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R

Robert T. Sauer

massachusetts institute of technology

H指数:109

被引数:3.9万

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An open axial channel of the AAA ClpXP protease enhances degradation of specific classes of protein substrates

PROTEIN SCIENCE

IF5.2

2025-12-230

OAAI

Structural insights into the Pseudomonas aeruginosa ClpP1•ClpP2 heterocomplex and its interactions with the AAA+ ClpX unfoldase

铜绿假单胞菌ClpP1•ClpP2异源复合体的结构解析及其与AAA+ ClpX解链酶的相互作用

Protein Science

IF5.2

2025-09-220

OAAI

A proteolytic AAA plus machine poised to unfold protein substrates

NATURE COMMUNICATIONS

IF15.7

2024-11-080

OAAI

How the double-ring ClpAP protease motor grips the substrate to unfold and degrade stable proteins

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-11-010

PRE

The membrane-cytoplasmic linker defines activity of FtsH proteases in Pseudomonas aeruginosa clone C

膜-细胞质接头定义了铜绿假单胞菌克隆C中FtsH蛋白酶的活性

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-02-011

OAAI

A closed translocation channel in the substrate-free AAA plus ClpXP protease diminishes rogue degradation

NATURE COMMUNICATIONS

IF15.7

2023-11-104

OAAI

Lon degrades stable substrates slowly but with enhanced processivity, redefining the attributes of a successful AAA plus protease

IF6.9

2023-09-012

OAAI

The SspB adaptor drives structural changes in the AAA plus ClpXP protease during ssrA-tagged substrate delivery

在ssrA标记的底物递送过程中，SspB衔接子驱动AAA加ClpXP蛋白酶的结构变化

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-02-024

OAAI

AAA plus protease-adaptor structures reveal altered conformations and ring specialization

AAA加蛋白酶接头结构揭示了改变的构象和环专业化

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2022-11-0310

OAAI

Structure and function of ClpXP, a AAA plus proteolytic machine powered by probabilistic ATP hydrolysis

由概率ATP水解驱动的AAA + 蛋白水解酶ClpXP的结构和功能

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

IF6.4

2021-12-1920

OA

Division of labor between the pore-1 loops of the D1 and D2 AAA+ rings coordinates substrate selectivity of the ClpAP protease

D1和D2 AAA环的pore-1环之间的分工协调ClpAP蛋白酶的底物选择性

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-12-013

OAAI

Heat activates the AAA plus HslUV protease by melting an axial autoinhibitory plug

IF6.9

2021-01-017

OAAI

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP

IF0

2020-12-0110

OA

Multistep substrate binding and engagement by the AAA plus ClpXP protease

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-10-2618

OAAI

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

IF0

2020-10-2233

OAAI

Modular and coordinated activity of AAA plus active sites in the double-ring ClpA unfoldase of the ClpAP protease

ClpAP蛋白酶的双环ClpA unfoldase中AAA加上活性位点的模块化和协调活性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-10-1311

OAAI

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

与蛋白质底物结合的ATP燃料ClpXP蛋白水解酶的结构

IF0

2020-02-28106

OA

Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in Vitro

酰基缩肽抗生素及其生物活性片段差异干扰结核分枝杆菌ClpXP1P2体外活性

ACS CHEMICAL BIOLOGY

IF3.8

2020-02-2111

OAAI

The Non-dominant AAA plus Ring in the ClpAP Protease Functions as an Anti-stalling Motor to Accelerate Protein Unfolding and Translocation

ClpAP蛋白酶中的非优势AAA plus环作为抗失速马达起作用，以加速蛋白质的展开和转运

IF6.9

2020-02-0123

OAAI

Interactions between a subset of substrate side chains and AAA plus motor pore loops determine grip during protein unfolding

IF0

2019-06-2815

OA