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C

Christine A. Iacobuzio-Donahue

Memorial Sloan Kettering Cancer Center
H指数:135
被引数:9.2万

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Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial

Pembrolizumab和olaparib治疗同源重组缺陷型转移性胰腺癌: 2期POLAR试验

Nature Medicine
IF50
2026-03-250
OAAI
Wungki Park; Catherine A. O’Connor; Joanne F. Chou; Marc Hilmi; Zeynep Tarcan; Carly Schwartz; Mary Larsen; Ramzi Homsi; Karthigayini Sivaprakasam; Shigeaki Umeda; Maria A. Perry; Anna M. Varghese; Kenneth H. Yu; Fiyinfolu Balogun; Alice Zervoudakis; Seth S. Katz; Tae-Hyung Kim; Ken Zhao; Allison L. Richards; Nicolas Lecomte; Daniel Martin Muldoon; Elias Karnoub; Walid Chatila; Jessica Yang; Imane El-Dika; Devika Rao; Smita Joshi; Michael B. Foote; Ryan Sugarman; James J. Harding; Andrew S. Epstein; David Kelsen; Sree Chalassani; Fergus Keane; Joshua D. Schoenfeld; Anupriya Singhal; Erin Diguglielmo; Chaitanya Bandlamudi; Junmin Song; Hulya Sahin Ozkan; Junguei Hong; Haochen Zhang; Agustin III Cardenas; Maria Lao; Jerry Melchor; Ronak Shah; Wenfei Kang; Francesca Mazzoni; Kevin Soares; Mark TA Donoghue; Ernesto Santos; Vineet Rolston; Marsha Reyngold; Alice Chia-chi Wei; Murray Tipping; Olca Basturk; Michael Berger; Richard Kihn Do; Mark Schattner; William R. Jarnagin; Nadeem Riaz; Vinod Balachandran; Dana Pe’er; Marinela Capanu; Christine Iacobuzio-Donahue; Eileen M. O’Reilly
Evidence that extra copies of chromosome 1q play a role in the early phases of pancreatic neoplasia

证据表明额外的1q染色体拷贝在胰腺新生物的早期阶段发挥作用

Science Advances
IF12.5
2026-02-200
OA
Christopher Douville; Jeeun Parksong; Marco Dal Molin; Sarah Graham; Patricia T. Greipp; Ryan Knudson; Samuel Curtis; Yuxuan Wang; Lisa Dobbyn; Maria Popoli; Janine Ptak; Natalie Silliman; Katharine Romans; Christine A. Iacobuzio-Donahue; Alvin P. Makoohon-Moore; Anne Marie Lennon; Michael Goggins; Ralph H. Hruban; Ashley Kiemen; Chetan Bettegowda; Kenneth W. Kinzler; Nickolas Papadopoulos; Laura D. Wood; Bert Vogelstein
Genomic evolution of pancreatic cancer at single-cell resolution

单细胞分辨率的胰腺癌基因组进化

Nature Genetics
IF29
2026-01-220
OAAI
Haochen Zhang; Palash Sashittal; Elias-Ramzey Karnoub; Akhil Jakatdar; Shigeaki Umeda; Jungeui Hong; Anne Marie Noronha; Agustin Cardenas; Amanda Erakky; Caitlin A. McIntyre; Akimasa Hayashi; Nicolas Lecomte; Marc Hilmi; Wungki Park; Nan Pang; Eileen M. O’Reilly; Alice C. Wei; Benjamin J. Raphael; Christine A. Iacobuzio-Donahue
Safety and Feasibility of Intra-Arterial Treatment of Pancreatic Cancer Using an Emulsion of Ethiodized Oil plus Bumetanide in an Oncopig Model

使用乙碘油与布美他尼乳剂进行经动脉治疗胰腺癌的安全性与可行性：一项在肿瘤猪模型中的研究

Journal of Vascular and Interventional Radiology
IF2.6
2025-11-050
PRE
Hooman Yarmohammadi; Sam Y. Son; Aaron W.P. Maxwell; Ahmed S. Elsakka; Vlasios S. Sotirchos; Olivier Chevallier; Fuad Nurili; Fourat Ridouani; Etay Ziv; Joseph P. Erinjeri; Ken Zhao; Christopher Cheleuitte-Nieves; Renata Mammone; Adam Michel; Christine A. Iacobuzio-Donahue; Alice C. Wei; Eileen M. O’Reilly; Stephen B. Solomon; F.Edward Boas
The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions

