William S. Hlavacek - Publications, H-index & Citations

William S. Hlavacek

united states department of energy (doe)

43H指数

174论文数

9.0K被引数

收录论文 47

发表时间

Using PyBioNetFit to leverage qualitative and quantitative data in biological model parameterization and uncertainty quantification 使用PyBioNetFit利用定性及定量数据在生物模型参数化与不确定性量化中

Frontiers in Immunology

IF5.9

2026-04-29

OAAI

EF Ely F. Miller †; AM Abhishek Mallela † ‡; JN Jacob Neumann; YT Yen Ting Lin; WS William S. Hlavacek; RG Richard G. Posner

Phase II Trial of Vemurafenib and Sorafenib Combination in Advanced KRAS-Mutated Metastatic Pancreatic Cancer vemurafenib和sorafenib联合治疗晚期KRAS突变型转移性胰腺癌的II期临床试验

Journal of Immunotherapy and Precision Oncology

IF3.2

2026-02-01

PREAI

Khawaja, Muhammad Rizwan; Jameson, Gayle; Cridebring, Derek; Shannon, Patricia; Han, Haiyong; Moore, Jaeger; Von Hoff, Daniel; Posner, Richard G.; Hlavacek, William S.; Kolch, Walter; Kholodenko, Boris N.; Rukhlenko, Oleksii S.; Roe, Denise J.; Wertheim, Betsy C.; Borazanci, Erkut

Phase II Trial of Vemurafenib plus Sorafenib in Advanced KRAS Mutated Pancreas Cancer

CANCER RESEARCH

IF16.6

2024-09-15

PREAI

Borazanci, Erkut; Jameson, Gayle; Khawaja, Muhammad; Cridebring, Derek; Shannon, Patricia; Gordon, Michael; Han, Haiyong; Moore, Jaeger; Von Hoff, Daniel; Posner, Richard; Hlavacek, William; Kolch, Walter; Kholodenko, Boris; Rukhlenko, Oleksii

Title evaluation of FluSight influenza forecasting in the 2021-22 and 2022-23 seasons with a new target laboratory-confirmed influenza hospitalizations

NATURE COMMUNICATIONS

IF15.7

2024-07-26

OAAI

Mathis, Sarabeth M.; Webber, Alexander E.; Leon, Tomas M.; Murray, Erin L.; Sun, Monica; White, Lauren A.; Brooks, Logan C.; Green, Alden; Hu, Addison J.; Rosenfeld, Roni; Shemetov, Dmitry; Tibshirani, Ryan J.; McDonald, Daniel J.; Kandula, Sasikiran; Pei, Sen; Yaari, Rami; Yamana, Teresa K.; Shaman, Jeffrey; Agarwal, Pulak; Balusu, Srikar; Gururajan, Gautham; Kamarthi, Harshavardhan; Prakash, B. Aditya; Raman, Rishi; Zhao, Zhiyuan; Rodriguez, Alexander; Meiyappan, Akilan; Omar, Shalina; Baccam, Prasith; Gurung, Heidi L.; Suchoski, Brad T.; Stage, Steve A.; Ajelli, Marco; Kummer, Allisandra G.; Litvinova, Maria; Ventura, Paulo C.; Wadsworth, Spencer; Niemi, Jarad; Carcelen, Erica; Hill, Alison L.; Loo, Sara L.; McKee, Clifton D.; Sato, Koji; Smith, Claire; Truelove, Shaun; Jung, Sung-mok; Lemaitre, Joseph C.; Lessler, Justin; McAndrew, Thomas; Ye, Wenxuan; Bosse, Nikos; Hlavacek, William S.; Lin, Yen Ting; Mallela, Abhishek; Gibson, Graham C.; Chen, Ye; Lamm, Shelby M.; Lee, Jaechoul; Posner, Richard G.; Perofsky, Amanda C.; Viboud, Cecile; Clemente, Leonardo; Lu, Fred; Meyer, Austin G.; Santillana, Mauricio; Chinazzi, Matteo; Davis, Jessica T.; Mu, Kunpeng; Pastore y Piontti, Ana; Vespignani, Alessandro; Xiong, Xinyue; Ben-Nun, Michal; Riley, Pete; Turtle, James; Hulme-Lowe, Chis; Jessa, Shakeel; Nagraj, V. P.; Turner, Stephen D.; Williams, Desiree; Basu, Avranil; Drake, John M.; Fox, Spencer J.; Suez, Ehsan; Cojocaru, Monica G.; Thommes, Edward W.; Cramer, Estee Y.; Gerding, Aaron; Stark, Ariane; Ray, Evan L.; Reich, Nicholas G.; Shandross, Li; Wattanachit, Nutcha; Wang, Yijin; Zorn, Martha W.; Al Aawar, Majd; Srivastava, Ajitesh; Meyers, Lauren A.; Adiga, Aniruddha; Hurt, Benjamin; Kaur, Gursharn; Lewis, Bryan L.; Marathe, Madhav; Venkatramanan, Srinivasan; Butler, Patrick; Farabow, Andrew; Ramakrishnan, Naren; Muralidhar, Nikhil; Reed, Carrie; Biggerstaff, Matthew; Borchering, Rebecca K.

Differential contagiousness of respiratory disease across the United States

EPIDEMICS

IF2.4

2023-12-01

OAAI

Mallela, Abhishek; Lin, Yen Ting; Hlavacek, William S.

