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Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil Chatterjee, Susanta; Naeli, Parisa; Onar, Okan; Simms, Nicole; Garzia, Aitor; Hackett, Angela; Coyle, Kelsey; Harris Snell, Patric; McGirr, Tom; Sawant, Tanvi Nitin; Dang, Kexin; Stoichkova, Zornitsa Vasileva; Azam, Yumna; Saunders, Mark P.; Braun, Michael; Alain, Tommy; Tuschl, Thomas; McDade, Simon S.; Longley, Daniel B.; Gkogkas, Christos G.; Adrain, Colin; Knight, John R. P.; Jafarnejad, Seyed Mehdi 分享 收藏
Spatial effects of infiltrating T cells on neighbouring cancer cells and prognosis in stage III CRC patients Azimi, Mohammadreza; Cho, Sanghee; Bozkurt, Emir; McDonough, Elizabeth; Kisakol, Batuhan; Matveeva, Anna; Salvucci, Manuela; Dussmann, Heiko; McDade, Simon; Firat, Canan; Urganci, Nil; Shia, Jinru; Longley, Daniel B.; Ginty, Fiona; Prehn, Jochen H. M. 分享 收藏
USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF Jurisic, Anamarija; Sung, Pei-Ju; Wappett, Mark; Daubriac, Julien; Lobb, Ian T.; Kung, Wei-Wei; Crawford, Nyree; Page, Natalie; Cassidy, Eamon; Feutren-Burton, Stephanie; Rountree, J. S. Shane; Helm, Matthew D.; O'Dowd, Colin R.; Kennedy, Richard D.; Gavory, Gerald; Cranston, Aaron N.; Longley, Daniel B.; Jacq, Xavier; Harrison, Timothy 分享 收藏
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A novel first-in-class USP19 inhibitor for the treatment of cancer-induced muscle atrophy Page, Natalie; Karthikaisamy, Vignesh; O'Hara, Darren; Cranston, Aaron N.; O'Dowd, Colin R.; Jacq, Xavier; Wilkinson, Richard; Burton, Stephanie; Gibson, Hayley; Costa, Joana; Longley, Daniel; Helm, Matthew; McGivern, Chris; Shepherd, Steven; Bell, Christina; Hewitt, Peter; McFarland, Mary; Miel, Hugues; Whitehead, Steven; Proctor, Lauren; Rountree, Shane J.; Wappett, Mark; Diaz, Mauricio Berriel; Herzig, Stephan; Harrison, Timothy 分享 收藏
Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features 上皮tgf β 参与生长因子信号传导以避免细胞凋亡并以侵袭性特征驱动肠道肿瘤发生 Flanagan, Dustin J.; Amirkhah, Raheleh; Vincent, David F.; Gunduz, Nuray; Gentaz, Pauline; Cammareri, Patrizia; McCooey, Aoife J.; McCorry, Amy M. B.; Fisher, Natalie C.; Davis, Hayley L.; Ridgway, Rachel A.; Lohuis, Jeroen; Leach, Joshua D. G.; Jackstadt, Rene; Gilroy, Kathryn; Mariella, Elisa; Nixon, Colin; Clark, William; Hedley, Ann; Markert, Elke K.; Strathdee, Douglas; Bartholin, Laurent; Redmond, Keara L.; Kerr, Emma M.; Longley, Daniel B.; Ginty, Fiona; Cho, Sanghee; Coleman, Helen G.; Loughrey, Maurice B.; Bardelli, Alberto; Maughan, Timothy S.; Campbell, Andrew D.; Lawler, Mark; Leedham, Simon J.; Barry, Simon T.; Inman, Gareth J.; van Rheenen, Jacco; Dunne, Philip D.; Sansom, Owen J. 分享 收藏
Multiplexed Immunofluorescence Imaging Reveals an Immune-Rich Tumor Microenvironment in Mucinous Rectal Cancer Characterized by Increased Lymphocyte Infiltration and Enhanced Programmed Cell Death Protein 1 Expression Duggan, William P.; Kisakol, Batuhan; O'Connell, Emer; Matveeva, Anna; O'Grady, Tony; McDonough, Elizabeth; Lindner, Andreas U.; McNamara, Deborah; Longley, Daniel; Ginty, Fiona; Burke, John P.; Prehn, Jochen H. M. 分享 收藏
Apoptotic and Necroptotic Mediators are Differentially Expressed in Mucinous and Non-Mucinous Colorectal Cancer O'Connell, Emer; Reynolds, Ian S.; Lindner, Andreas U.; Salvucci, Manuela; O'Grady, Tony; Bacon, Orna; Cho, Sanghee; McDonough, Elizabeth; Longley, Daniel; Ginty, Fiona; McNamara, Deborah A.; Burke, John P.; Prehn, Jochen H. M. 分享 收藏
Stratification of chemotherapy-treated stage III colorectal cancer patients using multiplexed imaging and single-cell analysis of T-cell populations Stachtea, Xanthi; Loughrey, Maurice B.; Salvucci, Manuela; Lindner, Andreas U.; Cho, Sanghee; McDonough, Elizabeth; Sood, Anup; Graf, John; Santamaria-Pang, Alberto; Corwin, Alex; Laurent-Puig, Pierre; Dasgupta, Sonali; Shia, Jinru; Owens, Jonathan R.; Abate, Samantha; Van Schaeybroeck, Sandra; Lawler, Mark; Prehn, Jochen H. M.; Ginty, Fiona; Longley, Daniel B. 分享 收藏
Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist-Treated Prostate Cancers 在AR拮抗剂治疗的前列腺癌中，减弱适应性vegf-a和IL8信号可恢复持久的肿瘤控制 Maxwell, Pamela J.; McKechnie, Melanie; Armstrong, Christopher W.; Manley, Judith M.; Ong, Chee Wee; Worthington, Jenny; Mills, Ian G.; Longley, Daniel B.; Quigley, James P.; Zoubeidi, Amina; de Bono, Johann S.; Deryugina, Elena; LaBonte, Melissa J.; Waugh, David J. J. 分享 收藏
Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists Grinkevitch, Vera; Wappett, Mark; Crawford, Nyree; Price, Stacey; Lees, Andrea; McCann, Christopher; McAllister, Katherine; Prehn, Jochen; Young, Jamie; Bateson, Jess; Gallagher, Lewis; Michaut, Magali; Iyer, Vivek; Chatzipli, Aikaterini; Barthorpe, Syd; Ciznadija, Daniel; Sloma, Ido; Wesa, Amy; Tice, David A.; Wessels, Lodewyk; Garnett, Mathew; Longley, Daniel B.; McDermott, Ultan; McDade, Simon S. 分享 收藏
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