Joan A. Geoghegan - Publications, H-index & Citations

Joan A. Geoghegan

university of birmingham

43H指数

97论文数

6.7K被引数

收录论文 48

发表时间

Genetic determinants of Staphylococcus aureus adhesion shape virulence trade-offs in bacteremia 金黄色葡萄球菌粘附的遗传决定因素塑造败血症中的毒力权衡

Nature Communications

IF15.7

2026-05-19

OAAI

Francesc Coll; Paula Rożen; Monika Budnik; Halina Marchel; Joan A. Geoghegan; Katarzyna Holcman; Magdalena Mizia-Szubryt; Adrianna Berger-Kucza; Aldona Olechowska-Jarząb; Karol Makuch; Coralie Bouchiat-Sarabi; François Vandenesch; Marta Zapotoczna

Nanoscale Mechanics of FnBPB-Mediated Adhesion of Staphylococcus aureus to Skin Ligands 金黄色葡萄球菌FnBPB介导的皮肤配体粘附的纳米尺度力学

ACS Nano

IF16

2026-02-19

PREAI

Zhiyong Zheng; Manon Dechene-Tempier; Telmo O. Paiva; Can Wang; Sophie Dunn; Julianne Clowry; Alan D. Irvine; Joan A. Geoghegan; Yves F. Dufrêne

Large-scale characterisation of the nasal microbiome redefines Staphylococcus aureus colonisation status 大规模鼻腔微生物组表征重新定义了金黄色葡萄球菌定植状态

Nature Communications

IF15.7

2025-12-02

OAAI

Dinesh Aggarwal; Katherine L. Bellis; Beth Blane; Marcus C. de Goffau; Josef Wagner; Duncan Y. K. Ng; Kathy E. Raven; Plamena Naydenova; Stephen Kaptoge; Susan Burton; Rachel Henry; Catherine Perry; Matthew R. Walker; Carmel Moore; Carol Churcher; Sophia T. Girgis; Catarina Ribeiro de Sousa; Lauma Sarkane; Joe Brennan; Asha Akram; Shannon Duthie; Elisha Johnson; Mercedesz Juhasz; David Anderson; Susan Irvine; Amy McMahon; Liz Lay; Susannah J. Salter; Claire Raisen; Xiaoliang Ba; Mark Holmes; Andries J. van Tonder; Emanuele Di Angelantonio; Adam S. Butterworth; Joan A. Geoghegan; John Danesh; Julian Parkhill; Sharon J. Peacock; Ewan M. Harrison

A single amino acid substitution in Fibronectin Binding protein A (FnBPA) governs Staphylococcus aureus virulence via host transglutaminase-mediated fibrin crosslinking FnBPA蛋白（Fibronectin Binding protein A）中的一个氨基酸替换通过宿主转谷氨酰胺酶介导的纤维蛋白交联来调控金黄色葡萄球菌（Staphylococcus aureus）的毒力。

PLOS PATHOGENS

IF4.9

2025-12-01

PREAI

Motta, Chiara; Turley, Mary; Barbieri, Giulia; Fama, Agata; Coppolino, Francesco; Bellan Menegussi, Elisa; Geoghegan, Joan; Beninati, Concetta; Pellegrini, Angelica; Pietrocola, Giampiero

Simultaneous viscoelasticity and sprayability in antimicrobial acetic acid-alginate fluid gels

BIOMATERIALS ADVANCES

IF6

2025-01-01

OAAI

Robinson, Thomas E.; Clark, Callum; Moakes, Richard J. A.; Schofield, Zoe; Moiemen, Naiem; Geoghegan, Joan A.; Grover, Liam M.

Computational Design of Cyclic Peptide Inhibitors of a Bacterial Membrane Lipoprotein Peptidase

ACS CHEMICAL BIOLOGY

IF3.8

2024-05-07

OAAI

Craven, Timothy W.; Nolan, Mark D.; Bailey, Jonathan; Olatunji, Samir; Bann, Samantha J.; Bowen, Katherine; Ostrovitsa, Nikita; Da Costa, Thaina M.; Ballantine, Ross D.; Weichert, Dietmar; Levine, Paul M.; Stewart, Lance J.; Bhardwaj, Gaurav; Geoghegan, Joan A.; Cochrane, Stephen A.; Scanlan, Eoin M.; Caffrey, Martin; Baker, David

Distinct T cell signatures are associated with Staphylococcus aureus skin infection in pediatric atopic dermatitis

JCI INSIGHT

IF6.1

2024-04-11

OAAI

Clowry, Julianne; Dempsey, Daniel J.; Claxton, Tracey J.; Towell, Aisling M.; Turley, Mary B.; Sutton, Martin; Geoghegan, Joan A.; Kezic, Sanja; Jakasa, Ivone; White, Arthur; Irvine, Alan D.; Mcloughlin, Rachel M.

von Willebrand factor-binding protein (vWbp)-activated factor XIII and transglutaminase 2 (TG2) promote cross-linking between FnBPA from Staphylococcus aureus and fibrinogen

SCIENTIFIC REPORTS

IF3.9

2023-07-19

OAAI

Motta, Chiara; Pellegrini, Angelica; Camaione, Stefano; Geoghegan, Joan; Speziale, Pietro; Barbieri, Giulia; Pietrocola, Giampiero

High-force catch bonds between the Staphylococcus aureus surface protein SdrE and complement regulator factor H drive immune evasion

COMMUNICATIONS BIOLOGY

IF5.1

2023-03-21

OAAI

Paiva, Telmo O.; Geoghegan, Joan A.; Dufrene, Yves F.

