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S

Steffen Boettcher

broad institute
H指数:27
被引数:4,857

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Functional Classification of Monoallelic TP53 Mutations Refines Prognostic Stratification in Myelodysplastic Neoplasms

单等位基因TP53突变的功能分类细化了骨髓增生异常性肿瘤的预后分层

Blood
IF23.1
2026-10-060
OAAI
Alexander Streuer; Yotaro Ochi; Stephan Hutter; Vladimir Riabov; Yasuhito Nannya; Laurenz Steiner; Mohammed Abba; Georgia Metzgeroth; Eva Altrock; Felicitas Rapp; Verena Nowak; Edin Hepgülüm; Steffen Boettcher; Torsten Haferlach; Daniel Nowak; Wolf-Karsten Hofmann; Seishi Ogawa; Nanni Schmitt
SLIT2 modulates leukaemic cell proliferation and stromal support in acute myeloid leukaemia models

SLIT2调节急性髓系白血病模型中白血病细胞的增殖和基质支持

British Journal of Haematology
IF3.8
2026-09-290
PRE
Luise Albuquerque-Simões; Isabel Weinhäuser; Diego A. Pereira-Martins; César Alexander Ortiz Rojas; Lúcio Henrique Sousa Pinheiro; Livia Bassani Lins de Miranda; Thiago Mantello Bianco; Rita de Cássia Cavaglieri; Mariane Cristina do Nascimento; Lynn Quek; Steffen Boettcher; Jan Jacob Schuringa; Eduardo Magalhães Rego
Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response

TP53突变型急性髓系白血病的化疗耐药性需要甲羟戊酸代谢产物法尼基焦磷酸，以诱导适应性应激反应。

Leukemia
IF13.4
2025-07-090
OAAI
Sarah J. Skuli; A’ishah Bakayoko; Marisa Kruidenier; Bryan Manning; Paige Pammer; Akmal Salimov; Owen Riley; Gisela Brake-Sillá; Derrick Dopkin; Michael Bowman; Leslie N. Martinez-Gutierrez; Colin C. Anderson; Julie A. Reisz; Roberta Buono; Madhuri Paul; Estelle Saland; Francesca Liccardo; Ann DeVine; Sarah Wong; Jimmy P. Xu; Eva Nee; Ryan Hausler; Steffen Boettcher; Said M. Sebti; Catherine Lai; Kara N. Maxwell; Jean-Emmanuel Sarry; David A. Fruman; Angelo D’Alessandro; Clementina Mesaros; Brian Keith; M. Celeste Simon; Pamela J. Sung; Gerald Wertheim; Nicolas Skuli; Robert L. Bowman; Andrew Matthews; Martin Carroll
Restoring p53-wild type conformation in TP53-Y220C mutant acute myeloid leukemia

在TP53-Y220C突变的急性髓系白血病中恢复p53野生型构象

Blood
IF23.1
2025-07-050
PRE
Bing Z. Carter; Po Yee Mak; Edward Ayoub; Xiaogang Wu; Baozhen Ke; Yuki Nishida; Andrew Futreal; Lauren B. Ostermann; Andrea D. Bedoy; Steffen Boettcher; Courtney D. DiNardo; Anna Puzio-Kuter; Masha V. Poyurovsky; Arnold Levine; Michael Andreeff
Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1 (vol 13, 53, 2023)

靶向表观遗传共依赖性增强了在MLL1-r或突变NPM1的AML中Menin抑制剂的抗AML疗效（卷13，53，2023）

BLOOD CANCER JOURNAL
IF11.6
2025-05-210
OA
Fiskus, Warren; Mill, Christopher P.; Birdwell, Christine; Davis, John A.; Das, Kaberi; Boettcher, Steffen; Kadia, Tapan M.; Dinardo, Courtney D.; Takahashi, Koichi; Loghavi, Sanam; Soth, Michael J.; Heffernan, Tim; Mcgeehan, Gerard M.; Ruan, Xinjia; Su, Xiaoping; Vakoc, Christopher R.; Daver, Naval; Bhalla, Kapil N.
Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway (vol 22, pg 91, 2012)

由结肠癌细胞诱导的内皮CCR2信号通过JAK2-Stat5和p38MAPK通路促进外渗 (vol 22, pg 91, 2012)

CANCER CELL
IF44.5
2025-05-010
PRE
Wolf, Monika Julia; Hoos, Alexandra; Bauer, Judith; Boettcher, Steffen; Knust, Markus; Weber, Achim; Simonavicius, Nicole; Schneider, Christoph; Lang, Matthias; Stuerzl, Michael; Croner, Roland S.; Konrad, Andreas; Manz, Markus G.; Moch, Holger; Aguzzi, Adriano; van Loo, Geert; Pasparakis, Manolis; Prinz, Marco; Borsig, Lubor; Heikenwalder, Mathias
Mutagenic DNA Lesions in Normal Hematopoietic Stem Cells Persist for Years Causing Distinct Patterns of Mutation