Bayesian Inference of State-Level COVID-19 Basic Reproduction Numbers across the United States

VIRUSES-BASEL

IF3.5

2022-01-15

OAAI

Mallela, Abhishek; Neumann, Jacob; Miller, Ely F.; Chen, Ye; Posner, Richard G.; Lin, Yen Ting; Hlavacek, William S.

Daily Forecasting of Regional Epidemics of Coronavirus Disease with Bayesian Uncertainty Quantification, United States

EMERGING INFECTIOUS DISEASES

IF6.6

2021-01-01

OAAI

Lin, Yen Ting; Neumann, Jacob; Miller, Ely F.; Posner, Richard G.; Mallela, Abhishek; Safta, Cosmin; Ray, Jaideep; Thakur, Gautam; Chinthavali, Supriya; Hlavacek, William S.

Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2020-03-19

OAAI

Salazar-Cavazos, Emanuel; Nitta, Carolina Franco; Mitra, Eshan D.; Wilson, Bridget S.; Lidke, Keith A.; Hlavacek, William S.; Lidke, Diane S.

Scaling methods for accelerating kinetic Monte Carlo simulations of chemical reaction networks

JOURNAL OF CHEMICAL PHYSICS

IF3.1

2019-06-24

OAAI

Lin, Yen Ting; Feng, Song; Hlavacek, William S.

Prediction of Optimal Drug Schedules for Controlling Autophagy

SCIENTIFIC REPORTS

IF3.9

2019-02-05

OAAI

Shirin, Afroza; Klickstein, Isaac S.; Feng, Song; Lin, Yen Ting; Hlavacek, William S.; Sorrentino, Francesco

New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling

SEMINARS IN CANCER BIOLOGY

IF15.7

2019-02-01

OAAI

Erickson, Keesha E.; Rukhlenko, Oleksii S.; Posner, Richard G.; Hlavacek, William S.; Kholodenko, Boris N.

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

SCIENCE SIGNALING

IF6.6

2018-10-09

OAAI

Civciristov, Srgjan; Ellisdon, Andrew M.; Suderman, Ryan; Pon, Cindy K.; Evans, Bronwyn A.; Kleifeld, Oded; Charlton, Steven J.; Hlavacek, William S.; Canals, Meritxell; Halls, Michelle L.

Using both qualitative and quantitative data in parameter identification for systems biology models

NATURE COMMUNICATIONS

IF15.7

2018-09-25

OAAI

Mitra, Eshan D.; Dias, Raquel; Posner, Richard G.; Hlavacek, William S.

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling

CELL SYSTEMS

IF7.7

2018-08-01

OAAI

Rukhlenko, Oleksii S.; Khorsand, Fahimeh; Krstic, Aleksandar; Rozanc, Jan; Alexopoulos, Leonidas G.; Rauch, Nora; Erickson, Keesha E.; Hlavacek, William S.; Posner, Richard G.; Gomez-Coca, Silvia; Rosta, Edina; Fitzgibbon, Cheree; Matallanas, David; Rauch, Jens; Kolch, Walter; Kholodenko, Boris N.

Timescale Separation of Positive and Negative Signaling Creates History-Dependent Responses to IgE Receptor Stimulation

SCIENTIFIC REPORTS

IF3.9

2017-11-14

OAAI

Harmon, Brooke; Chylek, Lily A.; Liu, Yanli; Mitra, Eshan D.; Mahajan, Avanika; Saada, Edwin A.; Schudel, Benjamin R.; Holowka, David A.; Baird, Barbara A.; Wilson, Bridget S.; Hlavacek, William S.; Singh, Anup K.

Differential mast cell outcomes are sensitive to FceRI-Syk binding kinetics

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2017-11-07

OAAI

Schwartz, Samantha L.; Cleyrat, Cedric; Olah, Mark J.; Relich, Peter K.; Phillips, Genevieve K.; Hlavacek, William S.; Lidke, Keith A.; Wilson, Bridget S.; Lidke, Diane S.

Allergen Valency, Dose, and FcERI Occupancy Set Thresholds for Secretory Responses to Pen a 1 and Motivate Design of Hypoallergens

JOURNAL OF IMMUNOLOGY

IF3.4

2017-02-01

OAAI

Mahajan, Avanika; Youssef, Lama A.; Cleyrat, Cedric; Grattan, Rachel; Lucero, Shayna R.; Mattison, Christopher P.; Erasmus, M. Frank; Jacobson, Bruna; Tapia, Lydia; Hlavacek, William S.; Schuyler, Mark; Wilson, Bridget S.

Relaxation oscillations and hierarchy of feedbacks in MAPK signaling

SCIENTIFIC REPORTS

IF3.9

2017-01-03

OAAI

Kochanczyk, Marek; Kocieniewski, Pawel; Kozlowska, Emilia; Jaruszewicz-Blonska, Joanna; Sparta, Breanne; Pargett, Michael; Albeck, John G.; Hlavacek, William S.; Lipniacki, Tomasz

Systems Biology Approach Reveals the Importance of SHC1-GRB2 Interactions in EGFR Phosphorylation Kinetics

BIOPHYSICAL JOURNAL

IF3.1

2016-02-01

OAAI

Salazar-Cavazos, Emanuel; Contreras-Vidal, Luis G.; Wilson, Bridget S.; Hlavacek, William S.; Lidke, Diane S.

Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2015-11-05

OAAI

Valley, Christopher C.; Arndt-Jovin, Donna J.; Karedla, Narain; Steinkamp, Mara P.; Chizhik, Alexey I.; Hlavacek, William S.; Wilson, Bridget S.; Lidke, Keith A.; Lidke, Diane S.

研究方向