Robert T. Sauer - Publications, H-index & Citations

Robert T. Sauer

Massachusetts Institute of Technology

109H指数

541论文数

4.0W被引数

收录论文 129

发表时间

An open axial channel of the AAA ClpXP protease enhances degradation of specific classes of protein substrates

PROTEIN SCIENCE

IF5.2

2025-12-23

OAAI

Lyu, Yifei; Bolstad, Isabella; Davis, Joseph H.; Sauer, Robert T.; Ghanbarpour, Alireza

Structural insights into the Pseudomonas aeruginosa ClpP1•ClpP2 heterocomplex and its interactions with the AAA+ ClpX unfoldase 铜绿假单胞菌ClpP1•ClpP2异源复合体的结构解析及其与AAA+ ClpX解链酶的相互作用

Protein Science

IF5.2

2025-09-22

OAAI

Alireza Ghanbarpour; Jia Jia Zhang; Joseph H. Davis; Tania A. Baker; Robert T. Sauer

A proteolytic AAA plus machine poised to unfold protein substrates

NATURE COMMUNICATIONS

IF15.7

2024-11-08

OAAI

Ghanbarpour, Alireza; Sauer, Robert T.; Davis, Joseph H.

How the double-ring ClpAP protease motor grips the substrate to unfold and degrade stable proteins

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-11-01

PREAI

Shih, Tsai-Ting; Sauer, Robert T.; Baker, Tania A.

The membrane-cytoplasmic linker defines activity of FtsH proteases in Pseudomonas aeruginosa clone C 膜-细胞质接头定义了铜绿假单胞菌克隆C中FtsH蛋白酶的活性

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-02-01

OAAI

Mawla, Gina D.; Kamal, Shady M.; Cao, Lian-Ying; Purhonen, Pasi; Hebert, Hans; Sauer, Robert T.; Baker, Tania A.; Romling, Ute

A closed translocation channel in the substrate-free AAA plus ClpXP protease diminishes rogue degradation

NATURE COMMUNICATIONS

IF15.7

2023-11-10

OAAI

Ghanbarpour, Alireza; Cohen, Steven E.; Fei, Xue; Kinman, Laurel F.; Bell, Tristan A.; Zhang, Jia Jia; Baker, Tania A.; Davis, Joseph H.; Sauer, Robert T.

Lon degrades stable substrates slowly but with enhanced processivity, redefining the attributes of a successful AAA plus protease

CELL REPORTS

IF6.9

2023-09-01

OAAI

Kasal, Meghann R.; Kotamarthi, Hema Chandra; Johnson, Madeline M.; Stephens, Hannah M.; Lang, Matthew J.; Sauer, Robert T.; Baker, Tania A.

The SspB adaptor drives structural changes in the AAA plus ClpXP protease during ssrA-tagged substrate delivery 在ssrA标记的底物递送过程中，SspB衔接子驱动AAA加ClpXP蛋白酶的结构变化

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-02-02

OAAI

Ghanbarpour, Alireza; Fei, Xue; Baker, Tania A.; Davis, Joseph H.; Sauer, Robert T.

AAA plus protease-adaptor structures reveal altered conformations and ring specialization AAA加蛋白酶接头结构揭示了改变的构象和环专业化

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2022-11-03

OAAI

Kim, Sora; Fei, Xue; Sauer, Robert T.; Baker, Tania A.

Structure and function of ClpXP, a AAA plus proteolytic machine powered by probabilistic ATP hydrolysis 由概率ATP水解驱动的AAA + 蛋白水解酶ClpXP的结构和功能

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

IF6.4

2021-12-19

OAAI

Sauer, Robert T.; Fei, Xue; Bell, Tristan A.; Baker, Tania A.

Division of labor between the pore-1 loops of the D1 and D2 AAA+ rings coordinates substrate selectivity of the ClpAP protease D1和D2 AAA环的pore-1环之间的分工协调ClpAP蛋白酶的底物选择性

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-12-01

OAAI

Zuromski, Kristin L.; Kim, Sora; Sauer, Robert T.; Baker, Tania A.

Heat activates the AAA plus HslUV protease by melting an axial autoinhibitory plug

CELL REPORTS

IF6.9

2021-01-01

OAAI

Baytshtok, Vladimir; Fei, Xue; Shih, Tsai-Ting; Grant, Robert A.; Santos, Justin C.; Baker, Tania A.; Sauer, Robert T.

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP

ELIFE

IF0

2020-12-01

OAAI

Kim, Sora; Zuromski, Kristin L.; Bell, Tristan A.; Sauer, Robert T.; Baker, Tania A.

Multistep substrate binding and engagement by the AAA plus ClpXP protease

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-10-26

OAAI

Saunders, Reuben A.; Stinson, Benjamin M.; Baker, Tania A.; Sauer, Robert T.

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

ELIFE

IF0

2020-10-22

OAAI

Fei, Xue; Bell, Tristan A.; Barkow, Sarah R.; Baker, Tania A.; Sauer, Robert T.

Modular and coordinated activity of AAA plus active sites in the double-ring ClpA unfoldase of the ClpAP protease ClpAP蛋白酶的双环ClpA unfoldase中AAA加上活性位点的模块化和协调活性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-10-13

OAAI

Zuromski, Kristin L.; Sauer, Robert T.; Baker, Tania A.

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate 与蛋白质底物结合的ATP燃料ClpXP蛋白水解酶的结构

ELIFE

IF0

2020-02-28

106

OAAI

Fei, Xue; Bell, Tristan A.; Jenni, Simon; Stinson, Benjamin M.; Baker, Tania A.; Harrison, Stephen C.; Sauer, Robert T.

Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in Vitro 酰基缩肽抗生素及其生物活性片段差异干扰结核分枝杆菌ClpXP1P2体外活性

ACS CHEMICAL BIOLOGY

IF3.8

2020-02-21

OAAI

Schmitz, Karl R.; Handy, Emma L.; Compton, Corey L.; Gupta, Shashank; Bishai, William R.; Sauer, Robert T.; Sello, Jason K.

The Non-dominant AAA plus Ring in the ClpAP Protease Functions as an Anti-stalling Motor to Accelerate Protein Unfolding and Translocation ClpAP蛋白酶中的非优势AAA plus环作为抗失速马达起作用，以加速蛋白质的展开和转运

CELL REPORTS

IF6.9

2020-02-01

OAAI

Kotamarthi, Hema Chandra; Sauer, Robert T.; Baker, Tania A.

Interactions between a subset of substrate side chains and AAA plus motor pore loops determine grip during protein unfolding

ELIFE

IF0

2019-06-28

OAAI

Bell, Tristan A.; Baker, Tania A.; Sauer, Robert T.

研究方向