正常造血干细胞中的致突变DNA损伤持续数年并导致特异的突变模式

BLOOD
IF23.1
2024-11-050
PRE
Chapman, Michael Spencer; Mitchell, Emily; Yoshida, Kenichi; Williams, Nicholas; Fabre, Margarete A.; Ranzoni, Anna Maria; Robinson, Philip S.; Kregar, Lori; Wilk, C. Matthias; Boettcher, Steffen; Mahbubani, Krishnaa; Saeb-Parsy, Kourosh; Ng, Stanley; Vassiliou, George S.; Gowers, Kate; Janes, Sam; Hoare, Matt; Green, Anthony R.; Cvejic, Ana; Manz, Markus G.; Laurenti, Elisa; Martincorena, Inigo; Stratton, Michael; Nangalia, Jyoti; Coorens, Tim H. H.; Campbell, Peter
Clonal dynamics after allogeneic haematopoietic cell transplantation

同种异基因造血细胞移植后的克隆动态

Nature
IF48.5
2024-10-300
OAAI
Michael Spencer Chapman; C. Matthias Wilk; Steffen Boettcher; Emily Mitchell; Kevin Dawson; Nicholas Williams; Jan Müller; Larisa Kovtonyuk; Hyunchul Jung; Francisco Caiado; Kirsty Roberts; Laura O’Neill; David G. Kent; Anthony R. Green; Jyoti Nangalia; Markus G. Manz; Peter J. Campbell
Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells

靶向甲羟戊酸或Wnt途径以克服TP53-mutant AML细胞中的CAR T细胞抗性

EMBO MOLECULAR MEDICINE
IF8.3
2024-02-143
OAAI
Mueller, Jan; Schimmer, Roman R.; Koch, Christian; Schneiter, Florin; Fullin, Jonas; Lysenko, Veronika; Pellegrino, Christian; Klemm, Nancy; Russkamp, Norman; Myburgh, Renier; Volta, Laura; Theocharides, Alexandre P. A.; Kurppa, Kari J.; Ebert, Benjamin L.; Schroeder, Timm; Manz, Markus G.; Boettcher, Steffen
Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias
SCIENCE ADVANCES
IF12.5
2023-12-013
OAAI
Nishida, Yuki; Ishizawa, Jo; Ayoub, Edward; Montoya, Rafael Heinz; Ostermann, Lauren B.; Muftuoglu, Muharrem; Ruvolo, Vivian R.; Patsilevas, Tallie; Scruggs, Darah A.; Khazaei, Shayaun; Mak, Po Yee; Tao, Wenjing; Carter, Bing Z.; Boettcher, Steffen; Ebert, Benjamin L.; Daver, Naval G.; Konopleva, Marina; Seki, Takahiko; Kojima, Kensuke; Andreeff, Michael
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders
IMMUNITY
IF26.3
2023-12-0111
OAAI
Wilk, C. Matthias; Cathomas, Flurin; Torok, Orsolya; Le Berichel, Jessica; Park, Matthew D.; Bigenwald, Camille; Heaton, George R.; Hamon, Pauline; Troncoso, Leanna; Scull, Brooks P.; Dangoor, Diana; Silvin, Aymeric; Fleischmann, Ryan; Belabed, Meriem; Lin, Howard; Taouli, Elias Merad; Boettcher, Steffen; Li, Long; Aubry, Antonio; Manz, Markus G.; Kofler, Julia K.; Yue, Zhenyu; Lira, Sergio A.; Ginhoux, Florent; Crary, John F.; McClain, Kenneth L.; Picarsic, Jennifer L.; Russo, Scott J.; Allen, Carl E.; Merad, Miriam
RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia
LEUKEMIA
IF13.4
2023-06-302
PRE
Marion, William; Koppe, Tiago; Chen, Chun-Chin; Wang, Dahai; Frenis, Katie; Fierstein, Sara; Sensharma, Prerana; Aumais, Olivia; Peters, Michael; Ruiz-Torres, Sonya; Chihanga, Tafadzwa; Boettcher, Steffen; Shimamura, Akiko; Bauer, Daniel E.; Schlaeger, Thorsten; Wells, Susanne I. I.; Ebert, Benjamin L. L.; Starczynowski, Daniel; da Rocha, Edroaldo Lummertz; Rowe, R. Grant

研究方向

暂未获取到该数据
M
Markus G. Manz
H 指数:79论文数:601被引数:3.0万
B
Benjamin L. Ebert
H 指数:122论文数:775被引数:15.4万
C
Courtney D. DiNardo
H 指数:94论文数:1,588被引数:4.8万
M
Michael Andreeff
H 指数:139论文数:1,997被引数:7.4万
B
Bing Z. Carter
H 指数:36论文数:260被引数:4,136
K
Kari J. Kurppa
H 指数:19论文数:87被引数:2,375
L
Lauren B. Ostermann
H 指数:10论文数:87被引数:395
S
Sanam Loghavi
H 指数:50论文数:645被引数:1.3万
N
Naval Daver
H 指数:89论文数:1,412被引数:3.3万
N
Nancy Klemm
H 指数:7论文数:36被引数:165