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收藏The common murine retroviral integration site activating Hhex marks a distal regulatory enhancer co-opted in human early T-cell precursor leukemia
Hardwick, Joyce; Rodriguez-Hernaez, Javier; Gambi, Giovanni; Venters, Bryan J.; Guo, Van; Li, Liqi; Love, Paul E.; Copeland, Neal G.; Jenkins, Nancy A.; Papaioannou, Dimitrios; Aifantis, Iannis; Tsirigos, Aristotelis; Ivan, Mircea; Dave, Utpal P.
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收藏Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunitymiR-17 ∼ 92家族在胸腺细胞发育、白血病发生和自身免疫中的关键作用
Liao, Kunyu; Chen, Pengda; Zhang, Mengdi; Wang, Jiazhen; Hatzihristidis, Teri; Lin, Xiaoxi; Yang, Liang; Yao, Nan; Liu, Chenfeng; Hong, Yazhen; Li, Xia; Liu, Hong; Zuniga-Pflucker, Juan Carlos; Love, Paul E.; Chen, Xiang; Liu, Wen-Hsien; Zhao, Bin; Xiao, Changchun
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收藏Antagonism-enforced braking system to enhance CAR T cell therapeutic specificity
Kondo, Taisuke; Bourassa, Francois X.; Achar, Sooraj; DuSold, Justyn; Cespedes, Pablo; Wahlsten, Madison; Kvalvaag, Audun; Gaud, Guillaume; Love, Paul; Dustin, Michael; Altan-Bonnet, Gregoire; Francois, Paul; Taylor, Naomi
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收藏CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides (vol 24, pg 2121, 2023)CD3ζ ITAMs通过抑制响应低亲和力肽的TCR信号传导来实现配体区分和拮抗作用 (第24卷,2121页,2023)
Gaud, Guillaume; Achar, Sooraj; Bourassa, Francois X. P.; Davies, John; Hatzihristidis, Teri; Choi, Seeyoung; Kondo, Taisuke; Gossa, Selamawit; Lee, Jan; Juneau, Paul; Taylor, Naomi; Hinrichs, Christian S.; McGavern, Dorian B.; Francois, Paul; Altan-Bonnet, Gregoire; Love, Paul E.
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收藏CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptidesCD3ζ ITAMs通过抑制响应低亲和力肽的TCR信号传导来实现配体区分和拮抗作用
Gaud, Guillaume; Achar, Sooraj; Bourassa, Francois X. P.; Davies, John; Hatzihristidis, Teri; Choi, Seeyoung; Kondo, Taisuke; Gossa, Selamawit; Lee, Jan; Juneau, Paul; Taylor, Naomi; Hinrichs, Christian S.; Mcgavern, Dorian B.; Francois, Paul; Altan-Bonnet, Gregoire; Love, Paul E.
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收藏THEMIS increases TCR signaling in CD4+CD8+thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1THEMIS通过抑制酪氨酸磷酸酶SHP1的活性增加CD4 CD8胸腺细胞中的TCR信号传导
Choi, Seeyoung; Lee, Jan; Hatzihristidis, Teri; Gaud, Guillaume; Dutta, Avik; Arya, Awadhesh; Clubb, Lauren M.; Stamos, Daniel B.; Markovics, Adrienn; Mikecz, Katalin; Love, Paul E.
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收藏TCR/Chimeric Antigen Receptor (CAR) Cross-Antagonism to Fine-Tune CAR-T cell Immunotherapy
Altan-Bonnet, Gregoire; Kondo, Taisuke; Bourassa, Francois X.; Achar, Sooraj; DuSold, Justyn; Cespedes, Pablo; Wahlsten, Madison; Gaud, Guillaume; Love, Paul E.; Dustin, Mike; Francois, Paul; Taylor, Naomi
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收藏GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1GRB2通过促进THEMIS介导的SHP1失活促进胸腺细胞正向选择
Choi, Seeyoung; Hatzihristidis, Teri; Gaud, Guillaume; Dutta, Avik; Lee, Jan; Arya, Awadhesh; Clubb, Lauren M.; Stamos, Daniel B.; Markovics, Adrienn; Mikecz, Katalin; Love, Paul
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收藏The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells
Park, JM; Kohn, MJ; Bruinsma, MW; Vech, C; Intine, RV; Fuhrmann, S; Grinberg, A; Mukherjee, I; Love, PE; Ko, MS; DePamphilis, ML; Maraia, RJ
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收藏THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signalsTHEMIS通过促进TCR非依赖性信号增强正常和神经炎性1型免疫反应的强度
Yang, Cui; Blaize, Gaetan; Marrocco, Remi; Rouquie, Nelly; Bories, Cyrielle; Gador, Mylene; Melique, Suzanne; Joulia, Emeline; Benamar, Mehdi; Dejean, Anne S.; Daniels-Treffandier, Helene; Love, Paul E.; Fazilleau, Nicolas; Saoudi, Abdelhadi; Lesourne, Renaud
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