胰腺癌的非编码突变景观揭示了增强子区域中的复发体细胞突变

CANCER RESEARCH COMMUNICATIONS
IF0
2025-10-010
PRE
Hayashi, Akimasa; Ho, Yu-Jui; Makohon-Moore, Alvin P.; Zucker, Amanda; Hong, Jungeui; Umeda, Shigeaki; Karnoub, Elias-Ramzey; Huang, Jinlong; Baez, Priscilla; Kappagantula, Rajya; Melchor, Jerry P.; Park, Wungki; O'Reilly, Eileen M.; Socci, Nicholas D.; Oki, Shinya; Iacobuzio-Donahue, Christine A.
SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence

SMAD4根据定居器官的不同，对胰腺肿瘤的转移性生长产生相反的影响。

Nature Cancer
IF28.5
2025-09-250
OAAI
Kaloyan M. Tsanov; Francisco M. Barriga; Yu-Jui Ho; Direna Alonso-Curbelo; Geulah Livshits; Sha Tian; Richard P. Koche; Timour Baslan; Janelle Simon; Alexandra N. Wuest; José Reyes; Jin Park; Wei Luan; John E. Wilkinson; Umesh Bhanot; Jordana Ray-Kirton; Ignas Masilionis; Nevenka Dimitrova; Christine A. Iacobuzio-Donahue; Ronan Chaligné; Dana Pe’er; Joan Massagué; Scott W. Lowe
Author Correction: Clonal evolution during metastatic spread in high-risk neuroblastoma

作者更正：高危神经母细胞瘤转移扩散过程中的克隆进化

Nature Genetics
IF0
2025-08-050
PRE
Gunes Gundem; Max F. Levine; Stephen S. Roberts; Irene Y. Cheung; Juan S. Medina-Martínez; Yi Feng; Juan E. Arango-Ossa; Loic Chadoutaud; Mathieu Rita; Georgios Asimomitis; Joe Zhou; Daoqi You; Nancy Bouvier; Barbara Spitzer; David B. Solit; Filemon Dela Cruz; Michael P. LaQuaglia; Brian H. Kushner; Shakeel Modak; Neerav Shukla; Christine A. Iacobuzio-Donahue; Andrew L. Kung; Nai-Kong V. Cheung; Elli Papaemmanuil
Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms

癌细胞通过不同机制限制反转录转座子表达的可免疫原性

IMMUNITY
IF26.3
2024-12-012
OAAI
Sun, Siyu; You, Eunae; Hong, Jungeui; Hoyos, David; Del Priore, Isabella; Tsanov, Kaloyan M.; Mattagajasingh, Om; Di Gioacchino, Andrea; Marhon, Sajid A.; Chacon-Barahona, Jonathan; Li, Hao; Jiang, Hua; Hozeifi, Samira; Rosas-Bringas, Omar; Xu, Katherine H.; Song, Yuhui; Lang, Evan R.; Rojas, Alexandra S.; Nieman, Linda T.; Patel, Bidish K.; Murali, Rajmohan; Chanda, Pharto; Karacay, Ali; Vabret, Nicolas; De Carvalho, Daniel D.; Zenklusen, Daniel; Lacava, John; Lowe, Scott W.; Ting, David T.; lacobuzio-Donahue, Christine A.; Solovyov, Alexander; Greenbaum, Benjamin D.
Phase II trial of Pembrolizumab and OLApaRib (POLAR) maintenance for select patients (pts) with metastatic pancreatic cancer (mPC) with (A) homologous recombination deficiency (HRD), (B) non-core HRD (ncHRD) and (C) exceptional response to platinum

II期临床试验，评估Pembrolizumab和OLApaRib（POLAR）用于具有同源重组缺陷（HRD）、非核心同源重组缺陷（ncHRD）以及对铂类药物有例外反应的转移性胰腺癌（mPC）患者的维持治疗。

