Laura; Bakowski, Malina A.; Mcnamara, Case W.; Catanzaro, Nicholas J.; Graham, Rachel L.; Schultz, David C.; Cherry, Sara; Kawaoka, Yoshihiro; Halfmann, Peter J.; Baric, Ralph S.; Denison, Mark R.; Sheahan, Timothy P.; Sacchettini, James C. 分享 收藏
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19 Boon, Adrianus C. M.; Bricker, Traci L.; Fritch, Ethan J.; Leist, Sarah R.; Gully, Kendra; Baric, Ralph S.; Graham, Rachel L.; Troan, Brigid V.; Mahoney, Matthew; Janetka, James W. 分享 收藏
Mapping of susceptibility loci for Ebola virus pathogenesis in mice Schafer, Alexandra; Marzi, Andrea; Furuyama, Wakako; Catanzaro, Nicholas J.; Nguyen, Cameron; Haddock, Elaine; Feldmann, Friederike; Meade-White, Kimberly; Thomas, Tina; Hubbard, Miranda L.; Gully, Kendra L.; Leist, Sarah R.; Hock, Pablo; Bell, Timothy A.; De la Cruz, Gabriela E.; Midkiff, Bentley R.; Martinez, David R.; Shaw, Ginger D.; Miller, Darla R.; Vernon, Michael J.; Graham, Rachel L.; Cowley, Dale O.; Montgomery, Stephanie A.; Schughart, Klaus; de Villena, Fernando Pardo Manuel; Wilkerson, Gregory K.; Ferris, Martin T.; Feldmann, Heinz; Baric, Ralph S. 分享 收藏
A Comparison of the Telemedicine Experience in the Early Pandemic (2020) Vs. Later Pandemic (2021) Periods: Results of a Mixed Methods Comparison Pring, Kelly; Thomson, Sharon; Olszewski, Carly; Cox, Siobhan; Merrill, Rebecca; Fishman, Emily; Ambrosini, Alexander; Soltany, Kevin; Bognet, Gabriella; Strauss, Lauren; Graham, Rachel; Guzik, Amy; Strowd, Roy 分享 收藏
1-O-Octadecyl-2-O-benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV-2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV-2 Activity Carlin, Aaron F.; Beadle, James R.; Clark, Alex E.; Gully, Kendra L.; Moreira, Fernando R.; Baric, Ralph S.; Graham, Rachel L.; Valiaeva, Nadejda; Leibel, Sandra L.; Bray, William; McMillan, Rachel E.; Freshman, Jonathan E.; Garretson, Aaron F.; McVicar, Rachael N.; Rana, Tariq; Zhang, Xing-Quan; Murphy, Joyce A.; Schooley, Robert T.; Hostetler, Karl Y. 分享 收藏
A Multitrait Locus Regulates Sarbecovirus Pathogenesis Schafer, Alexandra; Leist, Sarah R.; Gralinski, Lisa E.; Martinez, David R.; Winkler, Emma S.; Okuda, Kenichi; Hawkins, Padraig E.; Gully, Kendra L.; Graham, Rachel L.; Scobey, D. Trevor; Bell, Timothy A.; Hock, Pablo; Shaw, Ginger D.; Loome, Jennifer F.; Madden, Emily A.; Anderson, Elizabeth; Baxter, Victoria K.; Taft-Benz, Sharon A.; Zweigart, Mark R.; May, Samantha R.; Dong, Stephanie; Clark, Matthew; Miller, Darla R.; Lynch, Rachel M.; Heise, Mark T.; Tisch, Roland; Boucher, Richard C.; de Villena, Fernando Pardo Manuel; Montgomery, Stephanie A.; Diamond, Michael S.; Ferris, Martin T.; Baric, Ralph S. 分享 收藏
Novel modulators of p53-signaling encoded by unknown genes of emerging viruses Alzhanova, Dina; Corcoran, Kathleen; Bailey, Aubrey G.; Long, Kristin; Taft-Benz, Sharon; Graham, Rachel L.; Broussard, Grant S.; Heise, Mark; Neumann, Gabriele; Halfmann, Peter; Kawaoka, Yoshihiro; Baric, Ralph S.; Damania, Blossom; Dittmer, Dirk P. 分享 收藏
Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection Edwards, Caitlin E.; Yount, Boyd L.; Graham, Rachel L.; Leist, Sarah R.; Hou, Yixuan J.; Dinnon, Kenneth H., III; Sims, Amy C.; Swanstrom, Jesica; Gully, Kendra; Scobey, Trevor D.; Cooley, Michelle R.; Currie, Caroline G.; Randell, Scott H.; Baric, Ralph S. 分享 收藏
分享 收藏
Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice Remdesivir抑制人肺细胞和小鼠中表达SARS-CoV-2 RNA聚合酶的嵌合传染性非典型肺炎-CoV的SARS-CoV-2 Pruijssers, Andrea J.; George, Amelia S.; Schafer, Alexandra; Leist, Sarah R.; Gralinksi, Lisa E.; Dinnon, Kenneth H., III; Yount, Boyd L.; Agostini, Maria L.; Stevens, Laura J.; Chappell, James D.; Lu, Xiaotao; Hughes, Tia M.; Gully, Kendra; Martinez, David R.; Brown, Ariane J.; Graham, Rachel L.; Perry, Jason K.; Du Pont, Venice; Pitts, Jared; Ma, Bin; Babusis, Darius; Murakami, Eisuke; Feng, Joy Y.; Bilello, John P.; Porter, Danielle P.; Cihlar, Tomas; Baric, Ralph S.; Denison, Mark R.; Sheahan, Timothy P. 分享 收藏
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence (vol 21, pg 1508, 2015) Menachery, Vineet D.; Yount, Boyd L., Jr.; Debbink, Kari; Agnihothram, Sudhakar; Gralinski, Lisa E.; Plante, Jessica A.; Graham, Rachel L.; Scobey, Trevor; Ge, Xing-Yi; Donaldson, Eric F.; Randell, Scott H.; Lanzavecchia, Antonio; Marasco, Wayne A.; Shi, Zhengli-Li; Baric, Ralph S. 分享 收藏
分享 收藏
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice 口服生物可利用的广谱抗病毒药物抑制小鼠人类气道上皮细胞培养物和多种冠状病毒的SARS-CoV-2 Sheahan, Timothy P.; Sims, Amy C.; Zhou, Shuntai; Graham, Rachel L.; Pruijssers, Andrea J.; Agostini, Maria L.; Leist, Sarah R.; Schafer, Alexandra; Dinnon, Kenneth H., III; Stevens, Laura J.; Chappell, James D.; Lu, Xiaotao; Hughes, Tia M.; George, Amelia S.; Hill, Collin S.; Montgomery, Stephanie A.; Brown, Ariane J.; Bluemling, Gregory R.; Natchus, Michael G.; Saindane, Manohar; Kolykhalov, Alexander A.; Painter, George; Harcourt, Jennifer; Tamin, Azaibi; Thornburg, Natalie J.; Swanstrom, Ronald; Denison, Mark R.; Baric, Ralph S. 分享 收藏
分享 收藏
分享 收藏
Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection Menachery, Vineet D.; Dinnon, Kenneth H., III; Yount, Boyd L., Jr.; McAnarney, Eileen T.; Gralinski, Lisa E.; Hale, Andrew; Graham, Rachel L.; Scobey, Trevor; Anthony, Simon J.; Wang, Lingshu; Graham, Barney; Randell, Scott H.; Lipkin, W. Ian; Baric, Ralph S. 分享 收藏
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
未登录.png){kind=icon}