Staphylococcal Periscope proteins Aap, SasG, and Pls project noncanonical legume-like lectin adhesin domains from the bacterial surface

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-03-01

OAAI

Clark, Laura C.; Atkin, Kate E.; Whelan, Fiona; Brentnall, Andrew S.; Harris, Gemma; Towell, Aisling M.; Turkenburg, Johan P.; Liu, Yan; Feizi, Ten; Griffiths, Samuel C.; Geoghegan, Joan A.; Potts, Jennifer R.

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

CELL REPORTS MEDICINE

IF10.6

2023-01-01

OAAI

Munoz-Wolf, Natalia; Ward, Ross W.; Hearnden, Claire H.; Sharp, Fiona A.; Geoghegan, Joan; O'Grady, Katie; McEntee, Craig P.; Shanahan, Katharine A.; Guy, Coralie; Bowie, Andrew G.; Campbell, Matthew; Roces, Carla. B.; Anderluzzi, Giulia; Webb, Cameron; Perrie, Yvonne; Creagh, Emma; Lavelle, Ed C.

Allantodapsone is a Pan-Inhibitor of Staphylococcus aureus Adhesion to Fibrinogen, Loricrin, and Cytokeratin 10

MICROBIOLOGY SPECTRUM

IF3.8

2022-06-29

OAAI

Prencipe, Filippo; Alsibaee, Aishah; Khaddem, Zainab; Norton, Padraig; Towell, Aisling M.; Ali, Afnan F. M.; Reid, Gerard; Fleury, Orla M.; Foster, Timothy J.; Geoghegan, Joan A.; Rozas, Isabel; Brennan, Marian P.

Fibronectin binding protein B binds to loricrin and promotes corneocyte adhesion by Staphylococcus aureus

NATURE COMMUNICATIONS

IF15.7

2022-05-06

OAAI

da Costa, Thaina M.; Viljoen, Albertus; Towell, Aisling M.; Dufrene, Yves F.; Geoghegan, Joan A.

Enantioselective effect of cysteine functionalized mesoporous silica nanoparticles in U87 MG and GM08680 human cells and Staphylococcus aureus bacteria

JOURNAL OF MATERIALS CHEMISTRY B

IF5.7

2021-01-01

PREAI

Martinez-Carmona, Marina; Cela, Carmela; Kuznetsova, Vera A.; Geoghegan, Joan A.; Gun'ko, Yurii K.

Staphylococcus aureus binds to the N-terminal region of corneodesmosin to adhere to the stratum corneum in atopic dermatitis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-12-23

OAAI

Towell, Aisling M.; Feuillie, Cecile; Vitry, Pauline; Costa, Thaina M.; Mathelie-Guinlet, Marion; Kezic, Sanja; Fleury, Orla M.; McAleer, Maeve A.; Dufrene, Yves F.; Irvine, Alan D.; Geoghegan, Joan A.

Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation Tmem79突变小鼠皮肤屏障功能失调促进IL-17A-dependent自发性皮肤和肺部炎症

ALLERGY

IF12

2020-07-22

OAAI

Saunders, Sean P.; Floudas, Achilleas; Moran, Tara; Byrne, Ciara M.; Rooney, Michael D.; Fahy, Caoimhe M. R.; Geoghegan, Joan A.; Iwakura, Yoichiro; Fallon, Padraic G.; Schwartz, Christian

Editorial overview: Bacterial regulatory hierarchies and networks

CURRENT OPINION IN MICROBIOLOGY

IF7.5

2020-06-01

PREAI

Dorman, Charles J.; Geoghegan, Joan

Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin

NATURE COMMUNICATIONS

IF15.7

2020-01-09

OAAI

Olatunji, Samir; Yu, Xiaoxiao; Bailey, Jonathan; Huang, Chia-Ying; Zapotoczna, Marta; Bowen, Katherine; Remskar, Maja; Mueller, Rolf; Scanlan, Eoin M.; Geoghegan, Joan A.; Olieric, Vincent; Caffrey, Martin

Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion

PLOS PATHOGENS

IF4.9

2019-06-19

OAAI

Pickering, Amy C.; Vitry, Pauline; Prystopiuk, Valeriia; Garcia, Brandon; Hook, Magnus; Schoenebeck, Jeffrey; Geoghegan, Joan A.; Dufrene, Yves F.; Fitzgerald, J. Ross

Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target

PLOS PATHOGENS

IF4.9

2019-04-22

OAAI

Lacey, Keenan A.; Mulcahy, Michelle E.; Towell, Aisling M.; Geoghegan, Joan A.; McLoughlin, Rachel M.

研究方向