ANNALS OF ONCOLOGY
IF65.4
2024-09-010
PRE
Park, W.; Connor, C. O'; Chou, J.; Schwartz, C.; Larsen, M.; Varghese, A.; Yu, K.; Balogun, F.; Yang, J.; Katz, S.; Kelsen, D.; Umeda, S.; Bandlamudi, C.; Riaz, N.; Berger, M.; Balachandran, V.; Peer, D.; Capanu, M.; Iacobuzio-Donahue, C.; O'Reilly, E. M.
Combination immunohistochemistry for CK5/6, p63, GATA6, and HNF4a predicts clinical outcome in treatment-naïve pancreatic ductal adenocarcinoma
SCIENTIFIC REPORTS
IF3.9
2024-07-061
OAAI
Shibayama, Takahiro; Hayashi, Akimasa; Toki, Masao; Kitahama, Keiichiro; Ho, Yu-Jui; Kato, Kenichiro; Yamada, Takahiro; Kawamoto, Sho; Kambayashi, Komei; Ochiai, Kazushige; Gondo, Koichi; Okano, Naohiro; Melchor, Jerry P.; Iacobuzio-Donahue, Christine A.; Sakamoto, Yoshihiro; Hisamatsu, Tadakazu; Shibahara, Junji
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
NATURE MEDICINE
IF50
2024-06-284
OA
Bojmar, Linda; Zambirinis, Constantinos P.; Hernandez, Jonathan M.; Chakraborty, Jayasree; Shaashua, Lee; Kim, Junbum; Johnson, Kofi Ennu; Hanna, Samer; Askan, Gokce; Burman, Jonas; Ravichandran, Hiranmayi; Zheng, Jian; Jolissaint, Joshua S.; Srouji, Rami; Song, Yi; Choubey, Ankur; Kim, Han Sang; Cioffi, Michele; van Beek, Elke; Sigel, Carlie; Jessurun, Jose; Velasco Riestra, Paulina; Blomstrand, Hakon; Joensson, Carolin; Joensson, Anette; Lauritzen, Pernille; Buehring, Weston; Ararso, Yonathan; Hernandez, Dylanne; Vinagolu-Baur, Jessica P.; Friedman, Madison; Glidden, Caroline; Firmenich, Laetitia; Lieberman, Grace; Mejia, Dianna L.; Nasar, Naaz; Mutvei, Anders P.; Paul, Doru M.; Bram, Yaron; Costa-Silva, Bruno; Basturk, Olca; Boudreau, Nancy; Zhang, Haiying; Matei, Irina R.; Hoshino, Ayuko; Kelsen, David; Sagi, Irit; Scherz, Avigdor; Scherz-Shouval, Ruth; Yarden, Yosef; Oren, Moshe; Egeblad, Mikala; Lewis, Jason S.; Keshari, Kayvan; Grandgenett, Paul M.; Hollingsworth, Michael A.; Rajasekhar, Vinagolu K.; Healey, John H.; Bjoernsson, Bergthor; Simeone, Diane M.; Tuveson, David A.; Iacobuzio-Donahue, Christine A.; Bromberg, Jaqueline; Vincent, C. Theresa; O'Reilly, Eileen M.; DeMatteo, Ronald P.; Balachandran, Vinod P.; D'Angelica, Michael I.; Kingham, T. Peter; Allen, Peter J.; Simpson, Amber L.; Elemento, Olivier; Sandstroem, Per; Schwartz, Robert E.; Jarnagin, William R.; Lyden, David
A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
CLINICAL CANCER RESEARCH
IF10.2
2024-06-121
PRE
Song, Yi; Boerner, Thomas; Drill, Esther; Shin, Paul; Kumar, Sandeep; Sigel, Carlie; Cercek, Andrea; Kemeny, Nancy; Abou-Alfa, Ghassan; Iacobuzio-Donahue, Christine; Cowzer, Darren; Schultz, Nikolaus; Walch, Henry; Balachandran, Vinod; Koerkamp, Bas Groot; Kingham, Peter; Soares, Kevin; Wei, Alice; D'Angelica, Michael; Drebin, Jeffrey; Chandwani, Rohit; Harding, James J.; Jarnagin, William

研究方向

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R
Ralph H. Hruban
H 指数:209论文数:1,975被引数:20.4万
A
ArkingDan
H 指数:156论文数:1,818被引数:10.6万
A
Alvin P. Makohon-Moore
H 指数:21论文数:155被引数:3,901
E
Eileen M. O’Reilly
H 指数:100论文数:1,159被引数:4.3万
M
Michael Goggins
H 指数:132论文数:1,051被引数:6.8万
S
Shigeaki Umeda
H 指数:17论文数:138被引数:916
Y
Yi Zhong
H 指数:41论文数:156被引数:7,266
A
Akimasa Hayashi
H 指数:27论文数:203被引数:4,150
L
Laura D. Wood
H 指数:78论文数:583被引数:5.0万
J
Joseph M. Herman
H 指数:87论文数:916被引数:3.1万